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Microbial DNA and Host Immunity - - Bog - Humana Press Inc. - Plusbog.dk

Microbial DNA and Host Immunity - - Bog - Humana Press Inc. - Plusbog.dk

Leading researchers review the activation of the mammalian immune system by bacterial DNA and its immunostimulatory sequences (ISS), and consider the applications of ISS in clinical medicine. The authors survey the latest findings concerning the receptor-recognition and signaling pathways triggered by ISS , the process of cell activation, and the potential vaccination strategies using ISS. Specific pharmaceutical applications discussed include infectious disease (Hepatitis B, HIV, and mycobacterial infections), allergy (asthma and conjunctivitis), cancer (lymphoma), and inflammation and autoimmunity (arthritis and colitis).

DKK 816.00
1

Mitochondrial DNA, Mitochondria, Disease and Stem Cells - - Bog - Humana Press Inc. - Plusbog.dk

Mitochondrial DNA, Mitochondria, Disease and Stem Cells - - Bog - Humana Press Inc. - Plusbog.dk

This volume investigates how the mitochondrial genome is transmitted, segregated, and inherited. It starts by describing mtDNA mutations and deletions and how these impact on the offspring''s well-being. It progresses to discuss how mutations to the mtDNA-nuclear-encoded transcription, replication and translational factors lead to mtDNA-depletion syndromes and how these affect cellular function and lead to the pathology of human mitochondrial disease. It also highlights the importance of the mitochondrial assembly factors and how mutations to these can lead to mitochondrial disease. The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process. It then discusses how diseases like cancer are initiated and regulated by mutations to mitochondrial DNA and dysfunctional mitochondria. Finally, it draws on assisted reproductive technologies to discuss how some of these approaches might be adapted to prevent the transmission of mutant and deleted mtDNA from one generation to the next.

DKK 877.00
1

New Antibiotic Targets - - Bog - Humana Press Inc. - Plusbog.dk

New Antibiotic Targets - - Bog - Humana Press Inc. - Plusbog.dk

This book examines specific techniques which can be used to explore new drug targets and the effectiveness of new antibiotics. By testing new antimicrobial agents and modified existing drugs, the most vulnerable cell processes, such as cell wall and membrane synthesis, DNA replication, RNA transcription and protein synthesis, can be better exploited. This in-depth volume, however, delves even deeper by identifying additional novel cellular targets for these new therapies. The book will provide laboratory investigators with the vital tools they need to test the antimicrobial potential of products and to curb the rise of so many infectious diseases.

DKK 948.00
1

Platinum-Based Drugs in Cancer Therapy - - Bog - Humana Press Inc. - Plusbog.dk

Platinum-Based Drugs in Cancer Therapy - - Bog - Humana Press Inc. - Plusbog.dk

Leading international experts comprehensively review all aspects of platinum anticancer drugs and their current use in treatment, as well as examining their future therapeutic prospects. Writing from a variety of disciplines, these authorities discuss the chemistry of cisplatin in aqueous solution, the molecular interaction of platinum drugs with DNA, and such exciting new areas as DNA mismatch repair and replicative bypass, apoptosis, and the transport of platinum drugs into tumor cells. The emergent platinum drugs of the future-orally active agents, the sterically hindered ZD0473, and the polynuclear charged platinum BBR3464-are also fully considered. Timely and interdisciplinary, Platinum-Based Drugs in Cancer Therapy offers cancer therapeutics specialists an illuminating survey of every aspect of platinum drugs from mechanisms of action to toxicology, tumor resistance, and new analogs.

DKK 901.00
1

Haemophilus influenzae Protocols - - Bog - Humana Press Inc. - Plusbog.dk

Haemophilus influenzae Protocols - - Bog - Humana Press Inc. - Plusbog.dk

In HaemophilusiInfluenzae Protocols, leading research scientists and infectious disease specialists detail in a readily reproducible format the major molecular and immunological techniques for exploring the pathogenicity of H. influenzae. Described with step-by-instructions to ensure robust and successful experimental results, the techniques cover plasmid analysis, proteomics, genomics, DNA array technology, gene expression, mutagenesis (transposon and nontransposon), and structural analysis. These methods illuminate how the bacterium causes disease, as well as how best to develop novel vaccines and antibiotics against the organism.

DKK 816.00
1

On-Site Drug Testing - - Bog - Humana Press Inc. - Plusbog.dk

On-Site Drug Testing - - Bog - Humana Press Inc. - Plusbog.dk

It is at least a decade since scientists turned their imaginations to creating new compact, portable test instruments and self-contained test kits that could be used to analyze urine and saliva for alcohol, drugs, and their metabolites. Although the potential applications for such tests at the site of specimen collection, now called "on-site" or "point-of-care" testing, range far beyond hospital emergency rooms and law enforcement needs, it was catalyzed by the requirements of workplace drug testing and other drugs-of-abuse testing programs. These programs are now a minor national industry in the United States and in some western European countries, and cover populations as diverse as the military, incarcerated criminals, people suspected of driving under the influence of alcohol and other drugs, all athletes from college to professional ranks, and of course the general employed population, which is monitored for illegal drug use and numbers in the millions. It is not surprising, then, that the need for rapid and precise tests, conducted economically by trained professionals, has become a major goal. Current government approved and peer reviewed laboratory methods for urine analysis serve present needs very well and have become remarkably robust over the past twenty years, but the logistics of testing some moving populations, such as the military, the Coast Guard, workers on off-shore oil platforms, and athletes-perhaps the most mobile of these groups-are unacceptably cumbersome.

DKK 986.00
1

Mitochondrial Function in Lung Health and Disease - - Bog - Humana Press Inc. - Plusbog.dk

Mitochondrial Function in Lung Health and Disease - - Bog - Humana Press Inc. - Plusbog.dk

Chapter 1 Role of Mitochondrial Reactive Oxygen and Nitrogen Species in Respiratory Diseases Harijith Anantha, Prasad Kanteti, Panfeng Fu, Sainath R. Kotha, Narasimham L. Parinandi, and Viswanathan Natarajan Chapter 2Regulation of Mitochondrial Functions by Transcription Factor NRF2 Narsa Machireddy, Wajiha Qureshi, Haranath Potteti, Dhananjaya V. Kalvakolanu, and Sekhar P. Reddy Chapter 3 Mitochondrion: A Missing Link in Asthma Pathogenesis Ulaganathan Mabalirajan, Anurag Agrawal, and Balaram Ghosh Chapter 4 ROS Signaling in Cardiovascular Dysfunction Associated with Obstructive Sleep Apnea Ganesh K. Kumar, Gayatri Raghuraman, and Nanduri R. Prabhakar Chapter 5 Mitochondrial Excitation-Energy Coupling in Airway Smooth Muscle Niccole Schaible, Philippe Delmotte, and Gary C. Sieck Chapter 6 Mitochondrial Lipid Peroxidation in Lung Damage and Disease Sainath R. Kotha, Travis O. Gurney, Miles U. Magalang, Thomas J. Hund, Abhay R. Satoskar, Peter J. Mohler, Krishna Rao Maddipati, Viswanathan Natarajan, and Narasimham L. Parinandi Chapter 7 The Impact of DNA Damage on Epithelial Cell Maintenance of the Lung Lidza Kalifa and Michael A. O''Reilly Chapter 8 Mitochondrial Function in Lung Health and Disease Luis Puente-Maestu and Jorge Chancafe-Morgan Chapter 9Age-Specific Difference in Pulmonary Cellular Injury and Mitochondrial DamageKatherine L. Tuggle and Michelle V. Fanucchi

DKK 943.00
1

Pediatric Hematology - - Bog - Humana Press Inc. - Plusbog.dk

Pediatric Hematology - - Bog - Humana Press Inc. - Plusbog.dk

Much of the progress in the diagnosis, classification, and treatment of childhood hematological disorders has come from a partnership between clinicians and scientists. Indeed, access to molecular techniques is now an integral part of the practice of modern pediatric hematology. The aim of Pediatric Hematology: Methods and Protocols is to provide a collection of scientific protocols that cover the major aspects of the discipline. Most clinicians will be familiar with the difficulties inherent in establishing the underlying diagnosis in genetic marrow failure syndromes. A particular concern is failure to diagnose those associated with DNA repair defects. In Chapter 1, Dokal and colleagues present simple protocols for the molecular investigation of Fanconi anemia and dyskeratosis congenita. Molecular diagnosis is also important in children with congenital pure red cell aplasia, owing to the highly variable phenotype of this condition. In Chapter 2, Ball describes relevant protocols for the investigation of Diamond-Blackfan anemia. Hereditary hemoglobinopathy is a major cause of death and morbidity throughout the world. This area has seen great advances in screening and antenatal diagnosis. In Chapter 3, Old details protocols for the molecular diagnosis of most forms of hemoglobinopathy. High-quality, accurate molecular testing on small amounts of material has been fundamental to progress in antenatal diagnostics. The introduction to his comprehensive chapter includes a discussion of the general principles that underpin these studies. In contrast to hemoglobinopathy, severe hemophilia is uncommon.

DKK 816.00
1

Pediatric Hematology - - Bog - Humana Press Inc. - Plusbog.dk

Pediatric Hematology - - Bog - Humana Press Inc. - Plusbog.dk

Much of the progress in the diagnosis, classification, and treatment of childhood hematological disorders has come from a partnership between clinicians and scientists. Indeed, access to molecular techniques is now an integral part of the practice of modern pediatric hematology. The aim of Pediatric Hematology: Methods and Protocols is to provide a collection of scientific protocols that cover the major aspects of the discipline. Most clinicians will be familiar with the difficulties inherent in establishing the underlying diagnosis in genetic marrow failure syndromes. A particular concern is failure to diagnose those associated with DNA repair defects. In Chapter 1, Dokal and colleagues present simple protocols for the molecular investigation of Fanconi anemia and dyskeratosis congenita. Molecular diagnosis is also important in children with congenital pure red cell aplasia, owing to the highly variable phenotype of this condition. In Chapter 2, Ball describes relevant protocols for the investigation of Diamond-Blackfan anemia. Hereditary hemoglobinopathy is a major cause of death and morbidity throughout the world. This area has seen great advances in screening and antenatal diagnosis. In Chapter 3, Old details protocols for the molecular diagnosis of most forms of hemoglobinopathy. High-quality, accurate molecular testing on small amounts of material has been fundamental to progress in antenatal diagnostics. The introduction to his comprehensive chapter includes a discussion of the general principles that underpin these studies. In contrast to hemoglobinopathy, severe hemophilia is uncommon.

DKK 816.00
1

Pancreatic Cancer - - Bog - Humana Press Inc. - Plusbog.dk

Pancreatic Cancer - - Bog - Humana Press Inc. - Plusbog.dk

Pancreatic ductal adenocarcinoma is the fourth leading cause of cancer death in the United States. Annually approximately 30,000 Americans are diagnosed with the disease and most will die from it within five years. P- creatic ductal adenocarcinoma is unique because of its late onset in age, high mortality, small tumor samples infiltrated with normal cells, and a lack of both early detection and effective therapies. Some of these characteristics have made studying this disease a challenge. Pancreatic cancer develops as a result of the accumulation of genetic alterations in cancer-causing genes, such as the oncogenes and the tumor-s- pressor genes. In the last decade, major progress has been made in identifying important oncogenes and tumor-suppressor genes for the disease. In Panc- atic Cancer: Methods and Protocols, we review the classical techniques that have contributed to the advances in pancreatic research and introduce new strategies that we hope will add to future breakthroughs in the field of cancer biology. Pancreatic Cancer: Methods and Protocols provides a broad range of protocols for molecular, cellular, pathological, and statistical analyses of s- radic and familial pancreatic cancer. It covers topics from in vitro cell c- tures to in vivo mouse models, DNA to protein manipulation, and mutation analyses to treatment development. We believe that our book will prove an invaluable source of proven protocols for those who are interested in either basic or translational research in pancreatic cancer.

DKK 901.00
1

Epstein Barr Virus - - Bog - Humana Press Inc. - Plusbog.dk

Epstein Barr Virus - - Bog - Humana Press Inc. - Plusbog.dk

This volume explores data from the applications of molecular biological methods and the applications of recent immunological and cytogenetic methods in Epstein-Barr Virus (EBV) that will offer readers possible new solutions to the unresolved problems in the EBV field. Chapters in this book cover topics such as: viral life cycle, latency, EBV-associated diseases and EBV diagnostics; in vitro methods including organotypic cultures for the analysis of EBV-epithelial cell interactions; identification of the interacting viral and cellular proteins using affinity purification-mass spectrometry methods; 3D telomere FISH; transcription analysis using high-throughput RNA sequencing, qPCR and nuclear run-on assay; analysis of viral and cellular microRNAs; isolation and characterization of exosomes and the assessment of their function; characterization of the viral genome by terminal repeat analysis and sequencing; the use of chromatin immunoprecipitation coupled sequencing (ChIP-Seq) for the analysis of Zta-DNA interactions; epigenetic analysis by bisulfite sequencing and ChIP; novel in vivo models for the study of EBV infection; and how immunological, virological, tissue culture and molecular methods can be combined to yield Good Manufacturing Practice-compliant EBV-specific T cells for the immunotherapy of EBV-associated post-transplant lymphoproliferative diseases (PTLD). Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and comprehensive, Epstein Barr-Virus: Methods and Protocols is a valuable resource for anyone who is interested in this fascinating and evolving field.

DKK 773.00
1

Thyroid Disease - Emanuel O. Brams - Bog - Humana Press Inc. - Plusbog.dk

Thyroid Disease - Emanuel O. Brams - Bog - Humana Press Inc. - Plusbog.dk

Thyroid Disease: A Case-Based and Practical Guide for Primary Care, by Dr. Emanuel Brams, is a supremely readable cased-based approach to understanding the myriad of disorders that encompass thyroid disease. Using cases derived from his busy practice, Dr. Brams gives us the history and physical examination details of each case, along with test results. Then, through a series of questions similar to that which any good clinician asks while caring for a patient, Dr. Brams explains an optimal approach to diagnosis, treatment, and follow-up of thyroid disease, with an emphasis on the practical and common issues that primary care physicians see in their offices. This is an important book for primary care physicians because thyroid disease is common in the population we take care of and accounts for 3–5% of primary care visits. It is often cited as an area that primary care phy- cians find confusing. Dr. Brams clarifies thyroid disease and, through his generous sharing of cases, allows us to join him in making clear diagnoses as well as share in the ambiguity and decisions about approach when the diagnoses and course of treatment are not clear. In this way, the book is honest, and deals directly with the issues of thyroid disease as they are seen by us as physicians, not as we sometimes may wish they were seen if patients presented with the clarity of walking textbooks. Dr.

DKK 948.00
1

Thyroid Disease - Emanuel O. Brams - Bog - Humana Press Inc. - Plusbog.dk

Thyroid Disease - Emanuel O. Brams - Bog - Humana Press Inc. - Plusbog.dk

Thyroid Disease: A Case-Based and Practical Guide for Primary Care, by Dr. Emanuel Brams, is a supremely readable cased-based approach to understanding the myriad of disorders that encompass thyroid disease. Using cases derived from his busy practice, Dr. Brams gives us the history and physical examination details of each case, along with test results. Then, through a series of questions similar to that which any good clinician asks while caring for a patient, Dr. Brams explains an optimal approach to diagnosis, treatment, and follow-up of thyroid disease, with an emphasis on the practical and common issues that primary care physicians see in their offices. This is an important book for primary care physicians because thyroid disease is common in the population we take care of and accounts for 3-5% of primary care visits. It is often cited as an area that primary care phy- cians find confusing. Dr. Brams clarifies thyroid disease and, through his generous sharing of cases, allows us to join him in making clear diagnoses as well as share in the ambiguity and decisions about approach when the diagnoses and course of treatment are not clear. In this way, the book is honest, and deals directly with the issues of thyroid disease as they are seen by us as physicians, not as we sometimes may wish they were seen if patients presented with the clarity of walking textbooks. Dr.

DKK 816.00
1

The Practice of Electrocardiography - Thomas M. Blake - Bog - Humana Press Inc. - Plusbog.dk

The Practice of Electrocardiography - Thomas M. Blake - Bog - Humana Press Inc. - Plusbog.dk

Electrocardiography is a mature discipline, so familiar to both doctors and patients that it''s hardly noticed, one of those tests that have always been there, like the white count and hemoglobin, not something one has to think about much, or question. To some extent this view is valid, but it overlooks some important points. Like the white count and hemoglobin, electrocardiograms are produced by technicians using mechanical devices that turn out numbers, but there is a difference. The white count and hemoglobin are reported as single values to be interpreted by the doctor who knows the patient and ordered the test, but the graph produced by an EKG machine represents millions of numbers displayed as XY plots, a message written in a language different from one''s own. It requires transla­ tion, and this means that the translator must not only know the lan­ guage, but also be able to assess the effects on it of the many factors that may have modified its meaning between origin and delivery. There is potential for harm to the patient, as well as for help, in every facet of the process, and to lose sight of this, to see the tracing as a single whole, would be like seeing words as units without con­ sidering the letters that compose them. When we read, we do recog­ nize whole words, patterns, but, having learned the letters first, revert to this base intuitively when we encounter a new word, or one that is misspelled.

DKK 816.00
1

The Practice of Electrocardiography - Thomas M. Blake - Bog - Humana Press Inc. - Plusbog.dk

The Practice of Electrocardiography - Thomas M. Blake - Bog - Humana Press Inc. - Plusbog.dk

Electrocardiography is a mature discipline, so familiar to both doctors and patients that it''s hardly noticed, one of those tests that have always been there, like the white count and hemoglobin, not something one has to think about much, or question. To some extent this view is valid, but it overlooks some important points. Like the white count and hemoglobin, electrocardiograms are produced by technicians using mechanical devices that turn out numbers, but there is a difference. The white count and hemoglobin are reported as single values to be interpreted by the doctor who knows the patient and ordered the test, but the graph produced by an EKG machine represents millions of numbers displayed as XY plots, a message written in a language different from one''s own. It requires transla­ tion, and this means that the translator must not only know the lan­ guage, but also be able to assess the effects on it of the many factors that may have modified its meaning between origin and delivery. There is potential for harm to the patient, as well as for help, in every facet of the process, and to lose sight of this, to see the tracing as a single whole, would be like seeing words as units without con­ sidering the letters that compose them. When we read, we do recog­ nize whole words, patterns, but, having learned the letters first, revert to this base intuitively when we encounter a new word, or one that is misspelled.

DKK 434.00
1