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Protein Bioinformatics - Inge Jonassen - Bog - John Wiley & Sons Inc - Plusbog.dk

Protein Bioinformatics - Inge Jonassen - Bog - John Wiley & Sons Inc - Plusbog.dk

Genomics and bioinformatics play an increasingly important and transformative role in medicine, society and agriculture. The mapping of the human genome has revealed 35,000 or so genes which might code for more than one protein, resulting in 100,000 proteins for the humans alone. Since proteins are attractive targets for developing drugs, efforts are now underway to map sequences and assign functions to many novel proteins. This book takes the novel approach to cover both the sequence and structure analysis of proteins in one volume and from an algorithmic perspective. Key features of the book include: - - Provides a comprehensive introduction to the analysis of protein sequence and structure analysis. - - Takes an algorithmic approach, relying on computational methods rather than theoretical. - - Provides an integrated presentation of theory, examples, exercises and applications. - - Includes coverage of both protein structure, and sequence, analysis. - - Accessible enough for biologists, yet rigorous enough for computer scientists and mathematicians. - - Supported by a Web site featuring exercises, solutions, images, and computer programs. - Visit this website for exercises with solutions, computer programs, errata and additional material: http://www.ii.uib.no/proteinbioinformatics/

DKK 886.00
1

Bioinformatics - Francois Kepes - Bog - John Wiley & Sons Inc - Plusbog.dk

Bioinformatics - Francois Kepes - Bog - John Wiley & Sons Inc - Plusbog.dk

This book is an excellent introductory text describing the use of bioinformatics to analyze genomic and post-genomic data. It has been translated from the original popular French edition, which was based on a course taught at the well-respected École Polytechnique in Palaiseau. This edition has been fully revised and updated by the authors. After a brief introduction to gene structure and sequence determination, it describes the techniques used to identify genes, their protein-coding sequences and regulatory regions. The book discusses the methodology of comparative genomics, using information from different organisms to deduce information about unknown sequences. There is a comprehensive chapter on structure prediction, covering both RNA and protein. Finally, the book describes the complex networks of RNA and protein that exist within the cell and their interactions, ending with a discussion of the simulation approaches that can be used to model these networks. Praise from the reviews: “In context of the new developments the genomic era has brought, Bioinformatics: Genomics and Post-Genomics becomes a fundamental and indispensable resource for undergraduate and early graduate students…insightfully authored…will immensely help students…in establishing important foundations while shaping their careers.” NEWSLETTER, BRITISH SOCIETY OF CELL BIOLOGY

DKK 760.00
1

Hydrogen Exchange Mass Spectrometry of Proteins - - Bog - John Wiley & Sons Inc - Plusbog.dk

Hydrogen Exchange Mass Spectrometry of Proteins - - Bog - John Wiley & Sons Inc - Plusbog.dk

Hydrogen exchange mass spectrometry is widely recognized for its ability to probe the structure and dynamics of proteins. The application of this technique is becoming widespread due to its versatility for providing structural information about challenging biological macromolecules such as antibodies, flexible proteins and glycoproteins. Although the technique has been around for 25 years, this is the first definitive book devoted entirely to the topic. Hydrogen Exchange Mass Spectrometry of Proteins : Fundamentals, Methods and Applications brings into one comprehensive volume the theory, instrumentation and applications of Hydrogen Exchange Mass Spectrometry (HX-MS) - a technique relevant to bioanalytical chemistry, protein science and pharmaceuticals. The book provides a solid foundation in the basics of the technique and data interpretation to inform readers of current research in the method, and provides illustrative examples of its use in bio- and pharmaceutical chemistry and biophysics In-depth chapters on the fundamental theory of hydrogen exchange, and tutorial chapters on measurement and data analysis provide the essential background for those ready to adopt HX-MS. Expert users may advance their current understanding through chapters on methods including membrane protein analysis, alternative proteases, millisecond hydrogen exchange, top-down mass spectrometry, histidine exchange and method validation. All readers can explore the diversity of HX-MS applications in areas such as ligand binding, membrane proteins, drug discovery, therapeutic protein formulation, biocomparability, and intrinsically disordered proteins.

DKK 862.00
1

Why Didn't I Think of That? - Bob Golden - Bog - John Wiley & Sons Inc - Plusbog.dk

Why Didn't I Think of That? - Bob Golden - Bog - John Wiley & Sons Inc - Plusbog.dk

Ben & Jerry originally wanted to start a bagel business, but they couldn''t afford the bagel-making machine? * The Slinky(r) toy was born aboard a World War II battleship? * Band-Aids(r) were invented by a husband to help his accident-prone wife dress her own cuts and bruises at home? * The idea for Velcro(r) came from cockleburs that got stuck on an engineer''s wool trousers and in his dog''s fur? Ever wonder how anyone came up with the idea for a product you couldn''t imagine living without? Familiar products like Velcro(r) ,disposable diapers, Post-It Notes(r) ,and coffee filters. Read this book and you''ll discover - once more - that truth is indeed often stranger than fiction. You''ll also see that coming up with a million-dollar idea isn''t as difficult as you think. This collection of entrepreneurs ranges from housewives to PhDs. Filled with wacky and fascinating facts, awe-inspiring success statistics, and rags-to-riches stories, Why Didn''t I Think of That? chronicles the odd origins behind 50 famous inventions and reveals the business side of each product''s actual production, marketing, and distribution. You''ll discover how inventors from all walks of life struck it rich with unlikely contraptions that range from the practical (like Tampax(r) and Tupperware(r) ) to the curiously inane (like the Barbie(r) doll and Silly Putty(r) ). Inspirational, detailed, and always quirky, this delightful book captures all of the drama and colorful history of products like Heinz(r) ketchup, The Club(r) , Jell-O(r) ,Hallmark(r) cards, Trojan(r) condoms, Vaseline(r) , Rollerblades(r) , Kitty Litter(r) , the Swiss Army(r) Knife, Bic(r) pens, Dirt Devil(r) , Pampers(r) , S.O.S(r) pads, and many more.

DKK 219.00
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Main Street Festivals - Amanda B. West - Bog - John Wiley & Sons Inc - Plusbog.dk

Main Street Festivals - Amanda B. West - Bog - John Wiley & Sons Inc - Plusbog.dk

Main Street America is kicking up its heels--and you''re invited tothe party! Goodbye sprawl-and-mall--hello downtown! Long-neglected towncenters are coming to life once again, and the buzz is back on mainstreets all across the country. Come celebrate their rebirth withthis one-of-a-kind guide to over 700 local festivals and eventsnationwide. From the weird and wacky to the wild and wonderful, thefun starts with Main Street Festivals. Which will you dofirst? Enter a rubber duck race . . . Join a "walk of art" scavenger hunt. . . Find hot-rod heaven . . . Play cow patty bingo . . . See antiques and heirloom displays . . . Discover "bullistic" bull riding . . . Go to a hog slopping contest. . . Eat black dirt cake . . . Hear blues, bluegrass, and brass bands .. . Watch a Little Miss National Peanut Pageant . . . Inside you''ll also learn where to find: an onion rodeo, cornstalkshooting, a beautiful baby bagel contest, arts and craftsdemonstrations, the perfect-pierogie cookoff, a slugburger fest,quilting exhibitions, farmer olympics, and more. . . . There''ssomething for everyone in Main Street Festivals.

DKK 273.00
1

Crystals and Crystal Structures - Richard J. D. Tilley - Bog - John Wiley & Sons Inc - Plusbog.dk

Crystals and Crystal Structures - Richard J. D. Tilley - Bog - John Wiley & Sons Inc - Plusbog.dk

An authoritative, updated text that offers an introduction to crystals and crystal structure with coverage of crystallography, and microscopy of materials Written in a friendly, non-mathematical style, the updated second edition of Crystals and Crystal Structures offers a comprehensive exploration of the key elements of crystals and crystal structures. Starting with the basics, it includes information on multiple areas of crystallography, including modulated structures, quasicrystals and protein crystallography, and interdisciplinary applications as diverse as the relationship between physical properties and symmetry. To enhance comprehension of the material presented, the book contains a variety of problems and exercises. The revised second edition offers new material and updates in the field including: An introduction to the use of high intensity X-ray analysis of protein structuresAdvances in imaging, scanning electron microscopy, and cryo-electron microscopyThe relationship between symmetry and physical properties highlighting new findings and an introduction to tensor notation in describing these relationships in a concise fashionNanoparticles as well as crystallographic aspects, defects, surface defects and the impact of these crystallographic features on propertiesPerovskite structures and their variations and the inclusion of their wide-ranging properties Written for students ofcrystallography, chemistry, physics, materials science, biosciences and geology, Crystals and Crystal Structures, Second Edition provides an understanding of the subject and enables students to read scientific papers and articles describing a crystal structure or use crystallographic databases.

DKK 697.00
1

Reversible Ligand Binding - Jannette Carey - Bog - John Wiley & Sons Inc - Plusbog.dk

Reversible Ligand Binding - Jannette Carey - Bog - John Wiley & Sons Inc - Plusbog.dk

Presents the physical background of ligand binding and instructs on how experiments should be designed and analyzed Reversible Ligand Binding: Theory and Experiment discusses the physical background of protein-ligand interactions—providing a comprehensive view of the various biochemical considerations that govern reversible, as well as irreversible, ligand binding. Special consideration is devoted to enzymology, a field usually treated separately from ligand binding, but actually governed by identical thermodynamic relationships. Attention is given to the design of the experiment, which aids in showing clear evidence of biochemical features that may otherwise escape notice. Classical experiments are reviewed in order to further highlight the importance of the design of the experiment. Overall, the book supplies students with the understanding that is necessary for interpreting ligand binding experiments, formulating plausible reaction schemes, and analyzing the data according to the chosen model(s). Topics covered include: theory of ligand binding to monomeric proteins; practical considerations and commonly encountered problems; oligomeric proteins with multiple binding sites; ligand binding kinetics; hemoglobin and its ligands; single-substrate enzymes and their inhibitors; two-substrate enzymes and their inhibitors; and rapid kinetic methods for studying enzyme reactions. Bridges theory of ligand binding and allostery with experimentsApplies historical and physical insight to provide a clear understanding of ligand bindingWritten by a renowned author with long-standing research and teaching expertise in the area of ligand binding and allosteryBased on FEBS Advanced Course lectures on the topic Reversible Ligand Binding: Theory and Experiment is an ideal text reference for students and scientists involved in biophysical chemistry, physical biochemistry, biophysics, molecular biology, protein engineering, drug design, pharmacology, physiology, biotechnology, and bioengineering.

DKK 865.00
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Evolving Health - Noel T. Boaz - Bog - John Wiley & Sons Inc - Plusbog.dk

Evolving Health - Noel T. Boaz - Bog - John Wiley & Sons Inc - Plusbog.dk

Human illnesses can be understood as damage to those adaptations that we took on at various stages in our evolution from pre-life molecules to modern Homo sapiens. Preventing these illnesses entails avoiding what causes the damage — which too frequently are the everyday hazards of twenty-first-century life, as the chart below shows: Level of Evolution / Cause of adaptive failure / resulting disease or problem Pre-life / Environmental poisons / Certain birth defects Single cell (bacteria and amoeba-like) / Viral infection / Colds/flu/HIV Morula (sponge-like) / Cellular stress / Cancer Chordate / Physical stress / Back pain Fish / Excess dietary salt / Hypertension/heart disease Amphibian / Tobacco smoke / Lung cancer/emphysema Lower primate / Excess dietary sugar / Diabetes mellitus Higher primate / Vitamin C deficiency / Scurvy Ape / Excess dietary protein / Gout Homo sapiens / Reduced dietary variety / Nutritionaldiseases/food allergies

DKK 268.00
1

Computational Molecular Biology - Rolf Backofen - Bog - John Wiley & Sons Inc - Plusbog.dk

Computational Molecular Biology - Rolf Backofen - Bog - John Wiley & Sons Inc - Plusbog.dk

Recently molecular biology has undergone unprecedented development generating vast quantities of data needing sophisticated computational methods for analysis, processing and archiving. This requirement has given birth to the truly interdisciplinary field of computational biology, or bioinformatics, a subject reliant on both theoretical and practical contributions from statistics, mathematics, computer science and biology. * Provides the background mathematics required to understand why certain algorithms work * Guides the reader through probability theory, entropy and combinatorial optimization * In-depth coverage of molecular biology and protein structure prediction * Includes several less familiar algorithms such as DNA segmentation, quartet puzzling and DNA strand separation prediction * Includes class tested exercises useful for self-study * Source code of programs available on a Web site Primarily aimed at advanced undergraduate and graduate students from bioinformatics, computer science, statistics, mathematics and the biological sciences, this text will also interest researchers from these fields.

DKK 990.00
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The Healthy Body Cookbook - Joan D'amico - Bog - John Wiley & Sons Inc - Plusbog.dk

The Healthy Body Cookbook - Joan D'amico - Bog - John Wiley & Sons Inc - Plusbog.dk

Learning about health and science has never been so fun --anddelicious! What does a heartbeat sound like? How strong is my hair? Why do myeyes blink? What''s in a sports drink? With more than 50 safe andeasy recipes and activities to try, you''ll discover the nutritiousanswers to these and tons of other scrumptious mysteries. And bestof all, you get to eat the results when you''re finished! You''llmake carbohydrate-packed Blueberry Power-Snack Turnovers,protein-boosting Crunchy Chicken Fingers, calcium-rich Creamy,Dreamy Yogurt Orange-Banana Frozen Pops, and much more. The Healthy Body Cookbook is a delightfully clever smorgasbord ofhands-on lessons about the crucial role that diet and exercise playin the development of heart, blood, bones, muscles, skin, teeth,and the nervous and digestive systems. All activities arekid-tested and require only common ingredients and kitchenutensils. There''s also a helpful list of safety rules, anexplanation of tools and skills, and nutritional values for eachrecipe.

DKK 143.00
1

Biophysics - Rodney Cotterill - Bog - John Wiley & Sons Inc - Plusbog.dk

Biophysics - Rodney Cotterill - Bog - John Wiley & Sons Inc - Plusbog.dk

Biophysics is an evolving, multidisciplinary subject which applies physics to biological systems and promotes an understanding of their physical properties and behaviour. Biophysics: An Introductio n, is a concise balanced introduction to this subject. Written in an accessible and readable style, the book takes a fresh, modern approach with the author successfully combining key concepts and theory with relevant applications and examples drawn from the field as a whole. Beginning with a brief introduction to the origins of biophysics, the book takes the reader through successive levels of complexity, from atoms to molecules, structures, systems and ultimately to the behaviour of organisms. The book also includes extensive coverage of biopolymers, biomembranes, biological energy, and nervous systems. The text not only explores basic ideas, but also discusses recent developments, such as protein folding, DNA/RNA conformations, molecular motors, optical tweezers and the biological origins of consciousness and intelligence. Biophysics: An Introduction * Is a carefully structured introduction to biological and medical physics * Provides exercises at the end of each chapter to encourage student understanding Assuming little biological or medical knowledge, this book is invaluable to undergraduate students in physics, biophysics and medical physics. The book is also useful for graduate students and researchers looking for a broad introduction to the subject.

DKK 691.00
1

Bioinformatics Biocomputing and Perl - Paul Barry - Bog - John Wiley & Sons Inc - Plusbog.dk

Bioinformatics Biocomputing and Perl - Paul Barry - Bog - John Wiley & Sons Inc - Plusbog.dk

Bioinformatics, Biocomputing and Perl presents a modern introduction to bioinformatics computing skills and practice. Structuring its presentation around four main areas of study, this book covers the skills vital to the day-to-day activities of today’s bioinformatician. Each chapter contains a series of maxims designed to highlight key points and there are exercises to supplement and cement the introduced material. Working with Perl presents an extended tutorial introduction to programming through Perl, the premier programming technology of the bioinformatics community. Even though no previous programming experience is assumed, completing the tutorial equips the reader with the ability to produce powerful custom programs with ease. Working with Data applies the programming skills acquired to processing a variety of bioinformatics data. In addition to advice on working with important data stores such as the Protein DataBank, SWISS-PROT, EMBL and the GenBank, considerable discussion is devoted to using bioinformatics data to populate relational database systems. The popular MySQL database is used in all examples. Working with the Web presents a discussion of the Web-based technologies that allow the bioinformatics researcher to publish both data and applications on the Internet. Working with Applications shifts gear from creating custom programs to using them. The tools described include Clustal-W, EMBOSS, STRIDE, BLAST and Xmgrace. An introduction to the important Bioperl Project concludes this chapter and rounds off the book.

DKK 968.00
1