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Exploring and Exploiting Genetic Risk for Psychiatric Disorders - - Bog - MIT Press Ltd - Plusbog.dk

Exploring and Exploiting Genetic Risk for Psychiatric Disorders - - Bog - MIT Press Ltd - Plusbog.dk

An edited volume that looks at the state of psychiatric genetics and how to chart a path forward. In this edited collection, experts from psychiatric and statistical genetics, neurobiology, and clinical psychiatry investigate whether and how to pursue the discovery of additional genetic risk factors for mental illnesses. Using the existing knowledge and frameworks of genetic risk factors, they look at how a better understanding of the biology that underlies mental illnesses can improve and enhance the care that patients receive.

DKK 445.00
1

Evolutionary Programming IV - - Bog - MIT Press Ltd - Plusbog.dk

Evolutionary Programming IV - - Bog - MIT Press Ltd - Plusbog.dk

March 1-3, 1995, San Diego, California Evolutionary programming is one of the predominate algorithms withing the rapidly expanding field of evolutionary computation. These edited contributions to the Fourth Annual Conference on Evolutionary Programming are by leading scientists from academia, industry, and defense. The papers describe both the theory and practical application of evolutionary programming, as well as other methods of evolutionary computation including evolution strategies, genetic algorithms, genetic programming, and cultural algorithms. Topics include :- Novel Areas of Evolutionary Programming and Evolution Strategies.- Evolutionary Computation with Medical Applications.- Issues in Evolutionary Optimization Pattern Discovery, Pattern Recognition, and System Identification.- Hierarchical Levels of Learning.- Self-Adaptation in Evolutionary Computation.- Morphogenic Evolutionary Computation.- Issues in Evolutionary Optimization.- Evolutionary Applications to VLSI and Part Placement.- Applications of Evolutionary Computation to Biology and Biochemistry Control.- Applications of Evolutionary Computation.- Genetic and Inductive Logic Programming.- Genetic Neural Networks.- The Future of Evolutionary Computation. A Bradford Book. Complex Adaptive Systems series

DKK 168.00
1

A Woman's Right to Know - Jesse Olszynko Gryn - Bog - MIT Press Ltd - Plusbog.dk

A Woman's Right to Know - Jesse Olszynko Gryn - Bog - MIT Press Ltd - Plusbog.dk

The history of pregnancy testing, and how it transformed from an esoteric laboratory tool to a commonplace of everyday life. Pregnancy testing has never been easier. Waiting on one side or the other of the bathroom door for a “positive” or “negative” result has become a modern ritual and rite of passage. Today, the ubiquitous home pregnancy test is implicated in personal decisions and public debates about all aspects of reproduction, from miscarriage and abortion to the “biological clock” and IVF. Yet, only three generations ago, women typically waited not minutes but months to find out whether they were pregnant. A Woman’s Right to Know tells, for the first time, the story of pregnancy testing—one of the most significant and least studied technologies of reproduction.Focusing on Britain from around 1900 to the present day, Jesse Olszynko-Gryn shows how demand shifted from doctors to women, and then goes further to explain the remarkable transformation of pregnancy testing from an obscure laboratory service to an easily accessible (though fraught) tool for every woman. Lastly, the book reflects on resources the past might contain for the present and future of sexual and reproductive health.Solidly researched and compellingly argued, Olszynko-Gryn demonstrates that the rise of pregnancy testing has had significant—and not always expected—impact and has led to changes in the ways in which we conceive of pregnancy itself.

DKK 559.00
1

May We Make the World? - Laurie Zoloth - Bog - MIT Press Ltd - Plusbog.dk

May We Make the World? - Laurie Zoloth - Bog - MIT Press Ltd - Plusbog.dk

An in-depth look at genetic alteration in the natural world and the oppositions to it, seen through the case study of a gene drive for malaria. May We Make the World? is an engaging reflection on the history, nature, goal, and meaning of using a new technological idea—CRISPR-based genetic engineering—to alter the genome of the mosquito that carries malaria. This technology, called a “gene drive,” can alter the sex ratio in Anopheles gambiae mosquitoes, the key vector for the deadliest form of malaria, falciparum. Falciparum kills 400,000 people a year, and among those, largely the poorest children in the world. In her sobering examination of the issue, Laurie Zoloth considers the leading ethical arguments for and against gene drives, explores the regulatory efforts that have emerged long in advance of the science, and considers the philosophical questions raised by the struggle to eliminate malaria.The development of a gene drive for malaria will have far-reaching implications, for it represents the first use of genetic engineering of the natural world and the first creation of a genetic variant intended to spread in the African wild, beyond human control. Drawing on two decades of work, Zoloth brilliantly argues that we can understand the complex moral issues at stake only by carefully reflecting on the science, the nature of the local and global discourse about genetic engineering, and the long history of malaria, which—as it transformed from a worldwide disease to a tropical one—reshaped the world as we know it.

DKK 583.00
1

Inequality - Carles Lalueza Fox - Bog - MIT Press Ltd - Plusbog.dk

Inequality - Carles Lalueza Fox - Bog - MIT Press Ltd - Plusbog.dk

How genomics reveals deep histories of inequality, going back many thousands of years. Inequality is an urgent global concern, with pundits, politicians, academics, and best-selling books all taking up its causes and consequences. In Inequality , Carles Lalueza-Fox offers an entirely new perspective on the subject, examining the genetic marks left by inequality on humans throughout history. Lalueza-Fox describes genetic studies, made possible by novel DNA sequencing technologies, that reveal layers of inequality in past societies, manifested in patterns of migration, social structures, and funerary practices. Through their DNA, ancient skeletons have much to tell us, yielding anonymous stories of inequality, bias, and suffering. Lalueza-Fox, a leader in paleogenomics, offers the deep history of inequality. He explores the ancestral shifts associated with migration and describes the gender bias unearthed in these migrations—the brutal sexual asymmetries, for example, between male European explorers and the women of Latin America that are revealed by DNA analysis. He considers social structures, and the evidence that high social standing was inherited—the ancient world was not a meritocracy. He untangles social and genetic factors to consider whether wealth is an advantage in reproduction, showing why we are more likely to be descended from a king than a peasant. And he explores the effects of ancient inequality on the human gene pool. Marshaling a range of evidence, Lalueza-Fox shows that understanding past inequalities is key to understanding present ones.

DKK 249.00
1

Inequality - Carles Lalueza Fox - Bog - MIT Press Ltd - Plusbog.dk

Inequality - Carles Lalueza Fox - Bog - MIT Press Ltd - Plusbog.dk

How genomics reveals deep histories of inequality, going back many thousands of years. Inequality is an urgent global concern, with pundits, politicians, academics, and best-selling books all taking up its causes and consequences. In Inequality , Carles Lalueza-Fox offers an entirely new perspective on the subject, examining the genetic marks left by inequality on humans throughout history. Lalueza-Fox describes genetic studies, made possible by novel DNA sequencing technologies, that reveal layers of inequality in past societies, manifested in patterns of migration, social structures, and funerary practices. Through their DNA, ancient skeletons have much to tell us, yielding anonymous stories of inequality, bias, and suffering.Lalueza-Fox, a leader in paleogenomics, offers the deep history of inequality. He explores the ancestral shifts associated with migration and describes the gender bias unearthed in these migrations—the brutal sexual asymmetries, for example, between male European explorers and the women of Latin America that are revealed by DNA analysis. He considers social structures, and the evidence that high social standing was inherited—the ancient world was not a meritocracy. He untangles social and genetic factors to consider whether wealth is an advantage in reproduction, showing why we are more likely to be descended from a king than a peasant. And he explores the effects of ancient inequality on the human gene pool. Marshaling a range of evidence, Lalueza-Fox shows that understanding past inequalities is key to understanding present ones.

DKK 193.00
1

The Foundations of Population Genetics - Daniel M. Weinreich - Bog - MIT Press Ltd - Plusbog.dk

The Foundations of Population Genetics - Daniel M. Weinreich - Bog - MIT Press Ltd - Plusbog.dk

An accessible but rigorous treatment of the theoretical foundations of population genetics. Population genetics—the branch of evolutionary biology concerned with understanding how and why populations’ genetic compositions change over time—rests on a well-developed theoretical foundation that draws on genetics, mathematics, and computer science. This textbook provides an approachable but rigorous treatment for advanced undergraduate and graduate students interested in building a quantitative understanding of the genetics of evolution. Existing texts either assume very mathematically advanced readers, or avoid much of the underlying theory, instead focusing on current methods of data analysis. In contrast, The Foundations of Population Genetics develops the theory from first principles. Requiring only confidence in algebra, this self-contained, student-friendly book illustrates the conceptual framework, terminology, and methods of mathematical modeling. It progressively introduces concepts from genetics as needed, while emphasizing biological implications throughout. As a result, readers come away with a deep understanding of the structure of population genetics without needing to master its mathematics. - Connects theory with the most recent genetic data better than existing texts - Features engaging real-world examples and extensive original figures - Provides dozens of carefully scaffolded questions that deepen the reader''s understanding of key concepts - Ideal as a succinct reference for established scientists in biology, medicine, and computer science - Instructor resources available

DKK 475.00
1

Prison Media - Fredrik Stiernstedt - Bog - MIT Press Ltd - Plusbog.dk

Prison Media - Fredrik Stiernstedt - Bog - MIT Press Ltd - Plusbog.dk

How prisoners serve as media laborers, while the prison serves as a testing ground for new media technologies. Prisons are not typically known for cutting-edge media technologies. Yet from photography in the nineteenth century to AI-enhanced tracking cameras today, there is a long history of prisons being used as a testing ground for technologies that are later adopted by the general public. If we recognize the prison as a central site for the development of media technologies, how might that change our understanding of both media systems and carceral systems? Prison Media foregrounds the ways in which the prison is a model space for the control and transmission of information, a place where media is produced, and a medium in its own right. Examining the relationship between media and prison architecture, as surveillance and communication technologies are literally built into the facilities, this study also considers the ways in which prisoners themselves often do hard labor as media workers—labor that contributes in direct and indirect ways to the latest technologies developed and sold by multinational corporations like Amazon. There is a fine line between ankle monitors and Fitbits, and Prison Media helps us make sense of today’s carceral society.

DKK 326.00
1

How to Design Programs - Robert Bruce (associate Professor Of Computer Science Findler - Bog - MIT Press Ltd - Plusbog.dk

How to Design Programs - Robert Bruce (associate Professor Of Computer Science Findler - Bog - MIT Press Ltd - Plusbog.dk

A completely revised edition, offering new design recipes for interactive programs and support for images as plain values, testing, event-driven programming, and even distributed programming. This introduction to programming places computer science at the core of a liberal arts education. Unlike other introductory books, it focuses on the program design process, presenting program design guidelines that show the reader how to analyze a problem statement, how to formulate concise goals, how to make up examples, how to develop an outline of the solution, how to finish the program, and how to test it. Because learning to design programs is about the study of principles and the acquisition of transferable skills, the text does not use an off-the-shelf industrial language but presents a tailor-made teaching language. For the same reason, it offers DrRacket, a programming environment for novices that supports playful, feedback-oriented learning. The environment grows with readers as they master the material in the book until it supports a full-fledged language for the whole spectrum of programming tasks. This second edition has been completely revised. While the book continues to teach a systematic approach to program design, the second edition introduces different design recipes for interactive programs with graphical interfaces and batch programs. It also enriches its design recipes for functions with numerous new hints. Finally, the teaching languages and their IDE now come with support for images as plain values, testing, event-driven programming, and even distributed programming.

DKK 583.00
1

Genomic Citizenship - Ian Mcgonigle - Bog - MIT Press Ltd - Plusbog.dk

Genomic Citizenship - Ian Mcgonigle - Bog - MIT Press Ltd - Plusbog.dk

An anthropological study based on ethnographic work in Israel and Qatar explores the relationship between science, particularly genetics, and national identity. Based on ethnographic work in Israel and Qatar, two small Middle Eastern ethnonations with significant biomedical resources, Genomic Citizenship explores the relationship between science and identity. Ian McGonigle, originally trained as a biochemist, draws on anthropological theory, STS, intellectual history, critical theory, Middle Eastern studies, cultural studies, and critical legal studies. He connects biomedical research on ethnic populations to the political, economic, legal, and historical context of the state; to global trends in genetic medicine; and to the politics of identity in the context of global biomedical research. Genomic Citizenship is more an anthropology of scientific objects than an anthropology of scientists or an ethnography of the laboratory. McGonigle bases his untraditional project on traditional anthropological methods, including participant observation. Some of the most persuasive data in the book are from public records, legal and historical sources, published scientific papers, institutional reports, websites, and brochures. McGonigle discusses biological understandings of Jewishness, especially in relation to the intellectual history of Zionism and Jewish political thought, and considers the possibility of a novel application of genetics in assigning Israeli citizenship. He also describes developments in genetic medicine in Qatar and analyzes the Qatari Biobank in the context of Qatari nationalism and state-building projects. Considering possible consequences of findings on the diverse origins of the Qatari population for tribal identities, he argues that the nation cannot be defined as either a purely natural or biological entity. Rather, it is reified, reinscribed, and refracted through genomic research and discourse.

DKK 722.00
1

Why Have Children? - Christine (queen's University) Overall - Bog - MIT Press Ltd - Plusbog.dk

Why Have Children? - Christine (queen's University) Overall - Bog - MIT Press Ltd - Plusbog.dk

A wide-ranging exploration of whether or not choosing to procreate can be morally justified—and if so, how. In contemporary Western society, people are more often called upon to justify the choice not to have children than they are to supply reasons for having them. In this book, Christine Overall maintains that the burden of proof should be reversed: that the choice to have children calls for more careful justification and reasoning than the choice not to. Arguing that the choice to have children is not just a prudential or pragmatic decision but one with ethical repercussions, Overall offers a wide-ranging exploration of how we might think systematically and deeply about this fundamental aspect of human life. Writing from a feminist perspective, she also acknowledges the inevitably gendered nature of the decision; the choice has different meanings, implications, and risks for women than it has for men. After considering a series of ethical approaches to procreation, and finding them inadequate or incomplete, Overall offers instead a novel argument. Exploring the nature of the biological parent-child relationship—which is not only genetic but also psychological, physical, intellectual, and moral—she argues that the formation of that relationship is the best possible reason for choosing to have a child.

DKK 173.00
1

Discriminating Data - Wendy Hui Kyong Chun - Bog - MIT Press Ltd - Plusbog.dk

Discriminating Data - Wendy Hui Kyong Chun - Bog - MIT Press Ltd - Plusbog.dk

How big data and machine learning encode discrimination and create agitated clusters of comforting rage. In Discriminating Data , Wendy Hui Kyong Chun reveals how polarization is a goal—not an error—within big data and machine learning. These methods, she argues, encode segregation, eugenics, and identity politics through their default assumptions and conditions. Correlation, which grounds big data’s predictive potential, stems from twentieth-century eugenic attempts to “breed” a better future. Recommender systems foster angry clusters of sameness through homophily. Users are “trained” to become authentically predictable via a politics and technology of recognition. Machine learning and data analytics thus seek to disrupt the future by making disruption impossible. Chun, who has a background in systems design engineering as well as media studies and cultural theory, explains that although machine learning algorithms may not officially include race as a category, they embed whiteness as a default. Facial recognition technology, for example, relies on the faces of Hollywood celebrities and university undergraduates—groups not famous for their diversity. Homophily emerged as a concept to describe white U.S. resident attitudes to living in biracial yet segregated public housing. Predictive policing technology deploys models trained on studies of predominantly underserved neighborhoods. Trained on selected and often discriminatory or dirty data, these algorithms are only validated if they mirror this data. How can we release ourselves from the vice-like grip of discriminatory data? Chun calls for alternative algorithms, defaults, and interdisciplinary coalitions in order to desegregate networks and foster a more democratic big data.

DKK 227.00
1

The Great Remobilization - Olaf Groth - Bog - MIT Press Ltd - Plusbog.dk

The Great Remobilization - Olaf Groth - Bog - MIT Press Ltd - Plusbog.dk

How the turmoil of recent years gives leaders an unprecedented opportunity to redesign global strategies and systems and to remobilize toward a smarter, more resilient, and equitable future. How can leaders faced with tremendous global upheaval create more resilient and trustworthy systems? In The Great Remobilization , Olaf Groth, Mark Esposito, and Terence Tse (along with research partner Dan Zehr) diagnose tectonic shifts in the global economy with an eye toward designing a smarter “operating system” for the world. Through their FLP-IT (forces, logic, phenomena, impact, and triage) framework for strategic leadership, the authors chart a path forward, providing guidance for a new breed of “design activist leader.” Focusing on key tectonic shifts they call the Five Cs—COVID and pandemic management, the cognitive economy and crypto, cybersecurity, climate change and carbon management, and China—they examine the implications that new forces and logics will have on countries, organizations, and individuals.Drawing from one hundred interviews and conversations with top-level executives, entrepreneurs, policymakers, diplomats, generals, scholars, and other leading experts from around the world, the authors show how to create new inclusive visions with the aim of rebuilding the trust that will allow for both human and economic growth. Insightful and forward-thinking, The Great Remobilization powerfully illustrates the rare opportunity that we have in this historic moment to actively redesign our fragile, overpressurized global systems and develop new strategies and leadership approaches for the future. Authored by three scholar-practitioners, their synthetic perspectives and insights are at once rooted in deep research and focused on relevance for leaders and their organizations.

DKK 257.00
1

Frame Innovation - Kees Dorst - Bog - MIT Press Ltd - Plusbog.dk

Frame Innovation - Kees Dorst - Bog - MIT Press Ltd - Plusbog.dk

How organizations can use practices developed by expert designers to solve today’s open, complex, dynamic, and networked problems. When organizations apply old methods of problem-solving to new kinds of problems, they may accomplish only temporary fixes or some ineffectual tinkering around the edges. Today’s problems are a new breed—open, complex, dynamic, and networked—and require a radically different response. In this book, Kees Dorst describes a new, innovation-centered approach to problem-solving in organizations: frame creation. It applies “design thinking,” but it goes beyond the borrowed tricks and techniques that usually characterize that term. Frame creation focuses not on the generation of solutions but on the ability to create new approaches to the problem situation itself. The strategies Dorst presents are drawn from the unique, sophisticated, multilayered practices of top designers, and from insights that have emerged from fifty years of design research. Dorst describes the nine steps of the frame creation process and illustrates their application to real-world problems with a series of varied case studies. He maps innovative solutions that include rethinking a store layout so retail spaces encourage purchasing rather than stealing, applying the frame of a music festival to understand late-night problems of crime and congestion in a club district, and creative ways to attract young employees to a temporary staffing agency. Dorst provides tools and methods for implementing frame creation, offering not so much a how-to manual as a do-it-yourself handbook—a guide that will help practitioners develop their own approaches to problem-solving and creating innovation.

DKK 209.00
1

Discriminating Data - Wendy Hui Kyong Chun - Bog - MIT Press Ltd - Plusbog.dk

Discriminating Data - Wendy Hui Kyong Chun - Bog - MIT Press Ltd - Plusbog.dk

How big data and machine learning encode discrimination and create agitated clusters of comforting rage. In Discriminating Data, Wendy Hui Kyong Chun reveals how polarization is a goal—not an error—within big data and machine learning. These methods, she argues, encode segregation, eugenics, and identity politics through their default assumptions and conditions. Correlation, which grounds big data’s predictive potential, stems from twentieth-century eugenic attempts to “breed” a better future. Recommender systems foster angry clusters of sameness through homophily. Users are “trained” to become authentically predictable via a politics and technology of recognition. Machine learning and data analytics thus seek to disrupt the future by making disruption impossible. Chun, who has a background in systems design engineering as well as media studies and cultural theory, explains that although machine learning algorithms may not officially include race as a category, they embed whiteness as a default. Facial recognition technology, for example, relies on the faces of Hollywood celebrities and university undergraduates—groups not famous for their diversity. Homophily emerged as a concept to describe white U.S. resident attitudes to living in biracial yet segregated public housing. Predictive policing technology deploys models trained on studies of predominantly underserved neighborhoods. Trained on selected and often discriminatory or dirty data, these algorithms are only validated if they mirror this data. How can we release ourselves from the vice-like grip of discriminatory data? Chun calls for alternative algorithms, defaults, and interdisciplinary coalitions in order to desegregate networks and foster a more democratic big data.

DKK 230.00
1

Technoscience in History - Ursula Klein - Bog - MIT Press Ltd - Plusbog.dk

Technoscience in History - Ursula Klein - Bog - MIT Press Ltd - Plusbog.dk

The relationship of the current technosciences and the older engineering sciences, examined through the history of the “useful” sciences in Prussia. Do today''s technoscientific disciplines—including materials science, genetic engineering, nanotechnology, and robotics—signal a radical departure from traditional science? In Technoscience in History , Ursula Klein argues that these novel disciplines and projects are not an “epochal break,” but are part of a history that can be traced back to German “useful” sciences and beyond. Klein''s account traces a deeper history of technoscience, mapping the relationship between today''s cutting-edge disciplines and the development of the useful and technological sciences in Prussia from 1750 to 1850. Klein shows that institutions that coupled natural-scientific and technological inquiry existed well before the twentieth century. Focusing on the science of mining, technical chemistry, the science of forestry, and the science of building (later known as civil engineering), she examines the emergence of practitioners who were recognized as men of science as well as inventive technologists—key figures that she calls “scientific-technological experts.” Klein describes the Prussian state''s recruitment of experts for technical projects and manufacturing, including land surveys, the apothecary trade, and porcelain production; state-directed mining, mining science, and mining academies; the history and epistemology of useful science; and the founding of Prussian scientific institutions in the nineteenth century, including the University of Berlin, the Academy of Building, the Technical Deputation, and the Industrial Institute.

DKK 356.00
1

Quantitative Fundamentals of Molecular and Cellular Bioengineering - Bruce (professor Of Biological Engineering And Computer Science Tidor - Bog - MIT

Quantitative Fundamentals of Molecular and Cellular Bioengineering - Bruce (professor Of Biological Engineering And Computer Science Tidor - Bog - MIT

A comprehensive presentation of essential topics for biological engineers, focusing on the development and application of dynamic models of biomolecular and cellular phenomena. This book describes the fundamental molecular and cellular events responsible for biological function, develops models to study biomolecular and cellular phenomena, and shows, with examples, how models are applied in the design and interpretation of experiments on biological systems. Integrating molecular cell biology with quantitative engineering analysis and design, it is the first textbook to offer a comprehensive presentation of these essential topics for chemical and biological engineering. The book systematically develops the concepts necessary to understand and study complex biological phenomena, moving from the simplest elements at the smallest scale and progressively adding complexity at the cellular organizational level, focusing on experimental testing of mechanistic hypotheses. After introducing the motivations for formulation of mathematical rate process models in biology, the text goes on to cover such topics as noncovalent binding interactions; quantitative descriptions of the transient, steady state, and equilibrium interactions of proteins and their ligands; enzyme kinetics; gene expression and protein trafficking; network dynamics; quantitative descriptions of growth dynamics; coupled transport and reaction; and discrete stochastic processes. The textbook is intended for advanced undergraduate and graduate courses in chemical engineering and bioengineering, and has been developed by the authors for classes they teach at MIT and the University of Minnesota.

DKK 738.00
1