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Finding a Path to Safety in Food Allergy - Health And Medicine Division - Bog - National Academies Press - Plusbog.dk

Finding a Path to Safety in Food Allergy - Health And Medicine Division - Bog - National Academies Press - Plusbog.dk

Over the past 20 years, public concerns have grown in response to the apparent rising prevalence of food allergy and related atopic conditions, such as eczema. Although evidence on the true prevalence of food allergy is complicated by insufficient or inconsistent data and studies with variable methodologies, many health care experts who care for patients agree that a real increase in food allergy has occurred and that it is unlikely to be due simply to an increase in awareness and better tools for diagnosis. Many stakeholders are concerned about these increases, including the general public, policy makers, regulatory agencies, the food industry, scientists, clinicians, and especially families of children and young people suffering from food allergy. At the present time, however, despite a mounting body of data on the prevalence, health consequences, and associated costs of food allergy, this chronic disease has not garnered the level of societal attention that it warrants. Moreover, for patients and families at risk, recommendations and guidelines have not been clear about preventing exposure or the onset of reactions or for managing this disease. Finding a Path to Safety in Food Allergy examines critical issues related to food allergy, including the prevalence and severity of food allergy and its impact on affected individuals, families, and communities; and current understanding of food allergy as a disease, and in diagnostics, treatments, prevention, and public policy. This report seeks to: clarify the nature of the disease, its causes, and its current management; highlight gaps in knowledge; encourage the implementation of management tools at many levels and among many stakeholders; and delineate a roadmap to safety for those who have, or are at risk of developing, food allergy, as well as for others in society who are responsible for public health. Table of ContentsFront MatterSummary1 Introduction2 Definitions3 Prevalence4 Assessments, Diagnostic Testing, Disease Monitoring, and Prognosis5 Potential Genetic and Environmental Determinants of Food Allergy Risk and Possible Prevention Strategies6 Management in the Health Care Setting7 Management of Packaged Foods8 Managing Food Allergies in Retail, Food Service, Schools, Higher Education, and Travel Settings9 Research Needs10 Final Comments: A Roadmap to SafetyAppendix A: Open Session AgendasAppendix B: Food Allergy Prevalence Literature Search StrategyAppendix C: Risk Determinants Literature Search StrategyAppendix D: Acronyms and AbbreviationsAppendix E: DefinitionsAppendix F: Committee Members Biographical Sketches

DKK 474.00
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Improved Operational Testing and Evaluation and Methods of Combining Test Information for the Stryker Family of Vehicles and Related Army Systems -

Improved Operational Testing and Evaluation and Methods of Combining Test Information for the Stryker Family of Vehicles and Related Army Systems -

The U.S. Army Test and Evaluation Command (ATEC) is responsible for the operational testing and evaluation of Army systems in development. ATECrequested that the National Research Council form the Panel on Operational Test Design and Evaluation of the Interim Armored Vehicle (Stryker). The charge to this panel was to explore three issues concerning the IOT plans for the Stryker/SBCT. First, the panel was asked to examine the measures selected to assess the performance and effectiveness of the Stryker/SBCT in comparison both to requirements and to the baseline system. Second, the panel was asked to review the test design for the Stryker/SBCT initial operational test to see whether it is consistent with best practices. Third, the panel was asked to identify the advantages and disadvantages of techniques for combining operational test data with data from other sources and types of use. In a previous report (appended to the current report) the panel presented findings, conclusions, and recommendations pertaining to the first two issues: measures of performance and effectiveness, and test design. In the current report, the panel discusses techniques for combining information. Table of ContentsFront MatterExecutive Summary1. Introduction to Combining Information2. Examples of Combining Information3. Combining Information in Practice4. Prerequisites for Combining Information5. Testing Challenges and Opportunities Posed by the Future Combat SystemReferencesAppendix A: Further Details Concerning the Bearing Cage ExampleAppendix B: Technical Details on Combining Information in Estimation: A Treatment of Separate Failure ModesAppendix C: The Rocket Development ProgramAppendix D: Acronyms and AbbreviationsPhase I Report: Operational Test Design and Evaluation of the Interim Armored VehicleBiographical Sketches of Panel Members and Staff

DKK 409.00
1

Review of Department of Defense Test Protocols for Combat Helmets - National Research Council - Bog - National Academies Press - Plusbog.dk

Incentives and Test-Based Accountability in Education - Division Of Behavioral And Social Sciences And Education - Bog - National Academies Press -

Incentives and Test-Based Accountability in Education - Division Of Behavioral And Social Sciences And Education - Bog - National Academies Press -

In recent years there have been increasing efforts to use accountability systems based on large-scale tests of students as a mechanism for improving student achievement. The federal No Child Left Behind Act (NCLB) is a prominent example of such an effort, but it is only the continuation of a steady trend toward greater test-based accountability in education that has been going on for decades. Over time, such accountability systems included ever-stronger incentives to motivate school administrators, teachers, and students to perform better. Incentives and Test-Based Accountability in Education reviews and synthesizes relevant research from economics, psychology, education, and related fields about how incentives work in educational accountability systems. The book helps identify circumstances in which test-based incentives may have a positive or a negative impact on student learning and offers recommendations for how to improve current test-based accountability policies. The most important directions for further research are also highlighted. For the first time, research and theory on incentives from the fields of economics, psychology, and educational measurement have all been pulled together and synthesized. Incentives and Test-Based Accountability in Education will inform people about the motivation of educators and students and inform policy discussions about NCLB and state accountability systems. Education researchers, K-12 school administrators and teachers, as well as graduate students studying education policy and educational measurement will use this book to learn more about the motivation of educators and students. Education policy makers at all levels of government will rely on this book to inform policy discussions about NCLB and state accountability systems.

DKK 227.00
1

Technical Assessment of the Man-in-Simulant Test Program - National Research Council - Bog - National Academies Press - Plusbog.dk

Test and Evaluation Challenges in Artificial Intelligence-Enabled Systems for the Department of the Air Force - Air Force Studies Board - Bog -

Generating Evidence for Genomic Diagnostic Test Development - Institute Of Medicine - Bog - National Academies Press - Plusbog.dk

Generating Evidence for Genomic Diagnostic Test Development - Institute Of Medicine - Bog - National Academies Press - Plusbog.dk

Ten years after the sequencing of the human genome, scientists have developed genetic tests that can predict a person's response to certain drugs, estimate the risk of developing Alzheimer's disease, and make other predictions based on known links between genes and diseases. However, genetic tests have yet to become a routine part of medical care, in part because there is not enough evidence to show they help improve patients' health. The Institute of Medicine (IOM) held a workshop to explore how researchers can gather better evidence more efficiently on the clinical utility of genetic tests. Generating Evidence for Genomic Diagnostic Test Development compares the evidence that is required for decisions regarding clearance, use, and reimbursement, to the evidence that is currently generated. The report also addresses innovative and efficient ways to generate high-quality evidence, as well as barriers to generating this evidence. Generating Evidence for Genomic Diagnostic Test Development contains information that will be of great value to regulators and policymakers, payers, health-care providers, researchers, funders, and evidence-based review groups. Table of ContentsFront Matter1 Introduction2 Stakeholder Perspectives on Evidence3 Approaches to Evidence Generation4 Overcoming Barriers for Evidence Generation5 Considerations Moving Forward6 Final RemarksReferencesAppendix A: Workshop AgendaAppendix B: Speaker Biographical SketchesAppendix C: Registered Attendees

DKK 208.00
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The Comprehensive Nuclear Test Ban Treaty - National Research Council - Bog - National Academies Press - Plusbog.dk

The Comprehensive Nuclear Test Ban Treaty - National Research Council - Bog - National Academies Press - Plusbog.dk

This report reviews and updates the 2002 National Research Council report, Technical Issues Related to the Comprehensive Nuclear Test Ban Treaty (CTBT). This report also assesses various topics, including:the plans to maintain the safety and reliability of the U.S. nuclear stockpile without nuclear-explosion testing;the U.S. capability to detect, locate, and identify nuclear explosions;commitments necessary to sustain the stockpile and the U.S. and international monitoring systems; andpotential technical advances countries could achieve through evasive testing and unconstrained testing. Sustaining these technical capabilities will require action by the National Nuclear Security Administration, with the support of others, on a strong scientific and engineering base maintained through a continuing dynamic of experiments linked with analysis, a vigorous surveillance program, adequate ratio of performance margins to uncertainties. This report also emphasizes the use of modernized production facilities and a competent and capable workforce with a broad base of nuclear security expertise. Table of ContentsFront MatterEXECUTIVE SUMMARYSUMMARY1 SAFETY, SECURITY, AND RELIABILITY OF THE U.S. NUCLEAR WEAPONS STOCKPILE2 TECHNICAL MONITORING CAPABILITIES AND CHALLENGES3 SUSTAINING U.S. TECHNICAL CAPABILITIES UNDER THE CTBT4 POTENTIAL TECHNICAL ADVANCES FROM NUCLEAR-EXPLOSION TESTING5 COMPLETE LIST OF FINDINGS AND RECOMMENDATIONSAPPENDIX A Committee on Reviewing and Updating "Technical Issues Related to the Comprehensive Nuclear Test Ban Treaty" (CTBT)APPENDIX B List of CTBT Committee and Seismology Subcommittee MeetingsAPPENDIX C The U.S. National Capability to Monitor for Nuclear ExplosionsAPPENDIX D Monitoring Areas of High InterestAPPENDIX E Dealing with Evasive Underground Nuclear TestingAPPENDIX F Issues Related to Containment of RadioactivityAPPENDIX G U.S. Satellite Nuclear Detonation Detection Capability: Options and ImpactsAPPENDIX H Satellite-Based Challenges and SolutionsAPPENDIX I ReferencesAPPENDIX J List of AcronymsAPPENDIX K Glossary of Key Terms from the 2010 CTBT NIE

DKK 292.00
1

Review of the Need for a Large-Scale Test Facility for Research on the Effects of Extreme Winds on Structures - National Academy Of Sciences - Bog -

Improved Operational Testing and Evaluation - Division Of Behavioral And Social Sciences And Education - Bog - National Academies Press - Plusbog.dk

Improved Operational Testing and Evaluation - Division Of Behavioral And Social Sciences And Education - Bog - National Academies Press - Plusbog.dk

The U.S. Army Test and Evaluation Command (ATEC) is responsible for the operational testing and evaluation of Army systems in development. ATEC requested that the National Research Council form the Panel on Operational Test Design and Evaluation of the Interim Armored Vehicle (Stryker) to explore three issues concerning the initial operation test plans for the Stryker/Interim Brigade Combat Team (IBCT). First, the panel was asked to examine the measures selected to assess the performance and effectiveness of the Stryker/IBCT in comparison both to requirements and to the baseline system. Second, the panel was asked to review the test design for the Stryker/IBCT initial operational test to see whether it is consistent with best practices. Third, the panel was asked to identify the advantages and disadvantages of techniques for combining operational test data with data from other sources and types of use. In this report the panel presents findings, conclusions, and recommendations pertaining to the first two issues: measures of performance and effectiveness, and test design. The panel intends to prepare a second report that discusses techniques for combining information. Table of ContentsFront MatterExecutive Summary1. Introduction2. Test Process3. Test Measures4. Statistical Design5. Data Analysis6. Assessing the IBCT/Stryker Operational Test in a Broad ContextReferencesAppendix A: Letter Report of the Panel to the Army Test and Evalution CommandAppendix B: Force Exchange Ratio, Historical Win Probability, and Winning with Decisive ForceAppendix C: Biographical Sketches of Panel Members and Staff

DKK 286.00
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Evaluation of Demonstration Test Results of Alternative Technologies for Demilitarization of Assembled Chemical Weapons - Committee On Review And

Evaluation of Demonstration Test Results of Alternative Technologies for Demilitarization of Assembled Chemical Weapons - Committee On Review And

In 1996, the U.S. Congress enacted two laws, Public Law 104-201 (authorization legislation) and Public Law 104-208 (appropriation legislation), mandating that the U.S. Department of Defense (DOD) conduct an assessment of alternative technologies to the baseline incineration process for the demilitarization of assembled chemical munitions. The PMACWA had previously requested that the National Research Council (NRC) perform and publish an independent evaluation of the seven technologies packages that had been selected during earlier phases of the Assembled Chemical Weapons Assessment (ACWA) program and deliver a report by September 1, 1999. However, to meet that deadline, the NRC Committee on Review and Evaluation of Alternative Technologies for Demilitarization of Assembled Chemical Weapons (ACW Committee) had to terminate its data-gathering activities on March 15, 1999, prior to the completion of demonstration tests. In September 1999, the PMACWA requested that the ACW Committee examine the reports of the demonstration tests and determine if the results changed the committee's original findings, recommendations, and comments. Evaluation of Demonstration Test Results of Alternative Technologies for Demilitarization of Assembled Chemical Weapons documents the committee's reassessment of the findings and recommendations in the original report, Review and Evaluation of Alternative Technologies for Demilitarization of Assembled Chemical Weapons.

DKK 305.00
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Necessary DoD Range Capabilities to Ensure Operational Superiority of U.S. Defense Systems - Board On Army Research And Development - Bog - National

Necessary DoD Range Capabilities to Ensure Operational Superiority of U.S. Defense Systems - Board On Army Research And Development - Bog - National

Rigorous operational testing (OT) of weapon systems procured by the U.S. Department of Defense (DoD) is fundamental to ensuring that these sophisticated systems not only meet their stated requirements, but also perform under realistic operational conditions when faced by determined adversaries employing their own highly capable offensive and defensive weaponry. DoD's test and training range enterprise provides the geography, infrastructure, technology, expertise, processes, and management that make safe, secure, and comprehensive OT possible. The challenges facing the nation's range infrastructure are both increasing and accelerating. Limited test capacity in physical resources and workforce, the age of test infrastructure, the capability to test advanced technologies, and encroachment impact the ability to inform system performance, integrated system performance and the overall pace of testing. Necessary DoD Range Capabilities to Ensure Operational Superiority of U.S. Defense Systems assesses the physical and technical suitability of DoD test and evaluation ranges, infrastructure, and tools for determining the operational effectiveness, suitability, survivability, and lethality of military systems. This report explores modernization, sustainment, operations, and resource challenges for test and evaluation ranges, and makes recommendations to put the DoD range enterprise on a modernization trajectory to meet the needs of OT in the years ahead. Table of ContentsFront MatterExecutive Summary1 Introduction2 An Envisioned Future of Operational Test and Evaluation3 Testing for Future Combat: Multi-Domain Operations, Connected Concurrent Kill Chains, and Mitigating Encroachment4 Digital Infrastructure Needs for Operational Testing5 Speed-to-Field: Restructuring the Requirements and Resources Processes for DoD Test Ranges6 Conclusion and Summary of Recommendations by ActorAppendixesAppendix A: Statement of Task and Completion MatrixAppendix B: Site Visit SummariesAppendix C: Committee Member BiographiesAppendix D: Disclosure of Unavoidable Conflicts of InterestAppendix E: Abbreviations and Acronyms

DKK 240.00
1

The Five Series Study - Harriet Crawford - Bog - National Academies Press - Plusbog.dk

Evaluating Hearing Loss for Individuals with Cochlear Implants - Committee On Evaluating Hearing Loss For Individuals With Cochlear Implants - Bog -

Evaluating Hearing Loss for Individuals with Cochlear Implants - Committee On Evaluating Hearing Loss For Individuals With Cochlear Implants - Bog -

The U.S. Social Security Administration (SSA) administers programs that provide disability benefits. Once SSA establishes the presence of a severe impairment, it determines whether the impairment meets the criteria in the Listing of Impairments (Listings) that qualify a candidate for disability benefits. The current Listings that address hearing loss treated with cochlear implantation contain criteria that evaluate hearing ability through a speech recognition test called the Hearing in Noise Test (HINT). Since its development in 1994, the HINT has been widely used to measure cochlear implant candidacy and postoperative outcomes. However, the test characteristics, the state of cochlear implant technology, and the environment that made the HINT a common choice of assessment in 1994 are different in 2021. The HINT has several limitations in its characteristics and deviation from its intended use. At the request of SSA, the National Academies of Sciences, Engineering, and Medicine convened a consensus study committee to identify and recommend generalized testing procedures and criteria for evaluating the level of functional hearing ability needed to make a disability determination in adults and children after cochlear implantation. The committee's report, Evaluating Hearing Loss for Individuals with Cochlear Implants, details and supports its findings, conclusions, and recommendations based on published evidence and professional judgment. Table of ContentsFront MatterSummary1 Introduction2 Considerations for Evaluating Hearing Function3 Characteristics and Limitations of the Hearing in Noise Test4 Characteristics of Hearing and Speech Tests5 Evaluating Hearing Ability in Persons with Cochlear Implants with Single-Sided Deafness or Asymmetric Hearing Loss6 Test Comparisons and Recommendations

DKK 318.00
1

Indoor Allergens - Committee On The Health Effects Of Indoor Allergens - Bog - National Academies Press - Plusbog.dk

Indoor Allergens - Committee On The Health Effects Of Indoor Allergens - Bog - National Academies Press - Plusbog.dk

More than 50 million Americans, one out of five, suffer from hay fever, asthma, and other allergic diseases. Many of these conditions are caused by exposure to allergens in indoor environments such as the house, work, and school—where we spend as much as 98 percent of our time. Developed by medical, public health, and engineering professionals working together, this unique volume summarizes what is known about indoor allergens, how they affect human health, the magnitude of their effect on various populations, and how they can be controlled. The book addresses controversies, recommends research directions, and suggests how to assist and educate allergy patients, as well as professionals. Indoor Allergens presents a wealth of information about common indoor allergens and their varying effects, from significant hay fever to life-threatening asthma. The volume discusses sources of allergens, from fungi and dust mites to allergenic chemicals, plants, and animals, and examines practical measures for their control. Indoor Allergens discusses how the human airway and immune system respond to inhaled allergens and assesses patient testing methods, covering the importance of the patient's medical history and outlining procedures and approaches to interpretation for skin tests, in vitro diagnostic tests, and tests of patients' pulmonary function. This comprehensive and practical volume will be important to allergists and other health care providers; public health professionals; specialists in building design, construction, and maintenance; faculty and students in public health; and interested allergy patients. Table of ContentsFront MatterExecutive Summary1 Introduction2 Magnitude and Dimensions of Sensitization and Disease Caused by Indoor Allergens3 Agents, Sources, Source Controls, and Diseases4 Mechanisms of Immune Function5 Medical Testing Methods6 Assessing Exposure and Risk7 Engineering Control Strategies8 The Role of EducationReferencesAcronymsGlossaryCommittee and Staff BiographiesIndex

DKK 552.00
1

Challenges and Opportunities in Using Residual Newborn Screening Samples for Translational Research - Board On Health Sciences Policy - Bog - National

The Emerging Threat of Drug-Resistant Tuberculosis in Southern Africa - Board On Health Sciences Policy - Bog - National Academies Press - Plusbog.dk

Nuclear Proliferation and Arms Control Monitoring, Detection, and Verification - Verification Committee On The Review Of Capabilities For Detection -

Nuclear Proliferation and Arms Control Monitoring, Detection, and Verification - Verification Committee On The Review Of Capabilities For Detection -

At the request of Congress, this report presents findings and recommendations related to governance of the U.S. government's monitoring, detection, and verification (MDV) enterprise and offers findings and recommendations related to technical MDV capabilities and research, development, test, and evaluation efforts, focused in particular on the nuclear fuel cycle, nuclear test explosions, and arms control. Table of ContentsFront MatterSummary1 Introduction2 Governance of the MDV Enterprise3 Technical MDV Capabilities and Research and Development4 ConclusionAppendix A: Statement of TaskAppendix B: List of Findings and RecommendationsAppendix C: Summary of the Defense Science Board Task Force Report: Assessment of Nuclear Monitoring and Verification TechnologiesAppendix D: Summary of the 2018 Plan for Verification, Detection, and Monitoring of Nuclear Weapons and Fissile MaterialAppendix E: Table of Technology Readiness LevelsAppendix F: NNSA DNN (NA-20) Organizational ChartAppendix G: MDV at the Department of Energy National LaboratoriesAppendix H: NNSA's Over the Horizon InitiativeAppendix I: Example Charter for the National Security Council's External Advisory Board for Monitoring, Detection, and Verification AssessmentAppendix J: Table of Relevant Technical and Program ReviewsAppendix K: Summary of Currently Funded NNSA/DNN R&D University ConsortiaAppendix L: Table of MDV R&D Technical Capabilities Needed for the Nuclear Fuel Cycle, Nuclear Test Explosions, and Arms ControlAppendix M: MDV R&D Priorities Listed in the NDRD Strategic Plan for FY20202024Appendix N: Committee BiographiesAppendix O: List of Committee Meetings and Briefings

DKK 370.00
1