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A Comprehensive Guide to Genetic Counseling - - Bog - Nova Science Publishers Inc - Plusbog.dk

Genetic Discrimination - Leana J Albertson - Bog - Nova Science Publishers Inc - Plusbog.dk

Genetic Algorithms - - Bog - Nova Science Publishers Inc - Plusbog.dk

Nondestructive Testing - - Bog - Nova Science Publishers Inc - Plusbog.dk

Genetic Endocrinology of the Metabolic Syndrome - Tom R Gaunt - Bog - Nova Science Publishers Inc - Plusbog.dk

Genetic Endocrinology of the Metabolic Syndrome - Tom R Gaunt - Bog - Nova Science Publishers Inc - Plusbog.dk

Cardiovascular disease and mortality risk are significantly increased in people with metabolic syndrome, a cluster of interrelated metabolic disorders including obesity, insulin resistance, glucose intolerance, dyslipidemia and hypertension. A complex interplay between predisposing and protective factors ultimately determines whether an individual will develop this set of disorders or not. Genetic factors are one of the significant contributors that predispose to, or protect against, each component of the metabolic syndrome. As in other complex diseases and traits, such genetic factors are likely to be multiple and interacting, with individual polymorphisms producing only a moderate effect. The identification of genetic variants influencing the metabolic syndrome is of great importance to understanding pathogenesis, identifying groups of individuals with different relative risk, and developing or improving therapies against this cluster of metabolic disorders. This has greatly stimulated both theoretical and applied genetic research in recent years. A range of new analytical tools has been developed for the dissection of complex traits. Applied genetic analyses have identified large numbers of candidate markers and chromosomal regions (over 600 for obesity, which represents only one of the disorders of this cluster). In this chapter, the authors present a basic overview of the genetic approaches currently used for the identification of candidate genetic factors involved in the metabolic syndrome. The authors also summarise current evidence suggesting that genetic variants within elements of the endocrine system are directly involved in the risk of the metabolic syndrome. The authors focused their attention on endocrine pathways for which candidate genetic variants have been identified, and they introduced the foundations of a new hypothesis which postulates the involvement of a network of endocrine genetic setpoints as a combined contributor to the risk of the metabolic syndrome.

DKK 1034.00
1

Direct-to-Consumer Genetic Tests - - Bog - Nova Science Publishers Inc - Plusbog.dk

Plant Genetic Resources & Food Security - - Bog - Nova Science Publishers Inc - Plusbog.dk

Genetic Information - - Bog - Nova Science Publishers Inc - Plusbog.dk

Overview of Genetic Factors & Environmental Triggers in the Pathogenesis of Tourette's Syndrome - Ping Yang - Bog - Nova Science Publishers Inc -

Genetic & Epigenetic Alterations that Drive Leukemic Stem Cell Self-Renewal - Vincent Van Den Boom - Bog - Nova Science Publishers Inc - Plusbog.dk

Clinical, Genetic & Molecular Precursor Features in Colorectal, Neoplasia - - Bog - Nova Science Publishers Inc - Plusbog.dk

Clinical, Genetic & Molecular Precursor Features in Colorectal, Neoplasia - - Bog - Nova Science Publishers Inc - Plusbog.dk

The understanding of the mechanisms that explain the initiation and early evolution of colorectal cancer is evolving. This should facilitate the development of new approaches to effective prevention and intervention. Over the past years, deficiencies in the current adenoma-carcinoma model for colorectal cancer, in which APC mutation is placed at the point of initiation, have been suggested. Several pathways through which cancer may develop seem to exist, such as ''chromosomal instability'' (CIN), ''microsatellite instability'' (MSI), and most recently the ''serrated pathway'' involving epigenetic changes. Parallel to discoveries in molecular pathways are the increased awareness of early and precursor features of the colorectal mucosa detected and treated by endoscopic and minimal-invasive techniques. Thus, new staging and classification systems have been developed to guide the clinician in diagnosis and choice of treatment. This book sets focus on selected clinical and molecular aspects of colorectal precursor lesions; from the endoscopically detected colorectal polyp, major molecular mechanisms, and aspects of protease-systems in colorectal cancer development. Future research on colorectal cancer needs to be stratified according to the appropriate clinical features and their associated genetic pathways involved in order to further explore important molecular mechanisms and clinicopathological consequences of chromosomal, microsatellite and epigenetic mechanisms.

DKK 405.00
1

Immunogenetics - Sylvie Lesage - Bog - Nova Science Publishers Inc - Plusbog.dk

Germplasm - - Bog - Nova Science Publishers Inc - Plusbog.dk

Discrete Optimization for TSP-like Genome Mapping Problems - D Ronin - Bog - Nova Science Publishers Inc - Plusbog.dk

Cluster Effects in Mining Complex Data - M Ishaq Bhati - Bog - Nova Science Publishers Inc - Plusbog.dk

Genes & Nutrition - - Bog - Nova Science Publishers Inc - Plusbog.dk

Advances in Neuropathology - - Bog - Nova Science Publishers Inc - Plusbog.dk

Ballistic Resistance of Body Armor - Nova Science - Bog - Nova Science Publishers Inc - Plusbog.dk

Birth Defects - Ilkay Gungor - Bog - Nova Science Publishers Inc - Plusbog.dk

A Closer Look at Autopsies - - Bog - Nova Science Publishers Inc - Plusbog.dk

A Closer Look at Autopsies - - Bog - Nova Science Publishers Inc - Plusbog.dk

From its earliest forerunners in Egyptian mummification and the influence of Herophilus and Galen in ancient Greece, the autopsy has deep roots in the historical effort to understand the human body. Advances in modern post-mortem examination technique, such as non-invasive imaging, will continue to shape the structure and role of the autopsy as it evolves and changes into the future. The autopsy is a major aspect of the practice of medicine which is used to audit the effectiveness of clinical practice and assist the law courts in the adjudication of cases in which deaths occurred in suspicious circumstances in order to guarantee a safe society, prevent secret homicide, premature deaths and avoid miscarriage of justice. Practical, legal and ethical aspects of the molecular autopsy method are also discussed. Early diagnosis by genetic testing will force lifestyle modifications in individuals with genetic risk factors, which alone or in combination with other therapeutic options may delay the onset of the disease. On-site examinations at autopsy in forensic practice are discussed. Since such "on-site" examinations are simple and not time-consuming, the results can be obtained promptly and may be useful for forensic diagnosis. Autopsy rates have dramatically declined in the last several decades. As such, the authors explore the myriad of aspects that may be contributing to this downward trend. At a societal level, autopsies play a crucial role in public health and the justice system. They are necessary in understanding the causes and course of epidemic outbreaks and recognizing the emergence of new diseases. The goal of the concluding chapter is to examine religious beliefs around death and common reasons why religion may be invoked when deciding not to consent to an autopsy. Religions that will be examined include Judaism, Islam, Christianity, Christian Science, Church of Jesus Christ of Latter Day Saints, Jehovah's Witness, Hinduism, and Buddhism.

DKK 718.00
1

Quality Parameters in Canned Seafoods - - Bog - Nova Science Publishers Inc - Plusbog.dk

Education Law & Legislation - - Bog - Nova Science Publishers Inc - Plusbog.dk