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Protein Engineering - - Bog - Nova Science Publishers Inc - Plusbog.dk

Protein Engineering - - Bog - Nova Science Publishers Inc - Plusbog.dk

Protein engineering is the process of developing useful or valuable proteins. It is a young discipline, with much research currently taking place into the understanding of protein folding and protein recognition for protein design principles. There are two general strategies for protein engineering. The first is known as rational design, in which the scientist uses detailed knowledge of the structure and function of the protein to make desired changes. The second strategy is known as directed evolution and this is where random mutagenesis is applied to a protein, and a selection regime is used to pick out variants that have the desired qualities. This book presents and reviews important data on protein engineering, such as application of engineered proteins and cell adhesive surfaces as scaffolds or other biomedical devices which has the potential to promote tissue repair and regeneration for a wide variety of tissues including bone and skin.

DKK 890.00
1

New Research on Protein Synthesis - - Bog - Nova Science Publishers Inc - Plusbog.dk

New Research on Protein Synthesis - - Bog - Nova Science Publishers Inc - Plusbog.dk

In this book, the authors present current research from across the globe in the study of protein synthesis. Topics discussed in this compilation include protein synthesis elongation factors EF-Tu and eEF1A and their application in the improvement of heat tolerance in plants; myostatin function in muscle protein homeostasis and its link with the regulation of translation; and energy regeneration systems in cell free protein in vitro.

DKK 1034.00
1

Protein Water Interactions - - Bog - Nova Science Publishers Inc - Plusbog.dk

Protein Water Interactions - - Bog - Nova Science Publishers Inc - Plusbog.dk

This book is aimed at understanding which molecular parameters control the thermodynamics, structure, and functions of the protein-water systems. Proteins are one of the most important classes of biological molecules. Water binding (hydration or biological water) plays a crucial role in determining the structure, stability, and functions of proteins. Knowledge of processes occurring upon hydration or dehydration of protein macromolecules is very important in biotechnological and pharmaceutical applications of proteins such as their use as biocatalysts, biosensors, and selective adsorbents. There are essential differences between hydration and bulk water surrounding a protein. This means that a characterisation of the hydration of protein macromolecules requires elucidating the effects of both the protein on water and vice versa. Therefore, a quantitative estimation of the protein and water contributions to the thermodynamic functions of binary protein-water systems is of considerable fundamental importance and practical interest. This book describes the basic principles of a novel methodology to investigate the protein-water interactions. This methodology is based on the analysis of the excess thermodynamic functions of mixing. The thermodynamic properties (volume V, enthalpy H, entropy S, heat capacity Cp, and Gibbs free energy G) of a real binary water-protein system can be expressed in terms of the excess functions. They are the difference between the thermodynamic function of mixing in a real system and the value corresponding to an ideal system at the same temperature, pressure and composition. For an ideal system, all excess functions are zero. Deviations of the excess functions from zero indicate the extent to which the studied binary system is non-ideal due to strong specific interactions between components (ie: hydrogen bonding and charge-charge interactions).

DKK 890.00
1

Mechanical & Dynamical Principles of Protein Nanomotors - A R Khataeea - Bog - Nova Science Publishers Inc - Plusbog.dk

Mechanical & Dynamical Principles of Protein Nanomotors - A R Khataeea - Bog - Nova Science Publishers Inc - Plusbog.dk

It is obvious that movement is an essential concept of all living organisms. Molecular motility participates in many cellular functions including cell division, intracellular transport and movement of the organism itself. Thus, it is not surprising that nature has evolved a series of biological nanomotors that fulfil many of these tasks. A general class of these biological nanomotors is called protein nanomotors that move in a linear fashion (e.g. the kinesin or myosin or dynein motors) or rotate (e.g. F0F1-ATP synthase or bacterial flagellar motors). Protein nanomotors are natural motors responsible for the human activity and are also the subject of interest for nanotechnology. Protein nanomotors are ideal nanomotors because of their small size, perfect structure, smart and high efficiency. Recent advances in understanding how protein nanomotors work has raised the possibility that they might find applications as protein-based nanorobots. Thus bio-nanomotors could form the basis of bottom-up approaches for constructing active structuring and maintenance at the manometer scale. In this chapter, we have presented structures, mechanisms and potential applications of linear protein nanomotors. The three known families of protein nanomotors kinesin, dynein and myosin are multi-protein complexes and share a variety of important features. They are responsible for various dynamical processes for transporting single molecules over small distances to cell movement and growth. Our reviewing from the mechanism, regulation and co-ordination of linear nanomotors, indicate that the majority of active transport in the cell is driven by linear protein nanomotors. All of them convert the chemical energy into mechanical work directly rather than via an intermediate energy. Linear protein nanomotors are self-guiding systems. They have evolved to enable movement on their polymer filaments, either on cellular or supra-cellular levels and are able to recognise the direction of movement. Moreover, each class of nanomotor has different properties, but in the cell they are known to cooperate and even to compete with each others during their function. We have also reviewed the potential application of linear protein nanomotors. According to this, we predict that linear protein nanomotors may enable the creation of a new class of nanotechnology-based applications; for example, bio-nanorobots, molecular machines, nanomechanical devices and drug deliver systems. Thus, protein nanomotors field is very challenging field and is attracting a diverse group of researchers keen to find more.

DKK 633.00
1

The Diversified Benefits of Whey Protein - - Bog - Nova Science Publishers Inc - Plusbog.dk

The Diversified Benefits of Whey Protein - - Bog - Nova Science Publishers Inc - Plusbog.dk

The Diversified Benefits of Whey Protein provides an overview of the main benefits of using whey proteins as targeted delivery systems in encapsulation processes, considering prerequisite steps such as binding mechanisms. The authors discuss how, according to current scientific knowledge, whey protein can reduce blood pressure and the risk of hypertension due to the presence of individual bioactive peptides formed after hydrolysis. The effect of whey protein on appetite/satiety of healthy overweight and obese individuals is investigated through a questionnaire wherein subjects were asked to indicate their feelings on the taste, aroma and edibility of a test beverage.

DKK 624.00
1

Folding/Unfolding Kinetics of Lattice Proteins by Applying a Simple Statistical Mechanical Model for Protein Folding - Hiroshi Wako - Bog - Nova

Folding/Unfolding Kinetics of Lattice Proteins by Applying a Simple Statistical Mechanical Model for Protein Folding - Hiroshi Wako - Bog - Nova

The folding/unfolding kinetics of a three-dimensional lattice protein was studied using a simple statistical mechanical model for protein folding that was previously developed. The model considers the specificity of an amino acid sequence and the native structure of a given protein. The characteristic relaxation rate on the free energy surface was calculated starting from a completely unfolded structure (or native structure) that is assumed to associate with a folding rate (or an unfolding rate). To elucidate the roles of individual amino acid residues in protein folding/unfolding kinetics, the kinetic properties for all possible single amino acid substitutions of these proteins were calculated and their responses were examined. This book presents and discusses research results in the kinetics of protein folding/unfolding.

DKK 534.00
1

Handbook on Protein Purification - - Bog - Nova Science Publishers Inc - Plusbog.dk

Handbook on Protein Purification - - Bog - Nova Science Publishers Inc - Plusbog.dk

Proteins are important biomolecules that are vital for the cellular structure and function. They perform a vast array of functions within organisms, including the catalysis of metabolic reactions, DNA replication, response to stimuli, and transporting molecules from one location to another. The technological advances in the omics areas (e.g., genomics, transcriptomics, proteomics, metagenomics, etc.) have dramatically increased the rate of discovering new proteins. Some of them hold large opportunities for innovative research and the development of commercial products and applications. It is worth noting that the global protein ingredients market is poised to grow over the next decade to reach approximately 58.49 billion USD by 2022, with the protein therapeutics market valuing around USD 315.9 billion by 2025. Interestingly, about seventy monoclonal antibody products will be on the market by 2020 with a combined worldwide sales of about 125 billion USD.The most significant parameter for the successful commercial exploitation of proteins rely on the development of an efficient and effective isolation and purification technology, known as protein downstream processing. Downstream processing refers to the technology that involves the isolation and production of purified products from natural sources such as animal tissues, plant tissues, microorganisms or fermentation broth. The most important element of this technology is the high purification processes, most important of which is chromatography and in particular affinity chromatography.This book provides information on the resent developments of protein downstream processing and deals with the information gained over the last years from the application of protein purification technologies on different research areas. Each chapter gives key examples that cover a wide range of diverse scientific disciplines in order to provide the reader with a representative sample of the current status of the field. The present book would definitely be an ideal source of scientific information to the advanced students, junior researchers, and scientists involved in cellular and molecular biology, biochemistry, microbiology, biotechnology and other related areas.

DKK 820.00
1

Protein Hydrolysates - - Bog - Nova Science Publishers Inc - Plusbog.dk

Protein Hydrolysates - - Bog - Nova Science Publishers Inc - Plusbog.dk

In this collection, the authors aim to provide information the preparation of marine protein hydrolysates and their main bioactive properties such as antioxidant, antimicrobial, antitumor and antihypertensive. Applications of these compounds in the area food technology and pharmaceuticals are also discussed.Protein Hydrolysates: Uses, Properties and Health Effects goes on to present some biological properties of fish peptides and their beneficial effects on health, emphasizing properties such as antidiabetic neuroprotective and anti-inflammatory, as a natural alternative to drugs and possible strategies to delay cognitive impairment.As confectionery manufacturers are trying to be innovative in producing suitable fat fillings for various applications. As such, the authors examine the functional, rheological and sensory properties of confectionery fat filling supplemented with different concentrations of bioactive whey protein hydrolysate powders, produced by enzymatic and microbial modification of whey proteins.Next, the bioactive potential of hydrolysate powders produced by enzymatic and microbial hydrolysis of whey proteins followed by spray drying is examined in order to determine which process allows for a highly bioactive production.A strain-substrate combination is introduced which allows for the production of dairy protein hydrolysates with high antioxidant activity and improved functional properties, which may be used as high-quality food supplements.The traditional methods for the production of functional peptides from biological sources are time-consuming and tedious. In the drug industry, it takes about five to ten years from the discovery of an industrial bioactive peptide to market delivery. To overcome the drawbacks of these traditional methods, the authors propose that a fast and versatile method is necessary.The concluding chapter presents an overview of the production and applications of bioactive peptides, demonstrating their potential use as helper agents of health processes. These peptides may aid in traditional health treatments since they can be used in high concentrations without associated toxic effects.

DKK 718.00
1

Mitogen-Activated Protein Kinases (MAPKs) - - Bog - Nova Science Publishers Inc - Plusbog.dk

Mitogen-Activated Protein Kinases (MAPKs) - - Bog - Nova Science Publishers Inc - Plusbog.dk

Mitogen-Activated Protein Kinases (MAPKs): Activation, Functions and Regulation opens with a summary of the present knowledge about MAPK, with special emphasis on p38 and c-Jun N-terminal kinase. The authors focus on how these signaling pathways are engaged during some infections with intracellular parasites. The authors also describe selected regulatory aspects of circadian clocks in vertebrates, exploring an intriguing link to MAPK. Circadian clocks are time-tracking systems that provide organisms with a survival advantage. Cadmium, one of the toxic metals, is an important occupational and environmental pollutant that damages various organs, especially the kidney. The concluding study proposes that the type of kidney cell and severity of cadmium-induced cellular stress appear to determine the effect of MAPK on cell fate.

DKK 538.00
1

Modulation of Membrane-Protein Interactions Applied to Whey Fractionation - M Carmen Almecija - Bog - Nova Science Publishers Inc - Plusbog.dk

Modulation of Membrane-Protein Interactions Applied to Whey Fractionation - M Carmen Almecija - Bog - Nova Science Publishers Inc - Plusbog.dk

This book examines the effects of the interactions between membrane and proteins on the separation of whey proteins. These interactions can be modulated by modifying the chemical environment of the feed solution, for example, by changing the pH. In the experimental set-up, a tubular ceramic cross-flow ultrafiltration membrane was installed and continuous diafiltration was selected as operational mode. pH was found to be a crucial process variable since a wide variety of responses were obtained in permeate flow and protein transmission when this input was altered. As a conclusion, these results provide useful information for the design of filtration strategies in which particular whey fractions are targeted.

DKK 534.00
1

Preferential Solvation and Hydration of Proteins in Water-Organic Mixtures - - Bog - Nova Science Publishers Inc - Plusbog.dk

Preferential Solvation and Hydration of Proteins in Water-Organic Mixtures - - Bog - Nova Science Publishers Inc - Plusbog.dk

This book describes the basic principles of a novel methodology to investigate the preferential hydration and solvation of proteins in ternary protein-water-organic solvent systems. Protein-water interactions are well-known to play a critical role in determining the function, structure, and stability of protein macromolecules. Elucidation of the processes occurring upon protein hydration in the presence of third component (organic solvents, salts, urea) is essential in a wide range of biophysical, biomedical, and biotechnological applications. In particular, there are many advantages in employing water-poor organic solvents, including the suppression of undesirable side reactions caused by water, the biocatalysis of reversed hydrolytic reactions (transesterification, peptide synthesis), or increased thermostability. Distinct intermediate protein states induced by organic solvents may be responsible for numerous neurodegenerative diseases (Alzheimer''s disease, Parkinson''s disease, and Huntington''s disease). However, the manner in which organic solvents increase/decrease the thermal stability, induce/reduce the extent of denaturation, and stabilise/destabilise the partially folded conformations of proteins (amyloid fibrils and molten globules) is an intricate function of water content in organic liquids. Preferential hydration/solvation is an effective method for revealing the mechanism of the protein stabilisation or denaturation. When a protein interacts with a binary water-organic solvent mixture, the three components do not equally mix. Water or organic solvent molecules exist preferentially in the protein''s solvation shell. This difference between the solvation shell and bulk solvent in the solvent components has been termed preferential solvation. Preferential solvation is a thermodynamic quantity that describes the protein surface occupancy by the water and cosolvent molecules. This is associated with the actual numbers of water/cosolvent molecules that are in contact with the protein''s surface. It was also found that the protein destabilisation is directly associated with the preferential binding of the denaturant molecules to specific protein groups. The aim of our study is to monitor the preferential solvation and preferential hydration of the protein macromolecules at low, intermediate, and high water content in organic solvents at 25 oC. Our approach is based on the simultaneous measurements of the absolute values of the water and organic solvent sorption. The preferential solvation/hydration parameters were calculated using the water and organic solvent sorption values. The preferential solvation/hydration parameters were compared with the corresponding changes in the protein structure that transpire regarding the interaction of the protein with organic solvent and water molecules. The effect of organic solvent on the protein structure was investigated by FTIR (Fourier Transform Infrared) spectroscopy.

DKK 718.00
1

A Closer Look at Membrane Proteins - - Bog - Nova Science Publishers Inc - Plusbog.dk

A Closer Look at Membrane Proteins - - Bog - Nova Science Publishers Inc - Plusbog.dk

This book opens with a description of the insulin-like growth factor system, with focus on the insulin-like growth factor receptors and functions associated with them. The data on membrane proteins, their N-glycome and oxidation status id related to the authors'' findings on the receptors in different physiological and pathological conditions, such as normal and abnormal tissue growth and development. Next, a review of the current methods used to prepare and study membrane proteins is presented, with focus on large scale simulations and special emphasis on scalable parallel methods. In closing, commandments surrounding integral membrane protein expression and purification, integral membrane protein biochemistry, integral membrane protein functionality studies and integral membrane protein high-resolution structures are described.

DKK 718.00
1

Proteomics - - Bog - Nova Science Publishers Inc - Plusbog.dk

Proteomics - - Bog - Nova Science Publishers Inc - Plusbog.dk

Proteomics is the large-scale study of proteins, particularly their structures and functions. Proteins are vital parts of living organisms, as they are the main components of the physiological metabolic pathways of cells. The proteome is the entire complement of proteins, including the modifications made to a particular set of proteins, produced by an organism or system. This book presents and discusses various topical data on proteomics, including: proteomic technologies used in celiac disease, protein location in plant proteomics, the prediction of protein-protein interactions (PPIs) using proteomics, proteomic studies of mild cognitive impairment, among others.

DKK 718.00
1

Bioencapsulation in Silica-Based Nanoporous Sol-Gel Glasses - Farid Menaa - Bog - Nova Science Publishers Inc - Plusbog.dk

Bioencapsulation in Silica-Based Nanoporous Sol-Gel Glasses - Farid Menaa - Bog - Nova Science Publishers Inc - Plusbog.dk

In this book, the authors report the recent results on the influence of different parameters (such as surface hydration, hydrophobicity, solute effects, thermal stability, porosity, macromolecular crowding) on the protein conformation based on the design and the characterisation of nanoporous silica-based materials containing different functional groups (e.g., hydrophobic alkyl, phosphate and fluorinated groups). The enhancement of the protein folding owing the physical properties and microstructure of the host matrix induced by the nature of the functional groups and the siloxane network play a major role on the protein biological activity and therefore to the development efficient bionanodevices such as biocatalysts, sensors, drug delivery systems or implanted devices. This book enlightens the bioapplications of silica-based glasses prepared from functionalised organosilane precursors used to mimic and to understand the different factors that influencing the protein folding process.

DKK 633.00
1

Molecular Pathology of Proteins - - Bog - Nova Science Publishers Inc - Plusbog.dk

Molecular Pathology of Proteins - - Bog - Nova Science Publishers Inc - Plusbog.dk

This book is attempt to clarify some structural and functional protein disfunctions that are related with molecular pathologies. These consist of a wide group of diseases, which are induced by the disruption of the normal physiological processes because of the inability of some proteins to take part into inter-molecular interactions mediating these processes. It presents materials concerning autoimmune, folding and genetic pathologies, problems of the ensuring of functional activity of the protein preparations and biocompatibility of medical implants.

DKK 1034.00
1

HSP70s - - Bog - Nova Science Publishers Inc - Plusbog.dk

HSP70s - - Bog - Nova Science Publishers Inc - Plusbog.dk

This book covered the current knowledge on structural as well as functional attributes of Heat shock protein 70 (Hsp70), which is the prime as well as abundant stressor protein in biological systems. In this book, the authors discuss research including the Heat Shock Proteins: History, Discoveries, and Implications in Diseases, Therapeutic and Research Options; Intracellular Versus Extracellular Hsp70; Role of Hsp70 in Sperm Quality; Heat Stress and Livestock Adaptation: An HSP70 Perspectives; Bovine Heat Shock Protein 70 (Hsp70) and Its Role In Thermoregulation; The Role of Hsp70 in Sperm Quality; comprehensive review on HSP70 in shrimps and role of microbial heat shock protein70 (mHSP70) in the development of veterinary vaccines. This book will be convenient for researchers engaged in the fields of Medicine, Physiology, Clinical Trials, Biotechnology, Molecular Medicine and Pathology.

DKK 718.00
1

Foldases Catalyzing the Formation & Isomerization of Disulfide Bonds in Proteins - Natalya K Nagradova - Bog - Nova Science Publishers Inc -

Foldases Catalyzing the Formation & Isomerization of Disulfide Bonds in Proteins - Natalya K Nagradova - Bog - Nova Science Publishers Inc -

One of the rate-limiting steps in the folding pathways of many secretory proteins is the formation of correct disulfide bonds between cysteine residues. In eukaryotes, both disulfide bond formation and isomerisation which shuffles incorrectly formed disulfides are catalysed by protein disulfide isomerase (PDI), whereas in bacteria these two reactions are catalysed by separate enzymes. Both in eukaryotic and prokaryotic cells the oxidation and isomerisation steps proceed exclusively in extracytoplasmic environments (the lumen of the eukaryotic endoplasmic reticulum and the Gram-negative bacterial periplasmic space). The family of foldases under discussion is characterised by a conserved "thioredoxin fold" and a common active site motif: Cys-X-X-Cys. The process of disulfide bond formation relies on thiol-disulfide exchange between oxidised and reduced cysteine pairs in the catalyst and substrate protein. Two separate pathways involved in disulfide bond formation and isomerisation have been characterised both in eukaryotes and in bacteria. In the oxidative pathway, oxidizing equivalents flow from oxygen to a membrane protein (Ero1p in eukaryotes or DsbB in bacteria), and then to a folding protein containing reduced cysteines via PDI (in eukaryotes) or via DsbA (in bacteria). In the isomerisation pathway, DsbC (bacterial protein disulfide isomerase) or PDI (in eukaryotes) interacts with substrate proteins that contain non-native disulfide bonds, allowing these bonds to rearrange to their native pairings. Reducing equivalents which are necessary to maintain DsbC in a reduced form, able to attack misfolded disulfides, are transferred from the cytoplasm with the aid of the cytoplasmic membrane protein DsbD. In eukaryotes, reduced glutathione is the main source of reducing equivalents for PDI. A dual role of PDI as an oxidase and an isomerase is facilitated by its complex domain architecture.

DKK 405.00
1

Protein Kinase C - - Bog - Nova Science Publishers Inc - Plusbog.dk

Protein Kinase C - - Bog - Nova Science Publishers Inc - Plusbog.dk

In this compilation, the authors review the structural basis of PKC isozymes and focus on the C1 domain, as well as the plausible binding mechanisms of its activators. Additionally, the recent molecular dynamics simulation studies of how phorbol esters or bryostatin bind to the activator pocket are described and some of the key amino acid residues recently identified as important for activator binding are investigated. The following chapter focuses on the expression pattern and function of PKCα in cancer cells, and newly emerging PKCα-targeted cancer therapies. PKCα acts directly and/or indirectly in various signaling mechanisms in cancer cells, including proliferation, survival, invasion, migration, apoptosis and drug resistance. A final review is provided which dissects the crosstalk between p53 and PKCδ in the context of apoptotic cell death and cancer therapy. PKCδ is implicated in a transcriptional regulation of the p53 tumor suppressor that is critical for cell cycle arrest and apoptosis in response to DNA damage.

DKK 820.00
1

Novel Enzyme / DNA Inorganic Materials - Chall V Kumar - Bog - Nova Science Publishers Inc - Plusbog.dk

Novel Enzyme / DNA Inorganic Materials - Chall V Kumar - Bog - Nova Science Publishers Inc - Plusbog.dk

The very first examples of protein/DNA/inorganic nanocomposite materials are described. Surprisingly, the presence of DNA enhanced the properties of the bound protein. The layered inorganic solid, alpha-Zr(IV) phosphate (alpha-Zr(HPO4)2.H2O, abbreviated as alpha-ZrP) served as an excellent host for these studies, and the binding has been carried out under benign conditions (aqueous solutions at room temperature and neutral pH). These novel nanobiocomposite materials provide a simple method for the binding of DNA to negatively charged solids, and such approaches aid in engineering more effective synthetic materials for gene-delivery, RNA-delivery and drug delivery applications.

DKK 514.00
1

Surface Plasmon Resonance (SPR) - - Bog - Nova Science Publishers Inc - Plusbog.dk

Surface Plasmon Resonance (SPR) - - Bog - Nova Science Publishers Inc - Plusbog.dk

Chapter One demonstrates the applicability of devices based on surface plasmon resonabnce phenomenon (SPR) for investigations in the fields of medicine, veterinary, microbiology, and food industry. Considered here are the results of SPR measurements for two suspensions of erythrocytes the dense one (erythrocyte mass after centrifuging) and loose solution (whole blood). Chapter Two is focused on the variation of properties in the host liquid crystals (LCs) and dopant gold nanoparticles (GNPs). Surface-induced self-ordering of LC molecules in the vicinity of GNPs has been widely studied in the literature due to the fact that the optical, mechanical and electronic properties of both LCs and GNPs are found modulated to build the next generation of plasmonic devices. In Chapter Three, the authors present an overview of the recent research advances in the field of localised surface plasmon resonance (LSPR) spectroscopy, focusing on the works done to improve LSPR based biosensing by optimising shape, size, and materials of the nanostructure. They discuss biosensing/bioassay strategies performed on the surface of the noble metal nanostructures focusing on carbohydrate-protein and protein-protein interactions.

DKK 1034.00
1

Surface Plasmon Resonance - Pranveer Singh - Bog - Nova Science Publishers Inc - Plusbog.dk

Surface Plasmon Resonance - Pranveer Singh - Bog - Nova Science Publishers Inc - Plusbog.dk

SPR is real-time, label-free measurements of binding kinetics and affinity. This has distinct advantage over radioactive or fluorescent labelling methods, in terms of: 1) ligand-analyte binding kinetics, that can be probed without the costly and time-consuming labeling process that may interfere with molecular binding interactions; 2) binding rates and affinity can be measured directly and 3) low affinity interactions in high protein concentrations for can be characterized with less reagent consumption than other equilibrium measurement techniques; 4) Label-free detection of molecular interactions presents an attractive alternative. This is particularly true for protein targets where labels can compromise protein function. Label-free methods are also desirable because they are typically compatible with real-time detection, enabling the determination of rates of association. The success of SPR biosensors was indicated by the growing number of commercially available instruments. Since Biacore AB (originally Pharmacia Biosensor AB) launched the first commercial SPR biosensor on market in 1990, there have been many more competing SPR instruments including IASys (Affinity Sensors), SPR-670 (Nippon Laser Electronics), IBIS (IBIS Technology BV), TISPR (Texas Instruments), etc.

DKK 890.00
1

Phage Display as a Tool for Synthetic Biology - Santina Carnazza - Bog - Nova Science Publishers Inc - Plusbog.dk

Phage Display as a Tool for Synthetic Biology - Santina Carnazza - Bog - Nova Science Publishers Inc - Plusbog.dk

Phage display can be considered as a practical realisation of an artificial chemical evolution. As such, it is an useful tool for in vitro protein evolution, aimed to identifying new receptors and natural ligands for "orphan receptors", drug discovery (peptides might act as enzyme inhibitors and receptor agonists or antagonists, or otherwise modulate the enzyme/receptor''s biological effect), "epitope discovery" (a new approach to disease diagnosis and vaccine development), design of DNA-binding proteins, source of new materials, antibody phage and recombinant phage probes, next-generation nano-electronics, targeted therapy, molecular imaging, gene delivery and phage-display vaccination. All this can be regarded as a kind of synthetic biology in that it involves the reshaping and redirecting of natural molecular systems, phage, typically using the tools of protein and genetic engineering.

DKK 633.00
1

Handbook on Estrogen Receptors in the Brain - Vijay Paramanik - Bog - Nova Science Publishers Inc - Plusbog.dk

Handbook on Estrogen Receptors in the Brain - Vijay Paramanik - Bog - Nova Science Publishers Inc - Plusbog.dk

The present book covers estrogen, its receptors and estrogen mediated gene regulation in the brain. Further, it explains the mechanism of estrogen action and dysfunction leading to diseases. Briefly, estrogen mediates its multiple functions in the brain through two well-characterised receptors: ERα and ERβ. Upon binding with estrogen, ER recruits coregulators, which are responsible for tissue specific regulation. When coregulators activate the transcription of a particular gene, they become coactivators; when they repress the activity of particular gene, they are called corepressors. These coregulators make a bridge between the basal transcription machinery and the receptors by protein-protein interaction. Estrogen disrupters are also explained in this book. Furthermore, the role of estrogen and its receptors are explained in the context of aging. Taken together, this book shall be self-explanatory concerning estrogen action in the brain in various aspects. Therefore, it is intended for researchers interested in the aforementioned aspects.

DKK 1034.00
1

Macromolecular Chemistry - - Bog - Nova Science Publishers Inc - Plusbog.dk

Macromolecular Chemistry - - Bog - Nova Science Publishers Inc - Plusbog.dk

In this book, the authors present current research in the study of macromolecular chemistry. Topics include efficient biotechological tools on GM crops and bioinsecticide approaches; structuring polymer composites with chemically active fillers; enrichment of Sauvignon Blanc wine by heat stable wine macromolecules; protein transduction in human cells mediated by arginine-rich cell-penetrating peptides in mixed covalent and non-covalent manners; and cleavage of fibrinopeptides from fibrinogen during fibrin formation.

DKK 1132.00
1