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Insulin - The Crooked Timber - Kersten T. (school Of Philosophy Hall - Bog - Oxford University Press - Plusbog.dk

Insulin - The Crooked Timber - Kersten T. (school Of Philosophy Hall - Bog - Oxford University Press - Plusbog.dk

Before the discovery of insulin, a diagnosis of Type 1 diabetes was a death sentence. One hundred years after a milestone medical discovery, ''Insulin - The Crooked Timber'' tells the story of how insulin was transformed from what one clinician called ''thick brown muck'' into the very first drug to be produced using genetic engineering, one which would earn the founders of the US biotech company Genentech a small fortune.Yet when Canadian doctor Frederick Banting was told in 1923 that he had won the Nobel Prize for this life-saving discovery, he was furious. For the prize had not been awarded to him alone - but jointly with a man whom he felt had no right to this honour. The human story behind this discovery is one of ongoing political and scientific controversy.Taking the reader on a fascinating journey, starting with the discovery of insulin in the 1920s through to the present day, ''Insulin - The Crooked Timber'' reveals a story of monstrous egos, toxic career rivalries, and a few unsung heroes such as two little known scientists whose work on wool fibres, carried out in a fume-filled former stable, not only proved to be crucial in unravelling the puzzle of insulin but ushered in a revolution in biology.It was the author''s own shocking diagnosis with Type 1 diabetes that prompted him to sit down and write this book, but this story has lessons for us all about what technology can - and more importantly cannot - do for us. As the world pins its hopes on effective and lasting vaccines against Covid-19, these lessons from the story of insulin have never been more relevant.

DKK 349.00
1

Oxford Handbook of Diabetes Nursing - Ms Teffy Thomas - Bog - Oxford University Press - Plusbog.dk

Oxford Handbook of Diabetes Nursing - Ms Teffy Thomas - Bog - Oxford University Press - Plusbog.dk

The Oxford Handbook of Diabetes Nursing has been fully reviewed and updated for its second edition. This practical pocket-sized guide serves as an update to support knowledge for contemporaneous, holistic and gold standards of care in diabetes.Written by experienced diabetes practitioners, the focus is on adult diabetes care across all settings to include primary, community, and inpatient diabetes care. There is a wealth of evidenced based, practical guidance delivered in the easy-to-read, quick reference Oxford Handbook format. New chapters include; psychological issues in people living with diabetes, female health in diabetes, the perioperative management of diabetes, and technology for insulin delivery and glucose monitoring. Other chapters cover areas which have developed over more recent years such as type 2 diabetes prevention, the remission of type 2 diabetes, cardio-renal protection, frailty assessment, and multiple long-term conditions, with a comprehensive section on insulin, to include advice on insulin types, devices, safety and best practice technique.Many chapters include associated case studies to support enhanced learning. Throughout the handbook there is a focus on potential health inequalities, the importance of individualised care, and how underserved communities can best be supported. As we look to effective diabetes care delivery by the whole multi-disciplinary team the handbook continues to be a valuable resource providing high standards of education, guidance, and signposting for all healthcare professionals.

DKK 320.00
1

Type 1 Diabetes - David Levy - Bog - Oxford University Press - Plusbog.dk

Type 1 Diabetes - David Levy - Bog - Oxford University Press - Plusbog.dk

Providing clinicians with the latest developments in research, this new edition of Type 1 Diabetes is a succinct and practical guide to the diagnosis, evaluation, and management of Type 1 diabetes.Part of the Oxford Diabetes Library series, this pocketbook contains 12 fully updated chapters on key topics such as history, epidemiology, aetiology, presentation, insulin treatment, and microvascular and macrovascular complications. It also features new chapters on technology, diet and lifestyle, and pregnancy planning to ensure the reader is fully equipped with the latest understanding of Type 1 diabetes.

DKK 478.00
1

Diabetes in Pregnancy - - Bog - Oxford University Press - Plusbog.dk

Diabetes in Pregnancy - - Bog - Oxford University Press - Plusbog.dk

Diabetes is one of the most common medical conditions to complicate pregnancy. Gestational diabetes (diabetes with onset or first recognition in pregnancy) may complicate between 2 and 20% of pregnancies depending on the criteria used. Type 1 or Type 2 diabetes complicates over 1 in 300 pregnancies, and both have major implications for mother and child. The management of diabetes during pregnancy has seen a number of major innovations in recent years. Insulin analogues have been introduced, and technical innovations include improvements in insulin pumps and the development of continuous glucose monitoring devices. The evidence base for the management of gestational diabetes has improved markedly, and the investigations based around the Hyperglycaemia and Adverse Pregnancy Outcomes (HAPO) study promise to revolutionise our understanding of the risks of adverse outcomes in pregnancy. The Australian Carbohydrate Intolerance Study (ACHOIS) has demonstrated that identification and glycaemic management of gestational diabetes leads to reduction in birth weight, macrosomia and adverse pregnancy outcomes. Finally, recent randomised control trials have explored use of oral hypoglycaemics (metformin, glibenclamide) in pregnancy. Part of the Oxford Diabetes Library series, ''Diabetes in Pregnancy'' summarizes the key aspects of the medical management of diabetes during pregnancy with an emphasis on clinical management. The volume is designed for all members of the multidisciplinary team and will act as a practical introduction particularly for obstetricians and endocrinologists in training.

DKK 387.00
1

Type 1 Diabetes - David Levy - Bog - Oxford University Press - Plusbog.dk

Type 1 Diabetes - David Levy - Bog - Oxford University Press - Plusbog.dk

While Type 1 diabetes is still predominantly a hospital-based specialty, increasing numbers of patients are being supervised in primary care. This book emphasises both the unique nature of Type 1 diabetes and its fundamental differences from Type 2 diabetes (at least in its ''classic'' form), and also draws together the common threads of management - especially in the diagnosis and treatment of microvascular complications, its common coexistence with the insulin resistance syndrome, and the importance of late-onset Type 1 diabetes in older patients. This highly practical volume in the Oxford Diabetes Library is intended for all advanced practitioners in primary and secondary care. Wherever it is available, the limited RCT evidence base for practice in Type 1 diabetes is quoted and put into a practical context.

DKK 349.00
1

Graphene - E. L. (professor Of Physics Wolf - Bog - Oxford University Press - Plusbog.dk

Graphene - E. L. (professor Of Physics Wolf - Bog - Oxford University Press - Plusbog.dk

The book is an introduction to the science and possible applications of Graphene, the first one-atom-thick crystalline form of matter. Discovered in 2004 by now Nobelists Geim and Novoselov, the single layer of graphite, a hexagonal network of carbon atoms, has astonishing electrical and mechanical properties. It supports the highest electrical current density of any material, far exceeding metals copper and silver. Its absolute minimum thickness, 0.34 nanometers, provides an inherent advantage in possible forms of digital electronics past the era of Moore''s Law.The book describes the unusual physics of the material, that it offers linear rather than parabolic energy bands. The Dirac-like electron energy bands lead to high constant carrier speed, similar to light photons. The lattice symmetry further implies a two-component wave-function, which has a practical effect of cancelling direct backscattering of carriers. The resulting high carrier mobility allows observation of the Quantum Hall Effect at room temperature, unique to Graphene. The material is two-dimensional, but in sizes micrometers nearly to meters displays great tensile strength but vanishing resistance to bending.The book reviews theoretical predictions of excessive atomic vibrational motion, tied to the dimensionality. As explained, these predictions seem not of practical consequence, and such effects are unobservable in samples up to nearly one meter size. The disintegration temperature of this refractory material is estimated as 4900K, certainly higher than the measured sublimation temperature of graphite, 3900K. As explained, applications of Graphene come in classes that range from additives to composite materials to field effect transistor elements capable of extremely high frequency operation. The classes of applications correlate with differing methods of fabrication, from inexpensive chemical exfoliations of graphite, to chemical vapour deposition on catalytic substrates as Cu and Ni, at temperatures around 1300K. The book reviews potential applications within existing electronics, to include interconnect wires, flash-memory elements, and high frequency field effect transistors. The chance to supplant the dominant CMOS family of silicon logic devices is assessed.

DKK 500.00
1

The People and the British Economy, 1830-1914 - Roderick (provost Floud - Bog - Oxford University Press - Plusbog.dk

The People and the British Economy, 1830-1914 - Roderick (provost Floud - Bog - Oxford University Press - Plusbog.dk

The inspiration for this book comes from the words of Adam Smith: `Consumption is the sole end of and purpose of all production....'' This book concentrates, in that spirit, on people rather on things; it describes the overall income and wealth of Britain, its growth, and how that income and wealth was produced by and distributed between different people in the population. Population growth has a central place, as do the changes in home and workplace, in the transformation of the lives of successive generations in Victorian and Edwardian Britain. Between 1830 and 1914 Britain became the world''s major trading nation, carrier of the majority of the world''s goods, by far the largest investor overseas, and the centre of the world''s financial system. It was an exceptional time in the history of the country and one to which many look back, even a hundred years later, with nostalgia. This book seeks to describe and assess what was achieved in those eighty-five years.

DKK 447.00
1

One Hundred Patents That Shaped the Modern World - David Segal - Bog - Oxford University Press - Plusbog.dk

One Hundred Patents That Shaped the Modern World - David Segal - Bog - Oxford University Press - Plusbog.dk

What would our world today be like without inventions like tarmac, aspirin, liquid crystals, and barbed wire? This guide shows how patents and the inventions they describe have shaped the 21st century. It gives us insights into the inventions, big and small, that have had huge impacts, many unexpected, on multiple spheres of our lives, from popular culture and entertainment, to global health, to transportation, to the waging of war. It features patent documents that date from the mid-19th century to the present. Patent documents describe inventions and represent an accurate and rich source of information about the history and current state of modern technology, as patents are examined and their accuracy can be challenged.The subject matter covers many technical areas. Patents discussed include, for example, Morse code, the diode, triode, transistors, television, frozen foods, ring-pull for soft drink cans, board games such as Monopoly, gene editing, metamaterials, MRI, computerised tomography, insulin, and monoclonal antibodies such as Herceptin. The text is illustrated with drawings adapted from the original patent documents. Patent numbers are included to allow interested readers to trace the documents. Inventions described in the patents are placed in historical perspective. For example, the book discusses the role of the cavity magnetron and radar in World War II, and the influence of the diode on the development of broadcasting at the beginning of the 20th century.

DKK 496.00
1

One Plus One Equals One - John (professor Archibald - Bog - Oxford University Press - Plusbog.dk

One Plus One Equals One - John (professor Archibald - Bog - Oxford University Press - Plusbog.dk

We are in the midst of a revolution. It is a scientific revolution built upon the tools of molecular biology, with which we probe and prod the living world in ways unimaginable a few decades ago. Need to track a bacterium at the root of a hospital outbreak? No problem: the offending germ''s complete genetic profile can be obtained in 24 hours. We insert human DNA into E. coli bacteria to produce our insulin. It is natural to look at biotechnology in the 21st century with a mix of wonder and fear. But biotechnology is not as ''unnatural'' as one might think. All living organisms use the same molecular processes to replicate their genetic material and the same basic code to ''read'' their genes. The similarities can be seen in their DNA. Here, John Archibald shows how evolution has been ''plugging-and-playing'' with the subcellular components of life from the very beginning and continues to do so today. For evidence, we need look no further than the inner workings of our own cells. Molecular biology has allowed us to gaze back more than three billion years, revealing the microbial mergers and acquisitions that underpin the development of complex life. One Plus One Equals One tells the story of how we have come to this realization and its implications.

DKK 132.00
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The Rise of Yeast - Nicholas P. (professor Of Botany And Western Program Director At Miami University In Oxford Money - Bog - Oxford University Press

The Rise of Yeast - Nicholas P. (professor Of Botany And Western Program Director At Miami University In Oxford Money - Bog - Oxford University Press

From breakfast toast to evening wine, yeast is the microscopic thing that we cannot live without. We knew what yeast did as an invisible brewer and baker long before we had a clue about the existence of microorganisms. Ten thousand years ago, our ancestors abandoned bush meat and wild fruit in favor of farming animals and cultivating grain. Leaving the forests and grasslands, our desire for beer and wine produced by the fungus was a major stimulus for agricultural settlement. It takes a village to run a brewery or tend a vineyard. We domesticated wild yeast and yeast domesticated us. With the inevitable escape of the fungus from beer vats into bread dough, our marriage with yeast was secured by an appetite for fresh loaves of leavened bread. Over the millennia, we have adapted the technologies of brewing, winemaking, and baking and have come to rely on yeast more and more. Yeast produces corn ethanol and other biofuels and has become the genetically-modified darling of the pharmaceutical business as a source of human insulin and a range of life-saving medicines. These practical uses of yeast have been made possible by advances in our understanding of its biology, and the power of genetic engineering has been used to modify the fungus to do just about anything we wish. We know more about yeast than any other organism built from complex cells like our own. To understand yeast is to understand life. In this book Nicholas P. Money offers a celebration of our favorite microorganism.

DKK 206.00
1

Quantum Confined Laser Devices - Peter Blood - Bog - Oxford University Press - Plusbog.dk

Quantum Confined Laser Devices - Peter Blood - Bog - Oxford University Press - Plusbog.dk

The semiconductor laser, invented over 50 years ago, has had an enormous impact on the digital technologies that now dominate so many applications in business, commerce and the home. The laser is used in all types of optical fibre communication networks that enable the operation of the internet, e-mail, voice and skype transmission. Approximately one billion are produced each year for a market valued at around $5 billion. Nearly all semiconductor lasers now use extremely thin layers of light emitting materials (quantum well lasers). Increasingly smaller nanostructures are used in the form of quantum dots. The impact of the semiconductor laser is surprising in the light of the complexity of the physical processes that determine the operation of every device. This text takes the reader from the fundamental optical gain and carrier recombination processes in quantum wells and quantum dots, through descriptions of common device structures to an understanding of their operating characteristics. It has a consistent treatment of both quantum dot and quantum well structures taking full account of their dimensionality, which provides the reader with a complete account of contemporary quantum confined laser diodes. It includes plenty of illustrations from both model calculations and experimental observations. There are numerous exercises, many designed to give a feel for values of key parameters and experience obtaining quantitative results from equations. Some challenging concepts, previously the subject matter of research monographs, are treated here at this level for the first time.

DKK 1127.00
1

Great Britain, International Law, and the Evolution of Maritime Strategic Thought, 1856–1914 - Gabriela A. Frei - Bog - Oxford University Press -

Great Britain, International Law, and the Evolution of Maritime Strategic Thought, 1856–1914 - Gabriela A. Frei - Bog - Oxford University Press -

Gabriela A. Frei addresses the interaction between international maritime law and maritime strategy in a historical context, arguing that both international law and maritime strategy are based on long-term state interests. Great Britain as the predominant sea power in the nineteenth and early twentieth centuries shaped the relationship between international law and maritime strategy like no other power. This study explores how Great Britain used international maritime law as an instrument of foreign policy to protect its strategic and economic interests, and how maritime strategic thought evolved in parallel to the development of international legal norms. Frei offers an analysis of British state practice as well as an examination of the efforts of the international community to codify international maritime law in the late nineteenth and early twentieth centuries. Great Britain as the predominant sea power as well as the world''s largest carrier of goods had to balance its interests as both a belligerent and a neutral power. With the growing importance of international law in international politics, the volume examines the role of international lawyers, strategists, and government officials who shaped state practice. Great Britain''s neutrality for most of the period between 1856 and 1914 influenced its state practice and its perceptions of a future maritime conflict. Yet, the codification of international maritime law at the Hague and London conferences at the beginning of the twentieth century demanded a reassessment of Great Britain''s legal position.

DKK 873.00
1

Quantum Confined Laser Devices - Peter (honary Professor Blood - Bog - Oxford University Press - Plusbog.dk

Quantum Confined Laser Devices - Peter (honary Professor Blood - Bog - Oxford University Press - Plusbog.dk

The semiconductor laser, invented over 50 years ago, has had an enormous impact on the digital technologies that now dominate so many applications in business, commerce and the home. The laser is used in all types of optical fibre communication networks that enable the operation of the internet, e-mail, voice and skype transmission. Approximately one billion are produced each year for a market valued at around $5 billion. Nearly all semiconductor lasers now use extremely thin layers of light emitting materials (quantum well lasers). Increasingly smaller nanostructures are used in the form of quantum dots. The impact of the semiconductor laser is surprising in the light of the complexity of the physical processes that determine the operation of every device. This text takes the reader from the fundamental optical gain and carrier recombination processes in quantum wells and quantum dots, through descriptions of common device structures to an understanding of their operating characteristics. It has a consistent treatment of both quantum dot and quantum well structures taking full account of their dimensionality, which provides the reader with a complete account of contemporary quantum confined laser diodes. It includes plenty of illustrations from both model calculations and experimental observations. There are numerous exercises, many designed to give a feel for values of key parameters and experience obtaining quantitative results from equations. Some challenging concepts, previously the subject matter of research monographs, are treated here at this level for the first time.

DKK 410.00
1

Slavery in the Early Mughal World - Anooshahr - Bog - Oxford University Press - Plusbog.dk

Slavery in the Early Mughal World - Anooshahr - Bog - Oxford University Press - Plusbog.dk

Jawhar Aftabachi was enslaved as a child by the Ottomans in the Black Sea region in the early sixteenth century. He was then sold to the Ottoman admiral Selman Reis, who took him with his fleet to Egypt and Yemen during his wars with the Portuguese; carried, after the admiral''s death, by the admiral''s nephew Mustafa Bayram to Gujarat on the western coast of India; and finally, when the Mughal army invaded Gujarat in 1534, taken into imperial service along with thousands of Eurasian and Abyssinian slaves. Here he rose to the position of water-carrier for the Mughal Emperor Humayun and chronicled this experience in a remarkable , Persian text called Tazkirah-i Vaqi`at or “memoir of events”. Ali Anooshahr here uses Jawhar''s life and memoirs as a unique window into slavery, selfhood, and the rise of the early modern Indian Ocean world. Bringing a micro-historical study to a "subaltern Mughal author" offers the opportunity to reassess the history of slavery in South Asia from an original perspective and to reframe the connected history of the early modern world. Jawhar''s life shows in vivid detail the eruption of the Mediterranean and Black Sea cultural regions into the Indian Ocean world, shedding light onto the collapse of older bonds of interdependency in the face of impersonal structures of new centralized states, and bearing witness to the process of individualization of people which was experienced not as a triumphalist "rise of the self" but as alienation.

DKK 943.00
1

Energy... beyond oil - - Bog - Oxford University Press - Plusbog.dk

Energy... beyond oil - - Bog - Oxford University Press - Plusbog.dk

As the Earth''s oil supply runs out, and the effects of climate change threaten nations and their populations, the search for carbon-neutral sources of energy becomes more important and increasingly urgent. This book focuses on solutions to the energy problem, and not just the problem itself. It describes the major energy-generation technologies currently under development, and provides an authoritative summary of the current status of each one. It stresses the need for a balanced portfolio of alternative energy technologies. Certain solutions will be more appropriate than others in particular locations, due to the differences in availability of natural resources such as solar, wind, wave, tidal and geothermal. In addition, nuclear options (both fission and fusion), as well as technologies such as fuel cells, photovoltaics, artificial photosynthesis and hydrogen (as an energy carrier), all have a potential role to play. A state-of-the-art critique of energy efficiency in building design is also included. Each chapter is written by an acknowledged international expert and provides a non-technical overview of the competing and complementary approaches to energy generation. Broad in scope and comprehensive in treatment, Energy..beyond Oil provides an authoritative synthesis of the scientific and technological issues which are essential to the survival of the human race in the near future. The book will be of interest and use to graduate students and researchers in all areas of energy studies, and will also be highly useful for policy-makers and professionals in the environmental sector as well as a more general readership who wish to learn more about this extremely topical subject.

DKK 778.00
1

Redesigning Life - John (university Lecturer In Pharmacology Parrington - Bog - Oxford University Press - Plusbog.dk

Redesigning Life - John (university Lecturer In Pharmacology Parrington - Bog - Oxford University Press - Plusbog.dk

Since the birth of civilisation, human beings have manipulated other life-forms. We have selectively bred plants and animals for thousands of years to maximise agricultural production and cater to our taste in pets. The observation of the creation of artificial animal and plant variants was a key stimulant for Charles Darwin''s theory of evolution. The ability to directly engineer the genomes of organisms first became possible in the 1970s, when the gene for human insulin was introduced into bacteria to produce this protein for diabetics. At the same time, mice were modified to produce human growth hormone, and grew huge as a result. But these were only our first tottering steps into the possibilities of genetic engineering.In the past few years, the pace of progress has accelerated enormously. We can now cut and paste genes using molecular scissors with astonishing ease, and the new technology of genome editing can be applied to practically any species of plants or animals. ''Mutation chain reaction'' can be used to alter the genes of a population of pests, such as flies; as the modified creatures breed, the mutation is spread through the population, so that within a few generations the organism is almost completely altered. At the same time, scientists are also beginning to synthesize new organisms from scratch.These new technologies hold much promise for improving lives. Genome editing has already been used clinically to treat AIDS patients, by genetically modifying their white blood cells to be resistant to HIV. In agriculture, genome editing could be used to engineer species with increased food output, and the ability to thrive in challenging climates. New bacterial forms may be used to generate energy. But these powerful new techniques also raise important ethical dilemmas and potential dangers, pressing issues that are already upon us given the speed of scientific developments. To what extent should parents be able to manipulate the genetics of their offspring — and would designer babies be limited to the rich? Can we effectively weigh up the risks from introducing synthetic lifeforms into complex ecosystems? In this extensively revised paperback edition, John Parrington explains the nature and possibilities of these new scientific developments, which could usher in a brave, new world. We must rapidly come to understand its implications if we are to direct its huge potential to the good of humanity and the planet.

DKK 141.00
1