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The Microbiome - Richard Lucius - Bog - Springer International Publishing AG - Plusbog.dk

The Microbiome - Richard Lucius - Bog - Springer International Publishing AG - Plusbog.dk

This book unravels in an easily understandable way the exciting molecular connections between our gut microbiome, i.e. the collective microorganisms that we carry in our digestive system, nutrition and the immune system, and how an imbalance can lead to the development of inflammatory diseases. The totality of these gut microorganisms forms a complex ecosystem within us, consisting of hundreds of different species of bacteria. The author, microbiologist Professor Richard Lucius, introduces the historical context of microbiome research, discusses how our lives have changed in recent decades, and explains the composition and function of the microbiome and its connection to the gut and immune system. The book explains in detail and supported with appealing illustrations how allergies, chronic intestinal inflammation, type 1 diabetes, multiple sclerosis, rheumatoid arthritis, psoriasis and coeliac disease develop. Further chapters deal with the effects of nutrition on our intestinal flora and provide tips on building and maintaining a healthy microbiome. An intact bacterial community utilizes food residues that humans cannot digest and in return provides energy and vital substances. Only together with our inhabitants do we form a well-functioning "superorganism". Our immune system, which has developed over millions of years, is calibrated for a meagre, natural life. Under the influence of our modern way of life, the "Western lifestyle", our inner ecosystem is suffering from a loss of species, similar to our external environment. Highly processed foods, the influence of medication, lack of exercise and little contact with environmental bacteria are promoting this erosion process, which in the long term increases the risk of inflammatory diseases and obesity. As a result, more than 25% of people in modern societies suffer from allergies, autoimmune diseases and food intolerances that hardly existed in the past. This development can be counteracted by a healthy lifestyle that strengthens and diversifies the microbiome. This book is aimed at anyone who wants to understand the complex interplay between our gut microbiome, the immune system, nutrition and disease. The English translation of this volume, originally published in German language, was facilitated by artificial intelligence. A language editor has subsequently revised the text further in an endeavor to refine the work stylistically. The content was later revised by the author for accuracy.

DKK 385.00
1

The Gut in Parkinson's Disease - George Triadafilopoulos - Bog - Springer International Publishing AG - Plusbog.dk

The Gut in Parkinson's Disease - George Triadafilopoulos - Bog - Springer International Publishing AG - Plusbog.dk

At present, there is minimal and misleading knowledge of gastrointestinal dysfunction in Parkinson's disease among primary neurologists and gastroenterologists. This book reviews our current understanding of the GI involvement in PD, as many experiments suggest that the gut might be the site where the disease starts. Also discussed is how the gut dysfunction causes symptoms from the top (mouth) to the bottom (anal canal), and because of their frequency and severity, they contribute to disease progression and disability. In addition, the book covers the negative effects of small intestinal bacterial overgrowth (SIBO) and of a frequently silent stomach infection by Helicobacter pylori infection on the absorption of antiparkinsonian drugs, in turn causing motor fluctuations and inadequate treatment response. The Gut in Parkinson's Disease serves as a bridge between patients, their movement disorders specialists, and other health care providers who currently provide compartmentalized and at times conflicting care for such needy patients. The book distills the clinical and research experience of the author, who -as a Clinical Professor of Medicine (Gastroenterology) at Stanford University School of Medicine over the past 20 years- managed hundreds of patients with Parkinson’s Disease suffering from gut manifestations.

DKK 884.00
1

Microbiome in 3P Medicine Strategies - - Bog - Springer International Publishing AG - Plusbog.dk

Microbiome in 3P Medicine Strategies - - Bog - Springer International Publishing AG - Plusbog.dk

The book analyses microbiome-relevant findings focused on clinical needs providing the roadmap to implement recent achievements in the area representing a valuable contribution to the paradigm shift from reactive to predictive, preventive and personalised medicine (PPPM / 3PM) considered as the most advanced concept in medicine. Already well-acknowledged as well as future advantages of application of pre-, pro- and pharma-biotics are detailed in the book. Socio-economic impacts of the area are considered in the context of the entire spectrum of healthcare services from disease care provided to patients up to health care provided to persons in suboptimal health conditions. Innovative technologies including phenotyping, genotyping, individualised profiling, patient stratification, big data analysis, and multi-omics, amongst others are all involved in the book. The book is unique from view point of multi-professional expertise involved. International network presents more than 10 countries worldwide including Belgium, China, Germany, Israel, Ukraine and USA. The data presented are of great scientific value and of particular importance for educating a broad spectrum of professionals including researchers, healthcare givers, policy makers, business people, policy makers and general population.

DKK 884.00
1

Cytology of the Mediastinum and Gut Via Endoscopic Ultrasound-Guided Aspiration - - Bog - Springer International Publishing AG - Plusbog.dk

Cytology of the Mediastinum and Gut Via Endoscopic Ultrasound-Guided Aspiration - - Bog - Springer International Publishing AG - Plusbog.dk

This text provides a comprehensive review of the cytology of disease processes of the mediastinum and mediastinal lymph nodes with emphasis in lung and gut nodal cancer staging in specimens obtained by EUS-FNA. This book also reviews the cytology of intramural masses of the gastrointestinal tract using a pattern-based diagnostic approach. The cytomorphology of lesions obtained by EUS-FNA is peculiar by the common presence in the obtained sample of normal luminal gastrointestinal contents, and the cytopathologist should be familiar with this pattern not often seen when the sampling is done by percutaneous approach. Technical considerations pertaining to the operator performing the procedure as well as to the cytopathologist, with emphasis on rapid on-site interpretation are also covered. Most lesions described in the book also have endoscopic US image correlation. Cytology of the Mediastinum and Gut is a useful and practical guide for cytological interpretation and differential diagnosis of lesions obtained by EUS-FNA of mediastinum and gut. All chapters are written by experts with many years of experience in the field and contain the cytology, immuno-profile, molecular profile, and ultrasound features of the masses described.

DKK 423.00
1

Sex Differences in Reading and Math Test Scores of Children - Hoben Thomas - Bog - Springer International Publishing AG - Plusbog.dk

Sex Differences in Reading and Math Test Scores of Children - Hoben Thomas - Bog - Springer International Publishing AG - Plusbog.dk

This open access book examines why reading and math test scores for boys and girls have differed since the origins of testing in the United States. It details the pattern of differences that have remained largely unchanged for more than 100 years in the United States and worldwide. The book explores why boys have modestly larger math test score means than girls, and why girls have far larger reading test score means than boys. Boys have larger test score variances for both tasks. The only data of focus—and thus the only data to be explained—are boys’ and girls’ test score sample means and variances. In addition, the book provides the only coherent theory of gender differences explaining math and reading test score means and variances obtained in observational settings. It develops the simple genetical idea framed within a finite probability mixture model; it provides parameter estimates and displays numerous estimated probability distributions associated with the selected accessible studies chosen for analysis; and it extends the theory and provides explanations for never understood puzzling features of test score data. The book requires no auxiliary sources, although some understanding of random variables and probability theory is required to follow the formalization. It contains all technical details, including the estimation procedure and an R code implementation. Key areas of coverage include:· Extensive literature summary from a unique data inequalities perspective. · Perspective that challenges existing viewpoints on sex differences, falsifying conventional perspectives. · Illustrates probability modeling of psychological data. · Illustrates the failure of conventional statistics to explain data and the need for modeling data. Sex Differences in Reading and Math Test Scores of Children is an invaluable resource for researchers, professors, and graduate students in educational psychology, teaching and teacher education, literacy / language teaching and learning, mathematics education, curriculum studies, developmental psychology, statistics, and all interrelated disciplines.

DKK 349.00
1

VLSI Design and Test - - Bog - Springer International Publishing AG - Plusbog.dk

VLSI Design and Test - - Bog - Springer International Publishing AG - Plusbog.dk

This book constitutes the proceedings of the 26th International Symposium on VLSI Design and Test, VDAT 2022, which took place in Jammu, India, in July 2022. The 32 regular papers and 16 short papers presented in this volume were carefully reviewed and selected from 220 submissions. They were organized in topical sections as follows: Devices and Technology; Sensors; Analog/Mixed Signal; Digital Design; Emerging Technologies and Memory; System Design.

DKK 816.00
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Nutritional Management of Inflammatory Bowel Diseases - - Bog - Springer International Publishing AG - Plusbog.dk

Nutritional Management of Inflammatory Bowel Diseases - - Bog - Springer International Publishing AG - Plusbog.dk

This book is a state-of-the art review for clinicians and dieticians with an interest in nutrition and inflammatory bowel diseases (Crohn''s disease, ulcerative colitis). The volume covers new data about dietary risk factors for Crohn''s disease and ulcerative colitis, examines the association between diet and microbiome, describes the various diets in the management of these diseases, and discusses macro- and micronutrient deficiency that occurs in such patients. The book also examines the management of patients on total parenteral nutrition, and management of the short gut syndrome with TPN and novel pharmacologic therapies. Written by experts in their fields, Nutritional Management of Inflammatory Bowel Diseases: A Comprehensive Guide is a valuable and uniquely specialized resource for gastroenterologists, nutritionists, primary care physicians, and other health care providers and researchers dealing with the management of these complex illnesses.

DKK 689.00
1

Nutritional Management of Inflammatory Bowel Diseases - - Bog - Springer International Publishing AG - Plusbog.dk

Nutritional Management of Inflammatory Bowel Diseases - - Bog - Springer International Publishing AG - Plusbog.dk

This book is a state-of-the art review for clinicians and dieticians with an interest in nutrition and inflammatory bowel diseases (Crohn''s disease, ulcerative colitis). The volume covers new data about dietary risk factors for Crohn''s disease and ulcerative colitis, examines the association between diet and microbiome, describes the various diets in the management of these diseases, and discusses macro- and micronutrient deficiency that occurs in such patients. The book also examines the management of patients on total parenteral nutrition, and management of the short gut syndrome with TPN and novel pharmacologic therapies. Written by experts in their fields, Nutritional Management of Inflammatory Bowel Diseases: A Comprehensive Guide is a valuable and uniquely specialized resource for gastroenterologists, nutritionists, primary care physicians, and other health care providers and researchers dealing with the management of these complex illnesses.

DKK 795.00
1

Portal Hypertension VI - - Bog - Springer International Publishing AG - Plusbog.dk

Portal Hypertension VI - - Bog - Springer International Publishing AG - Plusbog.dk

This book will be an excellent tool for practitioners seeking an update on the latest developments in the diagnosis and management of cirrhosis and portal hypertension. Among the topics addressed are risk stratification, prognosis, screening and surveillance, impact of etiological and antifibrotic therapy, the gut microbiome and cirrhosis, prevention of decompensation/further decompensation, management of the acute bleeding episode, controversies in pediatrics, and vascular diseases of the liver in cirrhotic and noncirrhotic portal hypertension. The book is a compilation of lectures and important consensus statements from the Sixth Baveno International Consensus Workshop on Portal Hypertension, the most recent of a series of workshops held every 5 years for hepatologists with an interest in the field. Portal Hypertension VI will serve as a reference book for clinical and research fellows in Gastroenterology and Hepatology and should inspire new research projects in the areas identified as promising by the experts of the Baveno VI Faculty.

DKK 901.00
1

Simulating Information Retrieval Test Collections - Bodo Billerbeck - Bog - Springer International Publishing AG - Plusbog.dk

Simulating Information Retrieval Test Collections - Bodo Billerbeck - Bog - Springer International Publishing AG - Plusbog.dk

Simulated test collections may find application in situations where real datasets cannot easily be accessed due to confidentiality concerns or practical inconvenience. They can potentially support Information Retrieval (IR) experimentation, tuning, validation, performance prediction, and hardware sizing. Naturally, the accuracy and usefulness of results obtained from a simulation depend upon the fidelity and generality of the models which underpin it. The fidelity of emulation of a real corpus is likely to be limited by the requirement that confidential information in the real corpus should not be able to be extracted from the emulated version. We present a range of methods exploring trade-offs between emulation fidelity and degree of preservation of privacy. We present three different simple types of text generator which work at a micro level: Markov models, neural net models, and substitution ciphers. We also describe macro level methods where we can engineer macro properties of a corpus, giving a range of models for each of the salient properties: document length distribution, word frequency distribution (for independent and non-independent cases), word length and textual representation, and corpus growth. We present results of emulating existing corpora and for scaling up corpora by two orders of magnitude. We show that simulated collections generated with relatively simple methods are suitable for some purposes and can be generated very quickly. Indeed it may sometimes be feasible to embed a simple lightweight corpus generator into an indexer for the purpose of efficiency studies. Naturally, a corpus of artificial text cannot support IR experimentation in the absence of a set of compatible queries. We discuss and experiment with published methods for query generation and query log emulation. We present a proof-of-the-pudding study in which we observe the predictive accuracy of efficiency and effectiveness results obtained on emulated versions of TREC corpora. The study includes three open-source retrieval systems and several TREC datasets. There is a trade-off between confidentiality and prediction accuracy and there are interesting interactions between retrieval systems and datasets. Our tentative conclusion is that there are emulation methods which achieve useful prediction accuracy while providing a level of confidentiality adequate for many applications. Many of the methods described here have been implemented in the open source project SynthaCorpus, accessible at: https://bitbucket.org/davidhawking/synthacorpus/

DKK 509.00
1

A Practical Guide to Testing Wireless Smartphone Applications - Julian Harty - Bog - Springer International Publishing AG - Plusbog.dk

A Practical Guide to Testing Wireless Smartphone Applications - Julian Harty - Bog - Springer International Publishing AG - Plusbog.dk

Testing applications for mobile phones is difficult, time-consuming, and hard to do effectively. Many people have limited their testing efforts to hands-on testing of an application on a few physical handsets, and they have to repeat the process every time a new version of the software is ready to test. They may miss many of the permutations of real-world use, and as a consequence their users are left with the unpleasant mess of a failing application on their phone. Test automation can help to increase the range and scope of testing, while reducing the overhead of manual testing of each version of the software. However automation is not a panacea, particularly for mobile applications, so we need to pick our test automation challenges wisely. This book is intended to help software and test engineers pick appropriately to achieve more; and as a consequence deliver better quality, working software to users. This Synthesis lecture provides practical advice based on direct experience of using software test automation to help improve the testing of a wide range of mobile phone applications, including the latest AJAX applications. The focus is on applications that rely on a wireless network connection to a remote server, however the principles may apply to other related fields and applications. We start by explaining terms and some of the key challenges involved in testing smartphone applications. Subsequent chapters describe a type of application e.g. markup, AJAX, Client, followed by a related chapter on how to test each of these applications. Common test automation techniques are covered in a separate chapter, and finally there is a brief chapter on when to test manually. The book also contains numerous pointers and links to further material to help you to improve your testing using automation appropriately. Table of Contents: Introduction / Markup Languages / Testing Techniques for Markup Applications / AJAX Mobile Applications / Testing Mobile AJAX Applications / Client Applications / Testing Techniques for Client Applications / Common Techniques / When to Test Manually / Future Work / Appendix A: Links and References / Appendix B: Data Connectivity / Appendix C: Configuring Your Machine

DKK 260.00
1

Dysbiosis - - Bog - Springer International Publishing AG - Plusbog.dk

Dysbiosis - - Bog - Springer International Publishing AG - Plusbog.dk

This book discusses in detail the pathological aspects associated with alterations in the gut microbiota and the pathogenesis of different disorders related to dysbiosis. The volume describes the impact of dysbiosis on organs other than the gut and brain, such as metabolic diseases, cancer, gynecologic disorders, aging, or pediatric pathologies. Additionally, it associates the mechanisms and metabolic signaling pathways related to gut microbiota homeostasis and alterations with their clinical impact, highlighting the importance of translational research on dysbiosis. The volume is divided into 12 chapters: the first two chapters present diagnostic methods and therapeutic options, including prebiotics and probiotics. The remaining ten chapters specifically focus on diseases of different organs. Moreover, the relevance of these findings to precision medicine will be discussed. The book provides biomedical professionals, basic researchers, and clinical practitioners, especially those specialized in Precision Medicine and Integrative Medicine, with information about the effects of dysbiosis on the physiopathology of various diseases. It also includes updated evidence on the impact of dysbiosis on numerous pathologies, such as metabolic diseases, cancer, gynecologic disorders, aging, or pediatric pathologies, going beyond gastrointestinal and central nervous system diseases typically covered in many publications. Furthermore, the book addresses the translational aspect of dysbiosis. It starts with the basic research knowledge on dysbiosis and disease and aims to provide a translational approach applicable to clinical practice. By combining the fundamental knowledge of biomedical researchers with the clinical applicability of healthcare practitioners, this book bridges the gap between theory and practice.

DKK 816.00
1

Alternatives for Dermal Toxicity Testing - - Bog - Springer International Publishing AG - Plusbog.dk

Alternatives for Dermal Toxicity Testing - - Bog - Springer International Publishing AG - Plusbog.dk

This book provides comprehensive information on the alternative (non-animal) dermal toxicity test methods currently available for industrial, regulatory, and academic use and also explores potential future developments. It encompasses all areas of dermal toxicity, including skin irritation, skin corrosion, skin sensitization, UV-induced effects, and skin genotoxicity. An individual chapter is devoted to each test method, with coverage of the scientific basis, validation status and regulatory acceptance, applications and limitations, available protocols, and potential role within testing strategies. In addition, perspectives from the test developer are presented, for example regarding critical steps in the protocol. The closing section addresses areas that may be of relevance for the future of dermal toxicity safety testing, including the validation and regulatory acceptance of integrated testing strategies, novel complex skin models, and high-throughput screening techniques.

DKK 967.00
1

Experimental Mechanics of Fractured Porous Rocks - Fernando Samaniego V. - Bog - Springer International Publishing AG - Plusbog.dk

Experimental Mechanics of Fractured Porous Rocks - Fernando Samaniego V. - Bog - Springer International Publishing AG - Plusbog.dk

The book offers novel petrophysical methods for obtaining and characterizing physical properties of sandstone and fractured carbonate rocks. The proposed experimental petrophysical test for the determination of permeability tensor ellipses in fractured rocks at a laboratory scale is a methodology of easy application and does not require complicated equipment. Such a test can be extended with 3D digital petrophysics. The estimation of principal permeability directions is useful in the realization of immiscible or miscible displacements in the rock. This book is of interest for professionals and researchers in the field of petrophysics and oil and gas exploration.

DKK 884.00
1