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Small Molecules in Hematology - - Bog - Springer International Publishing AG - Plusbog.dk

Small Molecules in Hematology - - Bog - Springer International Publishing AG - Plusbog.dk

This book, written by respected experts, discusses in detail the latest developments in targeted therapy for hematologic malignancies using small molecules. It covers a wide range of small molecules including tyrosine kinase inhibitors, immunomodulatory drugs, the IDH-2 inhibitor enasidenib, the BCL-2 inhibitor venetoclax, and the proteasome inhibitor carfilzomib. For each molecule, aspects such as the chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed. Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of precision cancer therapy is now growing rapidly, and the advances being made will mean significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. An accompanying volume addresses the use of small molecules in oncology, and the two volumes together represent the third edition of the book originally published under the same title.

DKK 986.00
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Small State Behavior in Strategic and Intelligence Studies - Patrick C. Coaty - Bog - Springer International Publishing AG - Plusbog.dk

Small State Behavior in Strategic and Intelligence Studies - Patrick C. Coaty - Bog - Springer International Publishing AG - Plusbog.dk

Small state behavior has been largely ignored by academics in both international relations and strategic/intelligence studies. Yet, when we analyze the root causes of war, insurrections, rebellions, revolutions and general sociological human behavior, it is the small state actors that are usually at the epicenter of the tumultuous event. It is the spark from inside the small state actor - whether it is Serbia, Czechoslovakia, Cuba, Vietnam, Kuwait, Iraq or Syria -- that seemingly leads to internal and external confrontations that inevitably involve much larger states. To date, a book length analysis like this has yet to be published. The scope of this project is to provide an analysis of a sampling of small state''s behavior in order to build on a unifying theory of security/intelligence studies. This analysis will necessarily survey the breadth of security/intelligence studies from Clausewitz to current applicable United Nations'' Resolutions and international law. In short, if we can understand how political structures affect the behavior of small states, it will be a major contribution to the field of security/intelligence studies enabling policy makers, scholars and the general public to separate fact from myth in analyzing the strategic policies of small states.

DKK 816.00
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Discovering the Cosmos with Small Spacecraft - Brian Harvey - Bog - Springer International Publishing AG - Plusbog.dk

Discovering the Cosmos with Small Spacecraft - Brian Harvey - Bog - Springer International Publishing AG - Plusbog.dk

Explorer was the original American space program and Explorer 1 its first satellite, launched in 1958. Sixty years later, it is the longest continuously running space program in the world, demonstrating to the world how we can explore the cosmos with small spacecraft. Almost a hundred Explorers have already been launched. Explorers have made some of the fundamental discoveries of the Space Age. Explorer 1 discovered Earth’s radiation belts. Later Explorers surveyed the Sun, the X-ray and ultraviolet universes, black holes, magnetars and gamma ray bursts. An Explorer found the remnant of the Big Bang. One Explorer chased and was the first to intercept a comet. The program went through a period of few launches during the crisis of funding for space science in the 1980s. However, with the era of ‘faster, cheaper, better,’ the program was reinvented, and new exiting missions began to take shape, like Swift and the asteroid hunter WISE. Discovering the Cosmos with Small Spacecraft gives an account of each mission and its discoveries. It breaks down the program into its main periods of activity and examines the politics and debate on the role of small spacecraft in space science. It introduces the launchers (Juno, Thor, etc.), the launch centers, the ground centers and key personalities like James Van Allen who helped develop and run the spacecraft’s exciting programs.

DKK 326.00
1

Small States and Big Powers - - Bog - Springer International Publishing AG - Plusbog.dk

Small States and Big Powers - - Bog - Springer International Publishing AG - Plusbog.dk

Foreign policy is one of the most complex policies of every state, and Portugal and Iceland are no exception. The “Small States and Big Powers: Portugal and Iceland’s Foreign Relations” book analyses the importance of relations with big powers or regional and international organisations from a shelter theory perspective, detailing the degree of political, economic and societal shelter that they have provided to Portugal and to Iceland over time. Despite having followed distinct paths, Portugal and Iceland have some important similarities in their foreign policy, namely in relation to the European and the Atlantic dimensions and their participation in regional organisations. The book examines their decisions to join or not to join regional organisations, and both countries’ bilateral relations with other important parts of the world, namely Africa, the Nordic states and China. This book compares the foreign policies of Portugal and Iceland considering their commonly identified status as small states and place them within the shelter theory framework, and its findings indicate that both countries need to balance their international relations with shelter provided by different actors. Their size and political and economic capabilities matter in their bilateral and multilateral relations. It is therefore in both countries’ interest to maintain strong cooperation not only with big powers, but also regional and international organisations, depending on their field of action, in order to flourish politically, economically and socially.

DKK 986.00
1

Toward a Small Family Ethic - Travis N. Rieder - Bog - Springer International Publishing AG - Plusbog.dk

Toward a Small Family Ethic - Travis N. Rieder - Bog - Springer International Publishing AG - Plusbog.dk

This thought-provoking treatise argues that current human fertility rates are fueling a public health crisis that is at once local and global. Its analysis and data summarize the ecological costs of having children, presenting ethical dilemmas for prospective parents in an era of competition for scarce resources, huge disparities of wealth and poverty, and unsustainable practices putting irreparable stress on the planet. Questions of individual responsibility and integrity as well as personal moral and procreative issues are examined carefully against larger and more long-range concerns. The author''s assertion that even modest efforts toward reducing global fertility rates would help curb carbon emissions, slow rising global temperatures, and forestall large-scale climate disaster is well reasoned and more than plausible. Among the topics covered: · The multiplier effect: food, water, energy, and climate. · The role of population in mitigating climate change. · The carbon legacy of procreation. · Obligations to our possible children. · Rights, what is right, and the right to do wrong. · The moral burden to have small families. Toward a Small Family Ethic sounds a clarion call for bioethics students and working bioethicists. This brief, thought-rich volume steers readers toward challenges that need to be met, and consequences that will need to be addressed if they are not.

DKK 456.00
1

Practical Handbook for Small-Gauge Vitrectomy - Ulrich Spandau - Bog - Springer International Publishing AG - Plusbog.dk

Practical Handbook for Small-Gauge Vitrectomy - Ulrich Spandau - Bog - Springer International Publishing AG - Plusbog.dk

Since publication of the first edition of this book in 2012 vitreoretinal surgery has marched with huge steps forward. In 2012 23G was standard, today 25G and 27G are the most commonly used gauge sizes for vitrectomy. In 2012 the cutting rate was 5.000 cuts/min and today with the development of a novel vitreous cutter the cutting rate has increased to 16.000 cuts/min. The advent of 25G/27G made the instruments smaller and surgery less traumatic. Practical Handbook for Small-Gauge Vitrectomy: A Step-By-Step Introduction to Surgical Techniques, 2 nd Edition focuses on these new developments and features new chapters on PVR detachment, intraocular tumour, macular translocation, sub macular hemorrhages and ocular trauma. The surgeries are demonstrated step-by-step and the material is shown in detail and videos visualize the surgery.This book will serve as an immensely useful guide for all surgeons who are intending to make use of this exciting and increasingly used technique.

DKK 986.00
1

Entrepreneurial Crisis Management - Sukanlaya Sawang - Bog - Springer International Publishing AG - Plusbog.dk

Entrepreneurial Crisis Management - Sukanlaya Sawang - Bog - Springer International Publishing AG - Plusbog.dk

​This book explores the timely issue of how small businesses, micro firms and entrepreneurs respond to crises. A largely overlooked area of research, the author posits that by better understanding crisis management in small and micro firms, we can help to protect these businesses from the potentially devastating effects of a crisis. Offering guidance for scholars and practitioners, including small business owners, to better understand the concept, limitations and considerations of crisis management - specifically in the small business context - the author demonstrates that there is no single solution for a small business to cope with a crisis. Drawing from the thematic findings, the author offers valuable recommendations on how small business owners can strategically plan for the future and better manage their capability when faced with a crisis.

DKK 426.00
1

Poverty, Inequality, and Innovation in the Global South - - Bog - Springer International Publishing AG - Plusbog.dk

Poverty, Inequality, and Innovation in the Global South - - Bog - Springer International Publishing AG - Plusbog.dk

This edited volume analyzes the experiences learned in practice especially among small holder farmers to eradicate poverty. In other words, it discusses practical solutions which small scale farmers can use to alleviate poverty and reduce inequality. This addresses the issue of inclusive and sustainability of projects leading to the notion of not leaving anyone behind. The book provides insights that can be translated into policy with potential to inform practice. It also has the potential to address the issue of rural urban migration by providing knowledge that is usable by small scale farmers, policy makers and entrepreneurs alike. The volume is written by authors from different countries, Nigeria, Tanzania, and Zimbabwe, indicating the commonality of the problems of poverty and inequality. It contains insights from all these countries assembled together into an amalgam of practices ready to use and implement informed by evidence from the field as most of the chapters are based on empirical data.

DKK 986.00
1

Small Doses of the Future - Brad Aiken - Bog - Springer International Publishing AG - Plusbog.dk

Small Doses of the Future - Brad Aiken - Bog - Springer International Publishing AG - Plusbog.dk

Like many fields of science, the future of medicine is frequently predicted by the science fiction writers of today, very much as many of today’s medical advances were presaged by science fiction stories of the past. In this book, physician and science fiction author Brad Aiken conveys his own speculations about our medical future through nine highly entertaining and thought-provoking short stories. Touching upon a great variety of themes, including but not limited to telemedicine and remote surgery, vaccination strategies against unknown deathly pathogens, nanomedicine to cure diseases and retard ageing, bionics, cloning and euthanasia, we get a glimpse of what might be awaiting humanity. Yet, in these stories it is always the protagonists, humans after all, who remain at the center stage, not the new technologies. This provides the fictional material with a unique blend of science fiction and social fantasy. It also warns us to be wary of the pitfalls of too much reliance on dehumanizing technology and to make sure it remains our helper, not our master. Last but not least, an extensive scientific essay investigates the interplay between science fiction and both past and current advances in medical sciences and technology, making the link to the fictional material in the book as well as to the relevant scientific literature. Brad Aiken is the Medical Director for Rehabilitation at Baptist Hospital in Miami, Florida. He has published several scientific articles, and has presented to both professional and non-professional groups on a variety of topics. Dr. Aiken has received numerous science awards, including the Navy Science Award, as well as awards from the Army, the Air Force and NASA. He began writing science fiction while in college at Boston University, and published his first book, Starscape: The Silver Bullet , in 2000. His latest book, Zone of the Tenth Degree , was published in August 2012. His short stories have appeared in Analog Science Fiction and Fact, Padwolf Presents, and the vampire anthology New Blood.

DKK 179.00
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Sequential Experiments with Primes - Mihai Caragiu - Bog - Springer International Publishing AG - Plusbog.dk

Sequential Experiments with Primes - Mihai Caragiu - Bog - Springer International Publishing AG - Plusbog.dk

With a specific focus on the mathematical life in small undergraduate colleges, this book presents a variety of elementary number theory insights involving sequences largely built from prime numbers and contingent number-theoretic functions. Chapters include new mathematical ideas and open problems, some of which are proved in the text. Vector valued MGPF sequences, extensions of Conway’s Subprime Fibonacci sequences, and linear complexity of bit streams derived from GPF sequences are among the topics covered in this book. This book is perfect for the pure-mathematics-minded educator in a small undergraduate college as well as graduate students and advanced undergraduate students looking for a significant high-impact learning experience in mathematics.

DKK 234.00
1

Travel and Tourism in the Caribbean - Andrew Spencer - Bog - Springer International Publishing AG - Plusbog.dk

Travel and Tourism in the Caribbean - Andrew Spencer - Bog - Springer International Publishing AG - Plusbog.dk

This book explores the distinct nuisances and obstacles that are brought on by the tourism and travel industry within Caribbean small island developing countries (SIDS). The author explores best practices and measures that can be used to overcome or alleviate the hardship faced by the industry by giving voice to the nations that are often overshadowed or restrained by their developed counterparts. This book reflects on and assesses the transformative power that tourism has in Caribbean small island developing states, while unearthing the threats that affect the longevity and economic viability of the industry in general. It is an important and overdue text focusing on this unique group of islands and will inform students and researchers on the struggles and opportunities they face.

DKK 731.00
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Surface/Volume - Alan E. Rubin - Bog - Springer International Publishing AG - Plusbog.dk

Surface/Volume - Alan E. Rubin - Bog - Springer International Publishing AG - Plusbog.dk

This book explains that diffusion, osmosis, dissolution, evaporation, and heat loss all preferentially affect small bodies due to their high surface/volume ratios. Because surface area increases as the square of length, but volume (and mass) increase as the cube, large objects have low surface/volume ratios and small objects have high surface/volume ratios. This simple physical constraint governs much of the physical world. It accounts for why the Earth has active volcanoes, but the Moon does not, why the human brain has numerous folds, why deciduous trees lose their leaves every Fall, and why nanoparticles of gold melt at surprisingly low temperatures. It is a phenomenon well known to every scientist, but this book is the first comprehensive treatment of this effect.

DKK 307.00
1

High Performance Analog and Power Management Circuit Design Techniques for Modern SoCs - - Bog - Springer International Publishing AG - Plusbog.dk

High Performance Analog and Power Management Circuit Design Techniques for Modern SoCs - - Bog - Springer International Publishing AG - Plusbog.dk

This book illustrates some of the recent state-of-the-art advances in Analog and Power Management circuit design. Coverage includes design of advanced low-power/low-voltage analog circuits, small-signal and pole-zero analysis of multi-stage amplifiers, state-of-the-art frequency compensation topologies, and advanced power management circuits and control techniques. Readers will benefit from detailed small-signal techniques for complex multi-stage amplifiers and low drop-out voltage regulators (LDOs), a ubiquitous power management circuit. The authors provide tutorial treatment of frequency compensation techniques while illustrating some of the state-of-the-art techniques. The authors also discuss in detail the challenges in the design of modern power management circuits, including low dropout voltage regulators, switched-capacitor DC-to-DC converters and inductor-based DC-DC converters.

DKK 762.00
1

Introduction to the Physics of Massive and Mixed Neutrinos - Samoil Bilenky - Bog - Springer International Publishing AG - Plusbog.dk

Introduction to the Physics of Massive and Mixed Neutrinos - Samoil Bilenky - Bog - Springer International Publishing AG - Plusbog.dk

Small neutrino masses are the first signs of new physics beyond the Standard Model of particle physics. Since the first edition of this textbook appeared in 2010, the Nobel Prize has been awarded "for the discovery of neutrino oscillations, which shows that neutrinos have mass". The measurement of the small neutrino mixing angle $\theta_{13}$ in 2012, launched the precision stage of the investigation of neutrino oscillations. This measurement now allows such fundamental problems as the three-neutrino mass spectrum - is it normal or inverted? - and the $CP$ violation in the lepton sector to be tackled. In order to understand the origin of small neutrino masses, it remains crucial to reveal the nature of neutrinos with definite masses: are they Dirac neutrinos possessing a conserved lepton number, which distinguishes neutrinos and antineutrinos, or are they Majorana neutrinos with identical neutrinos and antineutrinos? Experiments searching for the neutrinoless double beta decay are presently under way to answer this fundamental question. The second edition of this book comprehensively discusses all these important recent developments. Based on numerous lectures given by the author, a pioneer of modern neutrino physics (recipient of the Bruno Pontecorvo Prize 2002), at different institutions and schools, it offers a gentle yet detailed introduction to the physics of massive and mixed neutrinos that prepares graduate students and young researchers entering the field for the exciting years ahead in neutrino physics.

DKK 519.00
1

Logic-Based Program Synthesis and Transformation - - Bog - Springer International Publishing AG - Plusbog.dk

Logic-Based Program Synthesis and Transformation - - Bog - Springer International Publishing AG - Plusbog.dk

This book constitutes the refereed proceedings of the 32 nd International Symposium on Logic-Based Synthesis and Transformation, LOPSTR 2022, which was held during September 21-23, 2022. The 8 full papers were selected from 17 submissions and cover different aspects of logic-based program development, all stages of the software life cycle, and issues of both programming-in-the-small and programming-in-the-large.

DKK 476.00
1