93 resultater (0,34373 sekunder)

Vis alle filtre

Mærke

Butik

Pris (EUR)

Nulstil filter

Produkter
Fra
Butikker

Mapping Genetic Interactions - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Mapping Genetic Interactions - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

This volume details methods of identifying synthetic lethal, genetic interactions by various approaches in different model systems including human cancer cells. Chapters guide readers through genetic interactions in model organisms, RNA interference, CRISPR/Cas9 based genome editing technologies, drug-gene interactions, mapping chemical genetic interactions, synergistic drug-gene relations, single cell sequencing, gene expression profiling, and novel genetic interactions. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Genetic Interaction Mapping aims to be a useful practical guide to researches to help further their study in this field.

DKK 986.00
1

Linear Genetic Programming - Markus F. Brameier - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Linear Genetic Programming - Markus F. Brameier - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Linear Genetic Programming presents a variant of Genetic Programming that evolves imperative computer programs as linear sequences of instructions, in contrast to the more traditional functional expressions or syntax trees. Typical GP phenomena, such as non-effective code, neutral variations, and code growth are investigated from the perspective of linear GP. This book serves as a reference for researchers; it includes sufficient introductory material for students and newcomers to the field.

DKK 919.00
1

Principles of Clinical Cancer Genetics - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Principles of Clinical Cancer Genetics - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Advances in genetics are transforming estimates of an individual''s risk of developing cancer and approaches to prevention and management of cancer in those who may have increased susceptibility. Identifying and caring for patients with hereditary cancer syndromes and their family members present a complex clinical, scientific and social challenge. This textbook, by leading experts at Massachusetts General Hospital Cancer Center, highlights the current understanding of the genetics of hereditary cancers of the breast, ovary, colorectum, stomach, pancreas, kidney, skin, and endocrine organs. Practical guidelines for the use of genetic testing, cancer screening and surveillance, prophylactic surgery, and promising targeted therapeutic agents are discussed. In addition, ongoing research involving genome-wide screens to identify novel modest risk-associated genetic loci are explored, along with new approaches to the application of genetic markers in guiding therapeutic options.

DKK 877.00
1

Single-Cell Mutation Monitoring Systems - Aftab A. Ansari - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Single-Cell Mutation Monitoring Systems - Aftab A. Ansari - Bog - Springer-Verlag New York Inc. - Plusbog.dk

There is general agreement that increased environmental pollution poses a potential health hazard to humans and that effective control of such genetic injury requires monitoring the exposed individuals for genetic damage and identifying chemicals that may cause mutation or cancer. Tests available for identifying mutagens or carcinogens range from relatively simple, rapid assays in prokaryotes and test systems utilizing mammalian cells in tissue culture to highly elaborate tests in intact animals. No single test can provide data for an unequivocal assessment of the mutagenicity of a given chemical and the risk it might pose to human health. A tier approach, therefore, was suggested for mutagenicity testing in which the suspected agents would be initially evaluated with simple, inexpensive tests that would give qualitative results. Chemicals found to be positive in the first-tier testing would then be evaluated with more complex tests, including those based on mammalian cells in culture. Testing in the final tier requires whole-animal studies, and is expensive and time-consum­ ing, and even the results from these studies need to be extrapolated for human risk assessment. The mutation systems based on whole animals require scoring large num­ bers of animals, and therefore are not practical for the routine testing of muta­ gens. As an alternative to monitoring the pedigree, cells from exposed individ­ uals may be considered for screening for point mutations through the use of an appropriate marker protein.

DKK 434.00
1

Genetic Models of Immune and Inflammatory Diseases - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Genetic Models of Immune and Inflammatory Diseases - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

This book contains the proceedings of the Serono Symposia USA interna­ tional symposium on Genetic Models of Immune and Inflammatory Dis­ eases held on October 20 to 23, 1994, in Savannah, Georgia. The advent of methods for introducing genes into the germlines of mice, and for targeted disruption of particular genes by homologous recombination, has provided scientists in many disciplines with an extraordinarily powerful set of analyti­ cal tools. Some of the most informative applications of transgenic and gene knockout technology have been in studies of lymphocyte development and activation. The goal of this symposium was to bring together investigators using these genetic approaches for analyzing the immune system, with a view to defining common themes and novel directions. Transgenic mice have a wide variety of important applications in immu­ nology. Defined proteins can be expressed in selected tissues throughout development, thus acquiring the essential characteristic of "self" antigens. Such models have been used to study how immune responses to these artificially created "self" antigens are controlled. Antigen receptors of lym­ phocytes have been expressed as transgenes, and because lymphocytes are endowed with the unique property of allelic exclusion, such transgenic mice become essentially monospecific. Immunomodulatory agents have been expressed in defined tissues or throughout the body, providing tools for studying the functional consequences of dysregulated expression of biologi­ cal response modifiers.

DKK 304.00
1

Genetic Toxicology - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Genetic Toxicology - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

To meet the needs of an ever-growing world population for food and fiber, agriculture uses an arsenal of chemicals to control insects, weeds and other pests that compete with man in the agricultural arena. In addition to their intended effect, many of these biologically active materials affect non-target organisms including man himself. There is concern about the resulting occupational exposure of those who work in agriculture and the environmental health of those who live in rural areas. Unintended side effects from the use of agricultural chemicals are further complicated by the dispersal of these substances well beyond the area of immediate use, through food chains, atmospheric transport, irrigation runoff, percolation to and diffusion through ground­ water, sometimes giving rise to public health and environmental problems at a distance from the place of application. In addition to toxic substances introduced into the agro­ ecosystem by man, one must be concerned about naturally occurring agents including mfcotoxins, plant poisons, infective biological agents and the levels of certain heavy metals. The formation of toxic substances, many of them mutagenic, during cooking and other processing of food is a related problem. While acute effects are more immediate and somewhat readily discerned, chronic and genetic effects tend to be more obscure and sometimes surface in a crisis situation long after substantial damage has been sustained. Genotoxicity assays and epidemiological studies play increasing roles in predicting and evaluating long­ term effects of low-level exposure to toxic materials.

DKK 434.00
1

Management of the Patient at High Risk for Breast Cancer - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Management of the Patient at High Risk for Breast Cancer - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Management of the Patient at High Risk for Breast Cancer provides a state-of-the art review of patients who are at high risk for breast cancer, how to identify them, the tools available for risk assessment and quantification and indications for genetic counseling and testing. The book summarizes the high risk breast imaging options, including newest techniques and schedules. Pathologic evaluation of high risk lesions are featured as well as the management issues surrounding these lesions. The volume also covers the management of concomitant cancer risk and screening strategies. A concise, yet comprehensive overview of the current status of the topic, Management of the Patient at High Risk for Breast Cancer serves as a useful resource for physicians and researchers dealing with and interested in patients at high risk for breast cancer.

DKK 960.00
1

Optic Nerve Disorders - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Optic Nerve Disorders - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Optic Nerve Disorders: Diagnosis and Management , Second Edition, is a thoroughly revised and updated reference, including new information on diagnostic techniques such as genetic testing for hereditary optic neuropathies, new data on toxic/drug-related optic neuropathies and recent data from clinical trial studies. Additional novel therapies, including stem cell therapies, the use of nanotechnology and gene therapies are featured highlights, as is spectral domain optical coherence tomography (OCT) for imaging of the optic nerve. The way in which OCT is used in differentiating optic nerve disorders from other retinal disorders and how OCT is used in monitoring the course of the disease, is also discussed. This practical reference focuses on common optic nerve disorders. It addresses diagnosis, pathophysiology, management and prognosis and is written in a clear, concise style for quick, easy reference in the clinic. With additional color photographs to better illustrate the material, the second edition will prove to be the go-to reference for ophthalmologists, neurologists and neurosurgeons working with optic nerve disorders.

DKK 941.00
1

Genetics and Mental Illness - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Genetics and Mental Illness - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

''Refreshing and informative....describe[s] the new complex research tools, directions and interpretations in a lucid and understandable fashion.'' --- Lancet, North American edition ''Beautifully crafted...The most significant contribution of this book involves its integration of areas that are not typically considered in genetic overviews.'' --- American Scientist, 1998 ''This book does an extraordinary job of making sense out of the many complex and controversial issues surrounding psychiatric genetics...It is worth the price.'' --- Journal of Genetic Counseling, Vol. 6, No. 3, 1997 This collection of essays clearly examines the complex nature of mental illness, focusing on the theory and state of the art of psychiatric genetics. This insightful volume is the first to present the diverse viewpoints of investigators, policy analysts, and psychiatric patients. Contributors explore the roles of genes in mental illness and describe various clinical, ethical, and social implications of psychiatric genetics. Additional discussions include trends in psychiatric genetic research, nature versus nurture in behavioral genetics, basic statistical principles of linkage analysis, and the many social domains relevant to psychiatric genetics.

DKK 816.00
1

Formation of Visual Images - V. P. Zinchenko - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Formation of Visual Images - V. P. Zinchenko - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Students of the ontogenesis of human behavior have the corresponding images become increasingly less long been aware that in the early stages of the obvious. child''s development it is impossible to distinguish The situation is similar as regards the analy­ between perceptual, intellectual, and operative acts. sis of relations and connections between external, With time, perception becomes relatively indepen­ practical and internal, intellectual activity. The dent of practical, operative actions, and thinking be­ work of P. Ya. Gal''perin has shown that mental ac­ comes independent of both. For this reason, general tion is formed on the basis of external material ac­ psychologists tend to forget the genetic link between tions, with real objects. On the basis of contempo­ perceptual, intellectual, and operative processes. rary psychological and genetic-epistemological re­ As a result, thinking is investigated without behav­ search, A. N. Leont''ev has given convincing proof ior and behavior without thinking, or skills are in­ of the genetic link between external and internal vestigated without perception and perception without activity. He emphasizes in particular the role of action.

DKK 663.00
1

Genotoxicology of N-Nitroso Compounds - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Genotoxicology of N-Nitroso Compounds - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Toph''s in Chemical Mutagenesis is a new series dedicated to studies in the areas of environmental chemical mutagenesis and genetic toxicology. In this series we will explore some of many topics that are emerging in these rapidly developing fields. The purpose of the present volume is to attempt to organize and compare the genotoxic properties of the N-nitroso compounds. This is a particularly interesting class of compounds because of the problems encountered with the Salmonella assay of Ames in generating both false positive and false negative results. The battery approach using a number of assay systems seems more appropriate to evaluate chemicals in this class. Topics to be discussed in other volumes in this series include single-cell mutation monitoring systems, the detection of genetic damage in mammalian germ cells, the mutagenicity of pesticides, problems in monitoring human populations in genetic toxicology, and a glossary of terms in genetic toxicology. All of these books are in various stages of development and should appear within the next few years. Frederick J. de Serres Series Editor vii Preface During the past ten years there has been an explosive development in the number of short-term tests to predict the biological risks, especially risks of cancer, in exposure to xenobiotic chemicals. The number of published articles in this area has reached many thousands a year and there are several new journals devoted almost entirely to the presentation of the results obtained in these tests.

DKK 434.00
1

Immunoassays in Coagulation Testing - Z. Parvez - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Immunoassays in Coagulation Testing - Z. Parvez - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Rapid progress in analytical methods, within the past few decades, has led to the widespread applications of newer immunological and radioimmunoassay techniques to the diagnosis and treatment of hemorrhagic and thrombotic disorders. Major advances were made to meet the multiple challenges of improving precision, accuracy, and availability of various measurements. These advances have been paralleled by the discoveries of a close relationship between biological activities and the absolute concentration of proteins that were measured by immunological techniques. This, in turn, assured the significance and usefulness of immunological methods in the management of patients. Numerous variants of immunological tests now are available, which allow us to both determine with precision minute quantities of antigenic proteins in serum and other biological fluids and differentiate the native protein from its genetically altered or degraded forms. Methods also have been designed to immunologically evaluate some serine proteases that are in complex with proteolytic inhibitors. Due to rapid progress in this field, different laboratories unavoidably become experts in one or the other approach. In the welter of possible choices, the non-expert usually is left to follow either the most recent but as yet to be confirmed method or his own anecdotal experience. This manual not only brought together various methods in current use, but it also set certain standardized criteria for the assessment of various deficiencies and abnormalities in hemostasis.

DKK 434.00
1

Rice Genome Engineering and Gene Editing - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Rice Genome Engineering and Gene Editing - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

This detailed volume explores rice molecular biology, genetic engineering, and genome editing technologies. Dividing into three parts, the book covers subjects such as genetic engineering and tissue culture of rice, including efficient methods for rice transformation and regeneration, genome editing, targeted integration, and gene stacking in rice, including multiple methods utilizing CRISPR systems for targeted gene knock-out or genome modification via base editing, and diverse methods describing bioinformatic, molecular, and cellular analyses in rice. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Rice Genome Engineering and Gene Editing: Methods and Protocols serves as a valuable resource for researchers worldwide striving to further their efforts on advancing research and producing genetically improved rice varieties.

DKK 967.00
1

Bioinformatics - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Bioinformatics - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Bioinformatics is a relatively new field of research. It evolved from the requirement to process, characterize, and apply the information being produced by DNA sequencing technology. The production of DNA sequence data continues to grow exponentially. At the same time, improved bioinformatics such as faster DNA sequence search methods have been combined with increasingly powerful computer systems to process this information. Methods are being developed for the ever more detailed quantification of gene expression, providing an insight into the function of the newly discovered genes, while molecular genetic tools provide a link between these genes and heritable traits. Genetic tests are now available to determine the likelihood of suffering specific ailments and can predict how plant cultivars may respond to the environment. The steps in the translation of the genetic blueprint to the observed phenotype is being increasingly understood through proteome, metabolome and phenome analysis, all underpinned by advances in bioinformatics. Bioinformatics is becoming increasingly central to the study of biology, and a day at a computer can often save a year or more in the laboratory. The volume is intended for graduate-level biology students as well as researchers who wish to gain a better understanding of applied bioinformatics and who wish to use bioinformatics technologies to assist in their research. The volume would also be of value to bioinformatics developers, particularly those from a computing background, who would like to understand the application of computational tools for biological research. Each chapter would include a comprehensive introduction giving an overview of the fundamentals, aimed at introducing graduate students and researchers from diverse backgrounds to the field and bring them up-to-date on the current state of knowledge. To accommodate the broad range of topics in applied bioinformatics, chapters have been grouped into themes: gene and genome analysis, molecular genetic analysis, gene expression analysis, protein and proteome analysis, metabolome analysis, phenome data analysis, literature mining and bioinformatics tool development. Each chapter and theme provides an introduction to the biology behind the data describes the requirements for data processing and details some of the methods applied to the data to enhance biological understanding.

DKK 423.00
1

Craniofacial Development - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Craniofacial Development - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

This volume explores scientific methodologies currently employed to integrate observational developmental biology, tissue explant and cell-based approaches and genetic/molecular technologies to develop a holistic understanding of craniofacial development. Chapters guide readers through the use of disparate models to study formation of the head and face ( c. elegans , zebrafish, mouse, alongside human imaging approaches), together with cell culture, tissue explant and in vivo cell imaging and analysis techniques. At the molecular level, chapters include analysing gene expression using in-situ hybridisation and single-cell RNA-Sequencing (scRNA-SEQ), as well as genetic modification techniques such as CRISPR/Cas9-mediated deletion. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Craniofacial Development: Methods and Protocols aims to be a guide in the field of craniofacial development for senior and new researchers looking to expand their existing research programs to encompass novel techniques.

DKK 986.00
1

Advances in Nutritional Research - Harold H. Draper - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Advances in Nutritional Research - Harold H. Draper - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Volume 4 of Advances in Nutritional Research reflects the increased importance that recently has been attached to nutrition in many fields of clinical medicine. This heightened interest in nutrition stems from the demonstration that the intake of specific nutrients may have far-reaching consequences, not only for normal metabolism, but also for metabolic processes affecting clinical or subclinical disease. Conversely, many disease states have been shown to have previously unrecognized effects on nutrient function and metabolism. In addition to topics of obvious relevance to human clinical nutrition, this volume contains chapters dealing with the nutrition of cells grown in culture and of species that may provide insights into nutritional disorders of man. To­ gether with its predecessors, Volume 4 provides graduate students and estab­ lished investigators with authoritative accounts of the status of research on a range of topics of current interest in experimental and clinical nutrition. vii Contents Chapter 1. Vitamin-Responsive Genetic Abnormalities .......... . S. Harvey Mudd 1. Introduction.............................................. 1 2. Historical Perspective ...................................... 2 3. Genetic Abnormalities Currently Known to Be Vitamin Responsive. 3 4. Mechanisms Underlying Vitamin Responsiveness. . . . . . . . . . . . . . . . 7 4.1. Defects in the Processing of a Vitamin Prior to Its Interaction in Cofactor Form with a Particular Apoenzyme ........ 7 4.2. Defects in Particular Apoenzymes that Interact with the Cofactor Forms of Vitamins. . . . . . . . . . . . . . . . . . 16 . . . . . .

DKK 816.00
1