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Nutrition and Mental Functions - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Nutrition and Mental Functions - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

The description of sequelae of nutritional deficien­ cies was equally oversimplified. Obviously, a disease like rickets, which affected hard tissues--the skeleton-­ had irreversible consequences. Destruction or alteration of tissues, such as in cancrum oris or severe xerophthal­ mia, was equally permanent and easily observed. Other models were beriberi or scurvy, where, by contrast, the vitamin treatment seemed to restore the individual to the completely normal status quo ante. Most nutritionists were therefore little prepared intellectually for the series of suggestive findings con­ cerning nutrition and mental development which has been the highlight of nutritional research in the past decade: the discovery that there are irreversible gaps in mental development not correlated with obvious permanent somatic lesions which follow acute malnutrition during the develop­ ment of the young infant. Furthermore, not only are ex­ isting somatic instruments--physical examination, the scale, and the measuring tape--inadequate to detect such intellectual and behavioral deficits, but some of the current psychological instruments, bound to traditions of Western culture, are often poorly adapted to measure fine differences in psychological development among poor populations. These initial discoveries have stimulated important methodological advances, ranging from better staining techniques for the study of fibers connecting brain neurons to better tests for the study of cognitive development.

DKK 434.00
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Nutrition and Physical Activity - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Pediatric Gastroenterology and Nutrition - Christine M. Houser - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Nonparametrics - Erich L. Lehmann - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Advances in Nutritional Research - Harold H. Draper - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Advances in Nutritional Research - Harold H. Draper - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Volume 4 of Advances in Nutritional Research reflects the increased importance that recently has been attached to nutrition in many fields of clinical medicine. This heightened interest in nutrition stems from the demonstration that the intake of specific nutrients may have far-reaching consequences, not only for normal metabolism, but also for metabolic processes affecting clinical or subclinical disease. Conversely, many disease states have been shown to have previously unrecognized effects on nutrient function and metabolism. In addition to topics of obvious relevance to human clinical nutrition, this volume contains chapters dealing with the nutrition of cells grown in culture and of species that may provide insights into nutritional disorders of man. To­ gether with its predecessors, Volume 4 provides graduate students and estab­ lished investigators with authoritative accounts of the status of research on a range of topics of current interest in experimental and clinical nutrition. vii Contents Chapter 1. Vitamin-Responsive Genetic Abnormalities .......... . S. Harvey Mudd 1. Introduction.............................................. 1 2. Historical Perspective ...................................... 2 3. Genetic Abnormalities Currently Known to Be Vitamin Responsive. 3 4. Mechanisms Underlying Vitamin Responsiveness. . . . . . . . . . . . . . . . 7 4.1. Defects in the Processing of a Vitamin Prior to Its Interaction in Cofactor Form with a Particular Apoenzyme ........ 7 4.2. Defects in Particular Apoenzymes that Interact with the Cofactor Forms of Vitamins. . . . . . . . . . . . . . . . . . 16 . . . . . .

DKK 816.00
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Single-Cell Mutation Monitoring Systems - Aftab A. Ansari - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Single-Cell Mutation Monitoring Systems - Aftab A. Ansari - Bog - Springer-Verlag New York Inc. - Plusbog.dk

There is general agreement that increased environmental pollution poses a potential health hazard to humans and that effective control of such genetic injury requires monitoring the exposed individuals for genetic damage and identifying chemicals that may cause mutation or cancer. Tests available for identifying mutagens or carcinogens range from relatively simple, rapid assays in prokaryotes and test systems utilizing mammalian cells in tissue culture to highly elaborate tests in intact animals. No single test can provide data for an unequivocal assessment of the mutagenicity of a given chemical and the risk it might pose to human health. A tier approach, therefore, was suggested for mutagenicity testing in which the suspected agents would be initially evaluated with simple, inexpensive tests that would give qualitative results. Chemicals found to be positive in the first-tier testing would then be evaluated with more complex tests, including those based on mammalian cells in culture. Testing in the final tier requires whole-animal studies, and is expensive and time-consum­ ing, and even the results from these studies need to be extrapolated for human risk assessment. The mutation systems based on whole animals require scoring large num­ bers of animals, and therefore are not practical for the routine testing of muta­ gens. As an alternative to monitoring the pedigree, cells from exposed individ­ uals may be considered for screening for point mutations through the use of an appropriate marker protein.

DKK 434.00
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Mesenteric Vascular Disease - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Management of Inpatient Inflammatory Bowel Disease - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Sensory Evaluation of Food - Hildegarde Heymann - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Atlas of Dermatological Manifestations of Gastrointestinal Disease - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Disease, Diagnoses, and Dollars - Robert M. Kaplan - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Induced Mutagenesis - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Induced Mutagenesis - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Concern is often expressed that our environment may include an increasingly large variety of mutagens, but the extent of the potential hazard they pose has yet to be fully evaluated. A variety of empirical procedures has been devised with which to estimate the mutagenic potency of suspect agents, and the relative merits of different tests are currently under debate. Although such tests are of great value, and are indeed indispensable, they are not, nevertheless, sufficient. In the long term, accurate estimation of hazard will also require a better understanding of the various mechanisms of mutagenesis, and in many instances these remain remarkably elusive. Our knowledge and appreciation of the problem has increased substantially over the last few years, but the precise way in which many mutagens cause mutations is not yet known. The aims of this conference were therefore two-fold. The first was to survey present information about mutagenic mechanisms, drawing together data from work with various experimental approaches and organisms, in order to discern the principles governing the action of different mutagens. The second was to examine the implications of such principles for the execution and evaluation of test procedures, and critically assess the research areas that need further attention in order to improve the interpretation of test results. Chris Lawrence v ACKNOWLEDGEMENT We gratefully acknowledge the support provided for this Conference by the U.,S. Department of Energy, The Foundation for Microbiology, Exxon Corporation and the University of Rochester.

DKK 434.00
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Genotoxicology of N-Nitroso Compounds - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Genotoxicology of N-Nitroso Compounds - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Toph''s in Chemical Mutagenesis is a new series dedicated to studies in the areas of environmental chemical mutagenesis and genetic toxicology. In this series we will explore some of many topics that are emerging in these rapidly developing fields. The purpose of the present volume is to attempt to organize and compare the genotoxic properties of the N-nitroso compounds. This is a particularly interesting class of compounds because of the problems encountered with the Salmonella assay of Ames in generating both false positive and false negative results. The battery approach using a number of assay systems seems more appropriate to evaluate chemicals in this class. Topics to be discussed in other volumes in this series include single-cell mutation monitoring systems, the detection of genetic damage in mammalian germ cells, the mutagenicity of pesticides, problems in monitoring human populations in genetic toxicology, and a glossary of terms in genetic toxicology. All of these books are in various stages of development and should appear within the next few years. Frederick J. de Serres Series Editor vii Preface During the past ten years there has been an explosive development in the number of short-term tests to predict the biological risks, especially risks of cancer, in exposure to xenobiotic chemicals. The number of published articles in this area has reached many thousands a year and there are several new journals devoted almost entirely to the presentation of the results obtained in these tests.

DKK 434.00
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Acute and Critical Care Formulas and Laboratory Values - Robert E. Fromm - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Introductory Statistics with R - Peter Dalgaard - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Soft Tissue Tumors of the Skin - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Epithelial Cell Culture - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Lung Cancer - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Evidence Based Pathology and Laboratory Medicine - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Elbow Ulnar Collateral Ligament Injury - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

The Patient - Hoyle Leigh - Bog - Springer-Verlag New York Inc. - Plusbog.dk