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Single-Cell Mutation Monitoring Systems - Aftab A. Ansari - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Single-Cell Mutation Monitoring Systems - Aftab A. Ansari - Bog - Springer-Verlag New York Inc. - Plusbog.dk

There is general agreement that increased environmental pollution poses a potential health hazard to humans and that effective control of such genetic injury requires monitoring the exposed individuals for genetic damage and identifying chemicals that may cause mutation or cancer. Tests available for identifying mutagens or carcinogens range from relatively simple, rapid assays in prokaryotes and test systems utilizing mammalian cells in tissue culture to highly elaborate tests in intact animals. No single test can provide data for an unequivocal assessment of the mutagenicity of a given chemical and the risk it might pose to human health. A tier approach, therefore, was suggested for mutagenicity testing in which the suspected agents would be initially evaluated with simple, inexpensive tests that would give qualitative results. Chemicals found to be positive in the first-tier testing would then be evaluated with more complex tests, including those based on mammalian cells in culture. Testing in the final tier requires whole-animal studies, and is expensive and time-consum­ ing, and even the results from these studies need to be extrapolated for human risk assessment. The mutation systems based on whole animals require scoring large num­ bers of animals, and therefore are not practical for the routine testing of muta­ gens. As an alternative to monitoring the pedigree, cells from exposed individ­ uals may be considered for screening for point mutations through the use of an appropriate marker protein.

DKK 434.00
1

Immunoassays in Coagulation Testing - Z. Parvez - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Immunoassays in Coagulation Testing - Z. Parvez - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Rapid progress in analytical methods, within the past few decades, has led to the widespread applications of newer immunological and radioimmunoassay techniques to the diagnosis and treatment of hemorrhagic and thrombotic disorders. Major advances were made to meet the multiple challenges of improving precision, accuracy, and availability of various measurements. These advances have been paralleled by the discoveries of a close relationship between biological activities and the absolute concentration of proteins that were measured by immunological techniques. This, in turn, assured the significance and usefulness of immunological methods in the management of patients. Numerous variants of immunological tests now are available, which allow us to both determine with precision minute quantities of antigenic proteins in serum and other biological fluids and differentiate the native protein from its genetically altered or degraded forms. Methods also have been designed to immunologically evaluate some serine proteases that are in complex with proteolytic inhibitors. Due to rapid progress in this field, different laboratories unavoidably become experts in one or the other approach. In the welter of possible choices, the non-expert usually is left to follow either the most recent but as yet to be confirmed method or his own anecdotal experience. This manual not only brought together various methods in current use, but it also set certain standardized criteria for the assessment of various deficiencies and abnormalities in hemostasis.

DKK 434.00
1

Sensory Evaluation of Food - Hildegarde Heymann - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Breast and Gynecological Cancers - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

The Microbiological Safety of Low Water Activity Foods and Spices - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

The Microbiological Safety of Low Water Activity Foods and Spices - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Low water activity (a w ) and dried foods such as dried dairy and meat products, grain-based and dried ready-to-eat cereal products, powdered infant formula, peanut and nut pastes, as well as flours and meals have increasingly been associated with product recalls and foodborne outbreaks due to contamination by pathogens such as Salmonella spp. and enterohemorrhagic E. coli . In particular, recent foodborne outbreaks and product recalls related to Salmonella -contaminated spices have raised the level of public health concern for spices as agents of foodborne illnesses. Presently, most spices are grown outside the U.S., mainly in 8 countries: India, Indonesia, China, Brazil, Peru, Madagascar, Mexico and Vietnam. Many of these countries are under-developed and spices are harvested and stored with little heed to sanitation. The FDA has regulatory oversight of spices in the United States; however, the agency''s control is largely limited to enforcing regulatory compliance through sampling and testing only after imported foodstuffs have crossed the U.S. border. Unfortunately, statistical sampling plans are inefficient tools for ensuring total food safety. As a result, the development and use of decontamination treatments is key. This book provides an understanding of the microbial challenges to the safety of low a w foods, and a historic backdrop to the paradigm shift now highlighting low a w foods as vehicles for foodborne pathogens. Up-to-date facts and figures of foodborne illness outbreaks and product recalls are included. Special attention is given to the uncanny ability of Salmonella to persist under dry conditions in food processing plants and foods. A section is dedicated specifically to processing plant investigations, providing practical approaches to determining sources of persistent bacterial strains in the industrial food processing environment. Readers are guided through dry cleaning, wet cleaning and alternatives to processing plant hygiene and sanitation. Separate chapters are devoted to low a w food commodities of interest including spices, dried dairy-based products, low a w meat products, dried ready-to-eat cereal products, powdered infant formula, nuts and nut pastes, flours and meals, chocolate and confectionary, dried teas and herbs, and pet foods. The book provides regulatory testing guidelines and recommendations as well as guidance through methodological and sampling challenges to testing spices and low a w foods for the presence of foodborne pathogens. Chapters also address decontamination processes for low a w foods, including heat, steam, irradiation, microwave, and alternative energy-based treatments.

DKK 780.00
1

Selecting the Mercury Seven - Colin Burgess - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Selecting the Mercury Seven - Colin Burgess - Bog - Springer-Verlag New York Inc. - Plusbog.dk

The names of the seven Mercury astronauts were announced in April 1959 amid a flurry of publicity and patriotism. This work provides biographical details of all thirty-two finalists for the seven coveted places as America''s pioneering astronauts. All of the candidates were among the nation''s elite pilots involved in testing new supersonic aircraft capabilities. Most had served as wartime fighter and bomber pilots; some were test pilots on top secret and sophisticated aviation projects, while others were fleet admirals, prisoners of war, and proposed pilots for spaceflight programs such as the Dyna-Soar (X-20). The names of all 32 finalists have been kept secret until very recently. "Selecting the Mercury Seven" also relates the history and difficulties behind the initial choice of candidates. The lives, motivations, military careers, and achievements of the unsuccessful twenty-five finalists are explored first in fully authorized biographies. Test pilots for the U.S. Navy, Air Force, and Marine Corps, each man has a fascinating and very different story to tell. All thirty-two men had to endure meticulous, demeaning, and brutal week-long medical examinations at the Lovelace Clinic in New Mexico. This was followed by another torturous week at the Wright Aeromedical Laboratory in Ohio, where they were subjected to extreme fitness and physiological testing, the sole purpose of which was to sort out the Supermen from the near-supermen. The final part of the book examines the accomplishments and spaceflights of the seven successful candidates, bringing their amazing stories right up to date.

DKK 493.00
1

Simulating Society - Louis J. D'andria - Bog - Springer-Verlag New York Inc. - Plusbog.dk

An Introduction to Statistical Learning - Gareth James - Bog - Springer-Verlag New York Inc. - Plusbog.dk

An Introduction to Statistical Learning - Gareth James - Bog - Springer-Verlag New York Inc. - Plusbog.dk

An Introduction to Statistical Learning provides an accessible overview of the field of statistical learning, an essential toolset for making sense of the vast and complex data sets that have emerged in fields ranging from biology to finance to marketing to astrophysics in the past twenty years. This book presents some of the most important modeling and prediction techniques, along with relevant applications. Topics include linear regression, classification, resampling methods, shrinkage approaches, tree-based methods, support vector machines, clustering, deep learning, survival analysis, multiple testing, and more. Color graphics and real-world examples are used to illustrate the methods presented. Since the goal of this textbook is to facilitate the use of these statistical learning techniques by practitioners in science, industry, and other fields, each chapter contains a tutorial on implementing the analyses and methods presented in R, an extremely popular open source statistical software platform. Two of the authors co-wrote The Elements of Statistical Learning (Hastie, Tibshirani and Friedman, 2nd edition 2009), a popular reference book for statistics and machine learning researchers. An Introduction to Statistical Learning covers many of the same topics, but at a level accessible to a much broader audience. This book is targeted at statisticians and non-statisticians alike who wish to use cutting-edge statistical learning techniques to analyze their data. The text assumes only a previous course in linear regression and no knowledge of matrix algebra. This Second Edition features new chapters on deep learning, survival analysis, and multiple testing, as well as expanded treatments of naïve Bayes, generalized linear models, Bayesian additive regression trees, and matrix completion. R code has been updated throughout to ensure compatibility.

DKK 644.00
1

An Introduction to Statistical Learning - Trevor Hastie - Bog - Springer-Verlag New York Inc. - Plusbog.dk

An Introduction to Statistical Learning - Trevor Hastie - Bog - Springer-Verlag New York Inc. - Plusbog.dk

An Introduction to Statistical Learning provides an accessible overview of the field of statistical learning, an essential toolset for making sense of the vast and complex data sets that have emerged in fields ranging from biology to finance to marketing to astrophysics in the past twenty years. This book presents some of the most important modeling and prediction techniques, along with relevant applications. Topics include linear regression, classification, resampling methods, shrinkage approaches, tree-based methods, support vector machines, clustering, deep learning, survival analysis, multiple testing, and more. Color graphics and real-world examples are used to illustrate the methods presented. Since the goal of this textbook is to facilitate the use of these statistical learning techniques by practitioners in science, industry, and other fields, each chapter contains a tutorial on implementing the analyses and methods presented in R, an extremely popular open source statistical software platform. Two of the authors co-wrote The Elements of Statistical Learning (Hastie, Tibshirani and Friedman, 2nd edition 2009), a popular reference book for statistics and machine learning researchers. An Introduction to Statistical Learning covers many of the same topics, but at a level accessible to a much broader audience. This book is targeted at statisticians and non-statisticians alike who wish to use cutting-edge statistical learning techniques to analyze their data. The text assumes only a previous course in linear regression and no knowledge of matrix algebra. This Second Edition features new chapters on deep learning, survival analysis, and multiple testing, as well as expanded treatments of naïve Bayes, generalized linear models, Bayesian additive regression trees, and matrix completion. R code has been updated throughout to ensure compatibility.

DKK 648.00
1

Pediatric Tricky Topics, Volume 1 - Christine M. Houser - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Management of the Patient at High Risk for Breast Cancer - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

High-Throughput Screening Assays in Toxicology - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Principles of Clinical Cancer Genetics - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Pediatric Tricky Topics, Volume 2 - Christine M. Houser - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Looking Back - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Omics Approaches to Understanding Muscle Biology - - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Pediatric Gastroenterology and Nutrition - Christine M. Houser - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Pediatric Genetics and Inborn Errors of Metabolism - Christine M. Houser - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Pediatric Cardiology and Pulmonology - Christine M. Houser - Bog - Springer-Verlag New York Inc. - Plusbog.dk

Pediatric Infectious Disease - Christine M. Houser - Bog - Springer-Verlag New York Inc. - Plusbog.dk