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Crossing the Boundaries of Life - Karl S. Matlin - Bog - The University of Chicago Press - Plusbog.dk

Crossing the Boundaries of Life - Karl S. Matlin - Bog - The University of Chicago Press - Plusbog.dk

A close look at Günter Blobel’s transformative contributions to molecular cell biology. The difficulty of reconciling chemical mechanisms with the functions of whole living systems has plagued biologists since the development of cell theory in the nineteenth century. As Karl S. Matlin argues in Crossing the Boundaries of Life, it is no coincidence that this longstanding knot of scientific inquiry was loosened most meaningfully by the work of a cell biologist, the Nobel laureate Günter Blobel. In 1975, using an experimental setup that did not contain any cells at all, Blobel was able to target newly made proteins to cell membrane vesicles, enabling him to theorize how proteins in the cell distribute spatially, an idea he called the signal hypothesis. Over the next twenty years, Blobel and other scientists were able to dissect this mechanism into its precise molecular details. For elaborating his signal concept into a process he termed membrane topogenesis—the idea that each protein in the cell is synthesized with an "address" that directs the protein to its correct destination within the cell—Blobel was awarded the Nobel Prize in Physiology or Medicine in 1999. Matlin argues that Blobel’s investigative strategy and its subsequent application addressed a fundamental unresolved dilemma that had bedeviled biology from its very beginning—the relationship between structure and function—allowing biology to achieve mechanistic molecular explanations of biological phenomena. Crossing the Boundaries of Life thus uses Blobel’s research and life story to shed light on the importance of cell biology for twentieth-century science, illustrating how it propelled the development of adjacent disciplines like biochemistry and molecular biology.

DKK 332.00
1

Crossing the Boundaries of Life - Karl S. Matlin - Bog - The University of Chicago Press - Plusbog.dk

Crossing the Boundaries of Life - Karl S. Matlin - Bog - The University of Chicago Press - Plusbog.dk

A close look at Günter Blobel’s transformative contributions to molecular cell biology. The difficulty of reconciling chemical mechanisms with the functions of whole living systems has plagued biologists since the development of cell theory in the nineteenth century. As Karl S. Matlin argues in Crossing the Boundaries of Life, it is no coincidence that this longstanding knot of scientific inquiry was loosened most meaningfully by the work of a cell biologist, the Nobel laureate Günter Blobel. In 1975, using an experimental setup that did not contain any cells at all, Blobel was able to target newly made proteins to cell membrane vesicles, enabling him to theorize how proteins in the cell distribute spatially, an idea he called the signal hypothesis. Over the next twenty years, Blobel and other scientists were able to dissect this mechanism into its precise molecular details. For elaborating his signal concept into a process he termed membrane topogenesis—the idea that each protein in the cell is synthesized with an "address" that directs the protein to its correct destination within the cell—Blobel was awarded the Nobel Prize in Physiology or Medicine in 1999. Matlin argues that Blobel’s investigative strategy and its subsequent application addressed a fundamental unresolved dilemma that had bedeviled biology from its very beginning—the relationship between structure and function—allowing biology to achieve mechanistic molecular explanations of biological phenomena. Crossing the Boundaries of Life thus uses Blobel’s research and life story to shed light on the importance of cell biology for twentieth-century science, illustrating how it propelled the development of adjacent disciplines like biochemistry and molecular biology.

DKK 1010.00
1

Love and Death in Renaissance Italy - Thomas V. Cohen - Bog - The University of Chicago Press - Plusbog.dk

Love and Death in Renaissance Italy - Thomas V. Cohen - Bog - The University of Chicago Press - Plusbog.dk

Gratuitous sex. Graphic violence. Lies, revenge, and murder. Before there was digital cable or reality television, there was Renaissance Italy and the courts in which Italian magistrates meted out justice to the vicious and the villainous, the scabrous and the scandalous. Love and Death in Renaissance Italy retells six piquant episodes from the Italian court just after 1550, as the Renaissance gave way to an era of Catholic reformation. Each of the chapters in this history chronicles a domestic drama around which the lives of ordinary Romans are suddenly and violently altered. You might read the gruesome murder that opens the book-when an Italian noble takes revenge on his wife and her bastard lover as he catches them in delicto flagrante-as straight from the pages of Boccaccio. But this tale, like the other stories Cohen recalls here, is true, and its recounting in this scintillating work is based on assiduous research in court proceedings kept in the state archives in Rome. Love and Death in Renaissance Italy contains stories of a forbidden love for an orphan nun, of brothers who cruelly exact a will from their dying teenage sister, and of a malicious papal prosecutor who not only rapes a band of sisters, but turns their shambling father into a pimp! Cohen retells each cruel episode with a blend of sly wit and warm sympathy and then wraps his tales in ruminations on their lessons, both for the history of their own time and for historians writing today. What results is a book at once poignant and painfully human as well as deliciously entertaining.

DKK 465.00
1

Soda Science - Susan Greenhalgh - Bog - The University of Chicago Press - Plusbog.dk

Soda Science - Susan Greenhalgh - Bog - The University of Chicago Press - Plusbog.dk

Takes readers deep inside the secret world of corporate science, where powerful companies and allied academic scientists mold research to meet industry needs. The 1990s were tough times for the soda industry. In the United States, obesity rates were exploding. Public health critics pointed to sugary soda as a main culprit and advocated for soda taxes that might decrease the consumption of sweetened beverages—and threaten the revenues of the giant soda companies. Soda Science tells the story of how industry leader Coca-Cola mobilized allies in academia to create a soda-defense science that would protect profits by advocating exercise, not dietary restraint, as the priority solution to obesity, a view few experts accept. Anthropologist and science studies specialist Susan Greenhalgh discovers a hidden world of science-making—with distinctive organizations, social networks, knowledge-making practices, and ethical claims—dedicated to creating industry-friendly science and keeping it under wraps. By tracing the birth, maturation, death, and afterlife of the science they made, Greenhalgh shows how corporate science has managed to gain such a hold over our lives. Spanning twenty years, her investigation takes her from the US, where the science was made, to China, a key market for sugary soda. In the US, soda science was a critical force in the making of today’s society of step-counting, fitness-tracking, weight-obsessed citizens. In China, this distorted science has left its mark not just on national obesity policies but on the apparatus for managing chronic disease generally. By following the scientists and their ambitious schemes to make the world safe for Coke, Greenhalgh offers an account that is more global—and yet more human—than the story that dominates public understanding today. Coke’s research isn’t fake science, Greenhalgh argues; it was real science, conducted by real and eminent scientists, but distorted by its aim. Her gripping book raises crucial questions about conflicts of interest in scientific research, the funding behind familiar messages about health, and the cunning ways giant corporations come to shape our diets, lifestyles, and health to their own needs.

DKK 241.00
1

Soda Science - Susan Greenhalgh - Bog - The University of Chicago Press - Plusbog.dk

Soda Science - Susan Greenhalgh - Bog - The University of Chicago Press - Plusbog.dk

Takes readers deep inside the secret world of corporate science, where powerful companies and allied academic scientists mold research to meet industry needs. The 1990s were tough times for the soda industry. In the United States, obesity rates were exploding. Public health critics pointed to sugary soda as a main culprit and advocated for soda taxes that might decrease the consumption of sweetened beverages—and threaten the revenues of the giant soda companies. Soda Science tells the story of how industry leader Coca-Cola mobilized allies in academia to create a soda-defense science that would protect profits by advocating exercise, not dietary restraint, as the priority solution to obesity, a view few experts accept. Anthropologist and science studies specialist Susan Greenhalgh discovers a hidden world of science-making—with distinctive organizations, social networks, knowledge-making practices, and ethical claims—dedicated to creating industry-friendly science and keeping it under wraps. By tracing the birth, maturation, death, and afterlife of the science they made, Greenhalgh shows how corporate science has managed to gain such a hold over our lives. Spanning twenty years, her investigation takes her from the US, where the science was made, to China, a key market for sugary soda. In the US, soda science was a critical force in the making of today’s society of step-counting, fitness-tracking, weight-obsessed citizens. In China, this distorted science has left its mark not just on national obesity policies but on the apparatus for managing chronic disease generally. By following the scientists and their ambitious schemes to make the world safe for Coke, Greenhalgh offers an account that is more global—and yet more human—than the story that dominates public understanding today. Coke’s research isn’t fake science, Greenhalgh argues; it was real science, conducted by real and eminent scientists, but distorted by its aim. Her gripping book raises crucial questions about conflicts of interest in scientific research, the funding behind familiar messages about health, and the cunning ways giant corporations come to shape our diets, lifestyles, and health to their own needs.

DKK 1004.00
1