21 resultater (0,29967 sekunder)

Vis alle filtre

Mærke

Butik

Pris (EUR)

Nulstil filter

Produkter
Fra
Butikker

Lectures On Statistical Physics And Protein Folding - Kerson Huang - Bog - World Scientific Publishing Co Pte Ltd - Plusbog.dk

Lectures On Statistical Physics And Protein Folding - Kerson Huang - Bog - World Scientific Publishing Co Pte Ltd - Plusbog.dk

This book introduces an approach to protein folding from the point of view of kinetic theory. There is an abundance of data on protein folding, but few proposals are available on the mechanism driving the process. Here, presented for the first time, are suggestions on possible research directions, as developed by the author in collaboration with C C Lin.The first half of this invaluable book contains a concise but relatively complete review of relevant topics in statistical mechanics and kinetic theory. It includes standard topics such as thermodynamics, the Maxwell-Boltzmann distribution, and ensemble theory. Special discussions include the dynamics of phase transitions, and Brownian motion as an illustration of stochastic processes.The second half develops topics in molecular biology and protein structure, with a view to discovering mechanisms underlying protein folding. Attention is focused on the energy flow through the protein in its folded state. A mathematical model, based on the Brownian motion of coupled harmonic oscillators, is worked out in the appendix.

DKK 476.00
1

Protein Folding Problem And Its Solutions, The - Arieh Ben Naim - Bog - World Scientific Publishing Co Pte Ltd - Plusbog.dk

Protein Folding Problem And Its Solutions, The - Arieh Ben Naim - Bog - World Scientific Publishing Co Pte Ltd - Plusbog.dk

This book presents a new approach to the Protein Folding Problem. It starts with a clear description of what the protein folding problem involves. Then, it suggests non-conventional answers to some of the questions posed. In particular, it emphasizes the importance of hydrophilic interactions and hydrophilic forces, rather than the hydrophobic effects, for the stability of the native structure of proteins, as well for the speed of the folding process.

DKK 1123.00
1

New Chemistry And New Opportunities From The Expanding Protein Universe - Proceedings Of The 23rd International Solvay Conference On Chemistry - - Bog

New Chemistry And New Opportunities From The Expanding Protein Universe - Proceedings Of The 23rd International Solvay Conference On Chemistry - - Bog

A select group of 40 eminent scientists from all parts of the world met to consider the current state of chemical and biological knowledge on the ever-expanding protein universe, and to discuss emerging opportunities for the foreseeable future. Scientific approaches to discover, characterize, and regulate protein functions were discussed over a range of disciplines, including natural product chemistry, microbiology, enzymology, biochemistry, structural biology, chemical biology, and glycobiology. Some notable highlights included discovery of new enzymatic pathways, innovative carbohydrate chemistry, design of proteins containing unnatural amino acids, structural elucidation of complex supramolecular machines, and design and application of small molecule drugs, biologics and biosimilars. This fascinating compendium of scientific presentations and in-depth discussions affords a unique perspective on today's protein chemistry and biology as well as on the challenges for tomorrow.

DKK 406.00
1

Myths And Verities In Protein Folding Theories - Arieh Ben Naim - Bog - World Scientific Publishing Co Pte Ltd - Plusbog.dk

Myths And Verities In Protein Folding Theories - Arieh Ben Naim - Bog - World Scientific Publishing Co Pte Ltd - Plusbog.dk

This book tells the story of a whole field of research which went disastrously wrong in many different directions when the wrong tools were used and the wrong targets aimed at, to solve a problem. It all started from the misinterpretation of Schellman's experiments which were carried out in the mid-1950s, and which were later encapsulated by the so-called "Hydrogen-bond inventory argument." As a result, hydrogen bonding was ignored in protein folding; along with that a whole repertoire of other possible hydrophilic effects were not even considered. Against this background the hydrophobic effects, as suggested by Kauzmann, became the single most important effects in protein folding. In addition, as a result of the misinterpretation of Anfinsen's hypothesis, as well as misunderstanding of the Second Law, people made futile attempts to search for the structure of proteins in the global minimum of either the Energy, or the Gibbs Energy Landscape.

DKK 628.00
1

Myths And Verities In Protein Folding Theories - Arieh Ben Naim - Bog - World Scientific Publishing Co Pte Ltd - Plusbog.dk

Myths And Verities In Protein Folding Theories - Arieh Ben Naim - Bog - World Scientific Publishing Co Pte Ltd - Plusbog.dk

This book tells the story of a whole field of research which went disastrously wrong in many different directions when the wrong tools were used and the wrong targets aimed at, to solve a problem. It all started from the misinterpretation of Schellman's experiments which were carried out in the mid-1950s, and which were later encapsulated by the so-called "Hydrogen-bond inventory argument." As a result, hydrogen bonding was ignored in protein folding; along with that a whole repertoire of other possible hydrophilic effects were not even considered. Against this background the hydrophobic effects, as suggested by Kauzmann, became the single most important effects in protein folding. In addition, as a result of the misinterpretation of Anfinsen's hypothesis, as well as misunderstanding of the Second Law, people made futile attempts to search for the structure of proteins in the global minimum of either the Energy, or the Gibbs Energy Landscape.

DKK 300.00
1

Bone Morphogenetic Protein And Collagen: An Advances In Tissue Banking Specialist Publication - - Bog - World Scientific Publishing Co Pte Ltd -

Bone Morphogenetic Protein And Collagen: An Advances In Tissue Banking Specialist Publication - - Bog - World Scientific Publishing Co Pte Ltd -

What are bone morphogenetic proteins (BMPs) and how can they be used in orthopaedic practice? Ever since Urist proposed in 1976 that protein factors from cortical bone appeared to modulate bone healing in animals, there has been a search for these mysterious osteoinductive components. Now that their structure has been elucidated, they have been purified and cloned, and are now available for the improvement of bone healing.The best source of BMPs is demineralised bone. This bone allograft is used to achieve greater osteoinductive capacity. But are the actions of procurement, processing, demineralisation and sterilisation harmful to the BMPs? Unless the BMPs can be assayed, neither their clinical nor their scientific effectiveness can be appraised. All these aspects are logically and scientifically described in this volume. In addition, there is a review of the biochemistry of one of the two main components of bone, namely collagen. This subject is itself a confusing but rapidly growing field. This comprehensive review describes the procedures for building up bone in vivo and in vitro.Bone Morphogenetic Protein and Collagen answers most of the questions of orthopaedic surgeons and tissue bankers on how BMPs can be produced and used to their maximum effectiveness.

DKK 603.00
1

Structure And Mechanism In Protein Science: A Guide To Enzyme Catalysis And Protein Folding - Alan R. Fersht - Bog - World Scientific Publishing Co

Structure And Mechanism In Protein Science: A Guide To Enzyme Catalysis And Protein Folding - Alan R. Fersht - Bog - World Scientific Publishing Co

This book is a guide for advanced undergraduates, post-graduates and researchers to the fundamental principles in studying kinetics and mechanism of processes concerning proteins. It provides a rare broad overview that concentrates on fundamental principles and understanding underlying the physics and chemistry. It is a single author text by someone who has direct experience in all of the areas covered.

DKK 544.00
1

Practical Bioinformatician, The - - Bog - World Scientific Publishing Co Pte Ltd - Plusbog.dk

Practical Bioinformatician, The - - Bog - World Scientific Publishing Co Pte Ltd - Plusbog.dk

Computer scientists have increasingly been enlisted as “bioinformaticians” to assist molecular biologists in their research. This book is a practical introduction to bioinformatics for these computer scientists. The chapters are in-depth discussions by expert bioinformaticians on both general techniques and specific approaches to a range of selected bioinformatics problems. The book is organized into clusters of chapters on the following topics: • Overview of modern molecular biology and a broad spectrum of techniques from computer science — data mining, machine learning, mathematical modeling, sequence alignment, data integration, workflow development, etc. • In-depth discussion of computational recognition of functional and regulatory sites in DNA sequences. • Incisive discussion of computational prediction of secondary structure of RNA sequences. • Overview of computational prediction of protein cellular localization, and selected discussions of inference of protein function. • Overview of methods for discovering protein–protein interactions. • Detailed discussion of approaches to gene expression analysis for the diagnosis of diseases, the treatment of diseases, and the understanding of gene functions. • Case studies on analysis of phylogenies, functional annotation of proteins, construction of purpose-built integrated biological databases, and development of workflows underlying the large-scale-effort gene discovery.

DKK 920.00
1

Biological Language Model: Theory And Application - Xiuzhen Hu - Bog - World Scientific Publishing Co Pte Ltd - Plusbog.dk

Biological Language Model: Theory And Application - Xiuzhen Hu - Bog - World Scientific Publishing Co Pte Ltd - Plusbog.dk

Conceived as a cross between natural language processing methods and biological sequences in DNA, RNA and protein, biological language model is a new scientific research topic in bioinformatics that has been extensively studied by the authors. The basic theory and applications of this model are presented in this book to serve as an reference for graduate students and researchers.

DKK 1014.00
1

Nobel Lectures In Physiology Or Medicine 1991-1995 - - Bog - World Scientific Publishing Co Pte Ltd - Plusbog.dk

Nobel Lectures In Physiology Or Medicine 1991-1995 - - Bog - World Scientific Publishing Co Pte Ltd - Plusbog.dk

During the period 1991 - 1995, important areas of physiological/medical research being recognized were ion channels in cells, protein phosphorylation, split genes, G-proteins and genetic control of embryonic development. The following is a list of the Nobel laureates for those years, with a description of the works that won them their prizes:(1991) E NEHER & B SAKMANN — for their discoveries concerning the function of single ion channels in cells; (1992) E H FISCHER & E G KREBS — for their discoveries concerning reversible protein phosphorylation as a biological regulatory mechanism; (1993) R J ROBERTS & P A SHARP — for their discoveries of split genes; (1994) A G GILMAN & M RODBELL — for their discovery of G-proteins and the role of these proteins in signal transduction in cells; (1995) E B LEWIS, C NÜSSLEIN-VOLHARD & E F WIESCHAUS — for their discoveries concerning the genetic control of early embryonic development.

DKK 329.00
1

Practical Guide To Cancer Systems Biology, A - - Bog - World Scientific Publishing Co Pte Ltd - Plusbog.dk

Practical Guide To Cancer Systems Biology, A - - Bog - World Scientific Publishing Co Pte Ltd - Plusbog.dk

Systems biology combines computational and experimental approaches to analyze complex biological systems and focuses on understanding functional activities from a systems-wide perspective. It provides an iterative process of experimental measurements, data analysis, and computational simulation to model biological behavior. This book provides explained protocols for high-throughput experiments and computational analysis procedures central to cancer systems biology research and education. Readers will learn how to generate and analyze high-throughput data, therapeutic target protein structure modeling and docking simulation for drug discovery. This is the first practical guide for students and scientists who wish to become systems biologists or utilize the approach for cancer research.

DKK 692.00
1

Introduction To Computational Neurobiology And Clustering - Enrico Ferraro - Bog - World Scientific Publishing Co Pte Ltd - Plusbog.dk

Introduction To Computational Neurobiology And Clustering - Enrico Ferraro - Bog - World Scientific Publishing Co Pte Ltd - Plusbog.dk

This volume provides students with the necessary tools to better understand the fields of neurobiological modeling, cluster analysis of proteins and genes. The theory is explained starting from the beginning and in the most elementary terms, there are many exercises solved and not useful for the understanding of the theory. The exercises are specially adapted for training and many useful Matlab programs are included, easily understood and generalizable to more complex situations. This self-contained text is particularly suitable for an undergraduate course of biology and biotechnology.New results are also provided for researchers such as the description and applications of the Kohonen neural networks to gene classification and protein classification with back propagation neutral networks.

DKK 831.00
1

Textbook Of Structural Biology - Goran (umea Univ Lindblom - Bog - World Scientific Publishing Co Pte Ltd - Plusbog.dk

Textbook Of Structural Biology - Goran (umea Univ Lindblom - Bog - World Scientific Publishing Co Pte Ltd - Plusbog.dk

This book provides a comprehensive coverage of the basic principles of structural biology, as well as an up-to-date summary of some main directions of research in the field. The relationship between structure and function is described in detail for soluble proteins, membrane proteins, membranes, and nucleic acids. There are several books covering protein structure and function, but none that give a complete picture, including nucleic acids, lipids, membranes and carbohydrates, all being of central importance in structural biology. The book covers state-of-the-art research in various areas. It is unique for its breadth of coverage by experts in the fields. The book is richly illustrated with more than 400 color figures to highlight the wide range of structures.

DKK 796.00
1

Luminous Pursuit: Jellyfish, Gfp, And The Unforeseen Path To The Nobel Prize - Sachi Shimomura - Bog - World Scientific Publishing Co Pte Ltd -

Luminous Pursuit: Jellyfish, Gfp, And The Unforeseen Path To The Nobel Prize - Sachi Shimomura - Bog - World Scientific Publishing Co Pte Ltd -

This book narrates the uniquely intertwined life and scientific career of Nobel laureate Osamu Shimomura, with particular attention to his discovery of aequorin and Green Fluorescent Protein (GFP). It includes his early memories of Manchuria and wartime Japan featuring an eyewitness account of the atomic bombing of Nagasaki, his postwar studies and his travels to collect and research more than fifteen bioluminescent species, in locations ranging from Japan to San Juan Island, Bermuda, New Zealand and Norway. Dr Shimomura describes the unique combination of serendipity and perseverance that led ultimately to his 2008 Nobel Prize in chemistry. The book provides an engaging account of the life of a dedicated scientist, emphasizing the value of determination in the pursuit of pure scientific knowledge, and showing how a general understanding of science helped him open up new areas of research that have led to unforeseen applications in cell biology and medicine.

DKK 356.00
1

Luminous Pursuit: Jellyfish, Gfp, And The Unforeseen Path To The Nobel Prize - Sachi Shimomura - Bog - World Scientific Publishing Co Pte Ltd -

Luminous Pursuit: Jellyfish, Gfp, And The Unforeseen Path To The Nobel Prize - Sachi Shimomura - Bog - World Scientific Publishing Co Pte Ltd -

This book narrates the uniquely intertwined life and scientific career of Nobel laureate Osamu Shimomura, with particular attention to his discovery of aequorin and Green Fluorescent Protein (GFP). It includes his early memories of Manchuria and wartime Japan featuring an eyewitness account of the atomic bombing of Nagasaki, his postwar studies and his travels to collect and research more than fifteen bioluminescent species, in locations ranging from Japan to San Juan Island, Bermuda, New Zealand and Norway. Dr Shimomura describes the unique combination of serendipity and perseverance that led ultimately to his 2008 Nobel Prize in chemistry. The book provides an engaging account of the life of a dedicated scientist, emphasizing the value of determination in the pursuit of pure scientific knowledge, and showing how a general understanding of science helped him open up new areas of research that have led to unforeseen applications in cell biology and medicine.

DKK 628.00
1

Mif Handbook, The - - Bog - World Scientific Publishing Co Pte Ltd - Plusbog.dk

Mif Handbook, The - - Bog - World Scientific Publishing Co Pte Ltd - Plusbog.dk

The role of the cytokine, macrophage migration inhibitory factor (MIF), in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well established. The aim of this handbook is to provide an authoritative volume covering all aspects of MIF, from basic molecular biology to structure-function relationships, pathophysiology, genetics, and drug development.Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, cardiac physiology, and neurodevelopment. MIF''s molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. Unique structural features of the protein, such as an intrinsic catalytic activity, and the continuing elucidation of its receptor-dependent mechanism of action offer attractive opportunities for therapeutic intervention. This volume will provide a comprehensive synthesis of the state of the art of MIF science.

DKK 1093.00
1

Nobel Lectures In Chemistry (2006-2010) - - Bog - World Scientific Publishing Co Pte Ltd - Plusbog.dk

Nobel Lectures In Chemistry (2006-2010) - - Bog - World Scientific Publishing Co Pte Ltd - Plusbog.dk

Mentioned as the second prize area in his will, Chemistry was the most important science for Alfred Nobel''s own work. The development of Nobel''s inventions as well as the industrial processes he employed were based upon chemical knowledge. This volume is a collection of the Nobel lectures delivered by the prizewinners, together with their biographies and the presentation speeches for the period 2006-2010. Each Nobel lecture is based on the work for which the laureate was awarded the prize.List of prizewinners and their award citations:(2006) Roger D Kornberg — for his studies of the molecular basis of eukaryotic transcription;(2007) Gerhard Ertl — for his studies of chemical processes on solid surfaces;(2008) Osamu Shimomura, Martin Chalfie and Roger Y Tsien — for the discovery and development of the green fluorescent protein, GFP;(2009) Venkatraman Ramakrishnan, Thomas A Steitz and Ada E Yonath — for studies of the structure and function of the ribosome;(2010) Richard F Heck, Ei-ichi Negishi and Akira Suzuki — for palladium-catalyzed cross couplings in organic synthesis.

DKK 406.00
1

Nobel Lectures In Chemistry, Vol 6 (1981-1990) - - Bog - World Scientific Publishing Co Pte Ltd - Plusbog.dk

Nobel Lectures In Chemistry, Vol 6 (1981-1990) - - Bog - World Scientific Publishing Co Pte Ltd - Plusbog.dk

Below is a list of the prizewinners during the period 1981 - 1990 with a description of the works which won them their prizes:(1981) K FUKUI & R HOFFMANN — for their theories, developed independently, concerning the course of chemical reactions; (1982) A KLUG — for his development of crystallographic electron microscopy and his structural elucidation of biologically important nuclei acid-protein complexes; (1983) H TAUBE — for his work on the mechanisms of electron transfer reactions, especially in metal complexes; (1984) R B MERRIFIELD — for his development of the methodology for chemical synthesis on a solid matrix; (1985) H A HAUPTMAN & J KARLE — for their outstanding achievements in the development of direct methods for the determination of crystal structures; (1986) D R HERSCHBACH, Y T LEE & J C POLANYI — for their contributions concerning the dynamics of chemical elementary processes; (1987) D J CRAM, J-M LEHN & C J PEDERSEN — for their development and use of molecules with structure-specific interactions of high selectivity; (1988) J DEISENHOFER, R HUBER & H MICHEL — for the determination of the three-dimensional structure of a photosynthetic reaction centre; (1989) S ALTMAN & T R CECH — for their discovery of catalytic properties of RNA; (1990) E J COREY — for his development of the theory and methodology of organic synthesis.

DKK 910.00
1

Nanopore Sequencing: An Introduction - Daniel Branton - Bog - World Scientific Publishing Co Pte Ltd - Plusbog.dk

Nanopore Sequencing: An Introduction - Daniel Branton - Bog - World Scientific Publishing Co Pte Ltd - Plusbog.dk

This is an introductory text and laboratory manual to be used primarily in undergraduate courses. It is also useful for graduate students and research scientists who require an introduction to the theory and methods of nanopore sequencing. The book has clear explanations of the principles of this emerging technology, together with instructional material written by experts that describes how to use a MinION nanopore instrument for sequencing in research or the classroom. At Harvard University the book serves as a textbook and lab manual for a university laboratory course designed to intensify the intellectual experience of incoming undergraduates while exploring biology as a field of concentration. Nanopore sequencing is an ideal topic as a path to encourage students about the range of courses they will take in Biology by pre-emptively addressing the complaint about having to take a course in Physics or Maths while majoring in Biology. The book addresses this complaint by concretely demonstrating the range of topics — from electricity to biochemistry, protein structure, molecular engineering, and informatics — that a student will have to master in subsequent courses if he or she is to become a scientist who truly understands what his or her biology instrument is measuring when investigating biological phenomena.

DKK 544.00
1

Nobel Lectures In Chemistry (2001-2005) - - Bog - World Scientific Publishing Co Pte Ltd - Plusbog.dk

Nobel Lectures In Chemistry (2001-2005) - - Bog - World Scientific Publishing Co Pte Ltd - Plusbog.dk

This volume is a collection of the Nobel Lectures delivered by the prizewinners, together with their biographies and the presentation speeches at the award ceremonies in Stockholm for the period 2001 - 2005. Each Nobel Lecture is based on the work for which the laureate was awarded the prize. This volume of inspiring lectures by outstanding chemists and biochemists should be on the bookshelf of every keen student, teacher and professor of chemistry as well as of those in related fields. Below is a list of the prizewinners during the period 2001 - 2005 with a description of the works which won them their prizes.(2001) William S Knowles, Ryoji Noyori — for their work on chirally catalyzed hydrogenation reactions & K Barry Sharpless — for his work on chirally catalyzed oxidation reactions; (2002) John B Fenn, Koichi Tanaka — for their development of soft desorption ionization methods for mass spectrometric analyses of biological macromolecules & Kurt Wüthrich — for his development of nuclear magnetic resonance spectroscopy for determining the three-dimensional structure of biological macromolecules in solution; (2003) Peter Agre — for the discovery of water channels & Roderick MacKinnon — for structural and mechanistic studies of ion channels; (2004) Aaron Ciechanover, Avram Hershko & Irwin Rose — for the discovery of ubiquitin-mediated protein degradation; (2005) Yves Chauvin, Robert H Grubbs & Richard R Schrock — for the development of the metathesis method in organic synthesis.

DKK 255.00
1