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Design of Experiments An Introduction Based on Linear Models

Design of Experiments An Introduction Based on Linear Models

Offering deep insight into the connections between design choice and the resulting statistical analysis Design of Experiments: An Introduction Based on Linear Models explores how experiments are designed using the language of linear statistical models. The book presents an organized framework for understanding the statistical aspects of experimental design as a whole within the structure provided by general linear models rather than as a collection of seemingly unrelated solutions to unique problems. The core material can be found in the first thirteen chapters. These chapters cover a review of linear statistical models completely randomized designs randomized complete blocks designs Latin squares analysis of data from orthogonally blocked designs balanced incomplete block designs random block effects split-plot designs and two-level factorial experiments. The remainder of the text discusses factorial group screening experiments regression model design and an introduction to optimal design. To emphasize the practical value of design most chapters contain a short example of a real-world experiment. Details of the calculations performed using R along with an overview of the R commands are provided in an appendix. This text enables students to fully appreciate the fundamental concepts and techniques of experimental design as well as the real-world value of design. It gives them a profound understanding of how design selection affects the information obtained in an experiment. | Design of Experiments An Introduction Based on Linear Models

GBP 74.99
1

Discrete Event Simulation for Health Technology Assessment

Discrete Event Simulation for Health Technology Assessment

Discover How to Apply DES to Problems Encountered in HTADiscrete event simulation (DES) has traditionally been used in the engineering and operations research fields. The use of DES to inform decisions about health technologies is still in its infancy. Written by specialists at the forefront of this area Discrete Event Simulation for Health Technology Assessment is the first book to make all the central concepts of DES relevant for health technology assessment (HTA). Accessible to beginners the book requires no prerequisites and describes the concepts with as little jargon as possible. The book first covers the essential concepts and their implementation. It next provides a fully worked out example using both a widely available spreadsheet program (Microsoft Excel) and a popular specialized simulation package (Arena). It then presents approaches to analyze the simulations including the treatment of uncertainty; tackles the development of the required equations; explains the techniques to verify that the models are as efficient as possible; and explores the indispensable topic of validation. The book also covers a variety of non-essential yet handy topics such as the animation of a simulation and extensions of DES and incorporates a real case study involving screening strategies for breast cancer surveillance. This book guides you in leveraging DES in your assessments of health technologies. After reading the chapters in sequence you will be able to construct a realistic model designed to help in the assessment of a new health technology.

GBP 44.99
1

Introduction to Statistical Modelling and Inference

Introduction to Statistical Modelling and Inference

The complexity of large-scale data sets (“Big Data”) has stimulated the development of advanced computational methods for analysing them. There are two different kinds of methods to aid this. The model-based method uses probability models and likelihood and Bayesian theory while the model-free method does not require a probability model likelihood or Bayesian theory. These two approaches are based on different philosophical principles of probability theory espoused by the famous statisticians Ronald Fisher and Jerzy Neyman. Introduction to Statistical Modelling and Inference covers simple experimental and survey designs and probability models up to and including generalised linear (regression) models and some extensions of these including finite mixtures. A wide range of examples from different application fields are also discussed and analysed. No special software is used beyond that needed for maximum likelihood analysis of generalised linear models. Students are expected to have a basic mathematical background in algebra coordinate geometry and calculus. Features• Probability models are developed from the shape of the sample empirical cumulative distribution function (cdf) or a transformation of it. • Bounds for the value of the population cumulative distribution function are obtained from the Beta distribution at each point of the empirical cdf. • Bayes’s theorem is developed from the properties of the screening test for a rare condition. • The multinomial distribution provides an always-true model for any randomly sampled data. • The model-free bootstrap method for finding the precision of a sample estimate has a model-based parallel – the Bayesian bootstrap – based on the always-true multinomial distribution. • The Bayesian posterior distributions of model parameters can be obtained from the maximum likelihood analysis of the model. This book is aimed at students in a wide range of disciplines including Data Science. The book is based on the model-based theory used widely by scientists in many fields and compares it in less detail with the model-free theory popular in computer science machine learning and official survey analysis. The development of the model-based theory is accelerated by recent developmentsin Bayesian analysis.

GBP 82.99
1

Geographic Data Science with R Visualizing and Analyzing Environmental Change

Geographic Data Science with R Visualizing and Analyzing Environmental Change

The burgeoning field of data science has provided a wealth of techniques for analysing large and complex geospatial datasets including descriptive explanatory and predictive analytics. However applying these methods is just one part of the overall process of geographic data science. Other critical steps include screening for suspect data values handling missing data harmonizing data from multiple sources summarizing the data and visualizing data and analysis results. Although there are many books available on statistical and machine learning methods few encompass the broader topic of scientific workflows for geospatial data processing and analysis. The purpose of Geographic Data Science with R is to fill this gap by providing a series of tutorials aimed at teaching good practices for using geospatial data to address problems in environmental geography. It is based on the R language and environment which currently provides the best option for working with diverse spatial and non-spatial data in a single platform. Fundamental techniques for processing and visualizing tabular vector and raster data are introduced through a series of practical examples followed by case studies that combine multiple types of data to address more complex problems. The book will have a broad audience. Both students and professionals can use it as a workbook to learn high-level techniques for geospatial data processing and analysis with R. It is also suitable as a textbook. Although not intended to provide a comprehensive introduction to R it is designed to be accessible to readers who have at least some knowledge of coding but little to no experience with R. Key Features: Focus on developing practical workflows for processing and integrating multiple sources of geospatial data in R Example-based approach that teaches R programming and data science concepts through real-world applications related to climate land cover and land use and natural hazards. Consistent use of tidyverse packages for tabular data manipulation and visualization. Strong focus on analysing continuous and categorical raster datasets using the new terra package Organized so that each chapter builds on the topics and techniques covered in the preceding chapters Can be used for self-study or as the textbook for a geospatial science course. | Geographic Data Science with R Visualizing and Analyzing Environmental Change

GBP 74.99
1

Real World AI Ethics for Data Scientists Practical Case Studies

Metabolomics Practical Guide to Design and Analysis

Metabolomics Practical Guide to Design and Analysis

Metabolomics is the scientific study of the chemical processes in a living system environment and nutrition. It is a relatively new omics science but the potential applications are wide including medicine personalized medicine and intervention studies food and nutrition plants agriculture and environmental science. The topics presented and discussed in this book are based on the European Molecular Biology Organization (EMBO) practical courses in metabolomics bioinformatics taught to those working in the field from masters to postgraduate students PhDs postdoctoral and early PIs. The book covers the basics and fundamentals of data acquisition and analytical technologies but the primary focus is data handling and data analysis. The mentioning and usage of a particular data analysis tool has been avoided; rather the focus is on the concepts and principles of data processing and analysis. The material has been class-tested and includes lots of examples computing and exercises. Key Features:Provides an overview of qualitative /quantitative methods in metabolomicsOffers an introduction to the key concepts of metabolomics including experimental design and technologyCovers data handling processing analysis data standards and sharingContains lots of examples to illustrate the topicsIncludes contributions from some of the leading researchers in the field of metabolomics with extensive teaching experiences | Metabolomics Practical Guide to Design and Analysis

GBP 44.99
1

Statistical Design and Analysis of Stability Studies

Statistical Design and Analysis of Stability Studies

The US Food and Drug Administration's Report to the Nation in 2004 and 2005 indicated that one of the top reasons for drug recall was that stability data did not support existing expiration dates. Pharmaceutical companies conduct stability studies to characterize the degradation of drug products and to estimate drug shelf life. Illustrating how stability studies play an important role in drug safety and quality assurance Statistical Design and Analysis of Stability Studies presents the principles and methodologies in the design and analysis of stability studies. After introducing the basic concepts of stability testing the book focuses on short-term stability studies and reviews several methods for estimating drug expiration dating periods. It then compares some commonly employed study designs and discusses both fixed and random batch statistical analyses. Following a chapter on the statistical methods for stability analysis under a linear mixed effects model the book examines stability analyses with discrete responses multiple components and frozen drug products. In addition the author provides statistical methods for dissolution testing and explores current issues and recent developments in stability studies. To ensure the safety of consumers professionals in the field must carry out stability studies to determine the reliability of drug products during their expiration period. This book provides the material necessary for you to perform stability designs and analyses in pharmaceutical research and development.

GBP 44.99
1

Measuring Society

Bioequivalence and Statistics in Clinical Pharmacology

Bioequivalence and Statistics in Clinical Pharmacology

Maintaining a practical perspective Bioequivalence and Statistics in Clinical Pharmacology Second Edition explores statistics used in day-to-day clinical pharmacology work. The book is a starting point for those involved in such research and covers the methods needed to design analyze and interpret bioequivalence trials; explores when how and why these studies are performed as part of drug development; and demonstrates the methods using real world examples. Drawing on knowledge gained directly from working in the pharmaceutical industry the authors set the stage by describing the general role of statistics. Once the foundation of clinical pharmacology drug development regulatory applications and the design and analysis of bioequivalence trials are established including recent regulatory changes in design and analysis and in particular sample-size adaptation they move on to related topics in clinical pharmacology involving the use of cross-over designs. These include but are not limited to safety studies in Phase I dose-response trials drug interaction trials food-effect and combination trials QTc and other pharmacodynamic equivalence trials proof-of-concept trials dose-proportionality trials and vaccines trials. This second edition addresses several recent developments in the field including new chapters on adaptive bioequivalence studies scaled average bioequivalence testing and vaccine trials. Purposefully designed to be instantly applicable Bioequivalence and Statistics in Clinical Pharmacology Second Edition provides examples of SAS and R code so that the analyses described can be immediately implemented. The authors have made extensive use of the proc mixed procedures available in SAS.

GBP 44.99
1

New Centrality Measures in Networks How to Take into Account the Parameters of the Nodes and Group Influence of Nodes to Nodes

New Centrality Measures in Networks How to Take into Account the Parameters of the Nodes and Group Influence of Nodes to Nodes

Over the last number of years there has been a growing interest in the analysis of complex networks which describe a wide range of real-world systems in nature and society. Identification of the central elements in such networks is one of the key research areas. Solutions to this problem are important for making strategic decisions and studying the behavior of dynamic processes e. g. epidemic spread. The importance of nodes has been studied using various centrality measures. Generally it should be considered that most real systems are not homogeneous: nodes may have individual attributes and influence each other in groups while connections between nodes may describe different types of relations. Thus critical nodes detection is not a straightforward process. New Centrality Measures in Networks presents a class of new centrality measures which take into account individual attributes of nodes the possibility of group influence and long-range interactions and discusses all their new features. The book provides a wide range of applications of network analysis in several fields – financial networks international migration global trade global food network arms transfers networks of terrorist groups and networks of international journals in economics. Real-world studies of networks indicate that the proposed centrality measures can identify important nodes in different applications. Starting from the basic ideas the development of the indices and their advantages compared to existing centrality measures are presented. Features Built around real-world case studies in a variety of different areas (finance migration trade etc. ) Suitable for students and professional researchers with an interest in complex network analysis Paired with a software package for readers who wish to apply the proposed models of centrality (in Python) available at https://github. com/SergSHV/slric. | New Centrality Measures in Networks How to Take into Account the Parameters of the Nodes and Group Influence of Nodes to Nodes

GBP 48.99
1

Model-Assisted Bayesian Designs for Dose Finding and Optimization Methods and Applications

Model-Assisted Bayesian Designs for Dose Finding and Optimization Methods and Applications

Bayesian adaptive designs provide a critical approach to improve the efficiency and success of drug development that has been embraced by the US Food and Drug Administration (FDA). This is particularly important for early phase trials as they form the basis for the development and success of subsequent phase II and III trials. The objective of this book is to describe the state-of-the-art model-assisted designs to facilitate and accelerate the use of novel adaptive designs for early phase clinical trials. Model-assisted designs possess avant-garde features where superiority meets simplicity. Model-assisted designs enjoy exceptional performance comparable to more complicated model-based adaptive designs yet their decision rules often can be pre-tabulated and included in the protocol—making implementation as simple as conventional algorithm-based designs. An example is the Bayesian optimal interval (BOIN) design the first dose-finding design to receive the fit-for-purpose designation from the FDA. This designation underscores the regulatory agency's support of the use of the novel adaptive design to improve drug development. Features Represents the first book to provide comprehensive coverage of model-assisted designs for various types of dose-finding and optimization clinical trials Describes the up-to-date theory and practice for model-assisted designs Presents many practical challenges issues and solutions arising from early-phase clinical trials Illustrates with many real trial applications Offers numerous tips and guidance on designing dose finding and optimization trials Provides step-by-step illustrations of using software to design trials Develops a companion website (www. trialdesign. org) to provide freely available easy-to-use software to assist learning and implementing model-assisted designs Written by internationally recognized research leaders who pioneered model-assisted designs from the University of Texas MD Anderson Cancer Center this book shows how model-assisted designs can greatly improve the efficiency and simplify the design conduct and optimization of early-phase dose-finding trials. It should therefore be a very useful practical reference for biostatisticians clinicians working in clinical trials and drug regulatory professionals as well as graduate students of biostatistics. Novel model-assisted designs showcase the new KISS principle: Keep it simple and smart! | Model-Assisted Bayesian Designs for Dose Finding and Optimization Methods and Applications

GBP 84.99
1