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The Blood-Cerebrospinal Fluid Barrier

The Blood-Cerebrospinal Fluid Barrier

Despite the existence of two barrier systems in the brain research over the last century has mostly focused on the blood-brain barrier rather than on the blood-CSF barrier. Today there is a greater understanding of the function of the blood-CSF barrier and of the choroid plexus a tissue that is the primary site of this barrier. With the growing number of studies that focus on the role of the blood-CSF barrier in CNS homeostasis and neurological disorders a modern overview of the blood-CSF barrier is long overdue. The Blood-Cerebrospinal Fluid Barrier is exclusively devoted to the blood-CSF barrier. Internationally renowned experts discuss the most recent progress in the field of choroid plexus physiology and update our knowledge of the function of the blood-CSF barrier. The book begins with an overview of the development and morphology of the choroid plexus and then covers various aspects of its function such as the regulation of choroidal blood flow ion transport and the production and transport of polypeptides. Following an extensive section on the role of the choroid plexus in CNS disorders the final section discusses in vitro in vivo and in situ models of the blood-CSF barrier. This unique book analyzes a wealth of new research on the proven and potential roles of the choroid plexus/blood-CSF barrier in the brain. It is a valuable resource that will foster future studies in neuroscience pharmacology and toxicology.

GBP 39.99
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Red Blood Cell Aggregation

Red Blood Cell Aggregation

Red blood cells in humans—and most other mammals—have a tendency to form aggregates with a characteristic face-to-face morphology similar to a stack of coins. Known as rouleaux these aggregates are a normally occurring phenomenon and have a major impact on blood rheology. What is the underlying mechanism that produces this pattern? Does this really happen in blood circulation? And do these rouleaux formations have a useful function? The first book to offer a comprehensive review of the subject Red Blood Cell Aggregation tackles these and other questions related to red blood cell (RBC) aggregates. The book covers basic clinical and physiological aspects of this important biophysical phenomenon and integrates these areas with concepts in bioengineering. It brings together state-of-the-art research on the determinants mechanisms and measurement and effects of RBC aggregation as well as on variations and comparative aspects. After an introductory overview the book outlines factors and conditions that affect RBC aggregation. It presents the two hypotheses—the bridging model and the depletion model—that provide potential mechanisms for the adhesive forces that lead to the regular packing of the cells in rouleaux formations. The book also reviews the methods used to quantify RBC aggregation in vitro focusing on their importance in clinical practice. Chapters discuss the effect of RBC aggregation on the in vitro rheology of blood as well as on tube flow. The book also looks at what happens in the circulation when red blood cells aggregate and examines variations due to physiological and pathophysiological challenges. The concluding chapter explores the formation of red blood cell aggregates in other mammals. Written by leading researchers in the field this is an invaluable resource for basic science medical and clinical researchers; graduate stu

GBP 59.99
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Controlling High Blood Pressure through Nutrition Supplements Lifestyle and Drugs

Controlling High Blood Pressure through Nutrition Supplements Lifestyle and Drugs

Controlling High Blood Pressure through Nutrition Nutritional Supplements Lifestyle and Drugs helps prevent and treat high blood pressure and hypertension the most common primary diagnosis in the United States and a leading cause of heart attack heart failure kidney failure and stroke. Written by two leading experts in nutrition and hypertension it takes an integrative and evidence-based approach based on scientific research and clinical studies. It explains what causes high blood pressure and includes easy-to-follow solutions for patients that help to treat and prevent it. These include: The ideal drugs to reduce blood pressure with fewest side effects and optimal efficacy A nutrition program to reduce weight and lower the risk of a cardiovascular problem A comprehensive review of nutritional supplements to improve blood pressure control and reduce cardiovascular disease A review of lifestyle changes to improve blood pressure such as a detailed exercise program. This book is for doctors nutritionists naturopaths pharmacists and other health practitioners as well as anyone with a family history of hypertension or overt blood pressure issues that would like to make better and healthier lifestyle choices. | Controlling High Blood Pressure through Nutrition Supplements Lifestyle and Drugs

GBP 52.99
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The Blood-Brain Barrier in Health and Disease Volume Two Pathophysiology and Pathology

The Blood-Brain Barrier in Health and Disease Volume Two Pathophysiology and Pathology

Located at the interface between blood and the brain the blood-brain barrier is a dynamic permeability barrier formed by a continuous layer of specialized endothelial cells endowed with important permeability transport and regulatory functions that both protect the internal milieu of the brain and allow essential nutrients to be transported into the brain. Abnormalities of the blood-brain barrier are increasingly recognized as a key component in the pathogenesis of a range of primary diseases of the brain and the secondary involvement of the brain from pathological processes in other organs. In The Blood-Brain Barrier in Health and Disease Volume 2 international experts present comprehensive reviews and research accounts on blood-brain barrier dysfunction in infectious and inflammatory diseases cerebrovascular diseases stroke trauma vitamin deficiency exposure to neurotoxicants primary and metastatic brain tumors and neurodegenerative diseases. This book is intended to serve as a guide and reference to basic and advanced information for researchers students and clinicians interested in this fast-expanding field and stimulate further research well into the future. | The Blood-Brain Barrier in Health and Disease Volume Two Pathophysiology and Pathology

GBP 44.99
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The Blood-Brain Barrier in Health and Disease Volume One Morphology Biology and Immune Function

The Blood-Brain Barrier in Health and Disease Volume One Morphology Biology and Immune Function

Located at the interface between blood and the brain the blood-brain barrier is a dynamic permeability barrier formed by a continuous layer of specialized endothelial cells endowed with important permeability transport and regulatory functions that both protect the internal milieu of the brain and allow essential nutrients to be transported into the brain. Over the last 25 years we have witnessed remarkable expansion of our knowledge of the structure biology and function of the cerebral endothelium. In The Blood-Brain Barrier in Health and Disease Volume 1 international experts discuss basic and new concepts and most recent advances pertaining to the development of the cerebral microvascular system. Subjects include the structure function permeability properties transport mechanisms and the inherent heterogeneity of the cerebral endothelium; the anatomy and physiological properties of the neurovascular unit; functional aspects of the choroid plexus; and important concepts and advances made over the last two decades that have shaped our understanding of the immunological function of the blood-brain barrier. This book is intended to serve as a valuable source of basic and advanced information for researchers students and clinicians interested in this fast-expanding field and stimulate further research well into the future. | The Blood-Brain Barrier in Health and Disease Volume One Morphology Biology and Immune Function

GBP 44.99
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Diagnostic Ultrasound Imaging and Blood Flow Measurements Second Edition

Diagnostic Ultrasound Imaging and Blood Flow Measurements Second Edition

Offers an Extensive Discussion on High Frequency Ultrasound Based on a course taught and developed by a foremost expert in diagnostic ultrasound technology Diagnostic Ultrasound: Imaging and Blood Flow Measurements Second Edition covers cutting-edge developments along with the fundamental physics instrumentation system architecture clinical applications and biological effects of ultrasound. This text addresses the technical side of diagnostic ultrasound and begins with an overview of the field of ultrasonic imaging and its role in diagnostic medicine relative to other imaging modalities. The author describes the fundamental physics involved in ultrasonic transducers as well as in conventional imaging approaches and Doppler measurements including contrast imaging and 4D imaging. He reviews the current status and standards on ultrasound bioeffect and discusses methods that have been used to measure ultrasonic properties of tissues. He also provides a list of relevant references and further reading materials at the end of each chapter. New in the Second Edition: Details the latest advances in ultrasound technology related to biomedical applications including elastrography portable scanners ultrasound molecular imaging preclinical high frequency imaging 2D array and 4D imaging techniques Updates and expands each chapter Adds a new chapter on new developments such as elastography and miniature scanners Includes new case studies and examples throughout the book Diagnostic Ultrasound: Imaging and Blood Flow Measurements Second Edition covers recent advances in ultrasound technology related to biomedical applications. Intended for senior- to graduate-level coursework in ultrasonic imaging this text also serves practicing physicists engineers clinicians and sonographers. | Diagnostic Ultrasound Imaging and Blood Flow Measurements Second Edition

GBP 74.99
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Rotating Machinery Research and Development Test Rigs

Rotating Machinery Research and Development Test Rigs

Rotating Machinery Research and Development Test Rigs presents the purpose and development processes for test apparatuses built for Research & Development in machinery technology and product development. Each R & D apparatus is the focus of an entire chapter with fifteen detailed case studies included from mechanical aerospace chemical and biomedical engineering. Specific machinery components covered include bearings seals power plant pumps rotors turbines and compressors. Machinery condition monitoring and product development processes have been integrated. The specific purpose and results for each test rig are comprehensively presented and explained.

GBP 150.00
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Test Quality for Construction Materials and Structures Proceedings of the International RILEM/ILAC Symposium

Test Quality for Construction Materials and Structures Proceedings of the International RILEM/ILAC Symposium

Testing of materials and manufactured items is a key element in the process from standard specifications though control and verification during manufacture to trade in actual products. Cooperative agreements and networks are being set up covering reference materials and calibration. This process is becoming more urgent with the development in the European market and other international developments. This book presents international views on this fast changing field with the main themes of: technical components of test quality; quality assurance in testing laboratories; laboratory accreditation and transnational recognition of test results. | Test Quality for Construction Materials and Structures Proceedings of the International RILEM/ILAC Symposium

GBP 62.99
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PgMP Exam Practice Test and Study Guide

PgMP Exam Practice Test and Study Guide

PgMP Exam Practice Test and Study Guide Fourth Edition is the book you need to pass the Program Management Professional (PgMP) exam the first time around. It reflects recent revisions based on PMI's Standard for Program Management - Third Edition (2013). Based on best practices that complement PMI‘s standards this is the most comprehensive and up-to-date resource available to help you prepare for the exam with new and changed terminology. It includes a list of the major topics covered on the exam organized by the five performance domains‘strategic program management program life cycle benefits management stakeholder management and governance as presented in the Program Management Professional Examination Content Outline. It also includes helpful tips on how to make the most of the time you have available to prepare for the exam. Just like its bestselling predecessors this indispensable study guide includes 20 multiple-choice practice questions for each domain along with a comprehensive answer key. The program life cycle domain includes 20 questions for each of the five phases. Each question also has a plainly written rationale for each correct answer with bibliographic references for further study. Two challenging 170-question practice tests that simulate the actual exam are included in the book and online so you can retake them as many times as necessary. They also include a rationale and reference. Scores for the online tests are presented as if each question is rated similarly but this edition also includes a new component: the authors own weighting system for the level of difficulty for each question. This system will show you what they feel meets the exam‘s criteria for Proficient Moderately Proficient and below Proficient. You then will see your scores by domain in both approaches. Supplying an in | PgMP® Exam Practice Test and Study Guide

GBP 175.00
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Engineered Concrete Mix Design and Test Methods Second Edition

Engineered Concrete Mix Design and Test Methods Second Edition

As every civil engineer knows Portland Cement is the most versatile and important material of construction and will probably remain so far into the future. Yet few books if any exist that offer an in-depth analysis of the mixing and testing methods of this vital hydraulic cement. This statement written about the first edition of Engineered Concrete: Mix Design and Test Methods remains as true today as it was ten years ago. Revised and updated the second edition of this groundbreaking resource completely covers Portland Cement Portland Cement Concrete and their uses. See what‘s new in the Second Edition: New coverage of the latest concrete technologies such as high-performance and lightweight concrete Several new tests and sample tearsheets Additional and updated data sheets The body of the book is divided into several sections with the first explaining how concrete batches are designed mixed and measured for various consistencies. Another section details the tests of the primary component materials of concrete other than water namely Portland Cement aggregates and mortar while the final section includes some of the fundamental concrete testing procedures for different strength parameters in conformity with the standards of the American Society for Testing Materials. Solidly researched and written the book supplies a fundamental understanding of cement concrete and mixing and testing methods that allow readers to produce the most economical combinations of concrete materials and satisfy performance requirements and specifications. | Engineered Concrete Mix Design and Test Methods Second Edition

GBP 180.00
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Numerical Modeling of COVID-19 Neurological Effects ODE/PDE Analysis in R

Numerical Modeling of COVID-19 Neurological Effects ODE/PDE Analysis in R

Covid-19 is primarily a respiratory disease which results in impaired oxygenation of blood. The O2-deficient blood then moves through the body and for the study in this book the focus is on the blood flowing to the brain. The dynamics of blood flow along the brain capillaries and tissue is modeled as systems of ordinary and partial differential equations (ODE/PDEs). The ODE/PDE methodology is presented through a series of examples 1. A basic one PDE model for O2 concentration in the brain capillary blood. 2. A two PDE model for O2 concentration in the brain capillary blood and in the brain tissue with O2 transport across the blood brain barrier (BBB). 3. The two model extended to three PDEs to include the brain functional neuron cell density. Cognitive impairment could result from reduced neuron cell density in time and space (in the brain) that follows from lowered O2 concentration (hypoxia). The computer-based implementation of the example models is presented through routines coded (programmed) in R a quality open-source scientific computing system that is readily available from the Internet. Formal mathematics is minimized e. g. no theorems and proofs. Rather the presentation is through detailed examples that the reader/researcher/analyst can execute on modest computers. The PDE analysis is based on the method of lines (MOL) an established general algorithm for PDEs implemented with finite differences. The routines are available from a download link so that the example models can be executed without having to first study numerical methods and computer coding. The routines can then be applied to variations and extensions of the blood/brain hypoxia models such as changes in the ODE/PDE parameters (constants) and form of the model equations. | Numerical Modeling of COVID-19 Neurological Effects ODE/PDE Analysis in R

GBP 82.99
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Hawkey's Atlas of Wild and Exotic Animal Haematology

Hawkey's Atlas of Wild and Exotic Animal Haematology

This revised updated and expanded edition of Christine Hawkey’s A Colour Atlas of Comparative Veterinary Haematology is bursting with high-quality images to aid identification of blood cells and haemoparasites in the different species commonly seen in private practice and zoological collections. It will assist veterinarians in the identification of normal and abnormal blood cells and in understanding the structural differences of blood cells between the various taxa within the Animal Kingdom. With the help of this guide readers will be able to understand haemoresponses in the presence of specific and non-specific disease processes and identify haemoparasites commonly seen in blood films from wild and exotic animals. This impressively illustrated comparative haematology atlas is unrivalled in its scope quality and accuracy. It is a must-have for veterinary students veterinary surgeons working in general and referral veterinary clinical practices clinicians working in zoological collections and specialists in exotic animal medicine. | Hawkey's Atlas of Wild and Exotic Animal Haematology

GBP 115.00
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Toxicology Biological Monitoring of Metals in Humans

Toxicology Biological Monitoring of Metals in Humans

As one of many tasks of an analytical chemistry program sponsored by the office of Pesticides and Toxic Substances Field Studies Branch U. S. Environmental Protection Agency (EPA) (EPA Prime Contract No. 68-02-3938) Midwest Research Institute (MRI) prepared these summaries of the mammalian toxicology of 52 individual elements (metals and metalloids) and the lanthanides (rare earth elements). MRI is assisting the EPA in developing protocols for the monitoring of selected metals and organic compounds in the blood of the general U. S. population. The monitoring will enable evaluation of changes in the blood levels over time and any trends associated with instituted control measures. This review will help EPA select the metals to be included in the monitoring effort based on toxicity relative exposure and the ability of blood measurements to reflect exposure. | Toxicology Biological Monitoring of Metals in Humans

GBP 59.99
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Small Animal Anesthesia and Pain Management A Color Handbook

Small Animal Anesthesia and Pain Management A Color Handbook

3* Doody's Review! This concise quick reference guide has been thoroughly updated in its second edition. It remains clinically focused based on experience underpinned by published research data. With 18 brand new chapters on topics ranging from perioperative blood works and urine analysis to light therapy in pain management and rehabilitation the book covers anesthetic equipment monitoring premedication intravenous induction agents injectable anesthetic combinations inhalant anesthesia anesthesia for specific diseases fluid therapy anesthetic emergencies and complications acute and chronic pain management. Nine new chapters address anaesthetic considerations for different surgeries. Drug dosages and anesthetic protocols are provided in tabular form. New to this edition are chapters covering anesthesia considerations for specific conditions and diseases including perioperative blood works and urine analysis blood transfusion medicine anesthetic considerations and interpretations rehabilitation and pain management for chronic pain patients pain management of oncologic pain and radiation therapy acupuncture and herbal medication for acute and chronic pain and low level light therapy in pain management. Containing over 300 color illustrations Small Animal Anesthesia and Pain Management is ideal for all those who need practical information easily to hand: small animal practitioners veterinary technicians/nurses and veterinary students. | Small Animal Anesthesia and Pain Management A Color Handbook

GBP 84.99
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Handbook Of Applied Econometrics And Statistical Inference

Handbook Of Applied Econometrics And Statistical Inference

Summarizing developments and techniques in the field this reference covers sample surveys nonparametric analysis hypothesis testing time series analysis Bayesian inference and distribution theory for applications in statistics economics medicine biology engineering sociology psychology and information technology. It supplies a geometric proof of an extended Gauss-Markov theorem approaches for the design and implementation of sample surveys advances in the theory of Neyman's smooth test and methods for pre-test and biased estimation. It includes discussions ofsample size requirements for estimation in SUR models innovative developments in nonparametric models and more. | Handbook Of Applied Econometrics And Statistical Inference

GBP 44.99
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The Omega-Factor Promoting Health Preventing Premature Aging and Reducing the Risk of Sudden Cardiac Death

The Omega-Factor Promoting Health Preventing Premature Aging and Reducing the Risk of Sudden Cardiac Death

Omega-3 fatty acids can limit the inflammation that is the underlying cause of many severe diseases of modern civilization including diabetes and cardiovascular disease. The Omega-Factor: Promoting Health Preventing Premature Aging and Reducing the Risk of Sudden Cardiac Death presents information on the mechanisms whereby inflammation damages organs and the blood vessels serving them as well as the hard science on the mechanisms by which the omega-3 fatty acids protect those tissues. It also features peer-reviewed evidence from clinical trials on these topics. The book gives cutting-edge information from state-of-the-art developments such as the test that can be done to measure the omega-3 status of one’s own tissues the “Omega-3 Index” which can give many years of early warning so that one can take preventive steps and decrease the odds of a heart attack stroke or kidney disease. It explains why a Mediterranean diet plan rich in omega-3 and omega-6 fatty acids is protective and it features a six-day meal plan with recipes that will improve body levels of omega-3s. This book helps readers understand the differences between various sources of omega-3 fatty acids namely flaxseed vs fish oil vs algae-derived oils. Features • Provides evidence-based information on why blood vessels require omega-3 fatty acids to maintain health • Details best sources of the various fatty acids including plant-based sources • Includes “at-home tests” to assess cardiovascular status • Presents literature on how to improve chances of avoiding heart attacks peripheral arterial disease strokes kidney disease and Type 2 diabetes The Omega-Factor: Promoting Health Preventing Premature Aging and Reducing the Risk of Sudden Cardiac Death is an essential resource for healthcare professionals clinicians and dietitians as well as for the reader who aims to achieve the goal of a much longer health-span not just a longer lifespan. | The Omega-Factor Promoting Health Preventing Premature Aging and Reducing the Risk of Sudden Cardiac Death

GBP 16.99
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Revival: Microspheres: Medical and Biological Applications (1988)

Revival: Microspheres: Medical and Biological Applications (1988)

We have previously described the syntheses of both magnetic and nonmagnetic polymeric microspheres and we have reported their application in removal of neuroblastoma cells from normal cells in bone marrow in the separation of red blood cells and the separation of human B and T lymphocytes. In the present study we describe a series of hydrophilic microspheres consisting of (1) poly-HEMA and (2) a copolymer sequence of HEMA-acrolein microspheres. | Revival: Microspheres: Medical and Biological Applications (1988)

GBP 48.99
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Food Phytates

Food Phytates

Food Phytates takes a new look at phytates including their potential health benefits. It includes the latest information on the beneficial heath effects of phytates the influence of phytates in disease prevention the potential use of phytate as an antioxidant in foods and phytase expression in transgenic plants. In 14 chapters leading researchers shed new light on phytates' potential ability to lower blood glucose reduce cholesterol and triacylglycerols and reduce the risks of cancer and heart disease.

GBP 59.99
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Reliability Analysis with Minitab

Reliability Analysis with Minitab

Statistical Analysis for the Reliability Engineering ProfessionalEffectively conduct reliability analysis using the world’s leading statistical software. Reliability Analysis with Minitab® outlines statistical concepts and applications explains the theory of probability reliability analysis and quality improvement and provides step-by-step instruction on the use of Minitab. Minitab introduces reliability analysis tools that can be used to perform tasks that range from checking the distribution fit of lifetime data to estimating the warranty costs of a product. Perform the Analyses Needed to Minimize Product Failures and Reduce CostsChock full of examples that include numerous case studies and over 200 screenshots this book is a comprehensive guide to quality and reliability in the service and manufacturing industries. It illustrates the shapes of the most commonly used statistical distributions in reliability analysis and in simple language demonstrates concepts that include parametric reliability analysis nonparametric reliability analysis warranty analysis accelerated life testing reliability test plans and probit analysis. Illustrating the application of Minitab for reliability analysis this book explains how to: Perform reliability analysis of a product with right-censored and exact failure time data Complete reliability analysis of a product with arbitrarily censored failure time dataAchieve nonparametric reliability analysis of a productPredict the amount of money that is needed to cover the warranty costs for products in a specific period of time in the futureAnalyze the results from accelerated life testing on two different productsDetermine the reliability test sample size when the test time and the number of failures are constrainedRegulate the testing time when test sample size and the number of failures are constrainedCompare the reliabilities of parts from different vendorsTest whether the reliability of a product depends on certain factorsPredict the stress level at which a product will fail after a certain test period

GBP 44.99
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Carotid Artery Stenosis Current and Emerging Treatments

Carotid Artery Stenosis Current and Emerging Treatments

Providing a thorough overview of rapid developments in medical therapy surgery and angioplasty this reference provides a complete review of carotid artery stenosis treatment as well as a clear overview of carotid surgery and stenting. Offering chapters by seasoned authorities on epidemiology imaging with ultrasound and angiography cholesterol lowering blood pressure management homocysteine treatment and diet modification this guide is a stand-alone source for current information and understanding of this burgeoning science. | Carotid Artery Stenosis Current and Emerging Treatments

GBP 59.99
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