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Diagnostics and Gene Therapy for Human Genetic Disorders

Diagnostics and Gene Therapy for Human Genetic Disorders

Diagnostics and Gene Therapy for Human Genetic Disorders provides an integrative and comprehensive source of information blending classical human genetics with the human genome. It provides a multidisciplinary overview of Mendelian inheritance and multifactorial inheritance genetic variations polymorphisms chromosomal multifactorial and mitochondrial disorders. PCR electrophoresis cytogenetics prenatal and HPLC based techniques applied for diagnosing genetic disorders are discussed with applications. Symptoms etiology diagnosis treatment of 14 major and 5 minor genetic disorders are discussed in detail. Methods employed for the preparation of kits for the diagnosis of diseases are provided. The role of gene therapy in the amelioration of genetic disorders and the methodology employed are discussed. The success of gene therapy in controlling various disorders such as immune system disorders neurodegenerative disorders cardiovascular disorders eye diseases and cancer has been described along with type studies. Features: A blend of classical human genetics with molecular and genome-based applications Techniques applied for the diagnosis of genetic disorders Diagnostics of 19 genetic disorders including symptoms etiology diagnosis and treatment Role of gene therapy in the amelioration of disorders Type studies describing the role of diagnostics in conserving the human health This book attempts to connect all the information about classical and modern human genetics genetic disorders and gene therapy to all types of diseases in one place. This work provides a comprehensive source of information that can serve as a reference book for scientific investigations and as a textbook for the graduate students.

GBP 110.00
1

Applied Genetic Programming and Machine Learning

The Driving Forces of Evolution Genetic Processes in Populations

Genetic Influences on Neural and Behavioral Functions

CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases

Embedded Software System Testing Automatic Testing Solution Based on Formal Method

RNA the Epicenter of Genetic Information

RNA the Epicenter of Genetic Information

The origin story and emergence of molecular biology is muddled. The early triumphs in bacterial genetics and the complexity of animal and plant genomes complicate an intricate history. This book documents the many advances as well as the prejudices and founder fallacies. It highlights the premature relegation of RNA to simply an intermediate between gene and protein the underestimation of the amount of information required to program the development of multicellular organisms and the dawning realization that RNA is the cornerstone of cell biology development brain function and probably evolution itself. Key personalities their hubris as well as prescient predictions are richly illustrated with quotes archival material photographs diagrams and references to bring the people ideas and discoveries to life from the conceptual cradles of molecular biology to the current revolution in the understanding of genetic information. Key Features Documents the confused early history of DNA RNA and proteins - a transformative history of molecular biology like no other. Integrates the influences of biochemistry and genetics on the landscape of molecular biology. Chronicles the important discoveries preconceptions and misconceptions that retarded or misdirected progress. Highlights major pioneers and contributors to molecular biology with a focus on RNA and noncoding DNA. Summarizes the mounting evidence for the central roles of non-protein-coding RNA in cell and developmental biology. Provides a thought-provoking retrospective and forward-looking perspective for advanced students and professional researchers. The Open Access version of this book available at www. taylorfrancis. com has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4. 0 license. | RNA the Epicenter of Genetic Information

GBP 39.99
1

Mulberry Genetic Improvement in Context of Climate Change

Load Testing of Bridges: Two Volume Set

Load Testing of Bridges: Two Volume Set

Load Testing of Bridges featuring contributions from almost fifty authors from around the world across two interrelated volumes deals with the practical aspects the scientific developments and the international views on the topic of load testing of bridges. Volume 12 Load Testing of Bridges: Current practice and Diagnostic Load Testing starts with a background to bridge load testing including the historical perspectives and evolutions and the current codes and guidelines that are governing in countries around the world. The second part of the book deals with preparation execution and post-processing of load tests on bridges. The third part focuses on diagnostic load testing of bridges. Volume 13 Load Testing of Bridges: Proof Load Testing and the Future of Load Testing focuses first on proof load testing of bridges. It discusses the specific aspects of proof load testing during the preparation execution and post-processing of such a test (Part 1). The second part covers the testing of buildings. The third part discusses novel ideas regarding measurement techniques used for load testing. Methods using non-contact sensors such as photography- and video-based measurement techniques are discussed. The fourth part discusses load testing in the framework of reliability-based decision-making and in the framework of a bridge management program. The final part of the book summarizes the knowledge presented across the two volumes as well as the remaining open questions for research and provides practical recommendations for engineers carrying out load tests. This work will be of interest to researchers and academics in the field of civil/structural engineering practicing engineers and road authorities worldwide. | Load Testing of Bridges: Two Volume Set

GBP 44.99
1

Principles of Toxicology Testing

Principles of Toxicology Testing

Nationally toxicology programs have evolved from a traditional exploration of the chemistry and applied toxicity of chemicals and drugs to a more comprehensive study of toxicology and toxicology testing as independent entities. Consequently the second edition of Principles of Toxicology Testing starts with basic toxicological principles including absorption distribution metabolism and elimination of toxins including chemicals and drugs. The book then continues with animal (in vivo) and in vitro toxicology testing methods associated with toxicological analysis and preclinical drug development. As in the first edition the book begins with an introduction into the fundamentals of toxicology (Section I) to prepare readers for the subsequent topics and continues through with a discussion of toxicokinetics and human risk assessment. This introductory material is useful in understanding the applications of toxicology testing. Section II describes the fundamental principles of toxicology testing in animals in greater detail. This section describes acute toxicity studies as well as subchronic and chronic studies performed on animals. Special emphasis is placed on study design and determination of classical indicators for acute and chronic testing such as the LD50. The book examines other short- and long-term animal toxicity testing methodologies including dermal ocular and reproductive toxicity testing. In addition mutagenicity and carcinogenicity studies are also discussed in separate chapters. Section III introduces and discusses in vitro alternatives to animal toxicology tests. This section emphasizes cell culture methodology and cellular methods for acute systemic toxicity target organ toxicity and local toxicity. The contributors present the advantages and disadvantages of alternative methods. They also describe the use of high-throughput screening and its applications the concepts of standardizatio

GBP 175.00
1

Miniaturized Testing of Engineering Materials

Thermal-Aware Testing of Digital VLSI Circuits and Systems

Induction Machines Handbook Transients Control Principles Design and Testing

Induction Machines Handbook Transients Control Principles Design and Testing

Induction Machines Handbook: Transients Control Principles Design and Testing presents a practical up-to-date treatment of intricate issues with induction machines (IM) required for design and testing in both rather constant- and variable-speed (with power electronics) drives. It contains ready-to-use industrial design and testing knowledge with numerous case studies to facilitate a thorough assimilation of new knowledge. Individual Chapters 1 through 14 discuss in detail the following: Three- and multiphase IM transients Single-phase source IM transients Super-high-frequency models and behavior of IM Motor specifications and design principles IM design below 100 kW and constant V1 and f1 IM design above 100 kW and constant V1 and f1 IM design principles for variable speed Optimization design Single-phase IM design Three-phase IM generators Single-phase IM generators Linear induction motors Testing of three-phase IMs Single-phase IM testing Fully revised and amply updated to add the new knowledge of the last decade this third edition includes special sections on Multiphase IM models for transients Doubly fed IMs models for transients Cage-rotor synchronized reluctance motors Cage-rotor PM synchronous motor Transient operation of self-excited induction generator Brushless doubly fed induction motor/generators Doubly fed induction generators with D. C. output Linear induction motor control with end effect Recent trends in IM testing with power electronics Cage-PM rotor line-start IM testing Linear induction motor (LIM) testing This up-to-date book discusses in detail the transients control principles and design and testing of various IMs for line-start and variable-speed applications in various topologies with numerous case studies. It will be of direct assistance to academia and industry in conceiving designing fabricating and testing IMs (for the future) of various industries from home appliances through robotics e-transport and renewable energy conversion. | Induction Machines Handbook Transients Control Principles Design and Testing

GBP 140.00
1

Ultrasonic Nondestructive Testing of Materials Theoretical Foundations

Ultrasonic Nondestructive Testing of Materials Theoretical Foundations

Ultrasonic Nondestructive Testing of Materials: Theoretical Foundations explores the mathematical foundations and emerging applications of this testing process which is based on elastic wave propagation in isotropic and anisotropic solids. In covering ultrasonic nondestructive testing methods the book emphasizes the engineering point of view yet it relies on the physics and mathematics aspects involved in elastic wave propagation theory. As a result this resource becomes a missing link in the literature by combining coverage of the theoretical aspects of testing and providing intuitive assessments of numerous standard problems to illustrate fundamental assertions. Content includes a brief description of the theory of acoustic and electromagnetic fields to underline the similarities and differences as compared to elastodynamics. It also covers vector algebra and analysis elastic plane and Rayleigh surface waves and ultrasonic beams as well as transducer radiation inverse scattering and ultrasonic nondestructive imaging. Includes numerical computations to explain wave propagation phenomena and compare results of analytical formulations Although ultrasonic nondestructive testing can often be roughly understood in terms of plane waves and beams this book addresses the key issues of transducer radiation and defect scattering and imaging respectively. The authors physically formulate point source synthesis and in mathematical terms they use representation integrals with Green functions always including intuitive interpretations with mathematical evaluations. Replacing cumbersome index notation with a coordinate-free version this reference offers step-by-step documentation of relevant tensorial elastodynamic cases involving isotropic and anisotropic materials. It provides all necessary mathematical tools readers require to understand the mathematical and physical basis for ultrasonic nondestructive testing. | Ultrasonic Nondestructive Testing of Materials Theoretical Foundations

GBP 94.99
1

Civil Engineering Materials Introduction and Laboratory Testing

Civil Engineering Materials Introduction and Laboratory Testing

Civil Engineering Materials: Introduction and Laboratory Testing discusses the properties characterization procedures and analysis techniques of primary civil engineering materials. It presents the latest design considerations and uses of engineering materials as well as theories for fully understanding them through numerous worked mathematical examples. The book also includes important laboratory tests which are clearly described in a step-by-step manner and further illustrated by high-quality figures. Also analysis equations and their applications are presented with appropriate examples and relevant practice problems including Fundamentals of Engineering (FE) styled questions as well those found on the American Concrete Institute (ACI) Concrete Field Testing Technician - Grade I certification exam. Features: Includes numerous worked examples to illustrate the theories presented Presents Fundamentals of Engineering (FE) examination sample questions in each chapter Reviews the ACI Concrete Field Testing Technician - Grade I certification exam Utilizes the latest laboratory testing standards and practices Includes additional resources for instructors teaching related courses This book is intended for students in civil engineering construction engineering civil engineering technology construction management engineering technology and construction management programs. | Civil Engineering Materials Introduction and Laboratory Testing

GBP 99.99
1

Mechanical Wear Fundamentals and Testing Revised and Expanded

Multiple Testing Problems in Pharmaceutical Statistics

Multiple Testing Problems in Pharmaceutical Statistics

Useful Statistical Approaches for Addressing Multiplicity IssuesIncludes practical examples from recent trials Bringing together leading statisticians scientists and clinicians from the pharmaceutical industry academia and regulatory agencies Multiple Testing Problems in Pharmaceutical Statistics explores the rapidly growing area of multiple comparison research with an emphasis on pharmaceutical applications. In each chapter the expert contributors describe important multiplicity problems encountered in pre-clinical and clinical trial settings. The book begins with a broad introduction from a regulatory perspective to different types of multiplicity problems that commonly arise in confirmatory controlled clinical trials before giving an overview of the concepts principles and procedures of multiple testing. It then presents statistical methods for analyzing clinical dose response studies that compare several dose levels with a control as well as statistical methods for analyzing multiple endpoints in clinical trials. After covering gatekeeping procedures for testing hierarchically ordered hypotheses the book discusses statistical approaches for the design and analysis of adaptive designs and related confirmatory hypothesis testing problems. The final chapter focuses on the design of pharmacogenomic studies based on established statistical principles. It also describes the analysis of data collected in these studies taking into account the numerous multiplicity issues that occur. This volume explains how to solve critical issues in multiple testing encountered in pre-clinical and clinical trial applications. It presents the necessary statistical methodology along with examples and software code to show how to use the methods in practice.

GBP 42.99
1

Cone Penetration Testing 2022 Abstracts Volume

Cone Penetration Testing 2018 Proceedings of the 4th International Symposium on Cone Penetration Testing (CPT'18) 21-22 June 2018 Delft

Testing of Concrete in Structures Fourth Edition

Pressure and Temperature Well Testing

Pressure and Temperature Well Testing

The book comprises two parts: Pressure and Flow Well Testing (Part I) and Temperature Well Testing (Part II) and contains numerous authors’ developments. Due to the similarity in Darcy’s and Fourier’s laws the same differential diffusivity equation describes the transient flow of incompressible fluid in porous medium and heat conduction in solids. Therefore it is reasonable to assume that the techniques and data processing procedures of pressure well tests can be applied to temperature well tests. The book presents new methods to determine the formation of permeability and skin factors from tests conducted in simulated wells designing interference well tests processing constant bottom-hole pressure tests estimation of the formation temperature and geothermal gradients from temperature surveys and logs in-situ determination of the formation thermal conductivity and contact thermal resistance of boreholes temperature regime of boreholes (cementing of production liners) and the recovery of thermal equilibrium in deep and superdeep wells. Processing and analysis of pressure and geothermal data are shown on numerous field examples from different regions of the world. The book is intended for students engineers and researchers in the field of hydrocarbon geophysics and geology groundwater searching and exploitation and subsurface environment examination. It will be also useful for specialists studying pressure and temperature in parametric deep and superdeep wells. | Pressure and Temperature Well Testing

GBP 59.99
1

Testing for Small-Delay Defects in Nanoscale CMOS Integrated Circuits

Testing for Small-Delay Defects in Nanoscale CMOS Integrated Circuits

Advances in design methods and process technologies have resulted in a continuous increase in the complexity of integrated circuits (ICs). However the increased complexity and nanometer-size features of modern ICs make them susceptible to manufacturing defects as well as performance and quality issues. Testing for Small-Delay Defects in Nanoscale CMOS Integrated Circuits covers common problems in areas such as process variations power supply noise crosstalk resistive opens/bridges and design-for-manufacturing (DfM)-related rule violations. The book also addresses testing for small-delay defects (SDDs) which can cause immediate timing failures on both critical and non-critical paths in the circuit. Overviews semiconductor industry test challenges and the need for SDD testing including basic concepts and introductory material Describes algorithmic solutions incorporated in commercial tools from Mentor Graphics Reviews SDD testing based on alternative methods that explores new metrics top-off ATPG and circuit topology-based solutions Highlights the advantages and disadvantages of a diverse set of metrics and identifies scope for improvement Written from the triple viewpoint of university researchers EDA tool developers and chip designers and tool users this book is the first of its kind to address all aspects of SDD testing from such a diverse perspective. The book is designed as a one-stop reference for current industrial practices research challenges in the domain of SDD testing and recent developments in SDD solutions.

GBP 74.99
1

Ransomware Penetration Testing and Contingency Planning

Introduction to Soil Mechanics Laboratory Testing

GBP 175.00
1