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The Blood-Cerebrospinal Fluid Barrier

Multiple Testing Problems in Pharmaceutical Statistics

Multiple Testing Problems in Pharmaceutical Statistics

Useful Statistical Approaches for Addressing Multiplicity IssuesIncludes practical examples from recent trials Bringing together leading statisticians scientists and clinicians from the pharmaceutical industry academia and regulatory agencies Multiple Testing Problems in Pharmaceutical Statistics explores the rapidly growing area of multiple comparison research with an emphasis on pharmaceutical applications. In each chapter the expert contributors describe important multiplicity problems encountered in pre-clinical and clinical trial settings. The book begins with a broad introduction from a regulatory perspective to different types of multiplicity problems that commonly arise in confirmatory controlled clinical trials before giving an overview of the concepts principles and procedures of multiple testing. It then presents statistical methods for analyzing clinical dose response studies that compare several dose levels with a control as well as statistical methods for analyzing multiple endpoints in clinical trials. After covering gatekeeping procedures for testing hierarchically ordered hypotheses the book discusses statistical approaches for the design and analysis of adaptive designs and related confirmatory hypothesis testing problems. The final chapter focuses on the design of pharmacogenomic studies based on established statistical principles. It also describes the analysis of data collected in these studies taking into account the numerous multiplicity issues that occur. This volume explains how to solve critical issues in multiple testing encountered in pre-clinical and clinical trial applications. It presents the necessary statistical methodology along with examples and software code to show how to use the methods in practice.

GBP 42.99
1

Thermal-Aware Testing of Digital VLSI Circuits and Systems

Ransomware Penetration Testing and Contingency Planning

The Pocket Mentor for Video Game Testing

Animation From Concepts and Production

Instant Wisdom for GPs Pearls from All the Specialities

Instant Wisdom for GPs Pearls from All the Specialities

Every consultant has pearls of wisdom they wish they could share with GPs: knowledge they have acquired from years of experience and evidence-based study which could lead to improved speed and decision in referral more efficient use of resources and overall better patient care. Instant Wisdom for GPs gathers these pearls together presenting ten bullet-point gems from a comprehensive range of clinical specialties together with advice on obscure or overlooked diagnoses guidance on how to distinguish tricky differentials and tips on prescribing. The content has been thoroughly revised and updated for this second edition. New chapters have been added on alcohol use disorders behavioural problems in children clinical biochemistry emergency presentations genetics and genomics obesity and bariatric medicine and women’s health all from contributors expert in these fields. Key Features: Each specialty chapter offers ten pearls of wisdom with detailed explanation from a leading consultant 'Obscure or overlooked diagnoses’ flag conditions which the GP might not have heard about or might overlook or confuse with others ‘Easily confused’ sections highlight at-a-glance diagnoses which can be challenging to distinguish from each other presented in an easy-to-read table ‘Prescribing points’ in each chapter highlight relevant issues around prescribing including tips warnings and clarifications Fully revised and updated with six new chapters Edited by Keith Hopcroft author of the critically acclaimed Symptom Sorter this practical and accessible guide distils years of knowledge experience and key evidence into 32 concise and easy-to-navigate chapters and is essential reading for trainee and practicing GPs. | Instant Wisdom for GPs Pearls from All the Specialities

GBP 29.99
1

Next Generation Safety Leadership From Compliance to Care

Tapestry Lawns Freed from Grass and Full of Flowers

Tapestry Lawns Freed from Grass and Full of Flowers

Swathes of the human world are covered in ornamental grass lawns; they are the single most commonly encountered horticultural feature on the planet. Unfortunately they are now often viewed as resource-draining green deserts due to the lack of plant and animal diversity the need for frequent mowing and watering and addition of lawn greening products to keep them looking at their best. It is a venerable horticultural feature that is essentially frozen in time and with few alternatives to whet the appetite the lawn has languished in its current grass-only format for decades. Until now. Tapestry lawns are a new practically researched and timely development of the ornamental lawn format that integrates both horticultural practice and ecological science and re-determines the potential of a lawn. Mown barely a handful of times a year and with no need for fertilisers or scarifying tapestry lawns are substantially richer in their diversity of plant and animal life compared to traditional grass-only lawns and see the return of flowers and colour to a format from which they are usually purposefully excluded. Tapestry Lawns: Freed from Grass and Full of Flowers traces the changes in the lawn format from its origins to the modern day and offers information on how and why the tapestry lawn construct is now achievable. It provides guidance on how to create and maintain a tapestry lawn of your own and champions the potential benefits for wildlife that can follow. Features Accessible and informative to all types of readers from academic to amateur Includes a refined and tested set of useful tapestry lawn plants Contains step-by-step instructions for creation and management methods of grass-free lawns Illustrated in full colour If you have ever thought about mowing your lawn much less making it much more colourful and wildlife friendly then this book will inform and guide you to create a perfect grass-free lawn. | Tapestry Lawns Freed from Grass and Full of Flowers

GBP 22.99
1

A Researcher's Guide to Using Electronic Health Records From Planning to Presentation

Death Decomposition and Detector Dogs From Science to Scene

Death Decomposition and Detector Dogs From Science to Scene

Death Decomposition and Detector Dogs: From Science to Scene Second Edition is designed to help canine handlers detectives death investigators crime scene personnel (including forensic laboratory personnel technicians and supervisors) and attorneys understand the science involved when utilizing human remains detector (HRD) canines as a locating tool. The book covers the basic anatomy and physiology of canine olfaction and the unique characteristics of their scenting ability that allows dogs to be trained to locate distinct odors. Using concise and clear explanations and photographs the book reviews the science of forensic taphonomy. Factors that may affect the decomposition process are highlighted along with what the potential outcomes that may be encountered. The book examines how the odor of human remains is generated through various stages of decomposition and the manner in which environmental conditions in both land and water settings may affect that odor. Different types of background information that may help in determining possible search locations for missing individuals are included as well as assist the HRD canine handler in developing search plans are covered. Different tools and technologies that may be used in addition to an HRD canine team are included to help readers understand that are many ways to address searching for a decedent. Several case reports involving decedents found in both land and water settings in addition to different weather conditions are included to help the reader understand how the environment may have affected the condition of the decedent. This edition includes more case reports explaining how environmental factors were considered in HRD canine deployments in both land and water settings. Understanding which variables—and how such variables—can affect the state and condition of human remains as well as dispersion of odor from human remains will help canine handlers utilize their HRD canine more effectively as a locating tool. Death Decomposition and Detector Dogs Second Edition will help HRD canine handlers and other law enforcement personnel be better prepared to meet the challenges of their jobs before during and after searches for the missing. | Death Decomposition and Detector Dogs From Science to Scene

GBP 42.99
1

Cyber Security for Industrial Control Systems From the Viewpoint of Close-Loop

From Proteins to Proteomics Basic Concepts Techniques and Applications

From Proteins to Proteomics Basic Concepts Techniques and Applications

Proteomics aims to study all the proteins of human and other living systems as well as their properties to provide an integrated view of cellular processes. The study of proteomics involves the application of rapidly evolving high-throughput technologies and new platforms that are coming forward regularly providing versatile novel tools for biomedical and pharmaceutical applications. This book provides a detailed understanding of the basics of proteins and proteomics gel based-proteomics techniques basics of mass spectrometry and quantitative proteomics interactomics: basics and applications and advancements in proteomics. It also covers basic knowledge about sample preparation mass spectrometry workflow different chromatography technologies and quantitative proteomics. The text highlights the application and challenges of various high-throughput integrated proteomics technologies capable of fast and accurate screening of thousands of biomolecules which are found to be very effective for studying disease pathobiology and identification of next-generation biomarkers and potential drug/vaccine targets; and are therefore considered valuable tools for multidisciplinary research. Features Basics of proteins and proteomics techniques In-depth understanding of mass spectrometry and quantitative proteomics An overview of interactomics and its application for translational research Advancement in the field of proteomics and challenges in clinical applications We hope the knowledge gained from reading this book will intrigue and motivate young minds to explore future opportunities in the constantly evolving field of proteomics. | From Proteins to Proteomics Basic Concepts Techniques and Applications

GBP 42.99
1

Empowering Women in STEM Personal Stories and Career Journeys from Around the World

Empowering Women in STEM Personal Stories and Career Journeys from Around the World

Women in STEM are constantly facing new challenges every day. By sharing their stories and the ways in which they already have and continue to overcome these hurdles they can help others find the strength to persevere and succeed in these fields. This mix of authors from varying backgrounds all share the same passion – to encourage more women into STEM – and they have placed their proverbial hearts on their sleeves and documented their journeys to inspire readers to either enter or stay within STEM fields. Empowering Women in STEM: Personal Stories and Career Journeys from Around the World discusses the application process of root cause analysis and ways to introduce STEM to other generations. It offers an insider view of the armed forces and allows readers to gain more perspective on ways male advocates can help female colleagues in STEM fields. It includes a father’s perspective on change within the engineering industry how he’s mentoring new female engineers and ways to help them as they evolve. The book captures firsthand accounts of STEM professionals in various fields as they recount experiences that have helped them to navigate their own career paths. This book also demonstrates how life doesn’t have to follow the timelines proposed by society and how females can become CEOs and command other top-level positions in engineering companies. In addition to having women from across the globe share their stories about various fields readers will hear from both military and civilian male advocates who share ways to empower others within the industry. This book is written for professionals who may be considering a switch of career or deciding to leave STEM. It is also useful to university students who are trying to figure out their career choices and paths and gain more insight into possible career opportunities in STEM. Meet the Authors! http://strategicreliabilitysolutions. com/empowering-women-in-stem-personal-stories-and-career-journeys-from-around-the-world/ | Empowering Women in STEM Personal Stories and Career Journeys from Around the World

GBP 26.99
1

Making Sense of the EEG From Basic Principles to Clinical Applications

Modern Medicines from Plants Botanical histories of some of modern medicine’s most important drugs

Modern Medicines from Plants Botanical histories of some of modern medicine’s most important drugs

The full colour beautifully illustrated Modern Medicines from Plants: Botanical histories of some of modern medicine’s most important drugs features information on plants from which we obtain modern prescription medicines. It outlines their historical uses as herbal medicines in the past two millennia using primary sources and describes how extracts from them and their semisynthetic and synthetic derivatives were developed to be today’s therapeutic drugs and diagnostic chemicals. This book describes medicinal plants and their habitats the diseases that their medicines treat and the science of how they work. This amazing and unique book is a wonderful read for those with an interest in both herbal and prescription medicines. Written with authority by physicians and gardeners at the Garden of Medicinal Plants at the Royal College of Physicians London chapters detail the history and modern scientific research on plants and their medicines. It is very useful to physicians pharmacists herbalists historians and gardeners bringing together information from every discipline to make it a work of interest as well as reference. Features Written for people interested in medicinal plants where medicines come from and how they treat our diseases Contains information on 50 plants mostly growing in the medicinal garden of the Royal College of Physicians in London describing how they became the source of modern pharmaceutical medicines Describes medicinal uses of plants in Classical Greece as written by Dioscorides Pliny and Galen through the flowering of Arabic medicine by physicians such as Paulus Aegineta Mesue and Avicenna to the 12th to 14th century compilations of Serapion and Sylvaticus and the European Renaissance of Peter Treveris William Turner Leonard Fuchs Pietro Mattioli John Gerarde John Parkinson Nicholas Culpeper and many others to the pharmacopoeias of the 16th century to the present day Fully referenced including a glossary for explanation of technical terms | Modern Medicines from Plants Botanical histories of some of modern medicine’s most important drugs

GBP 26.99
1

Practical Career Advice for Engineers Personal Letters from an Experienced Engineer to Students and New Engineers

Practical Career Advice for Engineers Personal Letters from an Experienced Engineer to Students and New Engineers

Written by an experienced engineer Practical Career Advice for Engineers: Personal Letters from an Experienced Engineer to Students and New Engineers is a series of personal conversation-style letters that offers practical career advice to all engineers. It guides them through their entire career from early education to professional certification on into the workplace and eventually to retirement. Important topics such as how to acquire leadership skills improve communication skills and develop the business side of engineering as well as how to find a good engineering job are also addressed. The book guides engineers on how to make good career decisions using precise and systematic processes. It offers inspiration and insight to student engineers and working engineers on how to have successful and satisfying educations and careers. It can also help experienced engineers to more effectively guide and mentor new engineers. It explores the important topics of creativity ethics intellectual property and scientific principles in engineering and at the same time weaves real-world stories concepts diagrams and tips throughout the book in the form of personal letters perfect for quick and easy comprehension. The book targets all engineers working in all disciplines all industry sectors and all locations. Engineering students can also learn more about a career in engineering and what they need to do to prepare for it by reading this book. Radovan Zdero PhD CEng MIMechE has decades of experience as an engineer and a mentor to engineers. His engineering background includes a master’s degree in aerodynamics (McMaster University Canada) and a doctoral degree in biomechanics (Queen’s University Canada). He is a Chartered Engineer a Member of the Institution of Mechanical Engineers and a Professor in the Division of Orthopaedic Surgery and the Department of Mechanical and Materials Engineering (Western University Canada). He has published many scholarly research articles in peer-reviewed engineering science and medical journals. He is also the editor of the engineering textbook Experimental Methods in Orthopaedic Biomechanics. Contact the author: dr. zdero@hotmail. com | Practical Career Advice for Engineers Personal Letters from an Experienced Engineer to Students and New Engineers

GBP 27.99
1

The Story of Industrial Engineering The Rise from Shop-Floor Management to Modern Digital Engineering

Pocket Guide to Crime Scene Photography

Revival: Principles of Seed Pathology (1987) Volume II

100 Cases in General Practice

Game Design Tools Cognitive Psychological and Practical Approaches

100 Cases in Paediatrics

Trauma Care Pre-Hospital Manual