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Thermal-Aware Testing of Digital VLSI Circuits and Systems

Multiple Testing Problems in Pharmaceutical Statistics

Multiple Testing Problems in Pharmaceutical Statistics

Useful Statistical Approaches for Addressing Multiplicity IssuesIncludes practical examples from recent trials Bringing together leading statisticians scientists and clinicians from the pharmaceutical industry academia and regulatory agencies Multiple Testing Problems in Pharmaceutical Statistics explores the rapidly growing area of multiple comparison research with an emphasis on pharmaceutical applications. In each chapter the expert contributors describe important multiplicity problems encountered in pre-clinical and clinical trial settings. The book begins with a broad introduction from a regulatory perspective to different types of multiplicity problems that commonly arise in confirmatory controlled clinical trials before giving an overview of the concepts principles and procedures of multiple testing. It then presents statistical methods for analyzing clinical dose response studies that compare several dose levels with a control as well as statistical methods for analyzing multiple endpoints in clinical trials. After covering gatekeeping procedures for testing hierarchically ordered hypotheses the book discusses statistical approaches for the design and analysis of adaptive designs and related confirmatory hypothesis testing problems. The final chapter focuses on the design of pharmacogenomic studies based on established statistical principles. It also describes the analysis of data collected in these studies taking into account the numerous multiplicity issues that occur. This volume explains how to solve critical issues in multiple testing encountered in pre-clinical and clinical trial applications. It presents the necessary statistical methodology along with examples and software code to show how to use the methods in practice.

GBP 42.99
1

The Pocket Mentor for Video Game Testing

Antimicrobials in Food

Antimicrobials in Food

Fifteen years have passed since the 3rd edition of Antimicrobials in Food was published. It was arguably considered the must-have reference for those needing information on chemical antimicrobials used in foods. In the years since the last edition the food industry has undergone radical transformations because of changes on several fronts. Reported consumer demands for the use of natural and clean-label antimicrobials have increased significantly. The discovery of new foodborne pathogen niches and potentially hazardous foods along with a critical need to reduce food spoilage waste has increased the need for suitable antimicrobial compounds or systems. Novel natural antimicrobials continue to be discovered and new research has been carried out on traditional compounds. These and other related issues led the editors to develop the 4th edition of Antimicrobials in Food. In the 4th edition the editors have compiled contemporary topics with information synthesized from internationally recognized authorities in their fields. In addition to updated information new chapters have been added in this latest release with content on the use of bacteriophages lauric arginate ester and various systems for antimicrobial encapsulation and delivery. Comprehensive revisions of landmark chapters in previous editions including naturally occurring antimicrobials from both animal and plant sources methods for determining antimicrobial activity new approaches to multifactorial food preservation or hurdle technology and mechanisms of action resistance and stress adaptation are included. Complementing these topics is new information on quantifying the capability of clean antimicrobials for food preservation when compared to traditional food preservatives and industry considerations when antimicrobials are evaluated for use in food manufacture. Features Covers all food antimicrobials natural and synthetic with the latest research on each type Contains 5 000+ references on every conceivable food antimicrobial Guides in the selection of appropriate additives for specific food products Includes innovations in antimicrobial delivery technologies and the use of multifactorial food preservation with antimicrobials

GBP 42.99
1

Chitin- and Chitosan-Based Biocomposites for Food Packaging Applications

Ransomware Penetration Testing and Contingency Planning

Pesticide Regulation Handbook A Guide for Users

No-Frills Physics A Concise Study Guide for Algebra-Based Physics

The Need for Critical Thinking and the Scientific Method

RCSI Handbook of Clinical Surgery for Finals

RCSI Handbook of Clinical Surgery for Finals

Developed over previous editions by the Royal College of Surgeons in Ireland to support students attending the three RCSI universities this convenient handbook provides pragmatic guidance to the principles and practice of surgery that students can expect to encounter during undergraduate studies. Spanning the full range of surgical specialties information is presented in a convenient and clinically relevant format that takes the students through the patient journey from presenting symptoms and aetiology to investigations management and follow-up. The text written as easy-to-read and easy-to-remember bullet lists is supplemented throughout by tables management algorithms and colour illustrations. Key Features: • Concise – specifically for the undergraduate medical student by a highly experienced team of surgical educators • Accessible – bullet text ideal for rapid reference • Flexible – for use when on the ward and during finals revision • Complete - print book supplemented by video clips online question and answer material and an image library for the full learning and revision package Thoroughly updated this fifth edition has enhanced pedagogy and for the first time is accompanied by video clips and questions for self-testing. Covering the core surgical knowledge needed to become a safe and competent doctor the book will be an invaluable companion for clinical placements and during the critical run-up to final examinations. | RCSI Handbook of Clinical Surgery for Finals

GBP 36.99
1

Farm Animal Welfare Law International Perspectives on Sustainable Agriculture and Wildlife Regulation

The Easy Guide to Focused History Taking for OSCEs

Foundational and Applied Statistics for Biologists Using R

Foundational and Applied Statistics for Biologists Using R

Full of biological applications exercises and interactive graphical examples Foundational and Applied Statistics for Biologists Using R presents comprehensive coverage of both modern analytical methods and statistical foundations. The author harnesses the inherent properties of the R environment to enable students to examine the code of complicated procedures step by step and thus better understand the process of obtaining analysis results. The graphical capabilities of R are used to provide interactive demonstrations of simple to complex statistical concepts. Assuming only familiarity with algebra and general calculus the text offers a flexible structure for both introductory and graduate-level biostatistics courses. The first seven chapters address fundamental topics in statistics such as the philosophy of science probability estimation hypothesis testing sampling and experimental design. The remaining four chapters focus on applications involving correlation regression ANOVA and tabular analyses. Unlike classic biometric texts this book provides students with an understanding of the underlying statistics involved in the analysis of biological applications. In particular it shows how a solid statistical foundation leads to the correct application of procedures a clear understanding of analyses and valid inferences concerning biological phenomena. Web ResourceAn R package (asbio) developed by the author is available from CRAN. Accessible to those without prior command-line interface experience this companion library contains hundreds of functions for statistical pedagogy and biological research. The author’s website also includes an overview of R for novices.

GBP 42.99
1

Force: Animal Drawing Animal Locomotion and Design Concepts for Animators

Scentwork for Horses

Scentwork for Horses

Scentwork for Horses is the first practical guide on how to implement scentwork into the lives of domesticated horses enhancing behaviour welfare and the human-animal bond. Scentwork is a new discipline in the field for horse and handler and expert author Rachaël Draaisma arms the reader with a palette of information to enable them to put this technique into action. As well as theoretical background information on the nose of the horse and biomechanics Draaisma discusses how scentwork improves horses’ learning abilities development socialisation and their bond with the handler. Readers will learn how to have their horses explore their environment participate in scentwork games and follow a footstep track to find a missing person or food bag. Easily accessible for anybody working with horses at any level scentwork can be done in small areas as well as in larger spaces on various surfaces. Whether veterinarian behaviourist trainer animal-assisted therapist equine physiotherapist osteopath or interested horse owner this book promises to bring both you and the horse enormous benefits strengthening the human-animal bond. Rachaël Draaisma has always lived with and had a passion for dogs and horses. In 2002 she decided to make it her profession. Achieving several diplomas she started to work full time as a trainer and behavioural consultant first with dogs later with horses. Her best-selling book Language Signs and Calming Signals of Horses published by CRC Press in 2017 has been translated into several languages. Another pillar of Draaisma’s working life with horses revolves around equine mental stimulation and scentwork and she has developed an extensive method to undertake scent tracking with horses a new tool in enriching the human-equine relationship. Draaisma travels throughout Europe and the globe to provide workshops and lectures on calming signals of horses equine mental stimulation and scentwork. You can purchase scent bags to aid your scentwork practice at the author's personal website: www. scentworkforhorses. com or www. calmingsignalsofhorses. com

GBP 31.99
1

The Building Blocks of Life A Nutrition Foundation for Healthcare Professionals

The Building Blocks of Life A Nutrition Foundation for Healthcare Professionals

Within the United Kingdom (UK) most mainstream healthcare practitioners receive little or no nutrition education during their years of training. As a consequence the understanding of nutrition amongst primary care practitioners such as general practitioners pharmacists midwives and practice nurses is limited and is largely focused on energy consumption and obesity. There is little knowledge of the wealth of micronutrients that underpin health nor of the ticking timebomb of insufficient intakes of those micronutrients amongst a significant proportion of the population in the UK. The Building Blocks of Life: A Nutrition Foundation for Healthcare Professionals is a step towards redressing that balance. It sets out an informative and engaging narrative on how and why nutrition is the basis for good health. It discusses UK-specific issues with regards to diet and intakes of vitamins minerals essential fatty acids and other micronutrients. It also raises concerns about the potential negative health implications of the generally poor UK diet and suggests ways that healthcare practitioners can support patients in improving their long-term health outlook. Nutrition policy in the UK needs to be dragged into the 21st century and this book sets out evidence-based arguments which challenge current public health myths such as the idea that 10 micrograms of vitamin D is all anyone needs or the messaging around the consumption of saturated fat vs highly processed seed oils or that everyone can get all the nutrients they need from a varied and balanced diet. Although The Building Blocks of Life: A Nutrition Foundation for Healthcare Professionals focuses on concerns around poor diet and the consequent micronutrient inadequacies in the UK the nutritional detail is relevant no matter where you are in the world. Everyone eats all the time. It is time that mainstream medicine looked towards food as both a cause and a solution to many of the chronic degenerative conditions that plague modern life. | The Building Blocks of Life A Nutrition Foundation for Healthcare Professionals

GBP 24.99
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AI for Arts

AI for Sports

Get Through MRCOG Part 3 Clinical Assessment Second Edition

AI for School Teachers

AI for Diversity