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Thermal-Aware Testing of Digital VLSI Circuits and Systems

Multiple Testing Problems in Pharmaceutical Statistics

Multiple Testing Problems in Pharmaceutical Statistics

Useful Statistical Approaches for Addressing Multiplicity IssuesIncludes practical examples from recent trials Bringing together leading statisticians scientists and clinicians from the pharmaceutical industry academia and regulatory agencies Multiple Testing Problems in Pharmaceutical Statistics explores the rapidly growing area of multiple comparison research with an emphasis on pharmaceutical applications. In each chapter the expert contributors describe important multiplicity problems encountered in pre-clinical and clinical trial settings. The book begins with a broad introduction from a regulatory perspective to different types of multiplicity problems that commonly arise in confirmatory controlled clinical trials before giving an overview of the concepts principles and procedures of multiple testing. It then presents statistical methods for analyzing clinical dose response studies that compare several dose levels with a control as well as statistical methods for analyzing multiple endpoints in clinical trials. After covering gatekeeping procedures for testing hierarchically ordered hypotheses the book discusses statistical approaches for the design and analysis of adaptive designs and related confirmatory hypothesis testing problems. The final chapter focuses on the design of pharmacogenomic studies based on established statistical principles. It also describes the analysis of data collected in these studies taking into account the numerous multiplicity issues that occur. This volume explains how to solve critical issues in multiple testing encountered in pre-clinical and clinical trial applications. It presents the necessary statistical methodology along with examples and software code to show how to use the methods in practice.

GBP 42.99
1

Ransomware Penetration Testing and Contingency Planning

The Pocket Mentor for Video Game Testing

Get Through MRCOG Part 3 Clinical Assessment Second Edition

No-Frills Physics A Concise Study Guide for Algebra-Based Physics

Revival: Principles of Seed Pathology (1987) Volume II

Game Design Tools Cognitive Psychological and Practical Approaches

Pesticide Regulation Handbook A Guide for Users

An Introduction to Statistical Inference and Its Applications with R

The Easy Guide to Focused History Taking for OSCEs

Handbook of Univariate and Multivariate Data Analysis with IBM SPSS

Handbook of Univariate and Multivariate Data Analysis with IBM SPSS

Using the same accessible hands-on approach as its best-selling predecessor the Handbook of Univariate and Multivariate Data Analysis with IBM SPSS Second Edition explains how to apply statistical tests to experimental findings identify the assumptions underlying the tests and interpret the findings. This second edition now covers more topics and has been updated with the SPSS statistical package for Windows. New to the Second EditionThree new chapters on multiple discriminant analysis logistic regression and canonical correlationNew section on how to deal with missing dataCoverage of tests of assumptions such as linearity outliers normality homogeneity of variance-covariance matrices and multicollinearityDiscussions of the calculation of Type I error and the procedure for testing statistical significance between two correlation coefficients obtained from two samples Expanded coverage of factor analysis path analysis (test of the mediation hypothesis) and structural equation modelingSuitable for both newcomers and seasoned researchers in the social sciences the handbook offers a clear guide to selecting the right statistical test executing a wide range of univariate and multivariate statistical tests via the Windows and syntax methods and interpreting the output results. The SPSS syntax files used for executing the statistical tests can be found in the appendix. Data sets employed in the examples are available on the book’s CRC Press web page.

GBP 42.99
1

RCSI Handbook of Clinical Surgery for Finals

RCSI Handbook of Clinical Surgery for Finals

Developed over previous editions by the Royal College of Surgeons in Ireland to support students attending the three RCSI universities this convenient handbook provides pragmatic guidance to the principles and practice of surgery that students can expect to encounter during undergraduate studies. Spanning the full range of surgical specialties information is presented in a convenient and clinically relevant format that takes the students through the patient journey from presenting symptoms and aetiology to investigations management and follow-up. The text written as easy-to-read and easy-to-remember bullet lists is supplemented throughout by tables management algorithms and colour illustrations. Key Features: • Concise – specifically for the undergraduate medical student by a highly experienced team of surgical educators • Accessible – bullet text ideal for rapid reference • Flexible – for use when on the ward and during finals revision • Complete - print book supplemented by video clips online question and answer material and an image library for the full learning and revision package Thoroughly updated this fifth edition has enhanced pedagogy and for the first time is accompanied by video clips and questions for self-testing. Covering the core surgical knowledge needed to become a safe and competent doctor the book will be an invaluable companion for clinical placements and during the critical run-up to final examinations. | RCSI Handbook of Clinical Surgery for Finals

GBP 36.99
1

Foundational and Applied Statistics for Biologists Using R

Foundational and Applied Statistics for Biologists Using R

Full of biological applications exercises and interactive graphical examples Foundational and Applied Statistics for Biologists Using R presents comprehensive coverage of both modern analytical methods and statistical foundations. The author harnesses the inherent properties of the R environment to enable students to examine the code of complicated procedures step by step and thus better understand the process of obtaining analysis results. The graphical capabilities of R are used to provide interactive demonstrations of simple to complex statistical concepts. Assuming only familiarity with algebra and general calculus the text offers a flexible structure for both introductory and graduate-level biostatistics courses. The first seven chapters address fundamental topics in statistics such as the philosophy of science probability estimation hypothesis testing sampling and experimental design. The remaining four chapters focus on applications involving correlation regression ANOVA and tabular analyses. Unlike classic biometric texts this book provides students with an understanding of the underlying statistics involved in the analysis of biological applications. In particular it shows how a solid statistical foundation leads to the correct application of procedures a clear understanding of analyses and valid inferences concerning biological phenomena. Web ResourceAn R package (asbio) developed by the author is available from CRAN. Accessible to those without prior command-line interface experience this companion library contains hundreds of functions for statistical pedagogy and biological research. The author’s website also includes an overview of R for novices.

GBP 42.99
1

Statistics In the Pharmaceutical Industry

Statistics In the Pharmaceutical Industry

The growth of the pharmaceutical industry over the past decade is astounding but the impact of this growth on statistics is somewhat confusing. While software has made analysis easier and more efficient regulatory bodies now demand deeper and more complex analyses and pharmacogenetic/genomic studies serve up an entirely new set of challenges. For more than two decades Statistics in the Pharmaceutical Industry has been the definitive guide to sorting through the challenges in the industry and this Third Edition continues that tradition. Updated and expanded to reflect the most recent trends and developments in the field Statistics in the Pharmaceutical Industry Third Edition presents chapters written by experts from both regulatory agencies and pharmaceutical companies who discuss everything from experimental design to post-marketing studies. This approach sheds light on what regulators consider acceptable methodologies and what methods have proven successful for industrial statisticians. Both new and revised chapters reflect the increasingly global nature of the industry as represented by authors from Japan and Europe the increasing trend toward non-inferiority/equivalence testing adaptive design in clinical trials global harmonization of regulatory standards and multiple comparison studies. The book also examines the latest considerations in anti-cancer studies. Statistics in the Pharmaceutical Industry Third Edition demystifies the approval process by combining regulatory and industrial points of view making it a must-read for anyone performing statistical analysis at any point in the drug approval process.

GBP 42.99
1

Proton Therapy Physics Second Edition

Proton Therapy Physics Second Edition

Expanding on the highly successful first edition this second edition of Proton Therapy Physics has been completely restructured and updated throughout and includes several new chapters. Suitable for both newcomers in medical physics and more seasoned specialists in radiation oncology this book provides an in-depth overview of the physics of this radiation therapy modality eliminating the need to dig through information scattered across medical physics literature. After tracing the history of proton therapy the book explores the atomic and nuclear physics background necessary for understanding proton interactions with tissue. The text then covers dosimetry including beam delivery shielding aspects computer simulations detector systems and measuring techniques for reference dosimetry. Important for daily operations acceptance testing commissioning quality assurance and monitor unit calibrations are outlined. The book moves on to discussions of treatment planning for single- and multiple-field uniform doses dose calculation concepts and algorithms and precision and uncertainties for nonmoving and moving targets. Imaging for treatment guidance as well as treatment monitoring is outlined. Finally the biological implications of using protons from a physics perspective are discussed. This book is an ideal practical guide for physicians dosimetrists radiation therapists and physicists who already have some experience in radiation oncology. It is also an invaluable reference for graduate students in medical physics programs physicians in their last year of medical school or residency and those considering a career in medical physics. Features: Updated with the latest technologies and methods in the field covering all delivery methods of proton therapy including beam scanning and passive scattering Discusses clinical aspects such as treatment planning and quality assurance Offers insight on the past present and future of proton therapy from a physics perspective | Proton Therapy Physics Second Edition

GBP 39.99
1

Field Guide to Clandestine Laboratory Identification and Investigation

Field Guide to Clandestine Laboratory Identification and Investigation

Clandestine labs that manufacture drugs or explosives may be encountered virtually anywhere. They can range from complex operations employing scientific equipment and exotic chemicals or simply kitchen utensils and chemicals purchased at a local grocery or hardware store. Regardless of their form the key to detecting clandestine labs is the ability to recognize the combinations of equipment and chemicals that constitute the lab in the first place. The first line of defense against the manufacturers—who supply the drug trade and terrorists with their tools of destruction—is law enforcement the fire services and other emergency responders. Field Guide to Clandestine Laboratory Identification and Investigation Second Edition provides the information necessary to recognize operations that produce these deadly brews. As with the prior edition the book has sections covering the chemicals and equipment commonly used in the manufacture of drugs and explosives. They are grouped in a manner that allows the emergency responder to quickly identify common combinations of equipment and chemicals that could potentially be used to manufacture drugs or explosives. Since many clandestine manufacturing operations use commonly available materials that have legitimate uses the author outlines how to quickly assess and recognize key indicators associated with clandestine laboratory operations. Sections within the book address information concerning both the hazards associated with those chemicals involved and the personal protective equipment needed to abate the hazards. In addition documentation requirements field-testing and sampling procedures are detailed for use once the operation has been seized and secured. Reproducible worksheets are provided to be used either as or to supplement the on-scene investigators’ field notes and assist in providing a standardized manner to objectively record information about the crime scene. The ability to identify the tools used to manufacture contraband drugs and explosives is a key element in the battle against drug abuse and terrorism making the Field Guide to Clandestine Laboratory Identification and Investigation Second Edition an indispensible resource for responders and investigators alike.

GBP 42.99
1

Advanced VLSI Design and Testability Issues

Advanced VLSI Design and Testability Issues

This book facilitates the VLSI-interested individuals with not only in-depth knowledge but also the broad aspects of it by explaining its applications in different fields including image processing and biomedical. The deep understanding of basic concepts gives you the power to develop a new application aspect which is very well taken care of in this book by using simple language in explaining the concepts. In the VLSI world the importance of hardware description languages cannot be ignored as the designing of such dense and complex circuits is not possible without them. Both Verilog and VHDL languages are used here for designing. The current needs of high-performance integrated circuits (ICs) including low power devices and new emerging materials which can play a very important role in achieving new functionalities are the most interesting part of the book. The testing of VLSI circuits becomes more crucial than the designing of the circuits in this nanometer technology era. The role of fault simulation algorithms is very well explained and its implementation using Verilog is the key aspect of this book. This book is well organized into 20 chapters. Chapter 1 emphasizes on uses of FPGA on various image processing and biomedical applications. Then the descriptions enlighten the basic understanding of digital design from the perspective of HDL in Chapters 2–5. The performance enhancement with alternate material or geometry for silicon-based FET designs is focused in Chapters 6 and 7. Chapters 8 and 9 describe the study of bimolecular interactions with biosensing FETs. Chapters 10–13 deal with advanced FET structures available in various shapes materials such as nanowire HFET and their comparison in terms of device performance metrics calculation. Chapters 14–18 describe different application-specific VLSI design techniques and challenges for analog and digital circuit designs. Chapter 19 explains the VLSI testability issues with the description of simulation and its categorization into logic and fault simulation for test pattern generation using Verilog HDL. Chapter 20 deals with a secured VLSI design with hardware obfuscation by hiding the IC’s structure and function which makes it much more difficult to reverse engineer. | Advanced VLSI Design and Testability Issues

GBP 38.99
1