2.572 results (0,25784 seconds)

Show all filters

Brand

Merchant

Price (EUR)

Reset filter

Products
From
Shops

Forensic DNA Transfer

Forensic DNA Transfer

Forensic DNA Transfer provides a guide to the recognition and current understanding of DNA transfer in forensic criminal investigations. Increased improvements in technology mean that it is now routinely possible to obtain DNA profiles from non-visible deposits. How or when the DNA in question was deposited may be an issue in the context of the case especially if the donor of the DNA is not in dispute. A DNA profile alone cannot reveal when or how that DNA was deposited at a crime scene nor can it reveal the body matter from which it originated. Issues of transfer associated with activities may be debated—which the traditional discrimination purpose of DNA profiling cannot address. DNA may be everywhere and anywhere—in homes at workplaces during transport and on personal items including clothing. DNA from a person may be on an object they have never contacted or in a room they have never entered. Concepts discussed in the book include non-self DNA on hands through day-to-day activities the prevalence of background DNA in the environment and perhaps on the exhibit the persistence of any DNA transferred and that a DNA result will depend on these variables as well as recovery techniques. Since DNA may be transferred to an exhibit: (a) during the commission of a crime (b) before the crime and/or (c) after the crime through handling examination and testing this book covers various transfer pathways and sources of DNA. Documented cases of inadvertent transfer of DNA resulting in wrongful convictions or the misdirection of criminal investigations are discussed—with an emphasis on contamination mitigation throughout the entire process. Forensic DNA Transfer examines the additional complexity resulting from non-visible deposits of DNA that impact on sampling and testing regimes. The changing understanding of the composition of purported 'touch DNA' deposits from the skin including extracellular DNA transported via body secretions is described. Further the newer focus on interpreting DNA evidence—using activity level propositions and the rationale and associated issues—is also discussed.

GBP 46.99
1

Forensic DNA Applications An Interdisciplinary Perspective

Forensic DNA Applications An Interdisciplinary Perspective

Forensic DNA Applications: An Interdisciplinary Perspective Second Edition is fully updated to outline the latest advances in forensic DNA testing techniques and applications. It continues to fill the need for a reference book for people working in the field of forensic molecular biology testing and research as well as individuals investigating and adjudicating cases involving DNA evidence whether they be civil or criminal cases. DNA techniques have greatly impacted obvious traditional forensic areas but such advances have also positively affected myriad new areas of research and inquiry. It is possible today to think about solving forensic problems that were simply unheard of even a few years ago. As such the book pulls all relevant research and applied science together into a detailed and comprehensive collection. Part I begins with the history and development of DNA typing and profiling for criminal and civil purposes. It discusses the statistical interpretation of results with case examples mitochondrial DNA testing Y single nucleotide polymorphisms (SNPs) and short tandem repeats (STRs) and X SNP and STR testing. It also explores low copy number DNA typing mixtures and quality assurance and control. Part II moves on to cover the various uses and applications of analyzing collected physical evidence victim identification in mass disasters analyzing animal DNA forensic botany and other unique applications. Part III is dedicated to the latest advances and developments in human molecular biology and Part IV looks at policies and laws and ethics governing DNA evidence and its utilization in various cases and the courts. Forensic DNA Applications Second Edition covers cutting-edge research and advancements in the field and is the most up-to-date reference available. Edited and contributed to by the world's foremost leaders in the field it is a must-have reference for established professionals and an essential resource to legal professionals—lawyers and judges dealing with civil and criminal cases involving DNA technology—as well as students entering the fields of genetics and forensic DNA analysis. | Forensic DNA Applications An Interdisciplinary Perspective

GBP 56.99
1

Forensic DNA Analysis Current Practices and Emerging Technologies

Forensic DNA Analysis Current Practices and Emerging Technologies

The field of forensic DNA analysis has grown immensely in the past two decades and genotyping of biological samples is now routinely performed in human identification (HID) laboratories. Application areas include paternity testing forensic casework family lineage studies identification of human remains and DNA databasing. Forensic DNA Analysis: Current Practices and Emerging Technologies explores the fundamental principles and the application of technologies for each aspect of forensic DNA analysis. The book begins by discussing the value of DNA evidence and how to properly recognize document collect and store it. The remaining chapters examine:The most widely adopted methods and the best practices for DNA isolation from forensic biological samples and human remainsStudies carried out on the use of both messenger RNA and small (micro) RNA profilingReal-time polymerase chain reaction (PCR) methods for quantification and assessment of human DNA prior to genotypingCapillary electrophoresis (CE) as a tool for forensic DNA analysisNext-generation short tandem repeat (STR) genotyping kits for forensic applications the biological nature of STR loci and Y-chromosome STRs (Y-STRs)Mitochondrial DNA (mtDNA) sequence analysisSingle nucleotide polymorphisms (SNPs) and insertion/deletion polymorphisms (indels) in typing highly degraded DNADeep-sequencing technologiesThe current state of integrated systems in forensic DNA analysis The book concludes by discussing various aspects of sample-processing training and the entities that provide such training programs. This volume is an essential resource for students researchers teaching faculties and other professionals interested in human identification/forensic DNA analysis. | Forensic DNA Analysis Current Practices and Emerging Technologies

GBP 77.99
1

Artificial DNA Methods and Applications

Artificial DNA Methods and Applications

Combining elements of biochemistry molecular biology and immunology artificial DNA can be employed in a number of scientific disciplines. Some of the varied applications include site-specific mutagenesis hybridization amplification protein engineering anti-sense technology DNA vaccines protein vaccines recombinant antibodies screening for genetic and pathogenic diseases development of materials with new biochemical and structural properties and many more. Artificial DNA: Methods and Applications introduces the concept of artificial DNA that has been rationally designed and explains how it may be exploited in order to develop products that will achieve your intended purpose. The first part of the book covers methods of oligonucleotide synthesis and direct applications of synthetic DNA. The second part describes methods of gene assembly from synthetic oligonucleotides and applications of synthetic genes. The authors also discuss the different trends and future developments within each application area . With state-of-the art research the contributing authors describe how to engineer proteins using rational and semi-rational design to exhibit the desired traits and detail the various amplification reactions and hybridization techniques for modeling evolution and for use in basic research. The only text devoted to this subject Artificial DNA offers a comprehensive review that allows you to understand the strategy design and applications of synthetic oligonucleotides. | Artificial DNA Methods and Applications

GBP 59.99
1

Forensic DNA Profiling A Practical Guide to Assigning Likelihood Ratios

Forensic DNA Profiling A Practical Guide to Assigning Likelihood Ratios

DNA testing and its forensic analysis are recognized as the “gold standard” in forensic identification science methods. However there is a great need for a hands-on step-by-step guide to teach the forensic DNA community how to interpret DNA mixtures how to assign a likelihood ratio and how to use the subsequent likelihood ratio when reporting interpretation conclusions. Forensic DNA Profiling: A Practical Guide to Assigning Likelihood Ratios will provide a roadmap for labs all over the world and the next generation of analysts who need this foundational understanding. The techniques used in forensic DNA analysis are based upon the accepted principles of molecular biology. The interpretation of a good-quality DNA profile generated from a crime scene stain from a single-source donor provides an unambiguous result when using the most modern forensic DNA methods. Unfortunately many crime scene profiles are not single source. They are described as mixed since they contain DNA from two or more individuals. Interpretation of DNA mixtures represents one of the greatest challenges to the forensic DNA analyst. As such the book introduces terms used to describe DNA profiles and profile interpretation. Chapters explain DNA extraction methods the polymerase chain reaction (PCR) capillary electrophoresis (CE) likelihood ratios (LRs) and their interpretation and population genetic models—including Mendelian inheritance and Hardy-Weinberg equilibrium. It is important that analysts understand how LRs are generated in a probabilistic framework ideally with an appreciation of both semicontinuous and fully continuous probabilistic approaches. KEY FEATURES:• The first book to focus entirely on DNA mixtures and the complexities involved with interpreting the results • Takes a hands-on approach offering theory with worked examples and exercises to be easily understood and implementable by laboratory personnel • New methods heretofore unpublished previously provide a means to innovate deconvoluting a mixed DNA profile assign an LR and appropriately report the weight of evidence • Includes a chapter on assigning LRs for close relatives (i. e. “It’s not me it was my brother”) and discusses strategies for the validation of probabilistic genotyping softwareForensic DNA Profiling fills the void for labs unfamiliar with LRs and moving to probabilistic solutions and for labs already familiar with LRs but wishing to understand how they are calculated in more detail. The book will be a welcome read for lab professionals and technicians students and legal professionals seeking to understand and apply the techniques covered. | Forensic DNA Profiling A Practical Guide to Assigning Likelihood Ratios

GBP 44.99
1

Test Quality for Construction Materials and Structures Proceedings of the International RILEM/ILAC Symposium

Test Quality for Construction Materials and Structures Proceedings of the International RILEM/ILAC Symposium

Testing of materials and manufactured items is a key element in the process from standard specifications though control and verification during manufacture to trade in actual products. Cooperative agreements and networks are being set up covering reference materials and calibration. This process is becoming more urgent with the development in the European market and other international developments. This book presents international views on this fast changing field with the main themes of: technical components of test quality; quality assurance in testing laboratories; laboratory accreditation and transnational recognition of test results. | Test Quality for Construction Materials and Structures Proceedings of the International RILEM/ILAC Symposium

GBP 62.99
1

Detector Dogs and Scent Movement How Weather Terrain and Vegetation Influence Search Strategies

Detector Dogs and Scent Movement How Weather Terrain and Vegetation Influence Search Strategies

Dogs detect scent from a source that is carried to them in a plume by the wind. The most important tool for a detector dog handler to have on searches is a knowledge of scent plume movement or scent dynamics (the science of scent movement). Such knowledge resides primarily in scientific journals that are largely inaccessible to detector dog handlers and written in language that is difficult to understand. Detector Dogs and the Science of Scent Movement: A Handler’s Guide to Environments and Procedures retrieves reviews and interprets the results of pertinent scientific research on scent dynamics and presents these results in terms that are easier for handlers to understand. Information on the physiology of the dog’s nose their sense of smell and the properties of scent provide the essential information on the process of scenting. The composition of training aids for explosives narcotics human remains and other sources is discussed. Recommendations are made on the use of training aids their placement during training and the resulting availability of scent. Potential problems and handler errors in the use of training aids are also examined. The characteristics of scent plumes and how wind influences their movement are a key focus of the book. The primary task for the handler is to get the dog into the scent plume so that the dog can detect the scent and follow it to the source the handler seeks. As such a knowledge of scent and scent plume movement will vastly improve the ability of the handler to accomplish this task. The influence of weather and physical settings such as terrain vegetation ground cover soil and water on scent movement are examined in detail. Strategies for searching detecting and locating sources in all physical settings are presented. Specific effects associated with hills and mountains fields and forests bare soils and soils covered by vegetation different soil types and lakes and rivers are examined in detail. This includes specific recommendations are made about weather and physical settings that result in higher probability of success on searches. Detector Dogs and the Science of Scent Movement will be a vital resource for K9 handles in the private and public sectors—including in Homeland Security law enforcement and military settings—as well as a useful guide for lawyers forensic and investigative professionals who need to better understand K9 operations. | Detector Dogs and Scent Movement How Weather Terrain and Vegetation Influence Search Strategies

GBP 44.99
1

Cadaver Dog Handbook Forensic Training and Tactics for the Recovery of Human Remains

Cadaver Dog Handbook Forensic Training and Tactics for the Recovery of Human Remains

Intended for those who train and handle cadaver dogs this book also encompasses information for those who work closely with them such as police death investigators and anthropologists. Its interdisciplinary approach is useful to any member of a forensic team who regularly participates in or evaluates the results of the human remains search effort. Cadaver Dog Handbook sets out the principles and procedures for the training and handling of dogs for the location of human remains. It explains scent theory and its applications introduces basic training and searching strategies/tactics and covers the legal and taphonomic issues associated with dog searches. Intended for those who train and handle cadaver dogs this book also encompasses information for those who work closely with them such as police death investigators and anthropologists. Its interdisciplinary approach is useful to any member of a forensic team who regularly participates in or evaluates the results of the human remains search effort. | Cadaver Dog Handbook Forensic Training and Tactics for the Recovery of Human Remains

GBP 66.99
1

Handbook of Mitochondrial Dysfunction

Handbook of Mitochondrial Dysfunction

Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book. Key FeaturesPresents the detailed structure of mitochondria mitochondrial function roles of oxidants and antioxidants in mitochondrial dysfunction. Includes summary of both causes and effects of these diseases. Discusses current and potential future therapies for mitochondrial dysfunction diseasesExplores a wide variety of diseases caused by dysfunctional mitochondria. | Handbook of Mitochondrial Dysfunction

GBP 44.99
1

Microfluidic Lab-on-a-Chip for Chemical and Biological Analysis and Discovery

Microfluidic Lab-on-a-Chip for Chemical and Biological Analysis and Discovery

The microfluidic lab-on-a-chip allows scientists to conduct chemical and biochemical analysis in a miniaturized format so small that properties and effects are successfully enhanced and processes seamlessly integrated. This microscale advantage translates into greater sensitivity more accurate results and better information. Microfluidic Lab-on-a-Chip for Chemical and Biological Analysis and Discovery focuses on all aspects of the microfluidic lab-on-a-chip technologies and offers an overview of the available technology its limitations and its breakthroughs over the years. It emphasizes analytical applications of microfluidic technology and offers in-depth coverage of micromachining methods microfluidic operations chemical separations sample preparation and injection methods detection technology and various chemical and biological analyses. Other topics of interest include the use of polymeric chips fluid flow valve and control single-cell analysis DNA and RNA amplification techniques DNA hybridization immunoassays and enzymatic assays. Originally conceived as a single chapter published in Ewing's Analytical Instrumentation this book is a gateway to the vast literature and conference proceedings on the topic. Microfluidic Lab-on-a-Chip for Chemical and Biological Analysis and Discovery expands upon its roots to present a comprehensive treatment of microfluidic lab-on-a-chip methods and applications for novices and advanced researchers alike.

GBP 44.99
1

Manipulation of the Avian Genome

Manipulation of the Avian Genome

Many genes have been cloned from chicken cells and during the next decade numerous laboratories will be concentrating their resources in developing ways of using these tools. Manipulation of the Avian Genome contains the most recent information from leading research laboratories in the areas of developmental and molecular genetics of the chicken. This information was presented at the Keystone Symposium held at Lake Tahoe in March 1991. The book discusses potential applications of emerging technology in basic science and poultry production. Various techniques for altering genomic DNA such as microinjection retroviral vectors and lipofection are covered. Genome evaluation using DNA fingerprinting and conventional breeding techniques are presented.

GBP 59.99
1

Genomes 5

Genomes 5

Genomes 5 has been completely revised and updated. It is a thoroughly modern textbook about genomes and how they are investigated. As with previous Genomes editions techniques come first then genome anatomies followed by genome function and finally genome evolution. The genomes of all types of organism are covered: viruses bacteria fungi plants and animals including humans and other hominids. Genome sequencing and assembly methods have been thoroughly revised to include new developments in long-read DNA sequencing. Coverage of genome annotation emphasizes genome-wide RNA mapping with CRISPR-Cas 9 and GWAS methods of determining gene function covered. The knowledge gained from these techniques forms the basis of the chapters that describe the three main types of genomes: eukaryotic prokaryotic (including eukaryotic organelles) and viral (including mobile genetic elements). Coverage of genome expression and replication is truly genomic concentrating on the genome-wide implications of DNA packaging epigenome modifications DNA-binding proteins non-coding RNAs regulatory genome sequences and protein-protein interactions. Also included are examples of the applications of metabolomics and systems biology. The final chapter is on genome evolution including the evolution of the epigenome using genomics to study human evolution and using population genomics to advance plant breeding. Established methods of molecular biology are included if they are still relevant today and there is always an explanation as to why the method is still important. Genomes 5 is the ideal text for upper-level courses focused on genomes and genomics. Key Features A highly accessible and well-structured book with chapters organized into four parts to aid navigation Superb artwork illustrates the key concepts and mechanisms Each chapter has a set of short-answer questions and in-depth problems to test the reader’s understanding of the material Thoroughly up to date with references to the latest research from the 2020s

GBP 64.99
1

Scientific Protocols for Forensic Examination of Clothing

Scientific Protocols for Forensic Examination of Clothing

When a crime or other incident takes place clothing items are often present or left behind and can become directly involved in the case itself. Items of clothing are thus one of the most common types of exhibit examined in court. They can provide valuable information in cases of violent crimes such as homicide or rape as well as in burglary robbery arson and vehicular accidents. A unique reference in the forensic arenaThe first of its kind Scientific Protocols for Forensic Examination of Clothing discusses the forensic examination of clothing in criminal cases. It examines the ramifications of DNA profiling and its effect on the screening approach to clothing examination. Coverage includes protocols and procedures preliminary assessment examination testing and sampling quality assurance and control and the significance of results. Applicable to a myriad of readersSuitable for a wide range of readers this book is designed for examiners trying to decide how to approach a clothing examination those looking for more information on a specific topic laboratory quality assurance officers in need of a reliable reference as well as attorneys investigators archaeologists and curators. Expert authors Author Jane Moira Taupin has testified as a forensic expert more than 130 times. Chesterene Cwiklik is a founder of the Pacific Coast Forensic Science Institute. Their expertise makes this a valuable resource for all those who examine clothing items and interpret subsequent findings.

GBP 69.99
1

Quality Control Training Manual Comprehensive Training Guide for API Finished Pharmaceutical and Biotechnologies Laboratories

Quality Control Training Manual Comprehensive Training Guide for API Finished Pharmaceutical and Biotechnologies Laboratories

Written to help companies comply with GMP GLP and validation requirements imposed by the FDA and regulatory bodies worldwide Quality Control Training Manual: Comprehensive Training Guide for API Finished Pharmaceutical and Biotechnologies Laboratories presents cost-effective training courses that cover how to apply advances in the life sciences to produce commercially viable biotech products and services in terms of quality safety and efficacy. This book and its accompanying downloadable resources comprise detailed text summaries test papers and answers to test papers providing an administrative solution for management. Provides the FDA Health Canada WHO and EMEA guidelines directly applicable to pharmaceutical laboratory-related issuesOffers generic formats and styles that can be customized to any organization and help management build quality into routine operations to comply with regulatory requirementsContains ready-to-use training courses that supply a good source of training material for experienced and inexperienced practitioners in the biotechnology/biopharmaceutical industriesIncludes downloadable resources with downloadable training courses that can be adopted and directly customized to a particular organizationSupplies ready-to-use test papers that allow end users to record all raw data up to the issuance of the attached certificateThe biotechnology/bioscience industries are regulated worldwide to be in compliance with cGMP and GLP principles with particular focus on safety issues. Each company must create a definite training matrix of its employees. The training procedures in this book enable end users to understand the principles and elements of manufacturing techniques and provide documentation language ranging from the generic to the specific. The training courses on the downloadable resources supply valuable tools for developing training matrices to achieve FDA Health Canada EMEA MHRA UK WHO and GLP compliance. | Quality Control Training Manual Comprehensive Training Guide for API Finished Pharmaceutical and Biotechnologies Laboratories

GBP 52.99
1

The Complete Guide to the ABC Molecular Biology Certification Exam

The Complete Guide to the ABC Molecular Biology Certification Exam

In 2009 the National Academy of Sciences (NAS) authored the report Strengthening Forensic Science in the United States: A Path Forward. In it the Committee expressed the need for accreditation and certification. Accreditation long recognized by public labs as an important benchmark in quality was recognized as an important way to standardize laboratories that provide forensic services. Certification can play an important role as a method of oversight in the forensic sciences—something also recommended by the - National Commission on Forensic Science in October 2014. The Complete Guide to the ABC's Molecular Biology is a professional certification examination preparation text for forensic scientists taking the American Board of Criminalistics Examination in Molecular Biology. The book serves as a resource for forensic scientists—who are facing more and more pressure to become certified—to support them in their pursuit of forensic certification. In the years since the NAS report was published there has been increased discussion of forensic certification requirements. ABC’s Molecular Biology exam is a quality certification and learning the concepts for it will invariably help any professional working in the field. The book prepares readers in all relevant topic areas including: accreditation safety biological screen principles anatomy and cell biology crime scene and evidence handling concepts in genetics biochemistry statistics DNA evidence and DNA testing. The book will be particularly helpful for forensic science laboratory technicians police and investigations professionals forensic serology and DNA analysts attorneys and forensic science students. This study guide follows the guidelines for the exam and presents all the information necessary to prepare individuals to pass the exam. | The Complete Guide to the ABC Molecular Biology Certification Exam

GBP 74.99
1

Canine Olfaction Science and Law Advances in Forensic Science Medicine Conservation and Environmental Remediation

Canine Olfaction Science and Law Advances in Forensic Science Medicine Conservation and Environmental Remediation

The value of the canine nose is well-documented and working dogs are being utilized for their olfactory skills in an increasing number of fields. Not only are dogs used by police security and the military but they are also now used in forensic science in medical detection of disease in calculating population trends of endangered species and eradicating invasive species in protected environments and in identifying infestations and chemical contaminants. Edited and contributed to by eminent scholars Canine Olfaction Science and Law: Advances in Forensic Science Medicine Conservation and Environmental Remediation takes a systematic scientific approach to canine olfaction. It includes work from scientists working in pure and applied disciplines trainers and handlers who have trained and deployed detection dogs and lawyers who have evaluated evidence produced with the aid of detection and scent identification dogs. The book is divided into six sections coveringThe anatomy genetics neurology and evolution of canine olfaction as well as diseases affecting itThe chemistry and aerodynamics of odorsBehavior learning and trainingUses of canine olfaction in forensics and lawUses in conservation and remediationUses in detection of diseases and medical conditionsThe various contributors describe cutting edge research some conclusions of which are the subject of vigorous debates between various laboratories and researchers. The editors have added cross-references so that readers can consider the different perspectives that are currently being advanced and understand where consensus is being built and where more research needs to be done. A useful practical reference Canine Olfaction Science and Law provides a wealth of information beneficial to a wide range of disciplines. It aids trainers and handlers of detection dogs as well as various professionals in healthcare law enforcement forensic science and environmental conservation to gain a better understanding of the remarkable power of the canine nose while encouraging further advances in applications. | Canine Olfaction Science and Law Advances in Forensic Science Medicine Conservation and Environmental Remediation

GBP 64.99
1

Fast Facts for the Primary FRCA and EDAIC Basic Science for Anaesthetists

Fast Facts for the Primary FRCA and EDAIC Basic Science for Anaesthetists

The Primary FRCA is a marathon exam that requires candidates to concentrate on solving MCQs first and then prepare for the OSCE and SOE viva. The EDAIC Part 1 involves MCQs and Part 2 uses viva to test candidates. All these exams demand a strong knowledge of basic sciences relevant to anaesthesia. The Fast Facts content aids quick revision in the lead up to the examinations and maximises the chances of exam success. Covering all the high-yield facts together with concept building the content ensures that students benefit at all stages of their preparation especially during the last few weeks before examinations. Past MCQs and core viva concepts have been presented in bullet points tabular format and diagrams for easy assimilation. The Primary FRCA is shifting towards asking SBAs and this book covers both the SBA and MTF formats of MCQs. It includes over 180 topics and is subdivided into sections on Physiology Pharmacology Physics and Anatomy. The key ingredient to get through any exam is confidence. By facilitating timely revision of the entire curriculum this book makes sure that candidates for both the Primary FRCA and for the EDAIC will enter the examination hall with a positive mindset and comprehensive knowledge of the basic sciences required by anaesthetists. | Fast Facts for the Primary FRCA and EDAIC Basic Science for Anaesthetists

GBP 46.99
1

Self-Assessment for Vascular and Endovascular Specialists

Self-Assessment for Vascular and Endovascular Specialists

Including over 500 multiple choice questions covering a wide range of vascular disorders to test the skills of all vascular specialists. Suitable for postgraduate trainee vascular medicine internists interventional radiologists vascular surgeons and endovascular therapists as they prepare for exams or ensure that they remain up to date. Divided into 21 subject specific-sections and meticulously written and researched the questions and their accompanying rationales are enhanced by explanatory illustrations and supported by key references. Students and experienced clinicians will be prepared for both testing and teaching in all aspects of clinical practice. Advances in the treatment of vascular disease have played a significant role in rising life expectancy over the past 70 years resulting in lower morbidity mortality and quicker recoveries. However there remains an urgent challenge in controlling risk factors such as obesity sedentary lifestyles and tobacco abuse. As explosive growth in endovascular technology continues it is more important than ever for vascular specialists to remain proficient and stay up to date. | Self-Assessment for Vascular and Endovascular Specialists

GBP 64.99
1

Next-Generation Sequencing Data Analysis

Next-Generation Sequencing Data Analysis

Next-generation DNA and RNA sequencing has revolutionized biology and medicine. With sequencing costs continuously dropping and our ability to generate large datasets rising data analysis becomes more important than ever. Next-Generation Sequencing Data Analysis walks readers through next-generation sequencing (NGS) data analysis step by step for a wide range of NGS applications. For each NGS application this book covers topics from experimental design sample processing sequencing strategy formulation to sequencing read quality control data preprocessing read mapping or assembly and more advanced stages that are specific to each application. Major applications include: RNA-seq: Both bulk and single cell (separate chapters) Genotyping and variant discovery through whole genome/exome sequencing Clinical sequencing and detection of actionable variants De novo genome assembly ChIP-seq to map protein-DNA interactions Epigenomics through DNA methylation sequencing Metagenome sequencing for microbiome analysis Before detailing the analytic steps for each of these applications the book presents introductory cellular and molecular biology as a refresher mostly for data scientists the ins and outs of widely used NGS platforms and an overview of computing needs for NGS data management and analysis. The book concludes with a chapter on the changing landscape of NGS technologies and data analytics. The second edition of this book builds on the well-received first edition by providing updates to each chapter. Two brand new chapters have been added to meet rising data analysis demands on single-cell RNA-seq and clinical sequencing. The increasing use of long-read sequencing has also been reflected in all NGS applications. This book discusses concepts and principles that underlie each analytic step along with software tools for implementation. It highlights key features of the tools while omitting tedious details to provide an easy-to-follow guide for practitioners in life sciences bioinformatics biostatistics and data science. Tools introduced in this book are open source and freely available.

GBP 74.99
1

Forensic Biology

Forensic Biology

Over the last several years new research and developments in analysis methods and practice have led to rapid advancements in forensic biology. Identifying critical points of knowledge and new methodological approaches in the field Forensic Biology Second Edition focuses on forensic serology and forensic DNA analysis. It provides students and professionals with a scientific grounding in biological evidence—both the techniques used to identify it and the methodology to analyze it. This second edition:Introduces the language of forensic biology enabling students to become comfortable with usage and terminologyProvides clear explanations of the principles of forensic identification and analysis of biological evidenceExplains forensic serology and DNA techniques used in the field and the laboratoryDiscusses the benefits and limitations that apply to various forensic biology techniquesIncludes schematic illustrations to clarify conceptsPresents three new chapters created for this edition Adds more than two hundred new color figures Covering the full scope of forensic biology the book uses an accessible straightforward style designed to enhance students’ education and training so they are prepared both in the laboratory and in the field.

GBP 66.99
1

Handbook Of Applied Econometrics And Statistical Inference

Handbook Of Applied Econometrics And Statistical Inference

Summarizing developments and techniques in the field this reference covers sample surveys nonparametric analysis hypothesis testing time series analysis Bayesian inference and distribution theory for applications in statistics economics medicine biology engineering sociology psychology and information technology. It supplies a geometric proof of an extended Gauss-Markov theorem approaches for the design and implementation of sample surveys advances in the theory of Neyman's smooth test and methods for pre-test and biased estimation. It includes discussions ofsample size requirements for estimation in SUR models innovative developments in nonparametric models and more. | Handbook Of Applied Econometrics And Statistical Inference

GBP 44.99
1

Fundamental QSARs for Metal Ions

Fundamental QSARs for Metal Ions

Fundamental QSARs for Metal Ions describes the basic and essential applications of quantitative structure–activity relationships (QSARs) for regulatory or industrial scientists who need to predict metal ion bioactivity. It includes 194 QSARs that have been used to predict metal ion toxicity and 86 QSARs that have been used to predict metal ion bioconcentration biosorption and binding. It is an excellent sourcebook for academic industrial and government scientists and policy makers and provides a wealth of information on the biological and chemical activities of metal ions as they impact health and the environment. Fundamental QSARs for Metal Ions was designed for regulatory and regulated organizations that need to use QSARs to predict metal ion bioactivity as they now do for organic chemicals. It has the potential to eliminate resources to test the toxicity of metal ions or to promulgate regulations that require toxicity testing of metal ions because the book illustrates how to construct QSARs to predict metal ion toxicity. In addition the book:Provides a historical perspective and introduction to developing QSARs for metal ionsExplains the electronic structures and atomic parameters of metals essential to understanding differences in chemical properties that influence cation toxicity bioconcentration biosorption and bindingDescribes the chemical properties of metals that are used to develop QSARs for metal ionsIllustrates the descriptors needed to develop metal ion-ligand binding QSARsDiscusses 280 QSARs for metal ions Explains the differences between QSARs for metal ions and Biotic Ligand ModelsLists the regulatory limits of metals and provides examples of regulatory applicationsIllustrates how to construct QSARs for metal ionsDr. John D. Walker is the winner of the 2013 SETAC Government Service Award.

GBP 59.99
1

Biophysics Tools and Techniques for the Physics of Life

Biophysics Tools and Techniques for the Physics of Life

Biophysics: Tools and Techniques for the Physics of Life covers the experimental theoretical and computational tools and techniques of biophysics. It addresses the purpose science and application of all physical science instrumentation theoretical analysis and biophysical computational methods used in current research labs. The book first presents the historical background concepts and motivation for using a physical science toolbox to understand biology. It then familiarizes undergraduate students from the physical sciences with essential biological knowledge. The text subsequently focuses on experimental biophysical techniques that primarily detect biological components or measure/control biological forces. The author describes the science and application of key tools used in imaging detection general quantitation and biomolecular interaction studies which span multiple length and time scales of biological processes both in the test tube and in the living organism. Moving on to theoretical and computational biophysics tools the book presents analytical mathematical methods and numerical simulation approaches for tackling challenging biological questions including exam-style questions at the end of each chapter as well as step-by-step solved exercises. It concludes with a discussion of the future of this exciting field. Future innovators will need to be trained in multidisciplinary science to be successful in industry academia and government support agencies. Addressing this challenge this textbook educates future leaders on the development and application of novel physical science approaches to solve complex problems linked to biological questions. Features: Provides the full modern physical science toolbox of experimental theoretical and computational techniques such as bulk ensemble methods single-molecule tools live-cell and test tube methods pencil-on-paper theory approaches and simulations. Incorporates worked examples for the most popular physical science tools by providing full diagrams and a summary of the science involved in the application of the tool. Reinforces the understanding of key concepts and biological questions. A solutions manual is available upon qualifying course adoption. | Biophysics Tools and Techniques for the Physics of Life

GBP 52.99
1