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The Gut Microbiome Bench to Table

The Microbiome and the Brain

The Microbiome and the Brain

Brain related disorders are among the most challenging health issues of our time. The development of effective therapeutic and preventive strategies for these disorders relies on a comprehensive understanding of the underlying causative mechanisms. And until recently these mechanisms have remained somewhat elusive. The newly discovered pivotal role of the intestinal microbiome in brain health functionality and resistance to disease is revolutionizing neuroscience. The Microbiome and the Brain through the contributions of some of the most forward thinking researchers and clinicians in the field comprehensively reveals the leading edge of our understanding of the fundamental role of gut microbes and their metabolites in a wide array of seemingly diverse brain issues including Alzheimer’s disease autism multiple sclerosis and mood disorders. In addition mechanisms defining these relationships are explored along with a presentation of the state-of-the-art as it relates to interpretation of relevant laboratory assessments. Finally novel therapeutic opportunities derived from this exciting science are presented. Readers will learn:The highly validated relationship between alterations of gut microbes and their metabolites and risk for Alzheimer’s disease. The important link between autism and intestinal dysbiosis. Appropriate interpretation of available laboratory assessments of the intestinal microbiome. The potential role of fecal microbial transplant in neurological diseases. The influence of diet and other lifestyle choices on the microbiome as it relates to brain health and functionality.

GBP 44.99
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Probiotics in Mental Health

Probiotics in Mental Health

The concept that the gut and brain are intricately linked is widely accepted not just within the lay community but increasingly within scientific and therapeutic circles as well. Terms such as heartache and gut wrenching are more than mere metaphor they represent key fundamental aspects of human experience which all individuals will invariably endure from time to time. The relationship between the gut and brain is complex but fundamental to health and wellbeing. Increasing and compelling evidence supports the existence of a relationship between the health and status of the gut and the manifestation of significant psychopathology. Uniquely within the field of mental health and psychiatry the role of gut flora and probiotics in both the understanding and treatment of mental illness represents an emerging science whether the potential for therapeutic intervention through the use of probiotics offers an opportunity to determine efficacy within a coherent evidence-based model of both action and pathology or moreover offers interventions that are comparatively benign compared to the side-effect profile associated with most drugs used to treat mental illness. Probiotics in Mental Health examines the role of probiotics in a range of clinical presentations associated with significant psychopathology and facilitates a reconsideration of how mental illness may be conceptualised within a coherent gut-brain model of health and wellbeing. Under the rubric of enhancing wellbeing rather than dwelling on illness and disease this exciting new volume not only comprises the latest evidence in the field but also advocates an approach characterised by the understanding of mental disorder within an evidence-based model and the pursuit of mental health and wellbeing through the most benign of interventions.

GBP 44.99
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Test Quality for Construction Materials and Structures Proceedings of the International RILEM/ILAC Symposium

Microbial Diversity in Honeybees

Nutrition and Cardiometabolic Health

Need-to-Know NAFLD The Complete Guide to Nonalcoholic Fatty Liver Disease

Need-to-Know NAFLD The Complete Guide to Nonalcoholic Fatty Liver Disease

Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the obesity and metabolic syndrome epidemics which this up-to-date book deals with comprehensively. The contents outline disease mechanisms diagnostic tests management varying manifestations and special populations. It covers the mechanistic pathways that contribute to NAFLD development including the role of genetic variants and the gut microbiome. It elaborates on noninvasive diagnostic tests to screen for NAFLD determine its severity and monitor response to lifestyle intervention and pharmacologic treatment. This book helps clinicians diagnose and treat this common and potentially deadly disease. Key Features: Reviews current drugs in development and provides practical advice to clinicians on the diagnosis and management of fatty liver. Proves attractive to primary care providers who are on the front line of managing patients with NAFLD to gastroenterologists and hepatologists who would benefit from updated data on how to risk-stratify patients and identify those who will be eligible for pharmacologic treatment and other specialists such as cardiologists endocrinologists and nephrologists who will find this book to be a useful reference on the extrahepatic manifestations of NAFLD. Focuses on extrahepatic manifestations and new insights on the mechanistic drivers of the disease. | Need-to-Know NAFLD The Complete Guide to Nonalcoholic Fatty Liver Disease

GBP 69.99
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Handbook of Prebiotics

Handbook of Prebiotics

In order to achieve optimal digestion absorption and nutritional health we must have appropriate populations of positive microflora. Prebiotics are functional foods that improve health by fortifying indigenous probiotics within the gut. This fast-growing area of nutrition and microbiology is rapidly amassing data and answering many questions about the necessity and benefit of such functional foods. Gathering contributions from leading experts in a range of disciplines Handbook of Prebiotics presents a balanced view of the current knowledge in many different areas of the field. It discusses concept definition and criteria for classification of a food component as prebiotics It then describes interactions with gut microbiota. Highlighting varying levels of evidence and agreement the book presents current arguments for and against prebiotic intake. Contributions discuss the biomechanics of prebiotics and their effects on immune status serum lipid concentrations mineral bioavailability and satiety modulation. They consider the health implications of prebiotic intake such as reduced incidence of gastroenteritis and chronic pathogenic gut disorders including intestinal cancers and inflammatory bowel diseases. Providing well-rounded coverage the book explores the varying effects of prebiotics in different populations and age groups such as infants and the elderly as well as livestock and pets. The final chapters describe food avenues and the safety implications for prebiotic use. Spanning several disciplines including food science nutrition microbiology biotechnology and the health sciences this seminal work makes a point to include sound research science and well-balanced views on the potential of prebiotics for promoting good health.

GBP 59.99
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Nutrition and Integrative Medicine A Primer for Clinicians

Introduction to Nutrition and Metabolism

Introduction to Nutrition and Metabolism

Introduction to Nutrition and Metabolism equips readers with an understanding of the scientific basis of what we call a healthy diet. Now in its sixth edition this highly recognized textbook provides clear explanations of how nutrients are metabolized and gives the principles of biochemistry needed for comprehending the science of nutrition. This full-color textbook explores the need for food and the uses to which food is put in the body as well as the interactions between health and diet. Outlining the scientific basis behind nutritional requirements and recommendations this new edition has been extensively revised to reflect current knowledge. Features: Lists key objectives at the beginning and summary points at the end of each chapter. Accompanying online resources include interactive tutorial exercises based on interpretation of clinical and research data. Covers topics including: Chemical reactions and catalysis by enzymes; the role of ATP; digestion and absorption of carbohydrates fats and proteins; issues associated with being overweight; problems of malnutrition; diet and health; and vitamin and mineral requirements and functions. Updated sections focus on the interaction of the gut microbiome and epigenetics with our metabolic responses to diet. Provides a foundation of scientific knowledge for the interpretation and evaluation of future advances in nutrition and health sciences. Following its predecessors this sixth edition is relevant to any student or practitioner interested in how diet influences our health including in the fields of nutrition dietetics medicine and public health.

GBP 66.99
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Data Plane Development Kit (DPDK) A Software Optimization Guide to the User Space-Based Network Applications

The Ergonomics Kit for General Industry

The Ergonomics Kit for General Industry

Written by Dan MacLeod one of the most experienced practitioners in the field The Ergonomics Kit for General Industry Second Edition contains everything you need to set up or improve your workplace ergonomics process. MacLeod describes the financial benefits of workplace ergonomics and ways to think about these tools that make good business sense. He uses case studies that illustrate positive bottom-line results and the actions that led to these results. Down to earth and practical the information in this book is rooted in what has actually succeeded on the workplace floor. See what's new in the Second Edition:Additional material on the actual process of solving problemsSuccess stories illustrate how the process works under various circumstances and organizational cultures to improve workplace conditions and maximize employee well being and productivityEmphasizes simple low tech and low cost approachesGuidance on how to create change and implement new processesElectronic copies of forms and worksheets PowerPoint presentation and guide for conducting basic training sessions available on the InternetThe book provides practical guidance on the process of identifying good low cost improvements. It describes best practices from major corporations on setting up committees establishing priorities and developing written plans and also covers controversial issues such as job rotation and back belts. The kit includes a multitude of forms: worksheets checklists planning guides employee feedback forms and a program audit as well as training handouts train-the-trainer background and basic PowerPoint presentations. Drawing on more than 30 years of experience the author delineates how to set up an effective and successful ergonomics program.

GBP 56.99
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Microbiomes and Their Functions Why Organisms Need Microbes

Microbiomes and Their Functions Why Organisms Need Microbes

This book provides a fundamental understanding of the importance of the microbiome in the life of virtually all multicellular organisms. It explains why microbes are an integral part of living organisms and describes the diverse roles they perform for their hosts. Although the significance of modified bacteria such as the mitochondrion and chloroplast is deeply rooted in the evolution of all complex organisms it is only recently that the contribution of microbial partners within and on their hosts is becoming fully evident. These communities of microbes are as essential to organisms as are the visible organs. Microbiomes are indeed “invisible organs. ” They participate in the digestive process assist in communication networks supply essential nutrients guard against foreign intrusion promote development and contribute to well-being. This unique approach where the dependence of the hosts on their microbiomes is explained will be a must-read for undergraduate and graduate students. Researchers and professionals probing microbial interactions with living organisms will find this book interesting and enriching. Key Features Emphasizes the roles microbiomes play within their hosts Includes many captivating illustrations enabling easy comprehension Explains microbiome functions from algae to vertebrates Reveals how microbiomes contribute to the health of the hosts and the ecosystems Describes the impact of dysbiosis on diseases food security and climate change Boxed sections provide a detailed analysis of concepts and are accompanied by vivid illustrations | Microbiomes and Their Functions Why Organisms Need Microbes

GBP 59.99
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Handbook Of Applied Econometrics And Statistical Inference

Reliability Analysis with Minitab

Reliability Analysis with Minitab

Statistical Analysis for the Reliability Engineering ProfessionalEffectively conduct reliability analysis using the world’s leading statistical software. Reliability Analysis with Minitab® outlines statistical concepts and applications explains the theory of probability reliability analysis and quality improvement and provides step-by-step instruction on the use of Minitab. Minitab introduces reliability analysis tools that can be used to perform tasks that range from checking the distribution fit of lifetime data to estimating the warranty costs of a product. Perform the Analyses Needed to Minimize Product Failures and Reduce CostsChock full of examples that include numerous case studies and over 200 screenshots this book is a comprehensive guide to quality and reliability in the service and manufacturing industries. It illustrates the shapes of the most commonly used statistical distributions in reliability analysis and in simple language demonstrates concepts that include parametric reliability analysis nonparametric reliability analysis warranty analysis accelerated life testing reliability test plans and probit analysis. Illustrating the application of Minitab for reliability analysis this book explains how to: Perform reliability analysis of a product with right-censored and exact failure time data Complete reliability analysis of a product with arbitrarily censored failure time dataAchieve nonparametric reliability analysis of a productPredict the amount of money that is needed to cover the warranty costs for products in a specific period of time in the futureAnalyze the results from accelerated life testing on two different productsDetermine the reliability test sample size when the test time and the number of failures are constrainedRegulate the testing time when test sample size and the number of failures are constrainedCompare the reliabilities of parts from different vendorsTest whether the reliability of a product depends on certain factorsPredict the stress level at which a product will fail after a certain test period

GBP 44.99
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Asphalt Mixture Specification and Testing

Handbook of Geotechnical Testing: Basic Theory Procedures and Comparison of Standards

Lactic Acid Bacteria A Functional Approach

Drug Discovery and Development Third Edition

Drug Discovery and Development Third Edition

Drug Discovery and Development Third Edition presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies biotechnology approaches and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology regulatory and business aspects of bringing new drugs to the market and offers coverage of essential topics for companies involved in drug development. Historical perspectives and predicted trends are also provided. Features:Highlights emerging scientific fields relevant to drug discovery such as the microbiome nanotechnology and cancer immunotherapy; and novel research tools such as CRISPR and DNA-encoded librariesCase study detailing the discovery of the anti-cancer drug lorlatinibVenture capitalist commentary on trends and best practices in drug discovery and developmentComprehensive review of regulations and their impact on drug development highlighting special populations orphan drugs and pharmaceutical compoundingMultidiscipline functioning of an Academic Research Enterprise plus a chapter on Ethical Concerns in ResearchContributions by 70+ experts from industry and academia specialists who developed and are practitioners of the science and business

GBP 44.99
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Clean Room Design Minimizing Contamination Through Proper Design

Safety Pharmacology in Pharmaceutical Development Approval and Post Marketing Surveillance Second Edition

Melatonin in the Promotion of Health

Melatonin in the Promotion of Health

Melatonin is a powerful hormone and antioxidant with numerous effects on the metabolism and the health of humans. Available as a dietary supplement in the United States since 1993 it is one of the most popular over-the-counter alternative remedies available. Comprising contributions from researchers who have studied the role of melatonin in various disease and physiological states Melatonin in the Promotion of Health Second Edition provides a wide variety of expert reviews on the biology of melatonin relevant to health. Beginning with a history of melatonin and its relation to circadian rhythms the book examines its use in a host of applications including: Gut motility and gastrointestinal diseases Anesthesia and surgery Bone health Breast cancer Cardiovascular diseases Diabetes Age-related macular degeneration and uveitis Melanoma solar skin damage and collagen synthesis The prevention of DNA damage Mental disorders sleep and issues related to jet lag and shift work The data gathered from a large number of carefully controlled animal and human studies have clearly implicated melatonin in the control mechanisms of a wide variety of physiological and psychological activities making it a potent candidate for therapeutic use in the treatment of a diverse range of diseases. This volume demonstrates that continued studies of this molecule raise the exciting prospect of providing new avenues of treating numerous diseases more effectively and with less side-effects than those found in conventional treatment modalities.

GBP 69.99
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Quality Control Training Manual Comprehensive Training Guide for API Finished Pharmaceutical and Biotechnologies Laboratories

Quality Control Training Manual Comprehensive Training Guide for API Finished Pharmaceutical and Biotechnologies Laboratories

Written to help companies comply with GMP GLP and validation requirements imposed by the FDA and regulatory bodies worldwide Quality Control Training Manual: Comprehensive Training Guide for API Finished Pharmaceutical and Biotechnologies Laboratories presents cost-effective training courses that cover how to apply advances in the life sciences to produce commercially viable biotech products and services in terms of quality safety and efficacy. This book and its accompanying downloadable resources comprise detailed text summaries test papers and answers to test papers providing an administrative solution for management. Provides the FDA Health Canada WHO and EMEA guidelines directly applicable to pharmaceutical laboratory-related issuesOffers generic formats and styles that can be customized to any organization and help management build quality into routine operations to comply with regulatory requirementsContains ready-to-use training courses that supply a good source of training material for experienced and inexperienced practitioners in the biotechnology/biopharmaceutical industriesIncludes downloadable resources with downloadable training courses that can be adopted and directly customized to a particular organizationSupplies ready-to-use test papers that allow end users to record all raw data up to the issuance of the attached certificateThe biotechnology/bioscience industries are regulated worldwide to be in compliance with cGMP and GLP principles with particular focus on safety issues. Each company must create a definite training matrix of its employees. The training procedures in this book enable end users to understand the principles and elements of manufacturing techniques and provide documentation language ranging from the generic to the specific. The training courses on the downloadable resources supply valuable tools for developing training matrices to achieve FDA Health Canada EMEA MHRA UK WHO and GLP compliance. | Quality Control Training Manual Comprehensive Training Guide for API Finished Pharmaceutical and Biotechnologies Laboratories

GBP 52.99
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