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Sequential Analysis Hypothesis Testing and Changepoint Detection

Sequential Analysis Hypothesis Testing and Changepoint Detection

Sequential Analysis: Hypothesis Testing and Changepoint Detection systematically develops the theory of sequential hypothesis testing and quickest changepoint detection. It also describes important applications in which theoretical results can be used efficiently. The book reviews recent accomplishments in hypothesis testing and changepoint detection both in decision-theoretic (Bayesian) and non-decision-theoretic (non-Bayesian) contexts. The authors not only emphasize traditional binary hypotheses but also substantially more difficult multiple decision problems. They address scenarios with simple hypotheses and more realistic cases of two and finitely many composite hypotheses. The book primarily focuses on practical discrete-time models with certain continuous-time models also examined when general results can be obtained very similarly in both cases. It treats both conventional i. i. d. and general non-i. i. d. stochastic models in detail including Markov hidden Markov state-space regression and autoregression models. Rigorous proofs are given for the most important results. Written by leading authorities in the field this book covers the theoretical developments and applications of sequential hypothesis testing and sequential quickest changepoint detection in a wide range of engineering and environmental domains. It explains how the theoretical aspects influence the hypothesis testing and changepoint detection problems as well as the design of algorithms. | Sequential Analysis Hypothesis Testing and Changepoint Detection

GBP 44.99
1

Statistical Testing Strategies in the Health Sciences

Statistical Testing Strategies in the Health Sciences

Statistical Testing Strategies in the Health Sciences provides a compendium of statistical approaches for decision making ranging from graphical methods and classical procedures through computationally intensive bootstrap strategies to advanced empirical likelihood techniques. It bridges the gap between theoretical statistical methods and practical procedures applied to the planning and analysis of health-related experiments. The book is organized primarily based on the type of questions to be answered by inference procedures or according to the general type of mathematical derivation. It establishes the theoretical framework for each method with a substantial amount of chapter notes included for additional reference. It then focuses on the practical application for each concept providing real-world examples that can be easily implemented using corresponding statistical software code in R and SAS. The book also explains the basic elements and methods for constructing correct and powerful statistical decision-making processes to be adapted for complex statistical applications. With techniques spanning robust statistical methods to more computationally intensive approaches this book shows how to apply correct and efficient testing mechanisms to various problems encountered in medical and epidemiological studies including clinical trials. Theoretical statisticians medical researchers and other practitioners in epidemiology and clinical research will appreciate the book’s novel theoretical and applied results. The book is also suitable for graduate students in biostatistics epidemiology health-related sciences and areas pertaining to formal decision-making mechanisms.

GBP 44.99
1

Handbook of Statistical Methods for Randomized Controlled Trials

Handbook of Statistical Methods for Randomized Controlled Trials

Statistical concepts provide scientific framework in experimental studies including randomized controlled trials. In order to design monitor analyze and draw conclusions scientifically from such clinical trials clinical investigators and statisticians should have a firm grasp of the requisite statistical concepts. The Handbook of Statistical Methods for Randomized Controlled Trials presents these statistical concepts in a logical sequence from beginning to end and can be used as a textbook in a course or as a reference on statistical methods for randomized controlled trials. Part I provides a brief historical background on modern randomized controlled trials and introduces statistical concepts central to planning monitoring and analysis of randomized controlled trials. Part II describes statistical methods for analysis of different types of outcomes and the associated statistical distributions used in testing the statistical hypotheses regarding the clinical questions. Part III describes some of the most used experimental designs for randomized controlled trials including the sample size estimation necessary in planning. Part IV describe statistical methods used in interim analysis for monitoring of efficacy and safety data. Part V describe important issues in statistical analyses such as multiple testing subgroup analysis competing risks and joint models for longitudinal markers and clinical outcomes. Part VI addresses selected miscellaneous topics in design and analysis including multiple assignment randomization trials analysis of safety outcomes non-inferiority trials incorporating historical data and validation of surrogate outcomes.

GBP 59.99
1

Software Engineering for Science

Software Engineering for Science

Software Engineering for Science provides an in-depth collection of peer-reviewed chapters that describe experiences with applying software engineering practices to the development of scientific software. It provides a better understanding of how software engineering is and should be practiced and which software engineering practices are effective for scientific software. The book starts with a detailed overview of the Scientific Software Lifecycle and a general overview of the scientific software development process. It highlights key issues commonly arising during scientific software development as well as solutions to these problems. The second part of the book provides examples of the use of testing in scientific software development including key issues and challenges. The chapters then describe solutions and case studies aimed at applying testing to scientific software development efforts. The final part of the book provides examples of applying software engineering techniques to scientific software including not only computational modeling but also software for data management and analysis. The authors describe their experiences and lessons learned from developing complex scientific software in different domains. About the EditorsJeffrey Carver is an Associate Professor in the Department of Computer Science at the University of Alabama. He is one of the primary organizers of the workshop series on Software Engineering for Science (http://www. SE4Science. org/workshops). Neil P. Chue Hong is Director of the Software Sustainability Institute at the University of Edinburgh. His research interests include barriers and incentives in research software ecosystems and the role of software as a research object. George K. Thiruvathukal is Professor of Computer Science at Loyola University Chicago and Visiting Faculty at Argonne National Laboratory. His current research is focused on software metrics in open source mathematical and scientific software.

GBP 44.99
1

Statistics for Technology A Course in Applied Statistics Third Edition

Machine Learning for Factor Investing Python Version

Machine Learning for Factor Investing Python Version

Machine learning (ML) is progressively reshaping the fields of quantitative finance and algorithmic trading. ML tools are increasingly adopted by hedge funds and asset managers notably for alpha signal generation and stocks selection. The technicality of the subject can make it hard for non-specialists to join the bandwagon as the jargon and coding requirements may seem out-of-reach. Machine learning for factor investing: Python version bridges this gap. It provides a comprehensive tour of modern ML-based investment strategies that rely on firm characteristics. The book covers a wide array of subjects which range from economic rationales to rigorous portfolio back-testing and encompass both data processing and model interpretability. Common supervised learning algorithms such as tree models and neural networks are explained in the context of style investing and the reader can also dig into more complex techniques like autoencoder asset returns Bayesian additive trees and causal models. All topics are illustrated with self-contained Python code samples and snippets that are applied to a large public dataset that contains over 90 predictors. The material is available online so that readers can reproduce and enhance the examples at their convenience. If you have even a basic knowledge of quantitative finance this combination of theoretical concepts and practical illustrations will help you learn quickly and deepen your financial and technical expertise. | Machine Learning for Factor Investing Python Version

GBP 66.99
1

Quantitative Methods for Traditional Chinese Medicine Development

Quantitative Methods for Traditional Chinese Medicine Development

A Western-Based Approach to Analyzing TCMsIn recent years many pharmaceutical companies and clinical research organizations have been focusing on the development of traditional Chinese (herbal) medicines (TCMs) as alternatives to treating critical or life-threatening diseases and as pathways to personalized medicine. Quantitative Methods for Traditional Chinese Medicine Development is the first book entirely devoted to the design and analysis of TCM development from a Western perspective i. e. evidence-based clinical research and development. The book provides not only a comprehensive summary of innovative quantitative methods for developing TCMs but also a useful desk reference for principal investigators involved in personalized medicine. Written by one of the world’s most prominent biostatistics researchers the book connects the pharmaceutical industry regulatory agencies and academia. It presents a state-of-the-art examination of the subject for:Scientists and researchers who are engaged in pharmaceutical/clinical research and development of TCMsThose in regulatory agencies who make decisions in the review and approval process of TCM regulatory submissions Biostatisticians who provide statistical support to assess clinical safety and effectiveness of TCMs and related issues regarding quality control and assurance as well as to test for consistency in the manufacturing processes for TCMsThis book covers all of the statistical issues encountered at various stages of pharmaceutical/clinical development of a TCM. It explains regulatory requirements; product specifications and standards; and various statistical techniques for evaluation of TCMs validation of diagnostic procedures and testing consistency. It also contains an entire chapter of case studies and addresses critical issues in TCM development and FAQs from a

GBP 59.99
1

Machine Learning for Factor Investing: R Version

Machine Learning for Factor Investing: R Version

Machine learning (ML) is progressively reshaping the fields of quantitative finance and algorithmic trading. ML tools are increasingly adopted by hedge funds and asset managers notably for alpha signal generation and stocks selection. The technicality of the subject can make it hard for non-specialists to join the bandwagon as the jargon and coding requirements may seem out of reach. Machine Learning for Factor Investing: R Version bridges this gap. It provides a comprehensive tour of modern ML-based investment strategies that rely on firm characteristics. The book covers a wide array of subjects which range from economic rationales to rigorous portfolio back-testing and encompass both data processing and model interpretability. Common supervised learning algorithms such as tree models and neural networks are explained in the context of style investing and the reader can also dig into more complex techniques like autoencoder asset returns Bayesian additive trees and causal models. All topics are illustrated with self-contained R code samples and snippets that are applied to a large public dataset that contains over 90 predictors. The material along with the content of the book is available online so that readers can reproduce and enhance the examples at their convenience. If you have even a basic knowledge of quantitative finance this combination of theoretical concepts and practical illustrations will help you learn quickly and deepen your financial and technical expertise.

GBP 66.99
1

The Weibull Distribution A Handbook

Probability and Statistics for Computer Scientists

Probability and Statistics for Computer Scientists

Praise for the Second Edition: The author has done his homework on the statistical tools needed for the particular challenges computer scientists encounter. [He] has taken great care to select examples that are interesting and practical for computer scientists. . The content is illustrated with numerous figures and concludes with appendices and an index. The book is erudite and … could work well as a required text for an advanced undergraduate or graduate course. Computing Reviews Probability and Statistics for Computer Scientists Third Edition helps students understand fundamental concepts of Probability and Statistics general methods of stochastic modeling simulation queuing and statistical data analysis; make optimal decisions under uncertainty; model and evaluate computer systems; and prepare for advanced probability-based courses. Written in a lively style with simple language and now including R as well as MATLAB this classroom-tested book can be used for one- or two-semester courses. Features: Axiomatic introduction of probability Expanded coverage of statistical inference and data analysis including estimation and testing Bayesian approach multivariate regression chi-square tests for independence and goodness of fit nonparametric statistics and bootstrap Numerous motivating examples and exercises including computer projects Fully annotated R codes in parallel to MATLAB Applications in computer science software engineering telecommunications and related areas In-Depth yet Accessible Treatment of Computer Science-Related TopicsStarting with the fundamentals of probability the text takes students through topics heavily featured in modern computer science computer engineering software engineering and associated fields such as computer simulations Monte Carlo methods stochastic processes Markov chains queuing theory statistical inference and regression. It also meets the requirements of the Accreditation Board for Engineering and Technology (ABET). About the Author Michael Baron is David Carroll Professor of Mathematics and Statistics at American University in Washington D. C. He conducts research in sequential analysis and optimal stopping change-point detection Bayesian inference and applications of statistics in epidemiology clinical trials semiconductor manufacturing and other fields. M. Baron is a Fellow of the American Statistical Association and a recipient of the Abraham Wald Prize for the best paper in Sequential Analysis and the Regents Outstanding Teaching Award. M. Baron holds a Ph. D. in statistics from the University of Maryland. In his turn he supervised twelve doctoral students mostly employed on academic and research positions.

GBP 99.99
1

Innovative Strategies Statistical Solutions and Simulations for Modern Clinical Trials

Innovative Strategies Statistical Solutions and Simulations for Modern Clinical Trials

This is truly an outstanding book. [It] brings together all of the latest research in clinical trials methodology and how it can be applied to drug development…. Chang et al provide applications to industry-supported trials. This will allow statisticians in the industry community to take these methods seriously. Jay Herson Johns Hopkins UniversityThe pharmaceutical industry's approach to drug discovery and development has rapidly transformed in the last decade from the more traditional Research and Development (R & D) approach to a more innovative approach in which strategies are employed to compress and optimize the clinical development plan and associated timelines. However these strategies are generally being considered on an individual trial basis and not as part of a fully integrated overall development program. Such optimization at the trial level is somewhat near-sighted and does not ensure cost time or development efficiency of the overall program. This book seeks to address this imbalance by establishing a statistical framework for overall/global clinical development optimization and providing tactics and techniques to support such optimization including clinical trial simulations. Provides a statistical framework for achieve global optimization in each phase of the drug development process. Describes specific techniques to support optimization including adaptive designs precision medicine survival-endpoints dose finding and multiple testing. Gives practical approaches to handling missing data in clinical trials using SAS. Looks at key controversial issues from both a clinical and statistical perspective. Presents a generous number of case studies from multiple therapeutic areas that help motivate and illustrate the statistical methods introduced in the book. Puts great emphasis on software implementation of the statistical methods with multiple examples of software code (both SAS and R). It is important for statisticians to possess a deep knowledge of the drug development process beyond statistical considerations. For these reasons this book incorporates both statistical and clinical/medical perspectives. | Innovative Strategies Statistical Solutions and Simulations for Modern Clinical Trials

GBP 44.99
1

Introduction to Bioinformatics with R A Practical Guide for Biologists

Introduction to Bioinformatics with R A Practical Guide for Biologists

In biological research the amount of data available to researchers has increased so much over recent years it is becoming increasingly difficult to understand the current state of the art without some experience and understanding of data analytics and bioinformatics. An Introduction to Bioinformatics with R: A Practical Guide for Biologists leads the reader through the basics of computational analysis of data encountered in modern biological research. With no previous experience with statistics or programming required readers will develop the ability to plan suitable analyses of biological datasets and to use the R programming environment to perform these analyses. This is achieved through a series of case studies using R to answer research questions using molecular biology datasets. Broadly applicable statistical methods are explained including linear and rank-based correlation distance metrics and hierarchical clustering hypothesis testing using linear regression proportional hazards regression for survival data and principal component analysis. These methods are then applied as appropriate throughout the case studies illustrating how they can be used to answer research questions. Key Features: · Provides a practical course in computational data analysis suitable for students or researchers with no previous exposure to computer programming. · Describes in detail the theoretical basis for statistical analysis techniques used throughout the textbook from basic principles · Presents walk-throughs of data analysis tasks using R and example datasets. All R commands are presented and explained in order to enable the reader to carry out these tasks themselves. · Uses outputs from a large range of molecular biology platforms including DNA methylation and genotyping microarrays; RNA-seq genome sequencing ChIP-seq and bisulphite sequencing; and high-throughput phenotypic screens. · Gives worked-out examples geared towards problems encountered in cancer research which can also be applied across many areas of molecular biology and medical research. This book has been developed over years of training biological scientists and clinicians to analyse the large datasets available in their cancer research projects. It is appropriate for use as a textbook or as a practical book for biological scientists looking to gain bioinformatics skills. | Introduction to Bioinformatics with R A Practical Guide for Biologists

GBP 52.99
1

An Introduction to Nonparametric Statistics

Accelerated Life Models Modeling and Statistical Analysis

Statistical Design and Analysis of Stability Studies

Statistical Design and Analysis of Stability Studies

The US Food and Drug Administration's Report to the Nation in 2004 and 2005 indicated that one of the top reasons for drug recall was that stability data did not support existing expiration dates. Pharmaceutical companies conduct stability studies to characterize the degradation of drug products and to estimate drug shelf life. Illustrating how stability studies play an important role in drug safety and quality assurance Statistical Design and Analysis of Stability Studies presents the principles and methodologies in the design and analysis of stability studies. After introducing the basic concepts of stability testing the book focuses on short-term stability studies and reviews several methods for estimating drug expiration dating periods. It then compares some commonly employed study designs and discusses both fixed and random batch statistical analyses. Following a chapter on the statistical methods for stability analysis under a linear mixed effects model the book examines stability analyses with discrete responses multiple components and frozen drug products. In addition the author provides statistical methods for dissolution testing and explores current issues and recent developments in stability studies. To ensure the safety of consumers professionals in the field must carry out stability studies to determine the reliability of drug products during their expiration period. This book provides the material necessary for you to perform stability designs and analyses in pharmaceutical research and development.

GBP 44.99
1

Python for Beginners

Python for Beginners

Python is an amazing programming language. It can be applied to almost any programming task. It allows for rapid development and debugging. Getting started with Python is like learning any new skill: it’s important to find a resource you connect with to guide your learning. Luckily there’s no shortage of excellent books that can help you learn both the basic concepts of programming and the specifics of programming in Python. With the abundance of resources it can be difficult to identify which book would be best for your situation. Python for Beginners is a concise single point of reference for all material on python. Provides concise need-to-know information on Python types and statements special method names built-in functions and exceptions commonly used standard library modules and other prominent Python tools Offers practical advice for each major area of development with both Python 3. x and Python 2. x Based on the latest research in cognitive science and learning theory Helps the reader learn how to write effective idiomatic Python code by leveraging its best—and possibly most neglected—features This book focuses on enthusiastic research aspirants who work on scripting languages for automating the modules and tools development of web applications handling big data complex calculations workflow creation rapid prototyping and other software development purposes. It also targets graduates postgraduates in computer science information technology academicians practitioners and research scholars.

GBP 120.00
1

A Course in the Large Sample Theory of Statistical Inference

Project-Based R Companion to Introductory Statistics

Project-Based R Companion to Introductory Statistics

Project-Based R Companion to Introductory Statistics is envisioned as a companion to a traditional statistics or biostatistics textbook with each chapter covering traditional topics such as descriptive statistics regression and hypothesis testing. However unlike a traditional textbook each chapter will present its material using a complete step-by-step analysis of a real publicly available dataset with an emphasis on the practical skills of testing assumptions data exploration and forming conclusions. The chapters in the main body of the book include a worked example showing the R code used at each step followed by a multi-part project for students to complete. These projects which could serve as alternatives to traditional discrete homework problems will illustrate how to put the pieces together and conduct a complete start-to-finish data analysis using the R statistical software package. At the end of the book there are several projects that require the use of multiple statistical techniques that could be used as a take-home final exam or final project for a class. Key features of the text: Organized in chapters focusing on the same topics found in typical introductory statistics textbooks (descriptive statistics regression two-way tables hypothesis testing for means and proportions etc. ) so instructors can easily pair this supplementary material with course plans Includes student projects for each chapter which can be assigned as laboratory exercises or homework assignments to supplement traditional homework Features real-world datasets from scientific publications in the fields of history pop culture business medicine and forensics for students to analyze Allows students to gain experience working through a variety of statistical analyses from start to finish The book is written at the undergraduate level to be used in an introductory statistical methods course or subject-specific research methods course such as biostatistics or research methods for psychology or business analytics. Author After a 10-year career as a research biostatistician in the Department of Ophthalmology and Visual Sciences at the University of Wisconsin-Madison Chelsea Myers teaches statistics and biostatistics at Rollins College and Valencia College in Central Florida. She has authored or co-authored more than 30 scientific papers and presentations and is the creator of the MCAT preparation website MCATMath. com.

GBP 48.99
1

C++ for Financial Mathematics

Python for Bioinformatics

Component-Based Software Engineering Methods and Metrics

Component-Based Software Engineering Methods and Metrics

This book focuses on a specialized branch of the vast domain of software engineering: component-based software engineering (CBSE). Component-Based Software Engineering: Methods and Metrics enhances the basic understanding of components by defining categories characteristics repository interaction complexity and composition. It divides the research domain of CBSE into three major sub-domains: (1) reusability issues (2) interaction and integration issues and (3) testing and reliability issues. This book covers the state-of-the-art literature survey of at least 20 years in the domain of reusability interaction and integration complexities and testing and reliability issues of component-based software engineering. The aim of this book is not only to review and analyze the previous works conducted by eminent researchers academicians and organizations in the context of CBSE but also suggests innovative efficient and better solutions. A rigorous and critical survey of traditional and advanced paradigms of software engineering is provided in the book. Features: In-interactions and Out-Interactions both are covered to assess the complexity. In the context of CBSE both white-box and black-box testing methods and their metrics are described. This work covers reliability estimation using reusability which is an innovative method. Case studies and real-life software examples are used to explore the problems and their solutions. Students research scholars software developers and software designers or individuals interested in software engineering especially in component-based software engineering can refer to this book to understand the concepts from scratch. These measures and metrics can be used to estimate the software before the actual coding commences. | Component-Based Software Engineering Methods and Metrics

GBP 105.00
1

Geometry for the Artist

Artificial Intelligence for Autonomous Networks

Metamodeling for Variable Annuities

Numerical Methods for Finance