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Research Methodologies for Beginners

Research Methodologies for Beginners

This textbook introduces the general points of view of research methodology in the scientific and engineering fields of studies and presents an overview of the technical and professional communication needed for article publication in journals. It comprises several practice exercises that will give beginners the confidence to move on the communicative activities. Every chapter provides problem sets that will help readers check their understanding of each concept. The book will also help readers formulate specific research topics research questions and hypotheses; conduct literature reviews relevant to the research topics; develop applicable research methodologies; and write and present their research outlining the key elements of the proposed projects. It is very useful for students and researchers opting for a course on research methodology and for seminars at undergraduate and graduate levels. | Research Methodologies for Beginners

GBP 44.99
1

Neuroscience for Artificial Intelligence

Neuroscience for Artificial Intelligence

The ongoing boom of applications for artificial intelligence (AI) is based on algorithms that were inspired by neuroscience discoveries in the 1960s. This is a timely book to introduce the new discoveries and ideas in neuroscience for the next wave of more powerful AI. AI researchers are all interested in the human brain which is more capable and energy-efficient but do not have good reading materials from the rather separate subfields of neuroscience all with plenty of jargons. Based on hundreds of publications from top journals the book fills in the gap between existing computational hardware/algorithms and emerging knowledge from neuroscience. | Neuroscience for Artificial Intelligence

GBP 116.00
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Nanomaterials for Spectroscopic Applications

Nanomaterials for Spectroscopic Applications

This book provides an overview of key current developments in the synthetic strategy of functional novel nanomaterials in various spectroscopic characterizations and evaluations and highlights possible future applications in nanotechnology and materials science. It illustrates the wide-ranging interest in these areas and provides a background to the later chapters which address the novel synthesis of high-yield nanomaterials and their biomaterials graphene polymeric nanomaterials green nanomaterials green polyester liquid crystal electro-optic switching applications nanobiotechnology transition metal oxides response characteristics of exclusive spectroscopic investigation as well as electron microscopic study flexible and transparent electrodes optoelectronics nanoelectronics smart displays switchable device modulation health care energy storage solar/fuel cells environmental and plant biology social ethical and regulatory implications of various aspects of green nanotechnology as well as significant foreseeable spectroscopic applications of key functional nanomaterials. Given appropriate regulation for and research on the topics covered commercial production of manufactured novel composite materials can be realized. Furthermore the many discoveries highlighted in the book can modulate spectroscopic performances with technical excellence in multidisciplinary research of high competence. | Nanomaterials for Spectroscopic Applications

GBP 116.00
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Cancer Genetics and Genomics for Personalized Medicine

Cancer Genetics and Genomics for Personalized Medicine

This book covers almost all fields of cancer genetics and genomics for personalized medicine. Targeted therapy or precision medicine or personalized medicine is becoming a standard treatment for many diseases including cancer. However how much do we know about the personalized medicine approach? This lucid book helps undergraduate and graduate students professional researchers and clinicians to better understand the key concept of personalized medicine. The most up-to-date topics on personalized medicine in this book cover the recent trends in and updates on lung gastric liver breast and other types of cancers. Circulating tumor cell cell-free circulating DNA and microRNAs are discussed as new diagnostic and prognostic markers for cancer. The avatar mouse model is also discussed for maximizing treatment efficacy and prognosis prediction and so is microenvironment as a drug resistance mechanism. With classical and new pathological approaches the book provides a systemic overview of personalized immunotherapies and hyperthermic intraperitoneal chemotherapy followed by new emerging fields of hereditary cancer thereby equipping readers to eventually contribute in developing more advanced tools and therapies for curing cancer.

GBP 108.00
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Mobile Microspies Particles for Sensing and Communication

Mobile Microspies Particles for Sensing and Communication

On the one hand particle-based sensing techniques are driven by new technologies for preparing and measuring micro- and nanoparticles and by a fascination of the possibilities for design and functionalization of all specificities in structure shapes and behavior of these tiny objects. On the other hand there evolves a fast-growing need for new sensing and communication paths for medicine biotechnology and analytical science as well as for new and efficient information transfer and storage systems. No longer are particles regarded only as special types of materials. However we have a better understanding of how they are bridging the gap between material and system between structure and function. Although there are numerous books on micro- and nanoparticles and on sensors there is to the best of my knowledge no book focusing on the general concept of particles as mobile microtransducers. This book clarifies that signal-transducing particles should be regarded as functional elements as part of a system not simply as special materials. It introduces concepts of bead-base sensing and mobile spies at the micro- and nanoscale and gives a representative overview of the variety of particle-based sensing. The state of the art in the development of particles as mobile spies for communication and information management allows us to speculate about future particle-based components and systems in a completely sustainable world economy. In addition the book reports on a fast-evolving technical field which is a typical example of the required convergence of technical strategies and mechanisms in living nature and would make a great reference for professionals and students of chemistry biochemistry biology pharmacy medicine agriculture mechatronics informatics materials science and systems engineering. | Mobile Microspies Particles for Sensing and Communication

GBP 100.00
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Handbook of Materials for Nanomedicine Lipid-Based and Inorganic Nanomaterials

Handbook of Materials for Nanomedicine Lipid-Based and Inorganic Nanomaterials

In the fast-developing field of nanomedicine a broad variety of materials have been used for the development of advanced delivery systems for drugs genes and diagnostic agents. With the recent breakthroughs in the field we are witnessing a new age of disease management which is governed by precise regulation of dosage and delivery. This book presents the advances in the use of lipid-based and inorganic nanomaterials for medical imaging diagnosis theranostics and drug delivery. The materials discussed include liposome-scaffold systems elastic liposomes targeted liposomes solid lipid nanoparticles lipoproteins exosomes porous inorganic nanomaterials silica nanoparticles and inorganic nanohybrids. The book provides all available information about them and describes in detail their advantages and disadvantages and the areas where they could be utilized successfully. | Handbook of Materials for Nanomedicine Lipid-Based and Inorganic Nanomaterials

GBP 193.00
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Designing Electrolytes for Lithium-Ion and Post-Lithium Batteries

Designing Electrolytes for Lithium-Ion and Post-Lithium Batteries

Every electrochemical source of electric current is composed of two electrodes with an electrolyte in between. Since storage capacity depends predominantly on the composition and design of the electrodes most research and development efforts have been focused on them. Considerably less attention has been paid to the electrolyte a battery’s basic component. This book fills this gap and shines more light on the role of electrolytes in modern batteries. Today limitations in lithium-ion batteries result from non-optimal properties of commercial electrolytes as well as scientific and engineering challenges related to novel electrolytes for improved lithium-ion as well as future post-lithium batteries. | Designing Electrolytes for Lithium-Ion and Post-Lithium Batteries

GBP 116.00
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Three Daughters Three Journeys Quest for Cancer Cure

Three Daughters Three Journeys Quest for Cancer Cure

Cancer threatens the lives of people around the world. Women in particular are at risk of certain cancers with a genetic cause. Certain mutations in the BRCA1 and BRCA2 genes put mothers and daughters at risk of breast and ovarian cancers. Unlike many cancers that most commonly occur after age 60 these inheritable cancers threaten women’s lives health and fertility even when they are young before most would even begin to go for annual mammogram screenings to check for breast cancer. Three Daughters Three Journeys takes on the biggest health issue of our time from a global perspective with three heroines fighting for their lives against cancer. Marzena a Polish oncology nurse has spent her life treating child patients with cancer. Then she confronts it in her own family and her own body. Kamola a rural Indian girl knows she has symptoms of the same disease that took her mother but feels afraid to discuss it with her father and brothers knowing her family cannot afford medical treatment. Kamola confides in Dr Rini Mishra a doctor testing a new treatment called Neelazin using a bacterial anticancer protein in food to destroy cancer cells. Selena a wealthy woman of color in Chicago finds out about her genetic risks of breast and ovarian cancer. She has a choice of preventative surgery that will save her life but remove any chance of having children. As she meets women who struggle to afford cancer treatment Selena dedicates her life to providing affordable homes and counseling to families affected by the disease. Although the drug Neelazin is fictional the possibility of new cancer treatments using bacterial anticancer proteins is being researched now. A problem with the current chemotherapy for cancer treatment is the high toxicity of most of these drugs as these drugs can enter both normal and cancer cells though preferably cancer cells causing the death of normal cells as well that are important in maintaining health. Another problem is that current chemotherapeutic drugs mostly target a single or few key steps that are important for cancer growth and proliferation and inhibit the growth of cancer cells. The cancer cells respond by quickly changing these single targets thereby becoming resistant to the drugs as is reflected in stage IV cancer patients. An alternative to chemotherapy would be to exploit the bacterial evolutionary wisdom and use certain proteins that can have preferential entry to cancer cells in order to minimize normal cell toxicity and multiple targets in cancer cells through protein–protein complex formation thus reducing resistance development in cancer cells. An interesting advantage of protein drugs is to express them as part of food and some recent research seems to suggest that oral consumption of such foods may allow the therapeutic protein to reach the blood stream to target the cancer. Women with the genetic risk factors could soon have the choice of taking a pill or such anticancer protein-expressing food to treat or prevent cancer rather than removing the healthy tissue of the breasts and ovaries. Hopefully they would not have to choose between fertility and survival as is the implied message in this book fictional as it is at this time. | Three Daughters Three Journeys Quest for Cancer Cure

GBP 31.99
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Handbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine

Handbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine

Millions of patients suffer from end-stage organ failure or tissue loss annually and the only solution might be organ and/or tissue transplantation. To avoid poor biocompatibility–related problems and donor organ shortage however around 20 years ago a new hybridized method combining cells and biomaterials was introduced as an alternative to whole-organ and tissue transplantation for diseased failing or malfunctioning organs—regenerative medicine and tissue engineering. This handbook focuses on all aspects of intelligent scaffolds from basic science to industry to clinical applications. Its 10 parts illustrated throughout with excellent figures cover stem cell engineering research drug delivery systems nanomaterials and nanodevices and novel and natural biomaterials. The book can be used by advanced undergraduate- and graduate-level students of stem cell and tissue engineering and researchers in macromolecular science ceramics metals for biomaterials nanotechnology chemistry biology and medicine especially those interested in tissue engineering stem cell engineering and regenerative medicine. | Handbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine

GBP 592.99
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Medical Regulatory Affairs An International Handbook for Medical Devices and Healthcare Products

Medical Regulatory Affairs An International Handbook for Medical Devices and Healthcare Products

This handbook covers medical device regulatory systems in different countries ISO standards for medical devices clinical trial and regulatory requirements and documentation for application. It is the first to cover the medical device regulatory affairs in Asia. Experts from influential international regulatory bodies including the US Food and Drug Administration (FDA) UK Medicines and Healthcare Products Regulatory Agency Japan Pharmaceuticals and Medical Devices Agency Saudi Food and Drug Authority Korea Testing Laboratory Taiwan FDA World Health Organization Asian Harmonization Working Party Regulatory Affairs Professionals Society and British Standards Institution have contributed to the book. Government bodies the medical device industry academics students and general readers will find the book immensely useful for understanding the global regulatory environment and in their research and development projects. | Medical Regulatory Affairs An International Handbook for Medical Devices and Healthcare Products

GBP 193.00
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Competitive Math for Middle School Algebra Probability and Number Theory

Competitive Math for Middle School Algebra Probability and Number Theory

The 39 self-contained sections in this book present worked-out examples as well as many sample problems categorized by the level of difficulty as Bronze Silver and Gold in order to help the readers gauge their progress and learning. Detailed solutions to all problems in each section are provided at the end of each chapter. The book can be used not only as a text but also for self-study. The text covers algebra (solving single equations and systems of equations of varying degrees algebraic manipulations for creative problem solving inequalities basic set theory sequences and series rates and proportions unit analysis and percentages) probability (counting techniques introductory probability theory more set theory permutations and combinations expected value and symmetry) and number theory (prime factorizations and their applications Diophantine equations number bases modular arithmetic and divisibility). It focuses on guiding students through creative problem-solving and on teaching them to apply their knowledge in a wide variety of scenarios rather than rote memorization of mathematical facts. It is aimed at but not limited to high-performing middle school students and goes further in depth and teaches new concepts not otherwise taught in traditional public schools. | Competitive Math for Middle School Algebra Probability and Number Theory

GBP 18.99
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Plasma Applications for Material Modification From Microelectronics to Biological Materials

Plasma Applications for Material Modification From Microelectronics to Biological Materials

This book is an up-to-date review of the most important plasma-based techniques for material modification from microelectronics to biological materials and from fusion plasmas to atmospheric ones. Each its technical chapters is written by long-experienced internationally recognised researchers. The book provides a deep and comprehensive insight into plasma technology and its associated elemental processes and is illustrated throughout with excellent figures and references to complement each section. Although some of the topics covered can be traced back several decades care has been taken to emphasize the most recent findings and expected evolution. The first time the word ‘plasma’ appeared in print in a scientific text related to the study of electrical discharges in gases was 1928 when Irving Langmuir published his article ‘Oscillations in Ionized Gases’. It was the baptism of the predominant state of matter in the known universe (it is estimated that up to 99% of matter is plasma) although not on earth where the conditions of pressure and temperature make normal the states of matter (solid liquid gas) which in global terms are exotic. It is enough to add energy to a solid (in the form of heat or electromagnetic radiation) to go into the liquid state from which gas is obtained through an additional supply of energy. If we continue adding energy to the gas we will partially or totally ionise it and reach a new state of matter plasma made up of free electrons atoms and molecules (electrically neutral particles) and ions (endowed with a positive or a negative electric charge). | Plasma Applications for Material Modification From Microelectronics to Biological Materials

GBP 116.00
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Clinical Biochemistry A Laboratory Guide

Clinical Biochemistry A Laboratory Guide

A knowledge of the practical aspects of clinical biochemistry is essential for medical students to understand the diagnostic and prognostic status of any ailment. This book addresses and compiles some of the invariably used protocols in biochemistry with the aim to enhance the understanding of the basics behind following the methodologies including those for urine analysis; carbohydrate protein and lipid analyses; and diabetes and lipid profile. It discusses organ function tests such as liver renal or pancreatic function tests in addition to exploring pH and buffer colorimeter spectrophotometer chromatography electrophoresis enzyme-linked adsorbent assay radioimmunoassay biosensor/glucometer fructosamine DNA isolation mass spectrometry flow cytometry centrifugation automation cerebrospinal fluid examination and oxalic acid test. The book also touches upon the basics of laboratory safety rules and laboratory glassware. The book is helpful for students to understand the relationship between quality management and specimen collection and processing them for their biological functions. It is well-suited for academic courses including undergraduate graduate postgraduate and professional courses and covers the practical syllabus for MBBS BDS BSc MLT BSc nursing and MSc students. For undergraduate students in the disciplines of biochemistry molecular biology chemistry and other related biological sciences the book forms an integral part of the syllabus with its case studies MCQs biochemistry OSPEs etc. It also demonstrates the actual experiments for understanding the concepts better and is a must read for students to acquire skills to work with a clinical biochemistry laboratory. | Clinical Biochemistry A Laboratory Guide

GBP 76.99
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Bioinspired Superhydrophobic Surfaces Advances and Applications with Metallic and Inorganic Materials

Bioinspired Superhydrophobic Surfaces Advances and Applications with Metallic and Inorganic Materials

Materials with superhydrophobic or related properties are one of the most studied subjects from a theoretical point of view and also for the large range of possible applications for example anticorrosion antibacteria optical devices and sensors. The study of natural species with special wettability has shown us the importance of surface structures and the surface energy of the resulting surface properties. Various strategies can be used to reproduce superhydrophobic phenomena in the laboratory. General reviews on superhydrophobic properties already exist but to our knowledge do not focus on metallic and inorganic materials. Here we focus especially on the strategies implemented for reaching superhydrophobic or related properties using metallic and inorganic materials. Indeed these materials present unique properties for example thermal and mechanical resistance chemical and ageing resistance and optical (transparency antireflection photoluminescence) and electrical properties (conducting semiconducting insulating). This book will be useful for graduate students of materials chemistry and physics and for researchers in surface science nanostructures and bioinspired or biomimetic materials. | Bioinspired Superhydrophobic Surfaces Advances and Applications with Metallic and Inorganic Materials

GBP 95.00
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The Theory of Everything Quantum and Relativity is everywhere – A Fermat Universe

The Theory of Everything Quantum and Relativity is everywhere – A Fermat Universe

The book unifies quantum theory and the general theory of relativity. As an unsolved problem for about 100 years and influencing so many fields this is probably of some importance to the scientific community. Examples like Higgs field limit to classical Dirac and Klein–Gordon or Schrödinger cases quantized Schwarzschild Kerr Kerr–Newman objects and the photon are considered for illustration. An interesting explanation for the asymmetry of matter and antimatter in the early universe was found while quantizing the Schwarzschild metric. | The Theory of Everything Quantum and Relativity is everywhere – A Fermat Universe

GBP 37.99
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Pharmaceutical Biocatalysis Fundamentals Enzyme Inhibitors and Enzymes in Health and Diseases

Pharmaceutical Biocatalysis Fundamentals Enzyme Inhibitors and Enzymes in Health and Diseases

This book provides an overview of the world market of therapeutic enzymes and enzyme inhibitors rare diseases orphan drugs the costs of drug development and therapies and enzymes in downstream processing of pharmaceuticals. It discusses carbonic anhydrase inhibitors and their multiple drug interactions carboxylesterase inhibitors for pharmaceutical applications employment of inhibitors for the treatment of neurodegenerative diseases use of engineered proteins bioactive peptides and fibrinolytic enzymes for thrombolytic therapy and enzymes important for the design and development of new drugs/drug metabolites such as aldehyde oxidases and cytochrome P450 enzymes and the role the latter play in vascular biology and pathophysiology. The treatment of cancer is explored in connection with enzymatic amino acid deprivation therapies and new drugs that act as chemical degraders of oncogenic proteins. The book also introduces the resistance mechanisms of cancer. Furthermore it provides an insight into the relationship between pathological conditions of cardiovascular disease and oxidative stress. The text also focuses on the potential use of nanoparticles as carriers for enzymes with medical relevance computer-aided drug design for the identification of multi-target directed ligands and the development of improved therapeutics through a glycan-“designer” approach. It concludes with an introduction to the chemoenzymatic synthesis of drugs. | Pharmaceutical Biocatalysis Fundamentals Enzyme Inhibitors and Enzymes in Health and Diseases

GBP 193.00
1

Functional Materials in Biomedical Applications

Functional Materials in Biomedical Applications

This book presents modern trends that regard the utilization of advanced functional materials for the development of innovative pharmaceuticals. Such materials include classes of lipids polymers proteins and peptides as well as inorganic materials which find application in nanomedicinal products drug delivery systems medical devices biotechnological products and several other technologies. These products are promising for the therapy and diagnosis of diseases. Special attention is given to the available analytical techniques utilized for the evaluation of materials their interactions and their properties as well as the functionality of the final pharmaceutical forms. In addition scale-up opportunities and limitations of nanomaterials and the current and emerging challenges in their clinical translation with reference to relative regulatory aspects are discussed. The book covers the latest advances in functional materials for biomedical applications and will serve as a guide for the industry and aid future research. It will be useful for upper undergraduate students and graduate students young researchers (in the fields of pharmaceutics and materials sciences) scientists who want to enrich their knowledge on advanced drug delivery nanocarriers and their applications researchers in the Big Pharma and readers who want to learn more about the role of nanoscience in the design and development of nanomedicines. | Functional Materials in Biomedical Applications

GBP 154.00
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Agricultural Biocatalysis Biological and Chemical Applications

Agricultural Biocatalysis Biological and Chemical Applications

Agricultural biocatalysis is of immense scientific interest nowadays owing to its increasing importance in the efforts for more sustainable agriculture while optimizing environmental impacts. Plant compatibility is essential for developing eco-friendly and sustainable microbial products. Therefore our search for novel technologies ought to be in the foreground for which a thorough understanding of biochemical processes applications of agricultural enzymes traits and viruses should get the highest priority. Volumes 8 to 10 in this series compile the recent research on agricultural biocatalysis by interdisciplinary teams from international institutes for chemistry biochemistry biotechnology and materials and chemical engineering who have been investigating agricultural-biocatalytic topics related to biochemical conversions or bioremediation and modern biological and chemical applications exemplified by the use of selected and highly innovative agricultural enzymes traits and viruses. The editors are prominent researchers in agrochemistry and theoretical biophysical chemistry and these three volumes are useful references for the students and researchers in the fields of agrochemistry biochemistry biology biophysical chemistry natural product chemistry materials and drug design. Volume 10 covers the research on biological control plant uptake and plant growth aspects plant stress including genome editing in plants and selected agrochemical classes as well as the importance of modern chiral agrochemicals. | Agricultural Biocatalysis Biological and Chemical Applications

GBP 270.00
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Pharmaceutical Biocatalysis Drugs Genetic Diseases and Epigenetics

Pharmaceutical Biocatalysis Drugs Genetic Diseases and Epigenetics

Volume 7 of the Jenny Stanford Series on Biocatalysis deals with several different aspects of pharmaceuticals which include not only various applications of drugs and their metabolism but also natural resources for active pharmaceutical ingredients as well as the removal of pharmaceutical pollution. In detail novel approaches for developing microbial fermentation processes to produce vitamin B6 using microorganisms are described together with novel routes for vitamin B6 biosynthesis. The other topics discussed are new approaches for producing the successful anticancer drug Taxol from naturally occurring precursors molecular farming through plant engineering as a cost-effective means to produce therapeutic and prophylactic proteins and successful screening of potent microorganisms producing L-asparaginase for various chemotherapeutic applications. Furthermore microbial biotransformations in the production and degradation of fluorinated pharmaceuticals are described. The other chapters inform the reader about the biotransformation of xenobiotics/drugs in living systems the degradation of pharmaceuticals by white-rot fungi and their ligninolytic enzymes and the removal of pharmaceutical pollution from municipal sewage using laccase. | Pharmaceutical Biocatalysis Drugs Genetic Diseases and Epigenetics

GBP 193.00
1

Bionanotechnology in Cancer Diagnosis and Therapy

Bionanotechnology in Cancer Diagnosis and Therapy

The cancer research world is looking forward to bionanotechnology to find the best solutions for a complete cure from cancer which is not possible with the current established treatment methods. The past decade of research on nano imaging and drug delivery in cancer has witnessed many interesting papers and reviews but there has not been a concise resource that discusses all fields related to nano cancer research in diagnosis and drug delivery. This book fills this gap and presents the latest bionano research in cancer focusing on nanodiagnostics and nanotherapy. The book is organized into two sections. The section on nanodiagnostics focuses on topics such as diagnostic methods in cancer-related therapy and use of radiolabeled nanoparticles magnetic nanoparticles acoustically reflective nanoparticles X-ray computed tomography and optical nanoprobes for diagnosis. The section on nanotherapy focuses on nanomaterials in chemotherapy magnetic nanoparticles for hyperthermia against cancer phototherapy nanotechnology-mediated radiation therapy nanoparticle-mediated small-RNA deliveries for molecular therapies and theranostics. The book will serve as the gateway to enter the beautiful and elegant field of bionanoscience which is considered the last hope for the fight against cancer and will be a highly useful resource for the students researchers teachers and curious readers working in this field or related fields. | Bionanotechnology in Cancer Diagnosis and Therapy

GBP 154.00
1

Nanoparticles in Life Sciences and Biomedicine

Nanoparticles in Life Sciences and Biomedicine

The creation of new and more efficient therapies for improving human health greatly depends on drug delivery systems. Nanotechnology has emerged as a powerful strategy for the development of nanoparticles such as nanoemulsions liposomes nanocrystals and nanocomplexes applied in the diagnosis treatment or theranostics of several pathologies and diseases. This book reviews the most recent research and development in nanotechnology and following a multidisciplinary approach presents new strategies for drug delivery including aspects from chemistry physics biology and imaging methodologies and exploiting several administration routes internalization pathways site-specific delivery strategies and the potential cytotoxicity of nanoparticles. Beginning with a description of the importance and application of nanotechnology for enhancing existing therapy the book moves on to detailing oral topical pulmonary brain cancer and anti-inflammatory drug delivery approaches; gene delivery approaches; theranostic approaches; and nanoparticle cytotoxicity. Practical and user friendly it is suitable for advanced undergraduate graduate and postgraduate students of nanoscience and nanotechnology; researchers in nanoscience nanotechnology chemistry biology biochemistry pharmaceutical sciences medicine and bioengineering especially those with an interest in drug delivery or theranostics; and academia and university readership. | Nanoparticles in Life Sciences and Biomedicine

GBP 139.00
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Pharmaceutical Biocatalysis Important Enzymes Novel Targets and Therapies

Pharmaceutical Biocatalysis Important Enzymes Novel Targets and Therapies

This volume of Pharmaceutical Biocatalysis starts with a discussion on the importance of biocatalytic synthesis approaches for a sustainable and environmentally friendly production of pharmaceuticals and active pharmaceutical ingredients. Among the enzymes discussed in detail with respect to their pharmaceutical relevance are cyclic nucleotide phosphodiesterases playing an important role in modulating signal transduction in various cell types; human DOPA decarboxylase related to Parkinson's disease and aromatic amino acid decarboxylase deficiency; and phospholipase D enzymes as drug targets. Isocitrate dehydrogenase 1 and 2 mutations are novel therapeutic targets in acute myeloid leukemia. An additional chapter is devoted to the use of enzymes for prodrug activation in cancer therapy. The other topics include small-molecule inhibitors targeting receptor tyrosine kinases in cancer β-Lactams and related compounds as antibacterials non-vitamin K oral anticoagulants for the treatment of thromboembolic diseases and the molecular mechanisms for statin pleiotropy and its clinical relevance in cardiovascular diseases. The last chapter is a review of lysosomal storage disorders with an overview of approved drugs for treating these disorders by enzyme replacement therapy. | Pharmaceutical Biocatalysis Important Enzymes Novel Targets and Therapies

GBP 193.00
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Fabless Semiconductor Manufacturing In the Era of Internet of Things

Fabless Semiconductor Manufacturing In the Era of Internet of Things

This book deals with 3D nanodevices such as nanowire and nanosheet transistors at 7 nm and smaller technology nodes. It discusses technology computer-aided design (TCAD) simulations of stress- and strain-engineered advanced semiconductor devices including III-nitride and RF FDSOI CMOS for flexible and stretchable electronics. The book focuses on how to set up 3D TCAD simulation tools from mask layout to process and device simulation including fabless intelligent manufacturing. The simulation examples chosen are from the most popular devices in use today and provide useful technology and device physics insights. In order to extend the role of TCAD in the More-than-Moore era the design issues related to strain engineering for flexible and stretchable electronics have been introduced for the first time. | Fabless Semiconductor Manufacturing In the Era of Internet of Things

GBP 116.00
1

Nanomaterials in Architecture and Art Conservation

Nanomaterials in Architecture and Art Conservation

The conservation and protection of buildings that constitute our cultural heritage are complex tasks calling for a comprehensive knowledge of the historical background of the buildings as well as the construction technologies and materials used. Nanomaterials in Architecture and Art Conservation gives a comprehensive overview of the state of the art of using nanomaterials in conservation sciences mainly for stone mortar and plaster strengthening but also for the consolidation of wall paintings. The book compiles and details deterioration mechanisms of stone and historical mortars as well as methods of characterising and testing consolidation effects. The non- or semi-destructive characterisation methods that will be presented allow additional measurements to characterise objects before and after any interventions. Besides general aspects of inorganic consolidants are targeted. The focus in particular is the application of nanolime as a new consolidation agent. Basic characteristics and application advices as well as beneficial combinations with other consolidation agents such as silicic acid esters are emphasised. What makes this book so special is the large number of practical applications described from the viewpoint of different restorers offering a direct inside view of the procedure for the conservation of historical monuments. Restorers dealing with stone mortar and plaster conservation; artists; advanced undergraduate- and graduate-level students of conservation science art and nanotechnology; offices for the protection of monuments and heritage agencies; and researchers in materials science conservation nanotechnology and chemistry especially those with an interest in applied sciences will find this book a great reference.

GBP 139.00
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Handbook of Medical Device Regulatory Affairs in Asia Second Edition

Handbook of Medical Device Regulatory Affairs in Asia Second Edition

Medical device regulation in Asia has gained more importance than ever. Governments and regulatory bodies across the region have put in place new regulatory systems or refined the existing ones. A registered product requires a lot of technical documentation to prove its efficacy safety and quality. A smooth and successful registration process demands soft skills for dealing with various key stakeholders in the government testing centers and hospitals and among doctors. This handbook covers medical device regulatory systems in different countries ISO standards for medical devices clinical trial and regulatory requirements and documentation for application. It is the first to cover the medical device regulatory affairs in Asia. Each chapter provides substantial background materials relevant to the particular area to have a better understanding of regulatory affairs. | Handbook of Medical Device Regulatory Affairs in Asia Second Edition

GBP 116.00
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