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Cancer Genetics and Genomics for Personalized Medicine

Cancer Genetics and Genomics for Personalized Medicine

This book covers almost all fields of cancer genetics and genomics for personalized medicine. Targeted therapy or precision medicine or personalized medicine is becoming a standard treatment for many diseases including cancer. However how much do we know about the personalized medicine approach? This lucid book helps undergraduate and graduate students professional researchers and clinicians to better understand the key concept of personalized medicine. The most up-to-date topics on personalized medicine in this book cover the recent trends in and updates on lung gastric liver breast and other types of cancers. Circulating tumor cell cell-free circulating DNA and microRNAs are discussed as new diagnostic and prognostic markers for cancer. The avatar mouse model is also discussed for maximizing treatment efficacy and prognosis prediction and so is microenvironment as a drug resistance mechanism. With classical and new pathological approaches the book provides a systemic overview of personalized immunotherapies and hyperthermic intraperitoneal chemotherapy followed by new emerging fields of hereditary cancer thereby equipping readers to eventually contribute in developing more advanced tools and therapies for curing cancer.

GBP 108.00
1

Pharmaceutical Biocatalysis Fundamentals Enzyme Inhibitors and Enzymes in Health and Diseases

Pharmaceutical Biocatalysis Fundamentals Enzyme Inhibitors and Enzymes in Health and Diseases

This book provides an overview of the world market of therapeutic enzymes and enzyme inhibitors rare diseases orphan drugs the costs of drug development and therapies and enzymes in downstream processing of pharmaceuticals. It discusses carbonic anhydrase inhibitors and their multiple drug interactions carboxylesterase inhibitors for pharmaceutical applications employment of inhibitors for the treatment of neurodegenerative diseases use of engineered proteins bioactive peptides and fibrinolytic enzymes for thrombolytic therapy and enzymes important for the design and development of new drugs/drug metabolites such as aldehyde oxidases and cytochrome P450 enzymes and the role the latter play in vascular biology and pathophysiology. The treatment of cancer is explored in connection with enzymatic amino acid deprivation therapies and new drugs that act as chemical degraders of oncogenic proteins. The book also introduces the resistance mechanisms of cancer. Furthermore it provides an insight into the relationship between pathological conditions of cardiovascular disease and oxidative stress. The text also focuses on the potential use of nanoparticles as carriers for enzymes with medical relevance computer-aided drug design for the identification of multi-target directed ligands and the development of improved therapeutics through a glycan-“designer” approach. It concludes with an introduction to the chemoenzymatic synthesis of drugs. | Pharmaceutical Biocatalysis Fundamentals Enzyme Inhibitors and Enzymes in Health and Diseases

GBP 193.00
1

Three Daughters Three Journeys Quest for Cancer Cure

Three Daughters Three Journeys Quest for Cancer Cure

Cancer threatens the lives of people around the world. Women in particular are at risk of certain cancers with a genetic cause. Certain mutations in the BRCA1 and BRCA2 genes put mothers and daughters at risk of breast and ovarian cancers. Unlike many cancers that most commonly occur after age 60 these inheritable cancers threaten women’s lives health and fertility even when they are young before most would even begin to go for annual mammogram screenings to check for breast cancer. Three Daughters Three Journeys takes on the biggest health issue of our time from a global perspective with three heroines fighting for their lives against cancer. Marzena a Polish oncology nurse has spent her life treating child patients with cancer. Then she confronts it in her own family and her own body. Kamola a rural Indian girl knows she has symptoms of the same disease that took her mother but feels afraid to discuss it with her father and brothers knowing her family cannot afford medical treatment. Kamola confides in Dr Rini Mishra a doctor testing a new treatment called Neelazin using a bacterial anticancer protein in food to destroy cancer cells. Selena a wealthy woman of color in Chicago finds out about her genetic risks of breast and ovarian cancer. She has a choice of preventative surgery that will save her life but remove any chance of having children. As she meets women who struggle to afford cancer treatment Selena dedicates her life to providing affordable homes and counseling to families affected by the disease. Although the drug Neelazin is fictional the possibility of new cancer treatments using bacterial anticancer proteins is being researched now. A problem with the current chemotherapy for cancer treatment is the high toxicity of most of these drugs as these drugs can enter both normal and cancer cells though preferably cancer cells causing the death of normal cells as well that are important in maintaining health. Another problem is that current chemotherapeutic drugs mostly target a single or few key steps that are important for cancer growth and proliferation and inhibit the growth of cancer cells. The cancer cells respond by quickly changing these single targets thereby becoming resistant to the drugs as is reflected in stage IV cancer patients. An alternative to chemotherapy would be to exploit the bacterial evolutionary wisdom and use certain proteins that can have preferential entry to cancer cells in order to minimize normal cell toxicity and multiple targets in cancer cells through protein–protein complex formation thus reducing resistance development in cancer cells. An interesting advantage of protein drugs is to express them as part of food and some recent research seems to suggest that oral consumption of such foods may allow the therapeutic protein to reach the blood stream to target the cancer. Women with the genetic risk factors could soon have the choice of taking a pill or such anticancer protein-expressing food to treat or prevent cancer rather than removing the healthy tissue of the breasts and ovaries. Hopefully they would not have to choose between fertility and survival as is the implied message in this book fictional as it is at this time. | Three Daughters Three Journeys Quest for Cancer Cure

GBP 31.99
1

How Enzymes Work From Structure to Function

How Enzymes Work From Structure to Function

The first edition of this book covered the basic treatment of the enzyme reaction using the overall reaction kinetics and stopped-flow method the general properties of protein and cofactors the control of enzyme reaction and the preparation of enzyme protein. These topics are the basis of enzyme research and thus suitable for the beginner in the field. The second edition presents the cofactors produced via the post-translational modification of the enzyme’s active site. These cofactors expand the function of enzymes and open a new research field. The carbonyl reagent phenylhydrazine and related compounds have been useful in finding some of the newly discovered cofactors and thus have been discussed in this edition. The topic of the control of enzyme activity through the channel of substrates and products in polyfunctional enzymes has also been expanded in this book. | How Enzymes Work From Structure to Function

GBP 116.00
1

Biomedical Engineering

Biomedical Engineering

Several developed countries are facing serious problems in medical environments owing to the aging society and extension of healthy lifetime has become a big challenge. Biomedical engineering in addition to life sciences and medicine can help tackle these problems. Innovative technologies concerning minimally invasive treatment prognosis and early diagnosis point-of-care testing regenerative medicine and personalized medicine need to be developed to realize a healthy aging society. This book presents cutting-edge research in biomedical engineering from materials devices imaging and information perspectives. The contributors are senior members of the Research Center for Biomedical Engineering supported by the Ministry of Education Culture Sports Science and Technology Japan. All chapters are results of collaborative research in engineering and life sciences and cover nanotechnology materials optical sensing technology imaging technology image processing technology and biomechanics all of which are important areas in biomedical engineering. The book will be a useful resource for researchers students and readers who are interested in biomedical engineering.

GBP 116.00
1

Companion Diagnostics (CDx) in Precision Medicine

Companion Diagnostics (CDx) in Precision Medicine

There is a new trend in anti-cancer therapeutics development: a targeted therapy and precision medicine that targets a subgroup of patients with specific biomarkers. An in vitro diagnostic (IVD) assay is required to identify a subgroup of cancer patients who would benefit from the targeted therapy or not likely benefit or have a high risk of side effects from the specific drug treatment. This IVD or medical device is called a companion diagnostic (CDx) assay. It is key to have a robust CDx assay or device for the success of targeted therapy and precision medicine. This book covers the technical historical clinical and regulatory aspects of CDx in precision medicine. Clearly more and more newly developed oncology drugs will require accompanying CDx assays and this book with chapters contributed by renowned oncologists provides a comprehensive foundation for the knowledge and application of CDx for precision medicine. | Companion Diagnostics (CDx) in Precision Medicine

GBP 116.00
1

Nanoparticles in Life Sciences and Biomedicine

Nanoparticles in Life Sciences and Biomedicine

The creation of new and more efficient therapies for improving human health greatly depends on drug delivery systems. Nanotechnology has emerged as a powerful strategy for the development of nanoparticles such as nanoemulsions liposomes nanocrystals and nanocomplexes applied in the diagnosis treatment or theranostics of several pathologies and diseases. This book reviews the most recent research and development in nanotechnology and following a multidisciplinary approach presents new strategies for drug delivery including aspects from chemistry physics biology and imaging methodologies and exploiting several administration routes internalization pathways site-specific delivery strategies and the potential cytotoxicity of nanoparticles. Beginning with a description of the importance and application of nanotechnology for enhancing existing therapy the book moves on to detailing oral topical pulmonary brain cancer and anti-inflammatory drug delivery approaches; gene delivery approaches; theranostic approaches; and nanoparticle cytotoxicity. Practical and user friendly it is suitable for advanced undergraduate graduate and postgraduate students of nanoscience and nanotechnology; researchers in nanoscience nanotechnology chemistry biology biochemistry pharmaceutical sciences medicine and bioengineering especially those with an interest in drug delivery or theranostics; and academia and university readership. | Nanoparticles in Life Sciences and Biomedicine

GBP 139.00
1

Pharmaceutical Biocatalysis Important Enzymes Novel Targets and Therapies

Pharmaceutical Biocatalysis Important Enzymes Novel Targets and Therapies

This volume of Pharmaceutical Biocatalysis starts with a discussion on the importance of biocatalytic synthesis approaches for a sustainable and environmentally friendly production of pharmaceuticals and active pharmaceutical ingredients. Among the enzymes discussed in detail with respect to their pharmaceutical relevance are cyclic nucleotide phosphodiesterases playing an important role in modulating signal transduction in various cell types; human DOPA decarboxylase related to Parkinson's disease and aromatic amino acid decarboxylase deficiency; and phospholipase D enzymes as drug targets. Isocitrate dehydrogenase 1 and 2 mutations are novel therapeutic targets in acute myeloid leukemia. An additional chapter is devoted to the use of enzymes for prodrug activation in cancer therapy. The other topics include small-molecule inhibitors targeting receptor tyrosine kinases in cancer β-Lactams and related compounds as antibacterials non-vitamin K oral anticoagulants for the treatment of thromboembolic diseases and the molecular mechanisms for statin pleiotropy and its clinical relevance in cardiovascular diseases. The last chapter is a review of lysosomal storage disorders with an overview of approved drugs for treating these disorders by enzyme replacement therapy. | Pharmaceutical Biocatalysis Important Enzymes Novel Targets and Therapies

GBP 193.00
1

Semi-Critical Assisted Extraction Applications and Commercialization in Biotechnology Food and Pharmacy

Semi-Critical Assisted Extraction Applications and Commercialization in Biotechnology Food and Pharmacy

In the past three decades great efforts have been made to develop new methods for the extraction of natural molecules. Improved extraction technologies have garnered scientific interest as they have helped in understanding how mass and energy transfer exhibited for a solvent and solute during a chemical extraction can be used as physical chemistry parameters leading to the modeling and design of new advantageous equipment. In situ data collected during a chemically assisted experiment is useful in a variety of scientific and technological applications especially in generating extractors that are safer more efficient and offer true opportunities to scale them up in a wide range of materials (among stainless steel). This book compiles empirical and traditional extraction methods applied to cutting-edge critical extraction research in the areas of food science phytochemistry pharmacy fragrance cosmetology and folk medicine. It presents extraction technology as an interdisciplinary area that applies the principles of physics and chemistry as tools to develop engineered models for the construction of more advanced extraction devices. It includes examples and problems related to data treatment in normal laboratory research work that will facilitate undergraduate- and graduate-level students as well as operators working in the area in solving real problems. | Semi-Critical Assisted Extraction Applications and Commercialization in Biotechnology Food and Pharmacy

GBP 116.00
1

Bionanotechnology in Cancer Diagnosis and Therapy

Bionanotechnology in Cancer Diagnosis and Therapy

The cancer research world is looking forward to bionanotechnology to find the best solutions for a complete cure from cancer which is not possible with the current established treatment methods. The past decade of research on nano imaging and drug delivery in cancer has witnessed many interesting papers and reviews but there has not been a concise resource that discusses all fields related to nano cancer research in diagnosis and drug delivery. This book fills this gap and presents the latest bionano research in cancer focusing on nanodiagnostics and nanotherapy. The book is organized into two sections. The section on nanodiagnostics focuses on topics such as diagnostic methods in cancer-related therapy and use of radiolabeled nanoparticles magnetic nanoparticles acoustically reflective nanoparticles X-ray computed tomography and optical nanoprobes for diagnosis. The section on nanotherapy focuses on nanomaterials in chemotherapy magnetic nanoparticles for hyperthermia against cancer phototherapy nanotechnology-mediated radiation therapy nanoparticle-mediated small-RNA deliveries for molecular therapies and theranostics. The book will serve as the gateway to enter the beautiful and elegant field of bionanoscience which is considered the last hope for the fight against cancer and will be a highly useful resource for the students researchers teachers and curious readers working in this field or related fields. | Bionanotechnology in Cancer Diagnosis and Therapy

GBP 154.00
1