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Physiological Consequences of Brain Insulin Action

Physiological Consequences of Brain Insulin Action

The brain is crucial for the regulation of whole-body metabolism and behavior. The pancreas-derived hormone insulin modulates brain function and affects energy metabolism as well as cognition. This is partially achieved by modulating several types of brain cell populations including those relevant to satiety and reward. Importantly brains of Alzheimer´s disease patients exhibit a signature of brain insulin resistance with perturbed brain metabolism. This book will cover the basics of insulin signaling in the brain and will describe concepts of insulin resistance a feature of type 2 diabetes. Moreover insulin´s effect on cognitive function will be pointed out and the association between brain insulin resistance and neurodegenerative diseases discussed. Additionally potential behavioral and pharmacological concepts which can affect brain insulin signaling will be summarized. Key Features: Summarizes insulin and the closely related IGF-1 receptor signaling Depicts concepts of insulin resistance Highlights the importance of conserved brain insulin signaling for brain function metabolism and behavior Describes potential behavioral and pharmacological approaches to support brain insulin signaling | Physiological Consequences of Brain Insulin Action

GBP 130.00
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Antidiabetic Plants for Drug Discovery Pharmacology Secondary Metabolite Profiling and Ingredients with Insulin Mimetic Activity

Antidiabetic Plants for Drug Discovery Pharmacology Secondary Metabolite Profiling and Ingredients with Insulin Mimetic Activity

This volume takes an in-depth look at the potential pharmacological applications of 11 important antidiabetic plants examining their antihyperglycemic hypoglycemic and anti-lipidemic properties along with current genome editing research perspectives. Plant natural products or phytoconstituents are promising candidates for antidiabetic pharmacological actions. The phytoconstituents such as fl avonoids terpenoids saponins carotenoids alkaloids and glycosides play vital roles in the current and future potent antidiabetic drug development programs Each chapter reviews a particular plant with antidiabetic properties explaining the therapeutic aspects its active antidiabetic compounds and relevant genome editing technology. The specific plants discussed include Azadirachta indica (commonly known as neem nimtree or Indian lilac) Gymnema sylvestre (commonly called gymnema Australian cowplant and Periploca of the woods) Syzygium cumini (commonly known as Malabar plum Java plum black plum jamun or jambolana) Ceylon cinnamon (or true cinnamon as opposed to cassia cinnamon) insulin plant (or Costus pictus) Trigonella foenum-graecum (better known as fenugreek) Mulberry Nigella sativa L. (black caraway also known as black cumin nigella kalojeera kalonji or kalanji) Aegle marmelos (L. ) (commonly known as bael (or bili or bhel) also Bengal quince golden apple Japanese bitter orange stone apple or wood apple) Ficus benghalensis (the banyan banyan fig and Indian banyan) and of course garlic (Allium sativum). Antidiabetic Plants for Drug Discovery: Pharmacology Secondary Metabolite Profiling and Ingredients with Insulin Mimetic Activity will serve as a valuable source of information for students drug researchers medical practitioners diabetic patients and many others in the effort to gain understand of how these plant drug molecules can help fight diabetes. | Antidiabetic Plants for Drug Discovery Pharmacology Secondary Metabolite Profiling and Ingredients with Insulin Mimetic Activity

GBP 139.00
1

Phospholipid Metabolism in Cellular Signaling

Phospholipid Metabolism in Cellular Signaling

Phospholipids are no longer considered exclusively as the building blocks of biomembranes but are now regarded to be exceptionally important to cellular signalling. Another conclusion resulting from studies over the past several years is that no single general scheme for the role of phospholipids during cell activation can be drawn as representative of all cells. This book presents a comprehensive view of the recent advances made in certain major research areas within the field of phospholipid metabolism in cellular signalling. Topics discussed within this volume include lipid composition of cellular membranes and their organization in biological systems the dynamic aspects of phospholipid metabolism and its regulation by extracellular stimuli and the role of newly discovered glycosyl-phosphatidylinositols in insulin action . The book also discusses two biologically active phospholipids: the sphingolipids and ether-linked glycerophospholipids (the platelet activating factor). Phospholipid Metabolism in Cellular Signaling is an important research reference that should be considered required reading by all scientists and graduate students working on cell activation (e. g. growth factors hormones and oncogenes).

GBP 89.99
1

Metabolism and Medicine The Metabolic Landscape of Health and Disease (Volume 2)

Metabolism and Medicine The Metabolic Landscape of Health and Disease (Volume 2)

Chronic disease states of aging should be viewed through the prism of metabolism and biophysical processes at all levels of physiological organization present in the human body. This book connects these insights to what causes them to go awry in the context of unhealthy human behaviors and aging aiming to buttress scientific creativity. It also provides links between the art and science of medicine that strengthens problem-solving in patient care. New and important discoveries in the area of metabolic health and metabolic diseases are discussed in exquisite detail. Key Features: Broad and up-to-date overview of the field of metabolic aspects of health and chronic disease development especially connecting the spectrum of topics that range from molecular clocks to stress response to nuclear hormone receptors and the role of microbiota in human health Provides a deeper basic science and interdisciplinary understanding of biological systems that broaden the perspectives and therapeutic problem solving by elaborating on the usefulness of the Physiological Fitness Landscape Describes the importance of insulin resistance in metabolic disease especially diabetes but also includes links to cancer and Alzheimer’s disease Examines the process of aging from the perspective of metabolic decline illustrating it with the Physiological Fitness Landscape This book the second volume in a two-volume set primarily targets an audience of clinical and science students biomedical researchers and physicians who would benefit from understanding each other’s language. | Metabolism and Medicine The Metabolic Landscape of Health and Disease (Volume 2)

GBP 130.00
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Handbook of Obesity - Volume 1 Epidemiology Etiology and Physiopathology

Handbook of Obesity - Volume 1 Epidemiology Etiology and Physiopathology

The fifth edition of Volume 1 of Handbook of Obesity written by global experts covers the basic science aspects under the broad topic areas of epidemiology etiology and pathophysiology of obesity. Divided into 5 sections and detailed in 66 chapters this edition covers the important advances occurring over the past decades. With a focus on science of obesity and factors participating in the etiology of obesity this topic is studied from biological behavioural and environmental perspectives. Volume 1 is structured into 5 parts: Part 1 focuses on the history definitions and prevalence of the obesity. It identifies the historical references to excess weight obesity in art and literature direct and surrogate measurements of adiposity and obesity related traits epidemiology of obesity around the globe and age sex and ethnic variation completes this part of the volume Part 2 explains the biological determinants of obesity. It explains the bioenergetics energy dissipation mechanisms and exposure to experimental overfeeding genetic and epigenetic evidence metabolic rates energy expenditure and energy partitioning and the evidence on infections and adiposity Part 3 describes the behavioral determinants of obesity. It deals with chapters related to food beverages and ingestive behavior dealing with smoking breast-feeding and sleep duration and pattern and sedentary behavior occupational work and leisure-time physical activity and obesity Part 4 comprises of chapters explaining the environmental social and cultural determinants of obesity. The chapters in this section focus on the role of agriculture and the food industry in the current obesity epidemic social and economic aspects of obesity and ethnic and cultural differences and environmental pollutants Part 5 of this volume discusses the health consequences of obesity. The chapters address important topics such obesity and heart disease lipoprotein metabolism insulin resistance and diabetes metabolic syndrome cancer hepatic biology pulmonary functions and arthritis and gout mental health and quality of life growth and health disorders in pediatric populations and on bias and discrimination affecting the obese persons. | Handbook of Obesity - Volume 1 Epidemiology Etiology and Physiopathology

GBP 150.00
1

Textbook of Ion Channels Volume III Regulation Physiology and Diseases

Textbook of Ion Channels Volume III Regulation Physiology and Diseases

The Textbook of Ion Channels is a set of three volumes that provides a wide-ranging reference source on ion channels for students instructors and researchers. Ion channels are mem- brane proteins that control the electrical properties of neurons and cardiac cells; medi- ate the detection and response to sensory stimuli like light sound odor and taste; and regulate the response to physical stimuli like temperature and pressure. In non-excitable tissues ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells giving them the unique ability to communicate with the environment as well as the membrane of intracellular organelles allowing them to regulate internal homeostasis. Ion channels are fundamentally important for human health and diseases and are important targets for pharmaceuticals in mental illness heart disease anesthesia pain and other clinical appli- cations. The modern methods used in their study are powerful and diverse ranging from single ion-channel measurement techniques to models of ion channel diseases in animals and human clinical trials for ion channel drugs. Volume III includes coverage of key ion channel regulators and their mechanisms the role of ion channels working in concert in selected physiological systems and examples of ion channel mutations and dysfunction in a selection of diseases. Chapters on ion channel regulation include splice variants calcium–calmodulin regulation regulation by G pro- teins and lipids. A selection of ion channels in physiological systems includes ion chan- nels of the heart ion channels in immune cells and their role in pancreatic beta cells and regulation of insulin secretion and the role of channels in sperm and eggs. While disease mechanisms are integrated into the chapters of Volume II Volume III offers special consid- eration of ion channels in epilepsy cystic fibrosis and pain syndromes. All three volumes give the reader an introduction to fundamental concepts needed to understand the mechanism of ion channels a guide to the technical aspects of ion channel research offer a modern guide to the properties of major ion channel families and includecoverage of key examples of regulatory physiological and disease roles for ion channels. | Textbook of Ion Channels Volume III Regulation Physiology and Diseases

GBP 89.99
1

Ultrashort Pulse Lasers and Ultrafast Phenomena

Ultrashort Pulse Lasers and Ultrafast Phenomena

This book describes the basic physical principles of techniques to generate and ultrashort pulse lasers and applications to ultrafast spectroscopy of various materials covering chemical molecular compounds solid-state materials exotic novel materials including topological materials biological molecules and bio- and synthetic polymers. It introduces non-linear optics which provides the basics of generation and measurement of pulses and application examples of ultrafast spectroscopy to solid state physics. Also it provide not only material properties but also material processing procedures. The book describes also details of the world shortest visible laser and DUV lasers developed by the author’s group. It is composed of the following 12 Sections: The special features of this book is that it is written by a single author with a few collaborators in a systematic way. Hence it provides a comprehensive and systematic description of the research field of ultrashort pulse lasers and ultrafast spectroscopy. Generation of ultrashort pulses in deep ultraviolet to near infrared Generation of ultrashort pulses in terahertz Carrier envelope phase (CEP) Simple NLO processes with a few colors Multi-color involved NLO processes Multi-color ultrashort pulse generation NLO materials NLO processes in time-resolved spectroscopy Low dimension materials Conductors and superconductors Chemical reactions and material processing Photobiological reactions | Ultrashort Pulse Lasers and Ultrafast Phenomena

GBP 160.00
1

The U.S. Navy and the Rise of Great Power Competition Looking Beyond the Western Pacific

The U.S. Navy and the Rise of Great Power Competition Looking Beyond the Western Pacific

This volume describes how technological and geo-political trends are rapidly transforming maritime affairs. A mix of original and previously published material this volume describes how the 21st-century great power competition is changing the face of naval operations in general and U. S. Navy operations in the Western Pacific in particular. The rise of an assertive China and its new anti-access and area-denial capabilities threaten the aircraft carrier-based maritime dominance of the U. S. Navy. Military and political trends in the Western Pacific and beyond suggest that the world is encountering a pivotal moment when existing weapons tactics and operations might be rendered obsolete by techno-strategic change. This volume considers these developments from three perspectives by describing: (1) the techno-strategic setting; (2) the institutional constraints that impede the ability of the U. S. Navy to respond to these changes; and (3) a new approach to naval force planning and strategy to cope with these developments. The volume culminates in a discussion of sophisticated strategies and operational concepts that position the U. S. Navy and its maritime allies and partners to prevail in today’s techno-strategic churn. This book will be of much interest to students of naval policy strategic studies Asia-Pacific politics and International Relations. | The U. S. Navy and the Rise of Great Power Competition Looking Beyond the Western Pacific

GBP 130.00
1

Thermal Spray Coatings

Thermal Spray Coatings

This book provides the latest information about the research being conducted and established solutions available in the field of thermal spray coatings for various engineering applications. The readers of this book will be mainly the graduates engineers and researchers who are pursuing their carrier in the field of thermal spraying. This book will cover the studies and research works of reputed scientists and engineers who have developed thermal spray coatings for thermal protection bio-implants renewal energy wear and corrosion in hydraulic turbines and jet engines hydrophobic surfaces etc. Hence the book serves as a valuable resource of latest advancement in thermal spray technology and consolidated references for aspirants and professionals of surface engineering community. The book covers following topics for different industrial applications: Introduction: Historical developments Science and Engineering aspects of thermal spray coating technology and different thermal spray coatings techniques and its comparison with other fabrication processes. Recent advancements and applications of thermal spray coatings Cold spray technology for additive manufacturing. High-temperature corrosion and erosion resistant coatings and thermal barrier coatings for power plants automotive sector and jet engines. Erosion and corrosion-resistant coatings for hydro-power plants offshore chemical and oil industries. Bio-coatings for human body implants. Thermal spray coating for super-hydrophobic surface. 3. Case study of boiler tubes failure and prevention by thermal spray coatings.

GBP 130.00
1

Heterogenous Computational Intelligence in Internet of Things

Heterogenous Computational Intelligence in Internet of Things

We have seen a sharp increase in the development of data transfer techniques in the networking industry over the past few years. We can see that the photos are assisting clinicians in detecting infection in patients even in the current COVID-19 pandemic condition. With the aid of ML/AI medical imaging such as lung X-rays for COVID-19 infection is crucial in the early detection of many diseases. We also learned that in the COVID-19 scenario both wired and wireless networking are improved for data transfer but have network congestion. An intriguing concept that has the ability to reduce spectrum congestion and continuously offer new network services is providing wireless network virtualization. The degree of virtualization and resource sharing varies between the paradigms. Each paradigm has both technical and non-technical issues that need to be handled before wireless virtualization becomes a common technology. For wireless network virtualization to be successful these issues need careful design and evaluation. Future wireless network architecture must adhere to a number of Quality of Service (QoS) requirements. Virtualization has been extended to wireless networks as well as conventional ones. By enabling multi-tenancy and tailored services with a wider range of carrier frequencies it improves efficiency and utilization. In the IoT environment wireless users are heterogeneous and the network state is dynamic making network control problems extremely difficult to solve as dimensionality and computational complexity keep rising quickly. Deep Reinforcement Learning (DRL) has been developed by the use of Deep Neural Networks (DNNs) as a potential approach to solve high-dimensional and continuous control issues effectively. Deep Reinforcement Learning techniques provide great potential in IoT edge and SDN scenarios and are used in heterogeneous networks for IoT-based management on the QoS required by each Software Defined Network (SDN) service. While DRL has shown great potential to solve emerging problems in complex wireless network virtualization there are still domain-specific challenges that require further study including the design of adequate DNN architectures with 5G network optimization issues resource discovery and allocation developing intelligent mechanisms that allow the automated and dynamic management of the virtual communications established in the SDNs which is considered as research perspective. | Heterogenous Computational Intelligence in Internet of Things

GBP 110.00
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