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Principles and Reactions of Protein Extraction Purification and Characterization

Principles and Reactions of Protein Extraction Purification and Characterization

Principles and Reactions of Protein Extraction Purification and Characterization provides the mechanisms and experimental procedures for classic to cutting-edge techniques used in protein extraction purification and characterization. The author presents the principles and reactions behind each procedure and uses tables to compare the different methods. The book also discusses the development of antibodies and immunochemical techniques as tools for characterizing proteins and modified proteins such as glycoproteins. Helpful illustrations diagrams and tables effectively transform theoretical concepts into practical knowledge. Along with methodical working procedures for most techniques the book also offers useful advice on which technique to use and when to apply a particular method. Presenting the advantages and disadvantages of the various protein techniques Principles and Reactions of Protein Extraction Purification and Characterization enables students and researchers to master the mechanisms behind the protocols and choose the best method for their purposes.

GBP 205.00
1

Intracellular Calcium-Dependent Proteolysis

Intracellular Calcium-Dependent Proteolysis

Intracellular Calcium-Dependent Proteolysis explains what is now known about calpains which are intracellular non-lysosomal enzymes involved in intracellular protein catabolism. The book provides a comprehensive overview of topics ranging from the molecular biology of the calpains and their specific inhibitor protein (calpastatin) to physiologic and pathologic consequences of the presence of this proteolytic system in many model cells and tissues. Several theoretical functions of the calpains are discussed including their potential roles in muscle protein turnover platelet activation membrane fusion and synaptic plasticity. Intracellular Calcium-Dependent Proteolysis is a valuable source of information for researchers and students interested in the regulation of intracellular protein catabolism and the general effects of Ca2+ on cell function.

GBP 180.00
1

Foods Nutrition and Sports Performance An international Scientific Consensus organized by Mars Incorporated with International Olympic Comm

Foods Nutrition and Sports Performance An international Scientific Consensus organized by Mars Incorporated with International Olympic Comm

This book includes all the papers presented at the meeting revised to take account of all the points made during discussions and the Consensus Statement itself. The topics covered include recommendations for optimum carbohydrate protein fat total energy fluid and electrolyte and vitamin mineral intakes to maximise sports performance. | Foods Nutrition and Sports Performance An international Scientific Consensus organized by Mars Incorporated with International Olympic Comm

GBP 180.00
1

Uses of Elemental Diets in Clinical Situations

Uses of Elemental Diets in Clinical Situations

The studies presented in this book demonstrate that a new concept in the management of carious intestinal disorders should be considered namely that common nutrients may protect or heal the mucosa by virtue of the particular form and mode in which they are delivered to the intestinal lumen and their availability to the mucosal cells. The substitution of intact protein in the formula by hydrolysate appears to me an important factor. | Uses of Elemental Diets in Clinical Situations

GBP 205.00
1

Introduction to High Performance Computing for Scientists and Engineers

Introduction to High Performance Computing for Scientists and Engineers

Written by high performance computing (HPC) experts Introduction to High Performance Computing for Scientists and Engineers provides a solid introduction to current mainstream computer architecture dominant parallel programming models and useful optimization strategies for scientific HPC. From working in a scientific computing center the authors gained a unique perspective on the requirements and attitudes of users as well as manufacturers of parallel computers. The text first introduces the architecture of modern cache-based microprocessors and discusses their inherent performance limitations before describing general optimization strategies for serial code on cache-based architectures. It next covers shared- and distributed-memory parallel computer architectures and the most relevant network topologies. After discussing parallel computing on a theoretical level the authors show how to avoid or ameliorate typical performance problems connected with OpenMP. They then present cache-coherent non-uniform memory access (ccNUMA) optimization techniques examine distributed-memory parallel programming with message passing interface (MPI) and explain how to write efficient MPI code. The final chapter focuses on hybrid programming with MPI and OpenMP. Users of high performance computers often have no idea what factors limit time to solution and whether it makes sense to think about optimization at all. This book facilitates an intuitive understanding of performance limitations without relying on heavy computer science knowledge. It also prepares readers for studying more advanced literature. Read about the authors' recent honor: Informatics Europe Curriculum Best Practices Award for Parallelism and Concurrency.

GBP 180.00
1

Statistical Modeling and Machine Learning for Molecular Biology

Statistical Modeling and Machine Learning for Molecular Biology

Molecular biologists are performing increasingly large and complicated experiments but often have little background in data analysis. The book is devoted to teaching the statistical and computational techniques molecular biologists need to analyze their data. It explains the big-picture concepts in data analysis using a wide variety of real-world molecular biological examples such as eQTLs ortholog identification motif finding inference of population structure protein fold prediction and many more. The book takes a pragmatic approach focusing on techniques that are based on elegant mathematics yet are the simplest to explain to scientists with little background in computers and statistics. | Statistical Modeling and Machine Learning for Molecular Biology

GBP 180.00
1

Pharmacokinetic and Pharmacodynamic Data Analysis Concepts and Applications Second Edition

Pharmacokinetic and Pharmacodynamic Data Analysis Concepts and Applications Second Edition

Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications teaches everyday biological data analysis to the undergraduate and graduate levels. Through numerous examples and over 100 tutorials scientists learn how to use PK/PD seamlessly in a variety of practical areas from simple plasma kinetics multi-compartment models nonlinear kinetics plasma protein binding pharmacodynamic models turnover concepts receptor binding functional adaption and rebound dose-response-time data analysis inter-species scaling and a lot more. A substantial effort has been invested into the new pharmacokineticsand pharmacodynamics including many new and updated Case Studies. The text develops a logical real-world approach to data and reasoning showing the reader how to: Think both analytically and visually about data Use graphics to make a point Impove your pattern recognition ability Make sound decisions Strategize your data analyses Appreciate more fully the exciting field of Quantitative Pharmacology | Pharmacokinetic and Pharmacodynamic Data Analysis Concepts and Applications Second Edition

GBP 200.00
1

Receptor Phosphorylation

Receptor Phosphorylation

The following chapters comprise invited contributions from eminent scientists who are internationally recognized authorities on the subject. The chapters have been written to provide the reader with adequate background necessary experimental details and discussion that is easy to comprehend. The book has been organized into four different sections. The introductory chapter is meant to briefly summarize the contributions of other authors and discuss phosphorylation of receptor systems not covered in the book in detail. The chapters in the second section on protein kinases and phosphatases are quite fundamental to the process of phosphorylation and will aid the reader in appreciating the observations and discussions reported in other chapters. The third and fourth sections present discussions on phosphorylation of various receptor systems which are involved in mediating actions of peptide amine and steroid hormones. It is hoped that this book will serve as a valuable resource and will be useful to all workers and students in the area of receptor-ligand interactions. | Receptor Phosphorylation

GBP 205.00
1

Organelle and Molecular Targeting

Organelle and Molecular Targeting

We have surpassed the omics era and are truly in the Age of Molecular Therapeutics. The fast-paced development of SARS-CoV-2 vaccines such as the mRNA vaccines encoding the viral spike protein demonstrated the need for and capability of molecular therapy and nanotechnology-based solutions for drug delivery. In record speed the SARS-CoV-2 viral RNA genome was sequenced and shared with the scientific community allowing the rapid design of molecular therapeutics. The mRNA vaccines exploit the host cell endoplasmic reticulum to produce viral spike proteins for antigen presentation and recognition by the innate and adaptive immune system. Lipid nanoparticles enable the delivery of the fragile degradation-sensitive nucleic acid payloads. Molecular-based therapeutics and nanotechnology solutions continue to drive the scientific and medical response to the COVID-19 pandemic as new mRNA DNA and protein-based vaccines are developed and approved and the emergency use approved vaccines are rapidly manufactured and distributed throughout the globe. The need for molecular therapies and drug delivery solutions is clear and as these therapies progress and become more specialized there will be important advancements in organelle targeting. For example using organelle targeting to direct lipid nanoparticles with mRNA payloads to the endoplasmic reticulum would increase the efficacy of mRNA vaccines reducing the required dose and therefore the biomanufacturing demand. Likewise improving the delivery of DNA therapeutics to the nucleus would improve efficacy. Organelles and molecules have always been drug targets but until recently we have not had the tools or capability to design and develop such highly specific therapeutics. Organelle targeting has far-reaching implications. For example mitochondria are central to both energy production and intrinsic apoptosis. Effectively targeting and manipulating mitochondria has therapeutic applications for diseases such as myopathies cancer neurodegeneration progerias diabetes and the natural aging process. The SARS-CoV-2 vaccines that exploit the endoplasmic reticulum (for mRNA vaccines) and the nucleic translational process (DNA vaccines) attest to the need for organelle and molecular therapeutics. This book covers the status demand and future of organelle- and molecularly targeted therapeutics that are critical to the advancement of modern medicine. Organelle and molecular targeting is the drug design and drug delivery approach of today and the future; understanding this approach is essential for students scientists and clinicians contributing to modern medicine.

GBP 200.00
1

Self Assembly The Science of Things That Put Themselves Together

Self Assembly The Science of Things That Put Themselves Together

Hailed as one of the key areas of nanoscience likely to shape future scientific research self-assembly offers the most promising route to true molecular nanotechnology. Focusing on this dynamic new field Self Assembly: The Science of Things That Put Themselves Together explores nature's self-assembly of structures the use of it to build engineered systems and the latest advances in the field. Reflecting the inherent progress of the science of self-assembly this definitive book first delves into natural self-assembling systems. It addresses crystal growth soap films and micelles; examines how nature builds viruses proteins and ribosomes; and introduces the protein folding problem. The author then discusses how physicists chemists biologists and engineers are applying nature's principles to self-assemble everything from DNA cubes to millimeter-scale electronic circuits. The final chapters cover theoretical and experimental approaches to understand the phenomenon of self-assembly and overcome its various challenges. With practical activities profiles of leading experts chapter highlights exercises and references Self Assembly provides the most current authoritative information on this exciting branch of nanoscience. | Self Assembly The Science of Things That Put Themselves Together

GBP 180.00
1

Bioactive Peptides Production Bioavailability Health Potential and Regulatory Issues

Bioactive Peptides Production Bioavailability Health Potential and Regulatory Issues

Bioactive peptides have been receiving attention recently due to their applications as health-promoting agents. Derived from food proteins and other natural sources they exhibit various beneficial effects such as preventing diseases or modulating physiological systems once absorbed. As the market for nutraceuticals and functional foods continues to expand consumer interest has also grown and there are many common foods that have shown an abundance of bioactive peptides including dairy products cereal legumes meat and numerous other sources. In this newest addition to the series Nutraceuticals: Basic Research and Clinical Applications Bioactive Peptides: Production Bioavailability Health Potential and Regulatory Issues provides a comprehensive review of the current state of knowledge in the field of food protein hydrolysates and bioactive peptides their food sources bioavailability production applications functionalities health potentials and regulatory issues governing their use. Features Discusses different methodologies employed for scaling up bioactive peptides commercially Provides information on optimizing the production process Explains various bioactive properties exerted by different types of bioactive peptides Explores the application of metabolomics to the study of bioactive peptides With over 20 chapters written by established subject matter experts in their field this book provides timely information and discusses the latest developments of bioactive peptides. It will be useful for researchers academics and industry experts and can serve as an excellent resource for anyone interested in enhancing their knowledge in the field of bioactive peptides. | Bioactive Peptides Production Bioavailability Health Potential and Regulatory Issues

GBP 190.00
1

Commercialization Secrets for Scientists and Engineers

Commercialization Secrets for Scientists and Engineers

Commercializing a knowledge-based product or service requires a realistic methodical approach combined with a great deal of perseverance. Commercialization Secrets for Scientists and Engineers serves as a high-level guide to answering key questions and critical issues that confront founding entrepreneurs on their quest to commercialize their knowledge-based innovations. It highlights the unique problems shared by all technologists across knowledge-intensive fields and how to overcome the most predictable obstacles faced by technology entrepreneurs. It demystifies the process of commercializing advanced products that require a high degree of specialized knowledge. Typically these are disruptive technologies with the potential to revolutionize whole industries. The book simplifies the launch of high-tech ventures such as pharmaceuticals genetic and biotechnology products wireless devices fuel cells and minimally invasive medical devices. Additionally it will help readers bring their disruptive technologies to profitability.

GBP 180.00
1

Frontiers of Civil Engineering and Disaster Prevention and Control SET Proceedings of the 3rd International Conference on Civil Architectur

Frontiers of Civil Engineering and Disaster Prevention and Control SET Proceedings of the 3rd International Conference on Civil Architectur

Frontiers of Civil Engineering and Disaster Prevention and Control is a compilation of selected papers from The 3rd International Conference on Civil Architecture and Disaster Prevention and Control (CADPC 2022) and focuses on the research of architecture and disaster prevention in civil engineering. The proceedings features the most cutting-edge research directions and achievements related to construction technology and prevention and control of disaster. Subjects in this proceedings include: Construction Technology Seismicity in Civil Engineering High-Rise Building Construction Disaster Preparedness and Risk Reduction Smart Post-Disaster Rescue These proceedings will promote development of civil engineering and risk reduction resource sharing flexibility and high efficiency. Moreover promote scientific information interchange between scholars from the top universities research centers and high-tech enterprises working all around the world. | Frontiers of Civil Engineering and Disaster Prevention and Control SET Proceedings of the 3rd International Conference on Civil Architectur

GBP 290.00
1

Advances in Frontier Research on Engineering Structures SET Proceedings of the 6th International Conference on Civil Architecture and Struct

Advances in Frontier Research on Engineering Structures SET Proceedings of the 6th International Conference on Civil Architecture and Struct

Advances in Frontier Research on Engineering Structures focuses on the research of advanced structures and anti-seismic design in civil engineering. The proceedings present the most cutting-edge research directions and achievements related to civil and structural engineering. Topics covered in the proceedings include: · Engineering Structure and Seismic Resistance · Structural Mechanics Analysis · Components and Materials · Structural Seismic Design · 3D Printing Concrete · Other Related Topics The works of this proceedings will promote development of civil and structural engineering resource sharing flexibility and high efficiency. Thereby promote scientific information interchange between scholars from the top universities research centers and high-tech enterprises working all around the world. | Advances in Frontier Research on Engineering Structures SET Proceedings of the 6th International Conference on Civil Architecture and Struct

GBP 200.00
1

Advances in Civil Engineering and Environmental Engineering SET Proceedings of the 4th International Conference on Civil Engineering and Env

Advances in Civil Engineering and Environmental Engineering SET Proceedings of the 4th International Conference on Civil Engineering and Env

Advances in Civil Engineering and Environmental Engineering focuses on the research of Civil Engineering and Environmental Engineering. The proceedings featurethe most cutting-edge research directions and achievements related to Civil Engineering and Environmental. Subjects in the proceedings include: Civil Engineering Technology Civil Engineering Surveying Geological Engineering Structural Engineering Tunnel and Bridge Engineering Environmental protection materials Pollution control project Building environment and equipment engineering The works of this proceedings can promote development of Civil Engineering and Environmental Engineering resource sharing flexibility and high efficiency. Thereby promote scientific information interchange between scholars from the top universities research centers and high-tech enterprises working all around the world. | Advances in Civil Engineering and Environmental Engineering SET Proceedings of the 4th International Conference on Civil Engineering and Env

GBP 220.00
1

Applied Optimal Control Optimization Estimation and Control

Applied Optimal Control Optimization Estimation and Control

This best-selling text focuses on the analysis and design of complicated dynamics systems. CHOICE called it a high-level concise book that could well be used as a reference by engineers applied mathematicians and undergraduates. The format is good the presentation clear the diagrams instructive the examples and problems helpful. References and a multiple-choice examination are included. | Applied Optimal Control Optimization Estimation and Control

GBP 180.00
1

Analytical Method Development and Validation

Analytical Method Development and Validation

Describes analytical methods development optimization and validation and provides examples of successful methods development and validation in high-performance liquid chromatography (HPLC) areas. The text presents an overview of Food and Drug Administration (FDA)/International Conference on Harmonization (ICH) regulatory guidelines compliance with validation requirements for regulatory agencies and methods validation criteria stipulated by the US Pharmacopia FDA and ICH. | Analytical Method Development and Validation

GBP 180.00
1

The Public Productivity and Performance Handbook

The Public Productivity and Performance Handbook

A productive society is dependent upon high-performing government. This third edition of The Public Performance and Productivity Handbook includes chapters from leading scholars consultants and practitioners to explore all of the core elements of improvement. Completely revised and focused on best practice the handbook comprehensively explores managing for high performance measurement and analysis costs and finances human resources and cutting-edge organizational tools. Its coverage of new and systematic management approaches and well-defined measurement systems provides guidance for organizations of all sizes to improve productivity and performance. The contributors discuss such topics as accountability organizational effectiveness after budget cuts the complementary roles of human capital and “big data ” and how to teach performance management in the classroom and in public organizations. The handbook is accompanied by an online companion volume providing examples of performance measurement and improvement manuals across a wide variety of public organizations. The Public Performance and Productivity Handbook Third Edition is required reading for all public administration practitioners as well as for students and scholars interested in the state of the public performance and productivity field. | The Public Productivity and Performance Handbook

GBP 230.00
1

Philosophic Classics Volume III Modern Philosophy

Philosophic Classics Volume III Modern Philosophy

Esteemed for providing the best available translations Philosophic Classics: Modern Philosophy features complete works or complete sections of the most important works by the major thinkers as well as shorter samples from transitional thinkers. First published in 1961 Forrest E. Baird's revision of Philosophic Classics continues the tradition of providing generations of students with high quality course material. Using the complete works or where appropriate complete sections of works this anthology allows philosophers to speak directly to students. | Philosophic Classics Volume III Modern Philosophy

GBP 190.00
1

A Concise Introduction to Pure Mathematics

A Concise Introduction to Pure Mathematics

Accessible to all students with a sound background in high school mathematics A Concise Introduction to Pure Mathematics Fourth Edition presents some of the most fundamental and beautiful ideas in pure mathematics. It covers not only standard material but also many interesting topics not usually encountered at this level such as the theory of solving cubic equations; Euler‘s formula for the numbers of corners edges and faces of a solid object and the five Platonic solids; the use of prime numbers to encode and decode secret information; the theory of how to compare the sizes of two infinite sets; and the rigorous theory of limits and continuous functions. New to the Fourth Edition Two new chapters that serve as an introduction to abstract algebra via the theory of groups covering abstract reasoning as well as many examples and applications New material on inequalities counting methods the inclusion-exclusion principle and Euler‘s phi function Numerous new exercises with solutions to the odd-numbered ones Through careful explanations and examples this popular textbook illustrates the power and beauty of basic mathematical concepts in number theory discrete mathematics analysis and abstract algebra. Written in a rigorous yet accessible style it continues to provide a robust bridge between high school and higher-level mathematics enabling students to study more advanced courses in abstract algebra and analysis.

GBP 180.00
1

CRC Handbook of Chemistry and Physics

CRC Handbook of Chemistry and Physics

High Quality Science requires High Quality Data! Today more than ever the CRC Handbook of Chemistry and Physics is critical in ensuring that researchers educators and students have the highest quality data for chemical compounds and physical particles. Available both in print and online the Handbook covers 390 chemistry physics and related subjects organized in easy-to-find well-organized tables. Every year new reported data and new scientific areas are added making the Handbook the largest comprehensive physical science data source available anywhere. The 104th Edition of the Handbook has been completely reorganized to meet the needs of today’s scientists. The first section has property data on the elements organic and inorganic compounds water bio-medical compounds and polymers. Other sections focus on applications of chemical and physical data data of importance in laboratory work and information of units and nomenclature. The purpose of the reorganization is to make sure users can easily find all data on related subjects. Handbook features include: All data reviewed and evaluated by subject matter experts Standardized chemical names structures property names and property units Important information on subjects such as chemical and laboratory safety and nomenclature Chemical and physical data critical for fields such as environmental science bio-medical chemistry organic and inorganic chemistry materials innovation geo- and astrophysics and solid-state science Digital tools in our Online Edition to analyze graph process and exploit our data content

GBP 180.00
1

Getting Started in ZBrush An Introduction to Digital Sculpting and Illustration

Getting Started in ZBrush An Introduction to Digital Sculpting and Illustration

Getting Started in ZBrush is a gentle introduction to ZBrush today‘s premier digital sculpting program. Beginning with the fundamentals of digital sculpting as well as a thorough introduction to the user interface Getting Started in ZBrush will have you creating a variety of professional-level 3D models in no-time. More than just another button-pushing manual this comprehensive guide is packed with start-to-finish projects that ease you into the workflow of the program while at the same time providing tips and tricks that will allow you to achieve certain tasks much more quickly. After progressing through the tutorials you will be shown how to customize brushes materials scripts and the interface so that you can utilize these tools to their full advantage. Special consideration is given to ZBrush‘s integration plug-ins with Maya and 3ds Max allowing you to properly import and export your models in all programs. Texturing painting mapping decimation baking and topology are also fully covered so your Zbrush creations can come to life without sacrificing that high-resolution look. Ease your way into this complex subject with this straight-forward approach to ZBrush Perfect your technique with step-by-step tutorials that allow you to create high res models from start to finish. Expand your knowledge by visiting the companion website which features video demonstrations project files texture and model files scripts customized menus brushes and additional resources. | Getting Started in ZBrush An Introduction to Digital Sculpting and Illustration

GBP 180.00
1