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Blood and Home in Early Modern Drama Domestic Identity on the Renaissance Stage

Nonparametric Statistical Tests A Computational Approach

Nonparametric Statistical Tests A Computational Approach

Nonparametric Statistical Tests: A Computational Approach describes classical nonparametric tests as well as novel and little-known methods such as the Baumgartner-Weiss-Schindler and the Cucconi tests. The book presents SAS and R programs allowing readers to carry out the different statistical methods such as permutation and bootstrap tests. The author considers example data sets in each chapter to illustrate methods. Numerous real-life data from various areas including the bible and their analyses provide for greatly diversified reading. The book covers: Nonparametric two-sample tests for the location-shift model specifically the Fisher-Pitman permutation test the Wilcoxon rank sum test and the Baumgartner-Weiss-Schindler test Permutation tests location-scale tests tests for the nonparametric Behrens-Fisher problem and tests for a difference in variability Tests for the general alternative including the (Kolmogorov-)Smirnov test ordered categorical and discrete numerical data Well-known one-sample tests such as the sign test and Wilcoxon’s signed rank test a modification suggested by Pratt (1959) a permutation test with original observations and a one-sample bootstrap test are presented. Tests for more than two groups the following tests are described in detail: the Kruskal-Wallis test the permutation F test the Jonckheere-Terpstra trend test tests for umbrella alternatives and the Friedman and Page tests for multiple dependent groups The concepts of independence and correlation and stratified tests such as the van Elteren test and combination tests The applicability of computer-intensive methods such as bootstrap and permutation tests for non-standard situations and complex designs Although the major development of nonparametric methods came to a certain end in the 1970s their importance undoubtedly persists. What is still needed is a computer assisted evaluation of their main properties. This book closes that gap. | Nonparametric Statistical Tests A Computational Approach

GBP 69.99
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Red Blood Cell Aggregation

Red Blood Cell Aggregation

Red blood cells in humans—and most other mammals—have a tendency to form aggregates with a characteristic face-to-face morphology similar to a stack of coins. Known as rouleaux these aggregates are a normally occurring phenomenon and have a major impact on blood rheology. What is the underlying mechanism that produces this pattern? Does this really happen in blood circulation? And do these rouleaux formations have a useful function? The first book to offer a comprehensive review of the subject Red Blood Cell Aggregation tackles these and other questions related to red blood cell (RBC) aggregates. The book covers basic clinical and physiological aspects of this important biophysical phenomenon and integrates these areas with concepts in bioengineering. It brings together state-of-the-art research on the determinants mechanisms and measurement and effects of RBC aggregation as well as on variations and comparative aspects. After an introductory overview the book outlines factors and conditions that affect RBC aggregation. It presents the two hypotheses—the bridging model and the depletion model—that provide potential mechanisms for the adhesive forces that lead to the regular packing of the cells in rouleaux formations. The book also reviews the methods used to quantify RBC aggregation in vitro focusing on their importance in clinical practice. Chapters discuss the effect of RBC aggregation on the in vitro rheology of blood as well as on tube flow. The book also looks at what happens in the circulation when red blood cells aggregate and examines variations due to physiological and pathophysiological challenges. The concluding chapter explores the formation of red blood cell aggregates in other mammals. Written by leading researchers in the field this is an invaluable resource for basic science medical and clinical researchers; graduate stu

GBP 59.99
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Equivalence and Noninferiority Tests for Quality Manufacturing and Test Engineers

Contemporary Intellectual Assessment Fourth Edition Theories Tests and Issues

GBP 54.99
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Controlling High Blood Pressure through Nutrition Supplements Lifestyle and Drugs

The Blood-Brain Barrier in Health and Disease Volume Two Pathophysiology and Pathology

Blood Libel and Its Derivatives The Scourge of Anti-Semitism

Blood Libel and Its Derivatives The Scourge of Anti-Semitism

At the doorstep of the twenty-first century one would expect that medieval concepts such as blood libel the accusation that Jews kill children to use their blood in religious ritual would have been discarded by any civilized human being. Certainly in the Christian world where the story originated and endured for centuries modern attitudes have nearly erased these barbaric accusations. But in Arab and Islamic worlds where enmity towards Israel and Zionism has conditioned beliefs attitudes positions and fantasies blood libel and similar charges are still part of life. Most people are unaware of the history of blood libel and do not perceive links between it and many of the false accusations currently hurled against the state of Israel. Raphael Israeli argues that individuals and organizations guilty of human rights crimes project crimes onto Israel to avoid awareness of their own guilt. Certainly when countries ruled by dictators set the agenda of the UN Council for human rights Israel is consistently censured and condemned. Accusations of apartheid and charges of discrimination against Muslims are frequently made. Israel is accused of plots against Muslims in order to harm their productive sectors of using weapons of mass destruction to commit genocide against Arabs of injecting poisonous substances into Palestinian children of poisoning Arab lands under the guise of agricultural aid and of laying siege to peaceful citizens. All of these charges are derivatives of blood libel and have been adopted by Middle East Jihadists in their struggle against Israel. This volume aims to explain the origins of the charge of blood libel and define the ways its derivatives have achieved acceptance in certain parts of the world today. | Blood Libel and Its Derivatives The Scourge of Anti-Semitism

GBP 51.99
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The Blood-Brain Barrier in Health and Disease Volume One Morphology Biology and Immune Function

The Blood-Brain Barrier in Health and Disease Volume One Morphology Biology and Immune Function

Located at the interface between blood and the brain the blood-brain barrier is a dynamic permeability barrier formed by a continuous layer of specialized endothelial cells endowed with important permeability transport and regulatory functions that both protect the internal milieu of the brain and allow essential nutrients to be transported into the brain. Over the last 25 years we have witnessed remarkable expansion of our knowledge of the structure biology and function of the cerebral endothelium. In The Blood-Brain Barrier in Health and Disease Volume 1 international experts discuss basic and new concepts and most recent advances pertaining to the development of the cerebral microvascular system. Subjects include the structure function permeability properties transport mechanisms and the inherent heterogeneity of the cerebral endothelium; the anatomy and physiological properties of the neurovascular unit; functional aspects of the choroid plexus; and important concepts and advances made over the last two decades that have shaped our understanding of the immunological function of the blood-brain barrier. This book is intended to serve as a valuable source of basic and advanced information for researchers students and clinicians interested in this fast-expanding field and stimulate further research well into the future. | The Blood-Brain Barrier in Health and Disease Volume One Morphology Biology and Immune Function

GBP 44.99
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Diagnostic Ultrasound Imaging and Blood Flow Measurements Second Edition

Diagnostic Ultrasound Imaging and Blood Flow Measurements Second Edition

Offers an Extensive Discussion on High Frequency Ultrasound Based on a course taught and developed by a foremost expert in diagnostic ultrasound technology Diagnostic Ultrasound: Imaging and Blood Flow Measurements Second Edition covers cutting-edge developments along with the fundamental physics instrumentation system architecture clinical applications and biological effects of ultrasound. This text addresses the technical side of diagnostic ultrasound and begins with an overview of the field of ultrasonic imaging and its role in diagnostic medicine relative to other imaging modalities. The author describes the fundamental physics involved in ultrasonic transducers as well as in conventional imaging approaches and Doppler measurements including contrast imaging and 4D imaging. He reviews the current status and standards on ultrasound bioeffect and discusses methods that have been used to measure ultrasonic properties of tissues. He also provides a list of relevant references and further reading materials at the end of each chapter. New in the Second Edition: Details the latest advances in ultrasound technology related to biomedical applications including elastrography portable scanners ultrasound molecular imaging preclinical high frequency imaging 2D array and 4D imaging techniques Updates and expands each chapter Adds a new chapter on new developments such as elastography and miniature scanners Includes new case studies and examples throughout the book Diagnostic Ultrasound: Imaging and Blood Flow Measurements Second Edition covers recent advances in ultrasound technology related to biomedical applications. Intended for senior- to graduate-level coursework in ultrasonic imaging this text also serves practicing physicists engineers clinicians and sonographers. | Diagnostic Ultrasound Imaging and Blood Flow Measurements Second Edition

GBP 74.99
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Statistical Power Analysis A Simple and General Model for Traditional and Modern Hypothesis Tests Fifth Edition

Statistical Power Analysis A Simple and General Model for Traditional and Modern Hypothesis Tests Fifth Edition

Statistical Power Analysis explains the key concepts in statistical power analysis and illustrates their application in both tests of traditional null hypotheses (that treatments or interventions have no effect in the population) and in tests of the minimum-effect hypotheses (that the population effects of treatments or interventions are so small that they can be safely treated as unimportant). It provides readers with the tools to understand and perform power analyses for virtually all the statistical methods used in the social and behavioral sciences. Brett Myors and Kevin Murphy apply the latest approaches of power analysis to both null hypothesis and minimum-effect testing using the same basic unified model. This book starts with a review of the key concepts that underly statistical power. It goes on to show how to perform and interpret power analyses and the ways to use them to diagnose and plan research. We discuss the uses of power analysis in correlation and regression in the analysis of experimental data and in multilevel studies. This edition includes new material and new power software. The programs used for power analysis in this book have been re-written in R a language that is widely used and freely available. The authors include R codes for all programs and we have also provided a web-based app that allows users who are not comfortable with R to perform a wide range of analyses using any computer or device that provides access to the web. Statistical Power Analysis helps readers design studies diagnose existing studies and understand why hypothesis tests come out the way they do. The fifth edition includes updates to all chapters to accommodate the most current scholarship as well as recalculations of all examples. This book is intended for graduate students and faculty in the behavioral and social sciences; researchers in other fields will find the concepts and methods laid out here valuable and applicable to studies in many domains. | Statistical Power Analysis A Simple and General Model for Traditional and Modern Hypothesis Tests Fifth Edition

GBP 49.99
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Outpatient Nutrition Care: GI Metabolic and Home Nutrition Support Practical Guidelines for Assessment and Management

Home Extension Design

Transforming Early Head Start Home Visiting A Family Life Education Approach

Extremophiles From Biology to Biotechnology

Extremophiles From Biology to Biotechnology

Highly recommended by CHOICE Oct 2018Extremophiles are nature’s ultimate survivors thriving in environments ranging from the frozen Antarctic to abyssal hot hydrothermal vents. Their lifeforms span bacteria to fishes and are categorized as halophiles from hypersaline environments acidophiles from acidic waters psychrophiles from cold habitats and thermophiles from warm waters. Extremophiles: From Biology to Biotechnology comprehensively covers the basic biology physiology habitats secondary metabolites for bioprospecting and biotechnology of these extreme survivors. The chapters focus on the novel genetic and biochemical traits that lend these organisms to biotechnological applications. Couples studies of marine extremophile biology/genomics and extremophile culture for biotechnological applications with the latest advances in bio-prospecting and bio-product developmentIncludes practical experiments that a laboratory can use to replicate extreme habitats for research purposesPresents latest advances in extremophile genomics to give the reader a better understanding of the regulatory mechanisms of extremophilesOffers insights into the production of commercially important extremozymes carotenoids bioactive compounds and secondary metabolites of medicinal value. This unique guide serves as a resource for biotechnologists who wish to explore extremophiles for their commercial potential as well as a valuable reference for teaching undergraduate graduate and postgraduate students. | Extremophiles From Biology to Biotechnology

GBP 48.99
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Design for Dementia Living Well at Home

Design for Dementia Living Well at Home

Design for Dementia is written by an interdisciplinary team of professionals and academics whose aim is to present lessons learnt from the Dementia Demonstration House at the Building Research Establishment’s Innovation Park. Known as Chris and Sally’s House the project represents a unique opportunity to show in practice what can be done to assist people living with dementia to continue to live at home and as part of the community with as much independence as possible. This book presents evidence based practical design guidance backed up by over 15 combined years of research by experienced professional designers. Beginning with an introduction which provides the background to the global dementia epidemic to allow readers to gain a better understanding of the issues they must consider the book then discusses how good design principles planning and construction standards can be used to effectively respond to the dementia crisis. The detailed findings from research using Chris and Sally’s House are presented and discussed along with practical examples and success stories ranging from simple design features to the more complex use of sensors and automated ventilation. The hope is that readers can apply the lessons learnt from Chris and Sally’s House to successfully integrate solutions into the design of new or refurbished housing for the elderly and also that the tools and insights shared will inform the wider context of good housing design as well as the spectrum of constraints and design standards which often apply. This book is important reading for architects designers engineers and project managers but also anyone with an interest in learning about practical solutions to aid those with dementia to live well at home. | Design for Dementia Living Well at Home

GBP 44.99
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Kava From Ethnology to Pharmacology

Cancer Inhibitors from Chinese Natural Medicines

Nanotherapeutics From Laboratory to Clinic

Nanotherapeutics From Laboratory to Clinic

The emergence of nanotherapeutics is attributable to the integration of nanotechnology recombinant DNA technology and synthetic organic chemistry with medicine for treating critical human diseases in a more efficient and specific molecular approach than therapy with conventionally-designed and formulated drugs. Nanotherapeutics: From Laboratory to Clinic comprehensively discusses the current shortcomings for delivery of classical (small) drugs macromolecular therapeutics and recombinant vaccine via the common intravascular and extravascular routes. The book describes the synthetic/chemical engineering methods as well as recombinant hybridoma and phage display technologies to fabricate different types of nanoparticulate carriers and drugs. It also reveals the diversified approaches undertaken by harnessing nanotechnology to overcome the multistep extracellular and intracellular barriers and to facilitate the development of novel strategies for therapeutic delivery and imaging. The author elaborates on the preclinical and clinical trials of potential nanoparticle-based products in animal models and patients and the approval/commercialization of nanotherapeutics addressing all relevant human diseases. A focus on the above issues in a concise but illustrative manner fills the gap between the laboratory findings originating from the research on identification of cellular and systemic barriers of classical and macromolecular drugs along with development of strategies for fabrication and testing of nanotherapeutics and the clinical outcomes emanating from the testing of the selected potential nanotherapeutics on patients of particular diseases. The book also fills a gap in the existing literature between the design and development of diversified nanotherapeutics for various purposes and the investigation and evaluation of potential barriers and resultant therapeutic efficacy of those nano-medicine formulations. | Nanotherapeutics From Laboratory to Clinic

GBP 44.99
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Numerical Modeling of COVID-19 Neurological Effects ODE/PDE Analysis in R

Numerical Modeling of COVID-19 Neurological Effects ODE/PDE Analysis in R

Covid-19 is primarily a respiratory disease which results in impaired oxygenation of blood. The O2-deficient blood then moves through the body and for the study in this book the focus is on the blood flowing to the brain. The dynamics of blood flow along the brain capillaries and tissue is modeled as systems of ordinary and partial differential equations (ODE/PDEs). The ODE/PDE methodology is presented through a series of examples 1. A basic one PDE model for O2 concentration in the brain capillary blood. 2. A two PDE model for O2 concentration in the brain capillary blood and in the brain tissue with O2 transport across the blood brain barrier (BBB). 3. The two model extended to three PDEs to include the brain functional neuron cell density. Cognitive impairment could result from reduced neuron cell density in time and space (in the brain) that follows from lowered O2 concentration (hypoxia). The computer-based implementation of the example models is presented through routines coded (programmed) in R a quality open-source scientific computing system that is readily available from the Internet. Formal mathematics is minimized e. g. no theorems and proofs. Rather the presentation is through detailed examples that the reader/researcher/analyst can execute on modest computers. The PDE analysis is based on the method of lines (MOL) an established general algorithm for PDEs implemented with finite differences. The routines are available from a download link so that the example models can be executed without having to first study numerical methods and computer coding. The routines can then be applied to variations and extensions of the blood/brain hypoxia models such as changes in the ODE/PDE parameters (constants) and form of the model equations. | Numerical Modeling of COVID-19 Neurological Effects ODE/PDE Analysis in R

GBP 82.99
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China's Transition from Communism – New Perspectives

Self-build How to design and build your own home

Self-build How to design and build your own home

If you’ve ever dreamt of designing and building your own home this book is for you. Becoming a ‘self-builder’ doesn’t necessarily mean learning to build a house physically from scratch. Anyone can be a self-builder – you can do so without ever having to lay a brick yourself. Self-built homes can also be more individual better designed and more economical than buying from a developer. This book is designed for homeowners and self-builders whether aspiring or on the brink of starting a project. It provides a jargon-free step-by-step guide to the process of designing and building your own home distilling all of the practical information needed to make your dream house a reality. Carefully crafted to offer friendly easy-to-understand practical guidance and packed with watch points hints and tips it also highlights the potential pitfalls and suggests ways of avoiding them. Including indications of costs and timescales Self-build demystifies the process of budgeting finding a site gaining planning permission designing your home and all of the surrounding issues to do with sustainability planning regulations procurement and the use of building contracts. Beautifully illustrated with over 230-colour photos diagrams and plans it provides all the inspiration and ideas you need to bring your own project to life. Featured houses include: Amphibious House by Baca Architects Corten Courtyard House by Barefoot Architects Haringey Brick House by Satish Jassal Architects Shawm House by Mawson Kerr Architects Sussex House by Wilkinson King Architects The Pocket House by Tikari Works Architects. | Self-build How to design and build your own home

GBP 45.00
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Structural Design from First Principles

Structural Design from First Principles

This enlightening textbook for undergraduates on civil engineering degree courses explains structural design from its mechanical principles showing the speed and simplicity of effective design from first principles. This text presents good approximate solutions to complex design problems such as Wembley-Arch type structures the design of thin-walled structures and long-span box girder bridges. Other more code-based textbooks concentrate on relatively simple member design and avoid some of the most interesting design problems because code compliant solutions are complex. Yet these problems can be addressed by relatively manageable techniques. The methods outlined here enable quick early stage ball-park design solutions to be considered and are also useful for checking finite element analysis solutions to complex problems. The conventions used in the book are in accordance with the Eurocodes especially where they provide convenient solutions that can be easily understood by students. Many of the topics such as composite beam design are straight applications of Eurocodes but with the underlying theory fully explained. The techniques are illustrated through a series of worked examples which develop in complexity with the more advanced questions forming extended exam type questions. A comprehensive range of fully worked tutorial questions are provided at the end of each section for students to practice in preparation for closed book exams. | Structural Design from First Principles

GBP 48.99
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