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Forensic DNA Transfer

Forensic DNA Transfer

Forensic DNA Transfer provides a guide to the recognition and current understanding of DNA transfer in forensic criminal investigations. Increased improvements in technology mean that it is now routinely possible to obtain DNA profiles from non-visible deposits. How or when the DNA in question was deposited may be an issue in the context of the case especially if the donor of the DNA is not in dispute. A DNA profile alone cannot reveal when or how that DNA was deposited at a crime scene nor can it reveal the body matter from which it originated. Issues of transfer associated with activities may be debated—which the traditional discrimination purpose of DNA profiling cannot address. DNA may be everywhere and anywhere—in homes at workplaces during transport and on personal items including clothing. DNA from a person may be on an object they have never contacted or in a room they have never entered. Concepts discussed in the book include non-self DNA on hands through day-to-day activities the prevalence of background DNA in the environment and perhaps on the exhibit the persistence of any DNA transferred and that a DNA result will depend on these variables as well as recovery techniques. Since DNA may be transferred to an exhibit: (a) during the commission of a crime (b) before the crime and/or (c) after the crime through handling examination and testing this book covers various transfer pathways and sources of DNA. Documented cases of inadvertent transfer of DNA resulting in wrongful convictions or the misdirection of criminal investigations are discussed—with an emphasis on contamination mitigation throughout the entire process. Forensic DNA Transfer examines the additional complexity resulting from non-visible deposits of DNA that impact on sampling and testing regimes. The changing understanding of the composition of purported 'touch DNA' deposits from the skin including extracellular DNA transported via body secretions is described. Further the newer focus on interpreting DNA evidence—using activity level propositions and the rationale and associated issues—is also discussed.

GBP 46.99
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Forensic DNA Profiling A Practical Guide to Assigning Likelihood Ratios

Forensic DNA Profiling A Practical Guide to Assigning Likelihood Ratios

DNA testing and its forensic analysis are recognized as the “gold standard” in forensic identification science methods. However there is a great need for a hands-on step-by-step guide to teach the forensic DNA community how to interpret DNA mixtures how to assign a likelihood ratio and how to use the subsequent likelihood ratio when reporting interpretation conclusions. Forensic DNA Profiling: A Practical Guide to Assigning Likelihood Ratios will provide a roadmap for labs all over the world and the next generation of analysts who need this foundational understanding. The techniques used in forensic DNA analysis are based upon the accepted principles of molecular biology. The interpretation of a good-quality DNA profile generated from a crime scene stain from a single-source donor provides an unambiguous result when using the most modern forensic DNA methods. Unfortunately many crime scene profiles are not single source. They are described as mixed since they contain DNA from two or more individuals. Interpretation of DNA mixtures represents one of the greatest challenges to the forensic DNA analyst. As such the book introduces terms used to describe DNA profiles and profile interpretation. Chapters explain DNA extraction methods the polymerase chain reaction (PCR) capillary electrophoresis (CE) likelihood ratios (LRs) and their interpretation and population genetic models—including Mendelian inheritance and Hardy-Weinberg equilibrium. It is important that analysts understand how LRs are generated in a probabilistic framework ideally with an appreciation of both semicontinuous and fully continuous probabilistic approaches. KEY FEATURES:• The first book to focus entirely on DNA mixtures and the complexities involved with interpreting the results • Takes a hands-on approach offering theory with worked examples and exercises to be easily understood and implementable by laboratory personnel • New methods heretofore unpublished previously provide a means to innovate deconvoluting a mixed DNA profile assign an LR and appropriately report the weight of evidence • Includes a chapter on assigning LRs for close relatives (i. e. “It’s not me it was my brother”) and discusses strategies for the validation of probabilistic genotyping softwareForensic DNA Profiling fills the void for labs unfamiliar with LRs and moving to probabilistic solutions and for labs already familiar with LRs but wishing to understand how they are calculated in more detail. The book will be a welcome read for lab professionals and technicians students and legal professionals seeking to understand and apply the techniques covered. | Forensic DNA Profiling A Practical Guide to Assigning Likelihood Ratios

GBP 44.99
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Forensic DNA Applications An Interdisciplinary Perspective

Forensic DNA Applications An Interdisciplinary Perspective

Forensic DNA Applications: An Interdisciplinary Perspective Second Edition is fully updated to outline the latest advances in forensic DNA testing techniques and applications. It continues to fill the need for a reference book for people working in the field of forensic molecular biology testing and research as well as individuals investigating and adjudicating cases involving DNA evidence whether they be civil or criminal cases. DNA techniques have greatly impacted obvious traditional forensic areas but such advances have also positively affected myriad new areas of research and inquiry. It is possible today to think about solving forensic problems that were simply unheard of even a few years ago. As such the book pulls all relevant research and applied science together into a detailed and comprehensive collection. Part I begins with the history and development of DNA typing and profiling for criminal and civil purposes. It discusses the statistical interpretation of results with case examples mitochondrial DNA testing Y single nucleotide polymorphisms (SNPs) and short tandem repeats (STRs) and X SNP and STR testing. It also explores low copy number DNA typing mixtures and quality assurance and control. Part II moves on to cover the various uses and applications of analyzing collected physical evidence victim identification in mass disasters analyzing animal DNA forensic botany and other unique applications. Part III is dedicated to the latest advances and developments in human molecular biology and Part IV looks at policies and laws and ethics governing DNA evidence and its utilization in various cases and the courts. Forensic DNA Applications Second Edition covers cutting-edge research and advancements in the field and is the most up-to-date reference available. Edited and contributed to by the world's foremost leaders in the field it is a must-have reference for established professionals and an essential resource to legal professionals—lawyers and judges dealing with civil and criminal cases involving DNA technology—as well as students entering the fields of genetics and forensic DNA analysis. | Forensic DNA Applications An Interdisciplinary Perspective

GBP 56.99
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Artificial DNA Methods and Applications

Artificial DNA Methods and Applications

Combining elements of biochemistry molecular biology and immunology artificial DNA can be employed in a number of scientific disciplines. Some of the varied applications include site-specific mutagenesis hybridization amplification protein engineering anti-sense technology DNA vaccines protein vaccines recombinant antibodies screening for genetic and pathogenic diseases development of materials with new biochemical and structural properties and many more. Artificial DNA: Methods and Applications introduces the concept of artificial DNA that has been rationally designed and explains how it may be exploited in order to develop products that will achieve your intended purpose. The first part of the book covers methods of oligonucleotide synthesis and direct applications of synthetic DNA. The second part describes methods of gene assembly from synthetic oligonucleotides and applications of synthetic genes. The authors also discuss the different trends and future developments within each application area . With state-of-the art research the contributing authors describe how to engineer proteins using rational and semi-rational design to exhibit the desired traits and detail the various amplification reactions and hybridization techniques for modeling evolution and for use in basic research. The only text devoted to this subject Artificial DNA offers a comprehensive review that allows you to understand the strategy design and applications of synthetic oligonucleotides. | Artificial DNA Methods and Applications

GBP 59.99
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Forensic DNA Analysis Current Practices and Emerging Technologies

Forensic DNA Analysis Current Practices and Emerging Technologies

The field of forensic DNA analysis has grown immensely in the past two decades and genotyping of biological samples is now routinely performed in human identification (HID) laboratories. Application areas include paternity testing forensic casework family lineage studies identification of human remains and DNA databasing. Forensic DNA Analysis: Current Practices and Emerging Technologies explores the fundamental principles and the application of technologies for each aspect of forensic DNA analysis. The book begins by discussing the value of DNA evidence and how to properly recognize document collect and store it. The remaining chapters examine:The most widely adopted methods and the best practices for DNA isolation from forensic biological samples and human remainsStudies carried out on the use of both messenger RNA and small (micro) RNA profilingReal-time polymerase chain reaction (PCR) methods for quantification and assessment of human DNA prior to genotypingCapillary electrophoresis (CE) as a tool for forensic DNA analysisNext-generation short tandem repeat (STR) genotyping kits for forensic applications the biological nature of STR loci and Y-chromosome STRs (Y-STRs)Mitochondrial DNA (mtDNA) sequence analysisSingle nucleotide polymorphisms (SNPs) and insertion/deletion polymorphisms (indels) in typing highly degraded DNADeep-sequencing technologiesThe current state of integrated systems in forensic DNA analysis The book concludes by discussing various aspects of sample-processing training and the entities that provide such training programs. This volume is an essential resource for students researchers teaching faculties and other professionals interested in human identification/forensic DNA analysis. | Forensic DNA Analysis Current Practices and Emerging Technologies

GBP 77.99
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DNA Repair and Replication Mechanisms and Clinical Significance

DNA Methylation Microarrays Experimental Design and Statistical Analysis

Analyzing High-Dimensional Gene Expression and DNA Methylation Data with R

Secure and Resilient Software Requirements Test Cases and Testing Methods

Secure and Resilient Software Requirements Test Cases and Testing Methods

Secure and Resilient Software: Requirements Test Cases and Testing Methods provides a comprehensive set of requirements for secure and resilient software development and operation. It supplies documented test cases for those requirements as well as best practices for testing nonfunctional requirements for improved information assurance. This resource-rich book includes:Pre-developed nonfunctional requirements that can be reused for any software development project Documented test cases that go along with the requirements and can be used to develop a Test Plan for the softwareTesting methods that can be applied to the test cases provided Downloadable resources with all security requirements and test cases as well as MS Word versions of the checklists requirements and test cases covered in the bookOffering ground-level already-developed software nonfunctional requirements and corresponding test cases and methods this book will help to ensure that your software meets its nonfunctional requirements for security and resilience. The accompanying downloadable resources filled with helpful checklists and reusable documentation provides you with the tools needed to integrate security into the requirements analysis design and testing phases of your software development lifecycle. Some Praise for the Book:This book pulls together the state of the art in thinking about this important issue in a holistic way with several examples. It takes you through the entire lifecycle from conception to implementation . . —Doug Cavit Chief Security Strategist Microsoft Corporation. provides the reader with the tools necessary to jump-start and mature security within the software development lifecycle (SDLC). —Jeff Weekes Sr. Security Architect at Terra Verde Services. full of useful insights and practical advice from two au | Secure and Resilient Software Requirements Test Cases and Testing Methods

GBP 56.99
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Infectious Diseases of the Dog and Cat A Color Handbook

Equivalence and Noninferiority Tests for Quality Manufacturing and Test Engineers

Test Quality for Construction Materials and Structures Proceedings of the International RILEM/ILAC Symposium

Cadaver Dog Handbook Forensic Training and Tactics for the Recovery of Human Remains

Skin Diseases of the Dog and Cat

Skin Diseases of the Dog and Cat

A Colour Handbook of Skin Diseases of the Dog and Cat was one of the first books to bring key information about skin diseases to clinicians in an easy-to-use problem-oriented format. This fully revised and updated Third Edition responds to the huge growth in knowledge about skin conditions over the last decade including the discovery of new conditions the development of new approaches to management and effective new treatment options. Chapters are organized based on symptoms each containing a decision tree giving basic and practical guidance. The clear user-friendly design provides one condition per page (or spread of pages). 13 chapters covering over 120 skin claw and ear conditions classified by their principle presenting sign. Concise systematically structured text covering definition aetiology and pathogenesis clinical features differential diagnoses diagnostic tests and management. Flow charts in each chapter to help clinicians get to the right diagnosis. Special focus on diseases affecting paediatric patients as well as chapters discussing paw ear and nasal planum diseases. Explanation of new treatments for atopic dermatitis. Over 350 superb colour photographs and diagrams mostly new for this this edition. A focus on clinical practice and the need to explain the disease to the owner. Up-to-date and fully referenced throughout. This practical book continues to provide an entirely comprehensive guide to the diagnosis and management of veterinary skin conditions in a format that is easily accessible for busy clinicians.

GBP 51.99
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British Nuclear Weapons and the Test Ban 1954–1973 Britain the United States Weapons Policies and Nuclear Testing: Tensions and Contradictions

British Nuclear Weapons and the Test Ban 1954–1973 Britain the United States Weapons Policies and Nuclear Testing: Tensions and Contradictions

In 1962 Dean Acheson famously described Britain as having lost an Empire but not yet found a role. Perhaps nowhere is this more apparent than in the realms of nuclear weapons. An increasingly marginal world power successive post-war British governments felt that an independent nuclear deterrent was essential if the country was to remain at the top table of world diplomacy. Focusing on a key twenty-year period this study explores Britain's role in efforts to bring about a nuclear test ban treaty between 1954 and 1973. Taking a broadly chronological approach it examines the nature of defence planning the scientific goals that nuclear tests were designed to secure Anglo-American relationships the efficacy of British diplomacy and its contribution to arms control and disarmament. A key theme of the study is to show how the UK managed to balance the conflicting pressures created by its determination to remain a credible nuclear power whilst wanting to pursue disarmament objectives and how these pressures shifted over the period in question. Based on a wealth of primary sources this book opens up the largely ignored subject of the impact of arms control on the UK nuclear weapons programme. Its appraisal of the relationship between the requirements and developments of the UK nuclear weapons programme against international and domestic pressures for a test ban treaty will be of interest to anyone studying post-war British defence and foreign policy history of science arms control disarmament and non-proliferation and international relations. It also provides important background information on current events involving nuclear proliferation and disarmament. | British Nuclear Weapons and the Test Ban 1954–1973 Britain the United States Weapons Policies and Nuclear Testing: Tensions and Contradictions

GBP 44.99
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Handbook of Mitochondrial Dysfunction

Genomes 5

Genomes 5

Genomes 5 has been completely revised and updated. It is a thoroughly modern textbook about genomes and how they are investigated. As with previous Genomes editions techniques come first then genome anatomies followed by genome function and finally genome evolution. The genomes of all types of organism are covered: viruses bacteria fungi plants and animals including humans and other hominids. Genome sequencing and assembly methods have been thoroughly revised to include new developments in long-read DNA sequencing. Coverage of genome annotation emphasizes genome-wide RNA mapping with CRISPR-Cas 9 and GWAS methods of determining gene function covered. The knowledge gained from these techniques forms the basis of the chapters that describe the three main types of genomes: eukaryotic prokaryotic (including eukaryotic organelles) and viral (including mobile genetic elements). Coverage of genome expression and replication is truly genomic concentrating on the genome-wide implications of DNA packaging epigenome modifications DNA-binding proteins non-coding RNAs regulatory genome sequences and protein-protein interactions. Also included are examples of the applications of metabolomics and systems biology. The final chapter is on genome evolution including the evolution of the epigenome using genomics to study human evolution and using population genomics to advance plant breeding. Established methods of molecular biology are included if they are still relevant today and there is always an explanation as to why the method is still important. Genomes 5 is the ideal text for upper-level courses focused on genomes and genomics. Key Features A highly accessible and well-structured book with chapters organized into four parts to aid navigation Superb artwork illustrates the key concepts and mechanisms Each chapter has a set of short-answer questions and in-depth problems to test the reader’s understanding of the material Thoroughly up to date with references to the latest research from the 2020s

GBP 64.99
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Manipulation of the Avian Genome

Nonparametric Statistical Tests A Computational Approach

Nonparametric Statistical Tests A Computational Approach

Nonparametric Statistical Tests: A Computational Approach describes classical nonparametric tests as well as novel and little-known methods such as the Baumgartner-Weiss-Schindler and the Cucconi tests. The book presents SAS and R programs allowing readers to carry out the different statistical methods such as permutation and bootstrap tests. The author considers example data sets in each chapter to illustrate methods. Numerous real-life data from various areas including the bible and their analyses provide for greatly diversified reading. The book covers: Nonparametric two-sample tests for the location-shift model specifically the Fisher-Pitman permutation test the Wilcoxon rank sum test and the Baumgartner-Weiss-Schindler test Permutation tests location-scale tests tests for the nonparametric Behrens-Fisher problem and tests for a difference in variability Tests for the general alternative including the (Kolmogorov-)Smirnov test ordered categorical and discrete numerical data Well-known one-sample tests such as the sign test and Wilcoxon’s signed rank test a modification suggested by Pratt (1959) a permutation test with original observations and a one-sample bootstrap test are presented. Tests for more than two groups the following tests are described in detail: the Kruskal-Wallis test the permutation F test the Jonckheere-Terpstra trend test tests for umbrella alternatives and the Friedman and Page tests for multiple dependent groups The concepts of independence and correlation and stratified tests such as the van Elteren test and combination tests The applicability of computer-intensive methods such as bootstrap and permutation tests for non-standard situations and complex designs Although the major development of nonparametric methods came to a certain end in the 1970s their importance undoubtedly persists. What is still needed is a computer assisted evaluation of their main properties. This book closes that gap. | Nonparametric Statistical Tests A Computational Approach

GBP 69.99
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Genomics and Proteomics Principles Technologies and Applications

Genomics and Proteomics Principles Technologies and Applications

The book provides scope and knowledge on advanced techniques and its applications into the modern fields of biotechnology—genomics and proteomics. In this book different genomics and proteomics technologies and principles are examined. The fundamental knowledge presented in this book opens up an entirely new way of approaching DNA chip technology DNA array assembly gene expression analysis assessing changes in genomic DNA structure-based functional genomics protein networks and so on. Topics in the book include:• Different gene products with a similar role in neuronal defense against oxidative • Gene-gene and gene-environment interactions in genetic epidemiology• Elucidation of proto-oncogene c-abl function with the use of mouse models and the disease model of chronic myeloid leukemia • Next-generation sequencing microbiome evaluation molecular microbiology and their impact on human health • Proteomics and prostate cancer • RNA interference therapeutics • Molecular mechanisms of hepatitis C virus entry • Molecular phylogenetics for elucidation of evolutionary processes from biological data • The impact of transgenic crops on soil quality microbial diversity and plant-associated communities. • Biotechnological and genomic approaches for abiotic stress tolerance in crop plantsThe book will be valuable for biotechnology researchers and bioinformatics professionals and students in all fields of biotechnology and will serve to broaden their knowledge about these newer tools techniques innovations and applications. | Genomics and Proteomics Principles Technologies and Applications

GBP 82.99
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Epigenetics Environment and Genes

The Handbook for Market Research for Life Sciences Companies Finding the Answers You Need to Understand Your Market

The Handbook for Market Research for Life Sciences Companies Finding the Answers You Need to Understand Your Market

As innovation moves from the lab to the market a new research phase begins for the entrepreneur: the market research phase. Inspired by a new technology that can change the world critical questions need to be addressed. Is there a market for my innovation? Who are my clients? What do they need? Is my innovation filling that gap in the market? Who are my competitors? How are they approaching the market? If these questions are unaswered entrepreneurs meet potential investors or partners with only a basic understanding of their market. The objective of this book is to fill this gap. It is a practical manual that gives entrepreneurs real-world advice and tools to build a solid market model. The book provides tips models and tools entrepreneurs can use to collect interpret and present their market and integrate it into their business plan. What the entrepreneur learns in this book will help him throughout his journey. After going over the market research process he will learn how to design and use a number of market research tools and how to adapt them in a life science context. From building a web survey to preparing interviews to doing your own secondary research this handbook will help him gain a comprehensive understanding of how to perform his own market research activities and how to analyze his data. Finally a number of frameworks (such as the TAM-SAM-SOM as well as the KANO Model) are described so that he can efficiently share what he has learned using models that simply yet effectively shares findings. | The Handbook for Market Research for Life Sciences Companies Finding the Answers You Need to Understand Your Market

GBP 52.99
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Forensic Biology