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Animal Models of Diabetes Frontiers in Research

Animal Models of Diabetes Frontiers in Research

As the incidence of diabetes increases worldwide the need for recommendations on how to prevent and treat the condition grows exponentially and so does the need for an authoritative source for information on the appropriate models to study the condition. The new edition of Animal Models of Diabetes is that source. The book presents updated and expanded information regarding the use of models in experiments with both Type 1 and Type 2 diabetes. The new edition compiles relevant time-saving information on well-recognized models including various mice rats minipigs and Rhesus monkeys and provides extensive references for more in-depth study. It contains new and updated referenced reviews on animals with induced obesity as well as observations on retinopathy in spontaneous diabetes resembling human lesions. The book discusses nutritionally diabetes-prone animals and considerations of insulin resistance and obesity. The contributors also address the importance of recent findings on the pathogenesis of diabetes and its complications in relation to human disease. Including contributions from prominent experts in the field the book brings together scattered data and lucidly presents it. This promotes the understanding of the etiopathology of diabetes and offers a new grasp of the insulin action its negative feedback leading to insulin resistance and its detrimental outcomes. The book also includes new knowledge on specific complications of diabetes offering an incentive to test advanced modalities to prevent and inhibit their occurrence. | Animal Models of Diabetes Frontiers in Research

GBP 59.99
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Medicinal Plants in Asia for Metabolic Syndrome Natural Products and Molecular Basis

Ethanol and the Liver Mechanisms and Management

Herbal Treatment of Major Depression Scientific Basis and Practical Use

Artificial Intelligence with Uncertainty

Controlled Drug Delivery Systems

Controlled Drug Delivery Systems

This book will describe current research on drug delivery systems that encompass four broad categories namely: routes of delivery delivery vehicles payload and targeting strategies. Where appropriate delivery vehicles and relevant release of specific agents in any of these categories in clinical application will be discussed. All chapters will highlight the translational aspects of the various technologies discussed and will provide insights into the advantages of such delivery systems over current ones in clinical or research use. Each technology reviewed in this book will have significant potential to improve patients' lives by enhancing the therapeutic efficacy of drugs. This book:Discusses the various factors that mitigate effective oral insulin delivery and the current status of research efforts to overcome these barriers along with recent clinical projectionsExamines the advantages and disadvantages of each drug delivery systemExamines the standard method of accomplishing controlled drug release through the incorporation of the drugs within polymeric biomaterials such as capsules and microcapsules as well as other vehicles such as liposomesDiscusses various controlled drug delivery systems including sustained release delivery systems and pulse or delayed release e. g. to target different regions of the gastrointestinal tract. In view of these wide-ranging technological areas and the up-to-date discussions of opportunities and challenges associated with these applications the book should provide readers from technology materials science pharmacology and clinical disciplines with very valuable information.

GBP 44.99
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Photonics Modelling and Design

Perinatal Growth and Nutrition

Perinatal Growth and Nutrition

Preterm infants grow poorly after birth and very commonly develop ex utero growth restriction (EUGR). However the risks and benefits of catch-up growth in preterm infants must be weighed and evidence addressing this warrants examination. Perinatal Growth and Nutrition explores the reasons for EUGR and the long-term effects on developmental outcome and on metabolic risks. It provides clear information on the risks and benefits of faster post-natal growth and catch-up growth in preterm infants and offers tools for better assessment of growth and earlier identification of faltering growth. This book is divided into three sections. The first section covers advances in preterm infant growth standards diagnosis and causes of EUGR and assessments of preterm infant diets. The second section considers the extensive human literature on the effects of in utero and ex utero growth restriction and catch-up growth on long-term metabolic outcomes—such as obesity insulin resistance type 2 diabetes and cardiac disease—and long-term neurodevelopmental outcomes including cognition. It also examines evidence for the effect of growth on these outcomes in term and preterm infants. The final section of the book considers ways to reduce the incidence of EUGR in preterm infants and when EUGR does occur to optimize catch-up growth. Topics include assessment of dietary requirements of the diverse population of preterm infants examination of tools for prescribing nutrition to neonatal intensive care unit patients consideration of whether to customize or generalize nutrient intake and fortification of human milk. In addition the last chapter proposes using a Z-score growth chart for improved interpretation of growth data.

GBP 74.99
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Lipoic Acid Energy Production Antioxidant Activity and Health Effects

Lipoic Acid Energy Production Antioxidant Activity and Health Effects

The recognition of oxidative stress as a major factor in health aging and disease has led to a surge in research aimed at uncovering effective countermeasures in the form of antioxidants. Unique in its two-fold protective function alpha-lipoic acid has drawn unprecedented interest as a coenzyme in mitochondrial energy metabolism and as an antioxidant and cell redox modulator. Mounting data regarding its potential health benefits demands an authoritative single-source reference to codify current knowledge and guide future research. A state-of-the-science compilation Lipoic Acid follows the history of this potent coenzyme and the latest discoveries regarding the chemistry biological action and significance in energy production antioxidant activity and health. The book is divided into three sections: · Section I: Discovery and Molecular Structure reviews the early studies leading to the discovery of alpha-lipoic acid and explains the molecular structure biosynthesis and the characterization of lipoic acid and its chemical derivatives. · Section II: Metabolic Aspects describes in detail the human pharmacokinetics of alpha-lipoic acid including the lipoic acid-derived dehydrogenase complexes and their roles in energy metabolism. It also explains antioxidant activity and redox modulation and how lipoic acid induces Phase II detoxification enzymes through activation of Nrf2-dependent gene expression. · Section III Clinical Aspects discusses enzyme deficiency disorders and the effects of lipoic acid on insulin. It defines lipoic acid influence on signaling pathways and AMP-activated kinase and considers the therapeutic implications for treatment of metabolic syndromes and the improvement of mitochondrial function by lipoic acid supplementation. Contributions from leading in | Lipoic Acid Energy Production Antioxidant Activity and Health Effects

GBP 59.99
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Primary Care Nutrition Writing the Nutrition Prescription

Primary Care Nutrition Writing the Nutrition Prescription

This book contains the necessary knowledge and tools to incorporate nutrition into primary care practice. As a practical matter this effort is led by a dedicated primary care physician with the help of motivated registered dietitians nurses psychologists physical therapists and office staff whether within a known practice or by referral to the community. It is essential that the nutrition prescription provided by the physician be as efficient as possible. While many team members have superior knowledge in the areas of nutrition exercise and psychology the health practitioner remains the focus of patient confidence in a therapy plan. Therefore the endorsement of the plan rather than the implementation of the plan is the most important task of the physician. This book proposes a significant change in attitude of primary health care providers in terms of the power of nutrition in prevention and treatment of common disease. It features detailed and referenced information on the role of nutrition in the most common conditions encountered in primary care practice. In the past treatment focused primarily on drugs and surgery for the treatment of disease with nutrition as an afterthought. Advanced technologies and drugs are effective for the treatment of acute disease but many of the most common diseases such as heart disease diabetes and cancer are not preventable with drugs and surgery. While there is mention of prevention of heart disease this largely relates to the use of statins with some modest discussion of a healthy diet. Similarly prevention of type 2 diabetes is the early introduction of metformin or intensive insulin therapy. | Primary Care Nutrition Writing the Nutrition Prescription

GBP 46.99
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Nutrition and Diabetes Pathophysiology and Management

Nutrition and Diabetes Pathophysiology and Management

Diabetes occurs at such an alarming rate that it can be described as a global epidemic. Following its predecessor Nutrition and Diabetes: Pathophysiology and Management Second Edition is a comprehensive resource that describes various factors that drive the accumulation of excess body weight and fat resulting in obesity. The book discusses the metabolic aberrations found in obesity and how they lead to the association of obesity with diabetes. This new edition highlights the role played by diet and the interrelationships in the metabolism of key nutrients in the pathogenesis of obesity and diabetes which provides the scientific basis for treatment and management approaches. FeaturesHighlights the role of nutrition in the pathogenesis of obesity and diabetes Organized logically into two easy-to-use sections - Pathophysiology and Management of Obesity and Pathophysiology and Treatment of DiabetesFeatures emerging therapeutic approaches for management of obesity and diabetesDiscusses experience in the management of obesity and diabetes in developing countries Presents challenges in insulin therapy and provides guidelines to overcome themThe first section of the book retains key topics from the previous edition and contains new chapters including genetic determinants of nutrient processing; fat distribution and diabetes mellitus; combined effect of diet and physical activity in the management of obesity; pharmacologic treatment of obesity; and the role of gut microbiota in the pathogenesis and treatment of obesity. The second section features updated versions of most of the other chapters in the first edition comprising a modified chapter on oxidative stress and the effects of dietary supplements on glycemic control in Type 2 diabetes. In addition new chapters are added in this section and include the contribution of iron and transition metal micronutrients to diabetes; role of microbiota in the pathogenesis and treatment of diabetes; primary prevention of Type 2 diabetes; and the pathophysiology and management of Type 1 diabetes. | Nutrition and Diabetes Pathophysiology and Management

GBP 44.99
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Advanced Digital Optical Communications

Advanced Digital Optical Communications

This second edition of Digital Optical Communications provides a comprehensive treatment of the modern aspects of coherent homodyne and self-coherent reception techniques using algorithms incorporated in digital signal processing (DSP) systems and DSP-based transmitters to overcome several linear and nonlinear transmission impairments and frequency mismatching between the local oscillator and the carrier as well as clock recovery and cycle slips. These modern transmission systems have emerged as the core technology for Tera-bits per second (bps) and Peta-bps optical Internet for the near future. Featuring extensive updates to all existing chapters Advanced Digital Optical Communications Second Edition: Contains new chapters on optical fiber structures and propagation optical coherent receivers DSP equalizer algorithms and high-order spectral DSP receivers Examines theoretical foundations practical case studies and MATLAB® and Simulink® models for simulation transmissions Includes new end-of-chapter practice problems and useful appendices to supplement technical information Downloadable content available with qualifying course adoption Advanced Digital Optical Communications Second Edition supplies a fundamental understanding of digital communication applications in optical communication technologies emphasizing operation principles versus heavy mathematical analysis. It is an ideal text for aspiring engineers and a valuable professional reference for those involved in optics telecommunications electronics photonics and digital signal processing.

GBP 84.99
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Designing Green Networks and Network Operations Saving Run-the-Engine Costs

Designing Green Networks and Network Operations Saving Run-the-Engine Costs

In recent years socio-political trends toward environmental responsibility and the pressing need to reduce Run-the-Engine (RTE) costs have resulted in the concept of Green IT. Although a significant amount of energy is used to operate routing switching and transmission equipment comparatively less attention has been paid to Green Networking. A clear and concise introduction to green networks and green network operations Designing Green Networks and Network Operations: Saving Run-the-Engine Costs guides you through the techniques available to achieve efficiency goals for corporate and carrier networks including deploying more efficient hardware blade form-factor routers and switches and pursuing consolidation virtualization and network and cloud computing. The book: Delineates techniques to minimize network power cooling floor space and online storage while optimizing service performance capacity and availability Discusses virtualization network computing and Web services as approaches for green data centers and networks Emphasizes best practices and compliance with international standards for green operations Extends the green data center techniques to the networking environment Incorporates green principles in the intranet extranet and the entire IT infrastructures Reviews networking power management HVAC and CRAC basics Presents methodical steps toward a seamless migration to Green IT and Green Networking | Designing Green Networks and Network Operations Saving Run-the-Engine Costs

GBP 69.99
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Health and the National Health Service

International Business Law and the Legal Environment A Transactional Approach

International Business Law and the Legal Environment A Transactional Approach

The fourth edition of International Business Law and the Legal Environment: A Transactional Approach gives business and law students a clear understanding of the legal principles that govern international business. This book goes beyond compliance by emphasizing how to use the law to create value and competitive advantage. DiMatteo’s transactional approach walks students through key business transactions—from import and export contracts and finance to countertrade dispute resolution licensing and more—giving them both context and providing real-world applications. More concise than previous editions this new edition also features: • Added coverage of new technologies such as smart contracts digital platforms and blockchain technology • Discussion of businesses and sustainability climate change and creating a circular economy • Greater focus on UNIDROIT Principles and a review of INCOTERMS 2020 • Expansion of common carrier coverage to include CMI trucking and CMR railway conventions • International perspective and use of a variety of national and international law materials • Great coverage of EU substantive law Upper-level undergraduate and postgraduate students of business law and international business will appreciate DiMatteo’s lucid writing style and professionals will find this book to be a comprehensive resource. Online resources include an instructor’s manual PowerPoint slides test bank and other tools to provide additional support for students and instructors. | International Business Law and the Legal Environment A Transactional Approach

GBP 66.99
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Air Transportation A Global Management Perspective

Air Transportation A Global Management Perspective

Now in its ninth edition Air Transportation: A Global Management Perspective by John Wensveen is a well-proven accessible textbook that offers a comprehensive introduction to the theory and practice of air transport management. In addition to explaining the fundamentals the book transports the reader to the leading edge of the discipline using past and present trends to forecast future challenges and opportunities the industry may face encouraging the reader to think deeply about the decisions a manager implements. The word Global has been added to the subtitle for this edition reflecting an increased emphasis on worldwide operations including North America Latin America/Caribbean Europe Asia-Pacific the Middle East and Africa. The ninth edition focuses on the Age of Acceleration addressing trends related to emerging technologies such as autonomy artificial intelligence augmented reality virtual reality 3-D printing data analytics blockchain cybersecurity etc. New material includes extra information on airport management and operations air carrier business models aviation risk safety and security and how changing political landscapes impact the aviation industry. Enhanced content is supported by the addition of new chapters and online supplemental resources including PowerPoint presentations chapter quizzes exam questions and links to online resources. This wide-ranging textbook is appropriate for nearly all aviation programs that feature business and management. Its student-friendly structure and style make it highly suitable for modular courses and distance-learning programs or for self-directed study and continuing personal professional development. | Air Transportation A Global Management Perspective

GBP 79.99
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Organic Solar Cells Materials Devices Interfaces and Modeling

Organic Solar Cells Materials Devices Interfaces and Modeling

Current energy consumption mainly depends on fossil fuels that are limited and can cause environmental issues such as greenhouse gas emissions and global warming. These factors have stimulated the search for alternate clean and renewable energy sources. Solar cells are some of the most promising clean and readily available energy sources. Plus the successful utilization of solar energy can help reduce the dependence on fossil fuels. Recently organic solar cells have gained extensive attention as a next-generation photovoltaic technology due to their light weight mechanical flexibility and solution-based cost-effective processing. Organic Solar Cells: Materials Devices Interfaces and Modeling provides an in-depth understanding of the current state of the art of organic solar cell technology. Encompassing the full spectrum of organic solar cell materials modeling and simulation and device physics and engineering this comprehensive text:Discusses active layer interfacial and transparent electrode materialsExplains how to relate synthesis parameters to morphology of the photoactive layer using molecular dynamics simulationsOffers insight into coupling morphology and interfaces with charge transport in organic solar cellsExplores photoexcited carrier dynamics defect states interface engineering and nanophase separationCovers inorganic–organic hybrids tandem structure and graphene-based polymer solar cellsOrganic Solar Cells: Materials Devices Interfaces and Modeling makes an ideal reference for scientists and engineers as well as researchers and students entering the field from broad disciplines including chemistry material science and engineering physics nanotechnology nanoscience and electrical engineering. | Organic Solar Cells Materials Devices Interfaces and Modeling

GBP 59.99
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Optical Techniques for Solid-State Materials Characterization

Optical Techniques for Solid-State Materials Characterization

Over the last century numerous optical techniques have been developed to characterize materials giving insight into their optical electronic magnetic and structural properties and elucidating such diverse phenomena as high-temperature superconductivity and protein folding. Optical Techniques for Solid-State Materials Characterization provides detailed descriptions of basic and advanced optical techniques commonly used to study materials from the simple to the complex. The book explains how to use these techniques to acquire analyze and interpret data for gaining insight into material properties. With chapters written by pioneering experts in various optical techniques the text first provides background on light–matter interactions semiconductors and metals before discussing linear time-integrated optical experiments for measuring basic material properties such as Fourier transform infrared spectroscopy photoluminescence and Raman scattering. The next section begins with a description of ultrashort pulse generation and carrier dynamics in semiconductors and metals. The book then discusses time-resolved optical techniques such as pump–probe spectroscopy terahertz spectroscopy and magneto-optical spectroscopy. The subsequent section describes spatially resolved optical spectroscopy including conventional optical microscopy and micro-optical and near-field scanning techniques. The book concludes with an overview of more advanced emerging optical techniques such as ultrafast x-ray and electron diffraction ultrafast photoemission spectroscopy and time-resolved optical microscopy. As optical techniques are among the first applied when studying new systems with novel properties the information presented in this comprehensive reference will only grow in importance. By supplying clear detailed explanations of these techniques the book enables researchers to readily implement them and acquire new insights into the materials they study. CRC Press Authors SpeakRohit P. Prasankumar speaks about his book. Watch the Video

GBP 44.99
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Nonlinear Optical Systems Principles Phenomena and Advanced Signal Processing

Nonlinear Optical Systems Principles Phenomena and Advanced Signal Processing

Nonlinear Optical Systems: Principles Phenomena and Advanced Signal Processing is a simplified overview of the evolution of technology associated with nonlinear systems and advanced signal processing. This book’s coverage ranges from fundamentals to phenomena to the most cutting-edge aspects of systems for next-generation biomedical monitoring and nonlinear optical transmission. The authors address how these systems are applied through photonic signal processing in contemporary optical systems for communications and/or laser systems. They include a concise but sufficient explanation of mathematical representation of nonlinear equations to provide insight into nonlinear dynamics at different phases. The book also describes advanced aspects of solitons and bound solitons for passive- and active-mode locked fiber lasers in which higher-order differential equations can be employed to represent the dynamics of amplitude evolution in the current or voltages of lightwaves in such systems. Covering a wide range of topics this book: Introduces nonlinear systems and some mathematical representations particularly the routes to chaos and bifurcation Describes nonlinear fiber lightwave lasing systems Covers nonlinear phenomena in fiber lasers including both passive and active energy storage cavities Experimentally and theoretically demonstrates soliton pulses in which lightwaves are the carrier under their envelopes Assembles and demonstrates sequences of both single and multiple solitons in a group and then assesses their dynamics in detail Examines the evolution of bound solitons which are transmitted through single-mode optical fibers that compose a phase variation system This text outlines the theory and techniques used in nonlinear physics and applications for physical systems. It also illustrates the use of MATLAB® and Simulink® computer models and processing techniques for nonlinear signals. Building on readers’ newly acquired fundamental understanding of nonlinear systems and associated signal processing the book then demonstrates the use of such applications in real-world practical environments. | Nonlinear Optical Systems Principles Phenomena and Advanced Signal Processing

GBP 77.99
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Nanoelectronics Quantum Engineering of Low-Dimensional Nanoensembles

Nanoelectronics Quantum Engineering of Low-Dimensional Nanoensembles

Brings the Band Structure of Carbon-Based Devices into the LimelightA shift to carbon is positioning biology as a process of synthesis in mainstream engineering. Silicon is quickly being replaced with carbon-based electronics devices are being reduced down to nanometer scale and further potential applications are being considered. While traditionally engineers are trained by way of physics chemistry and mathematics Nanoelectronics: Quantum Engineering of Low-Dimensional Nanoensembles establishes biology as an essential basic science for engineers to explore. Unifies Science and Engineering: from Quantum Physics to NanoengineeringDrawing heavily on published papers by the author this research-driven text offers a complete review of nanoelectronic transport starting from quantum waves to ohmic and ballistic conduction and saturation-limited extreme nonequilibrium conditions. In addition it highlights a new paradigm using non-equilibrium Arora’s Distribution Function (NEADF) and establishes this function as the starting point (from band theory to equilibrium to extreme nonequilibrium carrier statistics). The author focuses on nano-electronic device design and development including carbon-based devices and provides you with a vantage point for the global outlook on the future of nanoelectronics devices and ULSI. Encompassing ten chapters this illuminating text:Converts the electric-field response of drift velocity into current–voltage relationships that are driven by the presence of critical voltage and saturation current arising from the unidirectional drift of carriers Applies the effect of these scaled-down dimensions to nano-MOSFET (metal–oxide–semiconductor field-effect transistor)Considers specialized applications that can be tried through a number of suggested projects that are all feasible with MATLAB® codesNanoelectronics: Quantum Engineering of Low-Dimensional Nanoensembles contains the latest research in nanoelectronics identifies problems and other factors to consider when it comes to nanolayer design and application and ponders future trends. Print Versions of this book also include access to the ebook version. | Nanoelectronics Quantum Engineering of Low-Dimensional Nanoensembles

GBP 44.99
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