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The Gut Microbiome Bench to Table

The Microbiome and the Brain

The Microbiome and the Brain

Brain related disorders are among the most challenging health issues of our time. The development of effective therapeutic and preventive strategies for these disorders relies on a comprehensive understanding of the underlying causative mechanisms. And until recently these mechanisms have remained somewhat elusive. The newly discovered pivotal role of the intestinal microbiome in brain health functionality and resistance to disease is revolutionizing neuroscience. The Microbiome and the Brain through the contributions of some of the most forward thinking researchers and clinicians in the field comprehensively reveals the leading edge of our understanding of the fundamental role of gut microbes and their metabolites in a wide array of seemingly diverse brain issues including Alzheimer’s disease autism multiple sclerosis and mood disorders. In addition mechanisms defining these relationships are explored along with a presentation of the state-of-the-art as it relates to interpretation of relevant laboratory assessments. Finally novel therapeutic opportunities derived from this exciting science are presented. Readers will learn:The highly validated relationship between alterations of gut microbes and their metabolites and risk for Alzheimer’s disease. The important link between autism and intestinal dysbiosis. Appropriate interpretation of available laboratory assessments of the intestinal microbiome. The potential role of fecal microbial transplant in neurological diseases. The influence of diet and other lifestyle choices on the microbiome as it relates to brain health and functionality.

GBP 44.99
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Secure and Resilient Software Requirements Test Cases and Testing Methods

Secure and Resilient Software Requirements Test Cases and Testing Methods

Secure and Resilient Software: Requirements Test Cases and Testing Methods provides a comprehensive set of requirements for secure and resilient software development and operation. It supplies documented test cases for those requirements as well as best practices for testing nonfunctional requirements for improved information assurance. This resource-rich book includes:Pre-developed nonfunctional requirements that can be reused for any software development project Documented test cases that go along with the requirements and can be used to develop a Test Plan for the softwareTesting methods that can be applied to the test cases provided Downloadable resources with all security requirements and test cases as well as MS Word versions of the checklists requirements and test cases covered in the bookOffering ground-level already-developed software nonfunctional requirements and corresponding test cases and methods this book will help to ensure that your software meets its nonfunctional requirements for security and resilience. The accompanying downloadable resources filled with helpful checklists and reusable documentation provides you with the tools needed to integrate security into the requirements analysis design and testing phases of your software development lifecycle. Some Praise for the Book:This book pulls together the state of the art in thinking about this important issue in a holistic way with several examples. It takes you through the entire lifecycle from conception to implementation . . —Doug Cavit Chief Security Strategist Microsoft Corporation. provides the reader with the tools necessary to jump-start and mature security within the software development lifecycle (SDLC). —Jeff Weekes Sr. Security Architect at Terra Verde Services. full of useful insights and practical advice from two au | Secure and Resilient Software Requirements Test Cases and Testing Methods

GBP 56.99
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Equivalence and Noninferiority Tests for Quality Manufacturing and Test Engineers

Test Quality for Construction Materials and Structures Proceedings of the International RILEM/ILAC Symposium

Microbial Diversity in Honeybees

British Nuclear Weapons and the Test Ban 1954–1973 Britain the United States Weapons Policies and Nuclear Testing: Tensions and Contradictions

British Nuclear Weapons and the Test Ban 1954–1973 Britain the United States Weapons Policies and Nuclear Testing: Tensions and Contradictions

In 1962 Dean Acheson famously described Britain as having lost an Empire but not yet found a role. Perhaps nowhere is this more apparent than in the realms of nuclear weapons. An increasingly marginal world power successive post-war British governments felt that an independent nuclear deterrent was essential if the country was to remain at the top table of world diplomacy. Focusing on a key twenty-year period this study explores Britain's role in efforts to bring about a nuclear test ban treaty between 1954 and 1973. Taking a broadly chronological approach it examines the nature of defence planning the scientific goals that nuclear tests were designed to secure Anglo-American relationships the efficacy of British diplomacy and its contribution to arms control and disarmament. A key theme of the study is to show how the UK managed to balance the conflicting pressures created by its determination to remain a credible nuclear power whilst wanting to pursue disarmament objectives and how these pressures shifted over the period in question. Based on a wealth of primary sources this book opens up the largely ignored subject of the impact of arms control on the UK nuclear weapons programme. Its appraisal of the relationship between the requirements and developments of the UK nuclear weapons programme against international and domestic pressures for a test ban treaty will be of interest to anyone studying post-war British defence and foreign policy history of science arms control disarmament and non-proliferation and international relations. It also provides important background information on current events involving nuclear proliferation and disarmament. | British Nuclear Weapons and the Test Ban 1954–1973 Britain the United States Weapons Policies and Nuclear Testing: Tensions and Contradictions

GBP 44.99
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Nutrition and Integrative Medicine A Primer for Clinicians

Nonparametric Statistical Tests A Computational Approach

Nonparametric Statistical Tests A Computational Approach

Nonparametric Statistical Tests: A Computational Approach describes classical nonparametric tests as well as novel and little-known methods such as the Baumgartner-Weiss-Schindler and the Cucconi tests. The book presents SAS and R programs allowing readers to carry out the different statistical methods such as permutation and bootstrap tests. The author considers example data sets in each chapter to illustrate methods. Numerous real-life data from various areas including the bible and their analyses provide for greatly diversified reading. The book covers: Nonparametric two-sample tests for the location-shift model specifically the Fisher-Pitman permutation test the Wilcoxon rank sum test and the Baumgartner-Weiss-Schindler test Permutation tests location-scale tests tests for the nonparametric Behrens-Fisher problem and tests for a difference in variability Tests for the general alternative including the (Kolmogorov-)Smirnov test ordered categorical and discrete numerical data Well-known one-sample tests such as the sign test and Wilcoxon’s signed rank test a modification suggested by Pratt (1959) a permutation test with original observations and a one-sample bootstrap test are presented. Tests for more than two groups the following tests are described in detail: the Kruskal-Wallis test the permutation F test the Jonckheere-Terpstra trend test tests for umbrella alternatives and the Friedman and Page tests for multiple dependent groups The concepts of independence and correlation and stratified tests such as the van Elteren test and combination tests The applicability of computer-intensive methods such as bootstrap and permutation tests for non-standard situations and complex designs Although the major development of nonparametric methods came to a certain end in the 1970s their importance undoubtedly persists. What is still needed is a computer assisted evaluation of their main properties. This book closes that gap. | Nonparametric Statistical Tests A Computational Approach

GBP 69.99
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Microbiomes and Their Functions Why Organisms Need Microbes

Microbiomes and Their Functions Why Organisms Need Microbes

This book provides a fundamental understanding of the importance of the microbiome in the life of virtually all multicellular organisms. It explains why microbes are an integral part of living organisms and describes the diverse roles they perform for their hosts. Although the significance of modified bacteria such as the mitochondrion and chloroplast is deeply rooted in the evolution of all complex organisms it is only recently that the contribution of microbial partners within and on their hosts is becoming fully evident. These communities of microbes are as essential to organisms as are the visible organs. Microbiomes are indeed “invisible organs. ” They participate in the digestive process assist in communication networks supply essential nutrients guard against foreign intrusion promote development and contribute to well-being. This unique approach where the dependence of the hosts on their microbiomes is explained will be a must-read for undergraduate and graduate students. Researchers and professionals probing microbial interactions with living organisms will find this book interesting and enriching. Key Features Emphasizes the roles microbiomes play within their hosts Includes many captivating illustrations enabling easy comprehension Explains microbiome functions from algae to vertebrates Reveals how microbiomes contribute to the health of the hosts and the ecosystems Describes the impact of dysbiosis on diseases food security and climate change Boxed sections provide a detailed analysis of concepts and are accompanied by vivid illustrations | Microbiomes and Their Functions Why Organisms Need Microbes

GBP 59.99
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The Shroud of Christ Evidence of a 2 000 Year Antiquity

Educational and Psychological Measurement

Handbook Of Applied Econometrics And Statistical Inference

Reliability Analysis with Minitab

Reliability Analysis with Minitab

Statistical Analysis for the Reliability Engineering ProfessionalEffectively conduct reliability analysis using the world’s leading statistical software. Reliability Analysis with Minitab® outlines statistical concepts and applications explains the theory of probability reliability analysis and quality improvement and provides step-by-step instruction on the use of Minitab. Minitab introduces reliability analysis tools that can be used to perform tasks that range from checking the distribution fit of lifetime data to estimating the warranty costs of a product. Perform the Analyses Needed to Minimize Product Failures and Reduce CostsChock full of examples that include numerous case studies and over 200 screenshots this book is a comprehensive guide to quality and reliability in the service and manufacturing industries. It illustrates the shapes of the most commonly used statistical distributions in reliability analysis and in simple language demonstrates concepts that include parametric reliability analysis nonparametric reliability analysis warranty analysis accelerated life testing reliability test plans and probit analysis. Illustrating the application of Minitab for reliability analysis this book explains how to: Perform reliability analysis of a product with right-censored and exact failure time data Complete reliability analysis of a product with arbitrarily censored failure time dataAchieve nonparametric reliability analysis of a productPredict the amount of money that is needed to cover the warranty costs for products in a specific period of time in the futureAnalyze the results from accelerated life testing on two different productsDetermine the reliability test sample size when the test time and the number of failures are constrainedRegulate the testing time when test sample size and the number of failures are constrainedCompare the reliabilities of parts from different vendorsTest whether the reliability of a product depends on certain factorsPredict the stress level at which a product will fail after a certain test period

GBP 44.99
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Asphalt Mixture Specification and Testing

Contemporary Intellectual Assessment Fourth Edition Theories Tests and Issues

GBP 54.99
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Nutrition and Cardiometabolic Health

A Course in Item Response Theory and Modeling with Stata

Proportionate Share Impact Fees and Development Mitigation

Proportionate Share Impact Fees and Development Mitigation

After decades of evolving practice often tested in court development impact fees have become institutionalized in the American planning and local government finance systems. But they remain contentious especially as they continue to evolve. This book is the third in a series of impact fee guidebooks for practitioners following A Practitioner’s Guide to Development Impact Fees and Impact Fees: Proportionate Share Development Fees. Proportionate Share Impact Fees and Development Mitigation is the culmination of the authors’ careers devoted to pioneering applications of the dual rational nexus test. That test requires (1) establishing the rational nexus between the need for infrastructure broadly defined to mitigate the impacts of development and (2) ensuring that development mitigating its infrastructure impacts benefits proportionately. The book elevates professional practice in two ways. First it shows how the rational nexus test can be applied to all forms of development infrastructure impact mitigation. Second it establishes the link between professional ethics and equity as applied to proportionate share impact fees and development mitigation. The book is divided into four parts with the first reviewing policy and legal foundations the second detailing the planning calculation and implementation requirements the third exploring economic ethical and equity implications and the fourth presenting state-of-the-art case studies. Proportionate Share Impact Fees and Development Mitigation sets new standards for professional practice.

GBP 44.99
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Statistical Inference Based on Divergence Measures

Statistical Inference Based on Divergence Measures

The idea of using functionals of Information Theory such as entropies or divergences in statistical inference is not new. However in spite of the fact that divergence statistics have become a very good alternative to the classical likelihood ratio test and the Pearson-type statistic in discrete models many statisticians remain unaware of this powerful approach. Statistical Inference Based on Divergence Measures explores classical problems of statistical inference such as estimation and hypothesis testing on the basis of measures of entropy and divergence. The first two chapters form an overview from a statistical perspective of the most important measures of entropy and divergence and study their properties. The author then examines the statistical analysis of discrete multivariate data with emphasis is on problems in contingency tables and loglinear models using phi-divergence test statistics as well as minimum phi-divergence estimators. The final chapter looks at testing in general populations presenting the interesting possibility of introducing alternative test statistics to classical ones like Wald Rao and likelihood ratio. Each chapter concludes with exercises that clarify the theoretical results and present additional results that complement the main discussions. Clear comprehensive and logically developed this book offers a unique opportunity to gain not only a new perspective on some standard statistics problems but the tools to put it into practice.

GBP 44.99
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Handbook of Geotechnical Testing: Basic Theory Procedures and Comparison of Standards

Need-to-Know NAFLD The Complete Guide to Nonalcoholic Fatty Liver Disease

Need-to-Know NAFLD The Complete Guide to Nonalcoholic Fatty Liver Disease

Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the obesity and metabolic syndrome epidemics which this up-to-date book deals with comprehensively. The contents outline disease mechanisms diagnostic tests management varying manifestations and special populations. It covers the mechanistic pathways that contribute to NAFLD development including the role of genetic variants and the gut microbiome. It elaborates on noninvasive diagnostic tests to screen for NAFLD determine its severity and monitor response to lifestyle intervention and pharmacologic treatment. This book helps clinicians diagnose and treat this common and potentially deadly disease. Key Features: Reviews current drugs in development and provides practical advice to clinicians on the diagnosis and management of fatty liver. Proves attractive to primary care providers who are on the front line of managing patients with NAFLD to gastroenterologists and hepatologists who would benefit from updated data on how to risk-stratify patients and identify those who will be eligible for pharmacologic treatment and other specialists such as cardiologists endocrinologists and nephrologists who will find this book to be a useful reference on the extrahepatic manifestations of NAFLD. Focuses on extrahepatic manifestations and new insights on the mechanistic drivers of the disease. | Need-to-Know NAFLD The Complete Guide to Nonalcoholic Fatty Liver Disease

GBP 69.99
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Drug Discovery and Development Third Edition

Drug Discovery and Development Third Edition

Drug Discovery and Development Third Edition presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies biotechnology approaches and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology regulatory and business aspects of bringing new drugs to the market and offers coverage of essential topics for companies involved in drug development. Historical perspectives and predicted trends are also provided. Features:Highlights emerging scientific fields relevant to drug discovery such as the microbiome nanotechnology and cancer immunotherapy; and novel research tools such as CRISPR and DNA-encoded librariesCase study detailing the discovery of the anti-cancer drug lorlatinibVenture capitalist commentary on trends and best practices in drug discovery and developmentComprehensive review of regulations and their impact on drug development highlighting special populations orphan drugs and pharmaceutical compoundingMultidiscipline functioning of an Academic Research Enterprise plus a chapter on Ethical Concerns in ResearchContributions by 70+ experts from industry and academia specialists who developed and are practitioners of the science and business

GBP 44.99
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