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Cancer and Vitamin C

Cancer and Vitamin C

Vitamin C may offer significant therapeutic benefits in the treatment of cancer. This book includes chapters by a group of leading scientific researchers documenting the ways cancer can be affected by high doses of ascorbate. After an initial chapter providing a historical perspective subsequent chapters focus on cancer cell death reprogramming of somatic cells recent case studies and other ways vitamin C can improve outcomes of therapy. FeaturesIncludes chapters from a team of leading international scholarsReviews the history of beneficial uses of vitamin C in the treatment of cancerSummarizes recent case studiesDiscusses how vitamin C may synergistically affect other cancer treatment methods | Cancer and Vitamin C

GBP 44.99
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Vitamin C New Biochemical and Functional Insights

Vitamin C New Biochemical and Functional Insights

Vitamin C holds a unique place in scientific and cultural history. In this book a group of leading scientific researchers describe new insights into the myriad ways vitamin C is employed during normal physiological functioning. In addition the text provides an extensive overview of the following: the rationale for utilizing vitamin C in the clinic updates on recent uses of vitamin C in cancer treatment through high-dose intravenous therapies the role vitamin C plays in the treatment of sepsis and infectious disease management of the ways vitamin C can improve stem cell differentiation as well as vitamin C use in other important health situations. FeaturesIncludes chapters from a team of leading international scholarsReviews the history and recent research on the functions benefits and uses of vitamin CFocuses special attention on the way vitamin C can be used in the treatment of cancersDiscusses how vitamin C can be employed against infectious disease | Vitamin C New Biochemical and Functional Insights

GBP 44.99
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A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery

A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery

The development of suitable assays the integration of appropriate technology and the effective management of the essential infrastructure are all critical to the success of any high-throughput screening (HTS) endeavor. However few scientists have the multidisciplinary experience needed to control all aspects of an HTS drug discovery project. A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery integrates the experience of diverse experts who offer fundamental and practical guidance across numerous situations. The book first discusses assay developments for important target classes such as protein kinases and phosphatases proteases nuclear receptors G protein-coupled receptors ion channels and heat shock proteins. It next examines assay developments for cell viability apoptosis and infectious diseases. The contributors explore the application of emerging technologies and systems including image-based high content screening RNA interference and primary cells. Finally they discuss the essential components of the integrated HTS process such as screening automation compound library management the screening of natural products from botanical sources and screening informatics. Designed to motivate researchers to bring further advances to the field this volume provides practical guidance on how to initiate validate optimize and manage a bioassay intended to screen large collections of compounds. Drawing on the knowledge from experts actively involved in assay development and HTS this is a resource that is both comprehensive and focused.

GBP 59.99
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Vitamin B12 Advances and Insights

Vitamin B12 Advances and Insights

Cobalamin (vitamin B12) was discovered in the first half of the 20th century. Vast amount of information on the role of the vitamins in human health and disease became available. Cobalamin science was however based on theoretical concepts that have been accepted without further proof of facts and hypotheses. Recently the breath-taking pace of development in research technologies has changed our understanding for the role of nutrients and the complex interaction between diet environment and diseases. Conditions like aging diet and drugs increase the risk of developing cobalamin deficiency probably because of diminished ability to liberate absorb or distribute the food-derived vitamin. From a basic science point of view understanding of the transport and function of the vitamin may pave the road for using this system for drug delivery. This book represents up-to-date literature on the discoveries and developments in the field of cobalamin. It includes multifaceted aspects of the vitamin in health and disease conditions. The book has been written by leading scientists who have significant contributions in this field and represents therefore a timely unique encyclopaedia on cobalamin. | Vitamin B12 Advances and Insights

GBP 44.99
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Implementing Evidence-Based Practices in Gifted Education Professional Learning Modules on Universal Screening Grouping Acceleration and

Implementing Evidence-Based Practices in Gifted Education Professional Learning Modules on Universal Screening Grouping Acceleration and

According to the Every Student Succeeds Act (ESSA) evidence-based practices are supported by rigorous research designs and demonstrate that they improve student outcomes but the actual implementation of these practices in schools is limited. This essential guidebook assists coordinators of gifted education in implementing three evidence-based practices: universal screening grouping and acceleration. Each module includes an overview of research administrative and assessment considerations forms for implementing the practice scripted presentation slides for educators and parents and resources. Modules may be used by educators within a series of workshops for an entire school district on an individual campus or for important stakeholders. | Implementing Evidence-Based Practices in Gifted Education Professional Learning Modules on Universal Screening Grouping Acceleration and

GBP 66.99
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Queer Representation Visibility and Race in American Film and Television Screening the Closet

Queer Representation Visibility and Race in American Film and Television Screening the Closet

This book traces the uneven history of queer media visibility through crucial turning points including the Hollywood Production Code era the AIDS crisis of the 1980s the so-called explosion of gay visibility on television during the1990s and the re-imagination of queer representations on TV after the events of 9/11. Kohnen intervenes in previous academic and popular accounts that paint the increase in queer visibility over the past four decades as a largely progressive development. She examines how and why a limited and limiting concept of queer visibility structured around white gay and lesbian characters in committed relationships has become the embodiment of progressive LGBT media representations. She also investigates queer visibility across film TV and print media and highlights previously unexplored connections such as the lingering traces of classical Hollywood cinema's queer tropes in the X-Men franchise. Across all chapters narratives and arguments emerge that demonstrate how queer visibility shapes and reflects not only media representations but the real and imagined geographies histories and people of the American nation. | Queer Representation Visibility and Race in American Film and Television Screening the Closet

GBP 44.99
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German Façade Design Traditions of Screening from 1500 to Modernism

German Façade Design Traditions of Screening from 1500 to Modernism

German architecture prior to the modern period has received less systemic analytical study than that of Italy France and Britain. Scholarly discussion of broad traditions or continuities within Germanic or Central European façade design is even sparser. Baroque era studies of the region mostly devote themselves to isolated architects monuments or movements. Modernism's advent decisively changed this: Germanic architecture enjoyed sudden ascendancy. Yet even so study specifically of that region's façades still lagged – nothing compares to the dozens of treatments of Le Corbusier's façade systems for example and how these juxtapose with French neoclassical or Italian Renaissance methods. Given the paucity of multi-period studies one can be forgiven for believing Germany's effervescence of radical modern works seems unprecedented. This book takes up these multiple quandaries. It identifies and documents a previously unrecognized compositional tradition - characterized here as the 'screen façade' – and posits it as a counter-narrative critiquing the essentialist 'authentic' canon currently dominant in Western architectural history. By crossing evenly over the dividing line between the historical and modern periods it offers valuable insights on indigenous roots underlying some aspects of Germany's invigorating early twentieth-century architectural developments. The book chronologically examines 400 years of closely related facades concentrated in Germany but also found in Austria the Czech Republic German-speaking Switzerland and nearby areas of Central Europe. While nearly 75 buildings are mentioned and illustrated a dozen are given extensive analysis and the book focuses on the works of three architects – Schinkel Behrens and Mies. Relationships between examples of these three architects' façades far transcend mere homage amongst masters. Glimmers of the system they eventually codify are apparent as early as at Heidelberg Castle in 1559 and Nürnberg's Rathaus in 1622. The book argues that in Germany northern Gothic affinities for bisection intense repetition and rote aggregation intersected with southern Classical affinities for symmetry hierarchy and centrality thereby spawning a unique hybrid product – the screen. Instead of graphic formality this study is guided by on-site perceptions propositional contrasts means of approach interpretive conflicts and emotion and it relates the design of these façades to concepts proposed by contemporary philosophers including Novalis Hegel Nietzsche Freud Adorno and most importantly Gadamer on hermeneutics. | German Façade Design Traditions of Screening from 1500 to Modernism

GBP 46.99
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Phytochemistry of Plants of Genus Phyllanthus

Phytochemistry of Plants of Genus Phyllanthus

Several Phyllanthus species are widely used in traditional medicine and herbal formulation for the treatment of a variety of ailments such as flu dropsy diabetes jaundice and bladder calculus. The medicinal properties of these species are due to the presence of lignans flavonoids tannins alkaloids and terpenoids. Phyllanthin and hypophyllanthin are the major lignans from Phyllanthus species having estrogenic properties that reduce toxicity and vascular tension and protect hepatocytes. This book deals with the importance of separation techniques in screening of major lignans flavonoids and terpenoids in Phyllanthus species using HPLC/UPLC coupled with mass spectrometric techniques. Features: Collection of Ayurvedic features and scientific evidence of important medicinal plants. Screening of major lignans flavonoids and terpenoids in plant parts/whole plant extracts and their geographical variations in Phyllanthus amarus. Easy-to-use analytical procedure for the quality control of Phyllanthus and its products. | Phytochemistry of Plants of Genus Phyllanthus

GBP 56.99
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Prenatal Medicine

Prenatal Medicine

At the cutting-edge of maternal and neonatal management and research this reference presents the most recent advances in fetal DNA/RNA embryoscopy/fetoscopy open fetal surgery and ethnic population screening to manage pre-existing and newly detected maternal medical complications detect genetic and congenital abnormalities prevent preterm births and optimize pregnancy outcomes. With illustrative color photographs this source offers contributions by esteemed professionals at respected institutions around the globe and covers legal issues concerning prenatal assessment and diagnosis. | Prenatal Medicine

GBP 59.99
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Optimization of Hydraulic Fracture Stages and Sequencing in Unconventional Formations

Optimization of Hydraulic Fracture Stages and Sequencing in Unconventional Formations

Shale gas and/or oil play identification is subject to many screening processes for characteristics such as porosity permeability and brittleness. Evaluating shale gas and/or oil reservoirs and identifying potential sweet spots (portions of the reservoir rock that have high-quality kerogen content and brittle rock) requires taking into consideration multiple rock reservoir and geological parameters that govern production. The early determination of sweet spots for well site selection and fracturing in shale reservoirs is a challenge for many operators. With this limitation in mind Optimization of Hydraulic Fracture Stages and Sequencing in Unconventional Formations develops an approach to improve the industry’s ability to evaluate shale gas and oil plays and is structured to lead the reader from general shale oil and gas characteristics to detailed sweet-spot classifications. The approach uses a new candidate selection and evaluation algorithm and screening criteria based on key geomechanical petrophysical and geochemical parameters and indices to obtain results consistent with existing shale plays and gain insights on the best development strategies going forward. The work introduces new criteria that accurately guide the development process in unconventional reservoirs in addition to reducing uncertainty and cost.

GBP 44.99
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Establishing Family-School Partnerships in School Psychology Critical Skills

Establishing Family-School Partnerships in School Psychology Critical Skills

Establishing Family-School Partnerships in School Psychology provides actionable evidence-based practices toward effective family-school partnerships. Offering scoped and sequenced approaches to embed family-school partnership interventions within a three-tier prevention framework the book covers mental health screening cultural responsiveness technology use and more. This volume in the Foundations of School Psychology Research and Practice Series makes clear how sustained implementation of family-school partnerships can be achieved within existing educational infrastructures to promote student achievement across developmental periods and schooling levels. | Establishing Family-School Partnerships in School Psychology Critical Skills

GBP 44.99
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Geriatric Diabetes

Geriatric Diabetes

The number of elderly patients with diabetes is increasing at a significant rate. Responding to this growth this source serves as a solid arsenal of information on the varying presentations and challenges associated with diabetes in the geriatric patient and supplies clearly written sections on the screening diagnosis and treatment of diabetes in elderly populations. With contributions from renowned authorities from the national and international institutions this reference will depict the role of specific co-morbidities socioeconomic aspects and caregiver issues on the effective management of diabetes in the older adult. | Geriatric Diabetes

GBP 56.99
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Advances in Chromatography Volume 46

Advances in Chromatography Volume 46

Written by leading international experts in academia and industry Advances in Chromatography Volume 46 presents all new chapters with thorough reviews on the latest developments in the field. Volume 46 includes new advances in two-dimensional gas chromatography reversed phase liquid chromatography/shape selectivity and supercritical fluid chromatography. The book highlights enantioselective separations with emphasis on chiral recognition mechanisms screening approaches and separation speed. It also emphasizes hyphenated techniques and enhanced fluidity chromatography with emphasis on monolithic organo-silica hybrid columns. This volume provides an excellent starting point for gaining quick knowledge to the field of separation science.

GBP 59.99
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Hereditary Breast Cancer

Hereditary Breast Cancer

Intended for medical oncologists surgeons obstetricians gynecologists geneticists genetic counselors and primary care physicians this text presents the epidemiological biological and clinical issues associated with hereditary breast cancer. It offers clear guidance on the application and utilization of cancer risk assessment models genetic counseling and testing of high risk patients and screening and prevention options for individuals at risk of hereditary breast cancer. Addressing every essential aspect of hereditary breast cancer thissource offers comprehensive analyses of hereditary breast cancer-associated syndromes low penetrance genes and hereditary breast cancer associated with mutations in the BRCA1 and BRCA2 genes.

GBP 59.99
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Diabetes Clinician's Desk Reference

Diabetes Clinician's Desk Reference

The book explains the underlying pathophysiology of the disease and covers in detail all its main forms and complications. Separate chapters consider the range of treatment options together with summaries of key clinical trials. Coverage also includes epidemiology and classification as well as diagnosis screening limiting risk and other aspects of disease management and patient care. The book is illustrated throughout by explanatory diagrams graphs tables and photos. Key Features: 1. Builds on its strength of having excellent content on long-term management of hyperglycemia by including pancreas and islet transplantation. 2. Contains invaluable information on glucose monitoring for healthcare professionals interested in diabetes. | Diabetes Clinician's Desk Reference

GBP 56.99
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Drug-Drug Interactions

Drug-Drug Interactions

Authored by renowned leaders in the field this comprehensive volume covers all aspects of drug-drug interactions including preclinical clinical toxicological and regulatory perspectives. Thoroughly updated this second edition reflects the significant advances and includes extensive new material on: key interplay between transporters and enzymes in drug metabolism and drug interactions the integral role of pharmacogenetics in metabolism-based drug-drug interactions in vivo – in vitro correlations (reversible mechanism-based inhibition induction) in silico approaches enabling structure-activity and structure-function studies high-throughput screening and GLP methods for evaluating drug interactions in vitro the use of transgenic animal models to evaluate drug interactions Providing helpful case examples and computer-aided modeling Drug-Drug Interactions is filled with over 200 invaluable tables equations and figures to clarify key concepts and incorporates critical new updated information.

GBP 59.99
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Predictive Analytics in Human Resource Management A Hands-on Approach

Predictive Analytics in Human Resource Management A Hands-on Approach

This volume is a step-by-step guide to implementing predictive data analytics in human resource management (HRM). It demonstrates how to apply and predict various HR outcomes which have an organisational impact to aid in strategising and better decision-making. The book: Presents key concepts and expands on the need and role of HR analytics in business management. Utilises popular analytical tools like artificial neural networks (ANNs) and K-nearest neighbour (KNN) to provide practical demonstrations through R scripts for predicting turnover and applicant screening. Discusses real-world corporate examples and employee data collected first-hand by the authors. Includes individual chapter exercises and case studies for students and teachers. Comprehensive and accessible this guide will be useful for students teachers and researchers of data analytics Big Data human resource management statistics and economics. It will also be of interest to readers interested in learning more about statistics or programming. | Predictive Analytics in Human Resource Management A Hands-on Approach

GBP 44.99
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The Routledge History of Disease

The Routledge History of Disease

The Routledge History of Disease draws on innovative scholarship in the history of medicine to explore the challenges involved in writing about health and disease throughout the past and across the globe presenting a varied range of case studies and perspectives on the patterns technologies and narratives of disease that can be identified in the past and that continue to influence our present. Organized thematically chapters examine particular forms and conceptualizations of disease covering subjects from leprosy in medieval Europe and cancer screening practices in twentieth-century USA to the ayurvedic tradition in ancient India and the pioneering studies of mental illness that took place in nineteenth-century Paris as well as discussing the various sources and methods that can be used to understand the social and cultural contexts of disease. Chapter 24 of this book is freely available as a downloadable Open Access PDF under a Creative Commons Attribution-Non Commercial-No Derivatives 3. 0 license. https://www. routledgehandbooks. com/doi/10. 4324/9781315543420. ch24

GBP 44.99
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Biocontrol of Plant Diseases by Bacillus subtilis Basic and Practical Applications

Biocontrol of Plant Diseases by Bacillus subtilis Basic and Practical Applications

Plant diseases are a serious threat to food production. This unique volume provides the fundamental knowledge and practical use of B. subtilis as a promising biocontrol agent. In order to replace chemical pesticides one possibility is microbial pesticides using safe microbes. Bacillus subtilis is one of several candidates. Screening of the bacterium the application of plant tests clarification of its suppressive mechanism to plant pathogens and engineering aspects of suppressive peptides production are presented here. The author illustrates how B. subtilis is far more advantageous than for example Pseudomonas in biocontrol and can be considered as an useful candidate. Features:Bacterium B. subtilis suppresses many plant pathogens and is a biocontrol agent to replace chemical pesticidesThe book presents the bacterium's suppressive mechanism to plant pathogens and engineering aspects of suppressive peptides production Biological control of plant disease plays an important role in sustainable agricultural production practices and is expected to replace agricultural chemicals | Biocontrol of Plant Diseases by Bacillus subtilis Basic and Practical Applications

GBP 44.99
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TRP Channels

TRP Channels

The rapid expansion of the TRP field has generated a large amount of excellent original work across many different research fields. However investigators are not necessarily familiar with the pros and cons of the variety of methods used to study TRP channels. Because of functional and genetic diversity as well as the different physiological roles they play techniques used for studying TRP channels range from single molecular analysis to behavioral animal studies. Methods in multiple areas such as molecular biology fluorescence imaging electrophysiology cell biology genetics proteomics pharmacology system physiology and behavioral assessment are employed to investigate various aspects of these channels. Choosing among many possible topics in these broad areas was a daunting task. A comprehensive review of the field TRP Channels spans the information gap by providing broad coverage of current methods and techniques commonly used in TRP channel research and detailed protocols with thorough discussions of the advantages and disadvantages across methods. Some topics covered include Mammalian Drosophila and C. elegans TRP channels Practical protocols for functional studies of TRP channels including TRPC TRPV TRPA TRPM and the intracellularly localized TRPML channels ThermoTRPs including the new fast temperature jump apparatus and the high throughput random mutagenesis method for screening critical motifs involved in TRP channel regulation Cell-based high-throughput screening assays for TRP channels and their applications in drug discoveries TRP channel functions in native cells including smooth muscles neurons and cancers Showcasing the current status of the field TRP Channels covers the major techniques used in various areas of research. The majority of the chapters are protocol oriented with the goal of providing clear directions for laboratory use. Because of the breadth of the TRP field the applications of some methods are described in multiple chapters by experts working on a variety of channel types that serve different physiological functions highlighting distinctive views on how the methodology can be utilized. Some chapters include discussion on the usefulness and pitfalls associated with the use of certain techniques. Together with chapters that offer comprehensive reviews on the functional regulation and other roles of TRP channels students and investigators new to the field should find this book particularly informative.

GBP 69.99
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Computational Modelling and Imaging for SARS-CoV-2 and COVID-19

Computational Modelling and Imaging for SARS-CoV-2 and COVID-19

The aim of this book is to present new computational techniques and methodologies for the analysis of the clinical epidemiological and public health aspects of SARS-CoV-2 and COVID-19 pandemic. The book presents the use of soft computing techniques such as machine learning algorithms for analysis of the epidemiological aspects of the SARS-CoV-2. This book clearly explains novel computational image processing algorithms for the detection of COVID-19 lesions in lung CT and X-ray images. It explores various computational methods for computerized analysis of the SARS-CoV-2 infection including severity assessment. The book provides a detailed description of the algorithms which can potentially aid in mass screening of SARS-CoV-2 infected cases. Finally the book also explains the conventional epidemiological models and machine learning techniques for the prediction of the course of the COVID-19 epidemic. It also provides real life examples through case studies. The book is intended for biomedical engineers mathematicians postgraduate students; researchers; medical scientists working on identifying and tracking infectious diseases. | Computational Modelling and Imaging for SARS-CoV-2 and COVID-19

GBP 44.99
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Kinanthropometry and Exercise Physiology

Kinanthropometry and Exercise Physiology

Fully updated revised and consolidated into one single volume the fourth edition of Kinanthropometry and Exercise Physiology offers the best theoretically contextualised practical resource for instructors and students available. Incorporating substantial sections on kinanthropometry exercise physiology energy systems and the application of science in health and high performance settings the book covers the basics of measurement in exercise science through to advanced methods and includes brand new chapters on: Pre-exercise screening and health risk stratification Functional movement assessment Point of care testing Anthropometry standards Anaerobic power and capacity History of exercise for health benefits Monitoring training loads in high-performance athletes Measuring game style in team sports Offering on-line access to newly developed exercise science measurement tools through the Exercise Science Toolkit – www. exercisesciencetoolkit. com – no other book offers such a complete resource from the science of kinanthropometry and exercise physiology to their applications in health and performance through practical interactive learning. This book is an essential companion for students on any sport and exercise science-related degree programme and any instructor leading practical laboratory-based classes.

GBP 74.99
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