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Physiological Consequences of Brain Insulin Action

Physiological Consequences of Brain Insulin Action

The brain is crucial for the regulation of whole-body metabolism and behavior. The pancreas-derived hormone insulin modulates brain function and affects energy metabolism as well as cognition. This is partially achieved by modulating several types of brain cell populations including those relevant to satiety and reward. Importantly brains of Alzheimer´s disease patients exhibit a signature of brain insulin resistance with perturbed brain metabolism. This book will cover the basics of insulin signaling in the brain and will describe concepts of insulin resistance a feature of type 2 diabetes. Moreover insulin´s effect on cognitive function will be pointed out and the association between brain insulin resistance and neurodegenerative diseases discussed. Additionally potential behavioral and pharmacological concepts which can affect brain insulin signaling will be summarized. Key Features: Summarizes insulin and the closely related IGF-1 receptor signaling Depicts concepts of insulin resistance Highlights the importance of conserved brain insulin signaling for brain function metabolism and behavior Describes potential behavioral and pharmacological approaches to support brain insulin signaling | Physiological Consequences of Brain Insulin Action

GBP 130.00
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Antidiabetic Plants for Drug Discovery Pharmacology Secondary Metabolite Profiling and Ingredients with Insulin Mimetic Activity

Antidiabetic Plants for Drug Discovery Pharmacology Secondary Metabolite Profiling and Ingredients with Insulin Mimetic Activity

This volume takes an in-depth look at the potential pharmacological applications of 11 important antidiabetic plants examining their antihyperglycemic hypoglycemic and anti-lipidemic properties along with current genome editing research perspectives. Plant natural products or phytoconstituents are promising candidates for antidiabetic pharmacological actions. The phytoconstituents such as fl avonoids terpenoids saponins carotenoids alkaloids and glycosides play vital roles in the current and future potent antidiabetic drug development programs Each chapter reviews a particular plant with antidiabetic properties explaining the therapeutic aspects its active antidiabetic compounds and relevant genome editing technology. The specific plants discussed include Azadirachta indica (commonly known as neem nimtree or Indian lilac) Gymnema sylvestre (commonly called gymnema Australian cowplant and Periploca of the woods) Syzygium cumini (commonly known as Malabar plum Java plum black plum jamun or jambolana) Ceylon cinnamon (or true cinnamon as opposed to cassia cinnamon) insulin plant (or Costus pictus) Trigonella foenum-graecum (better known as fenugreek) Mulberry Nigella sativa L. (black caraway also known as black cumin nigella kalojeera kalonji or kalanji) Aegle marmelos (L. ) (commonly known as bael (or bili or bhel) also Bengal quince golden apple Japanese bitter orange stone apple or wood apple) Ficus benghalensis (the banyan banyan fig and Indian banyan) and of course garlic (Allium sativum). Antidiabetic Plants for Drug Discovery: Pharmacology Secondary Metabolite Profiling and Ingredients with Insulin Mimetic Activity will serve as a valuable source of information for students drug researchers medical practitioners diabetic patients and many others in the effort to gain understand of how these plant drug molecules can help fight diabetes. | Antidiabetic Plants for Drug Discovery Pharmacology Secondary Metabolite Profiling and Ingredients with Insulin Mimetic Activity

GBP 139.00
1

Animal Models of Diabetes Frontiers in Research

Animal Models of Diabetes Frontiers in Research

As the incidence of diabetes increases worldwide the need for recommendations on how to prevent and treat the condition grows exponentially and so does the need for an authoritative source for information on the appropriate models to study the condition. The new edition of Animal Models of Diabetes is that source. The book presents updated and expanded information regarding the use of models in experiments with both Type 1 and Type 2 diabetes. The new edition compiles relevant time-saving information on well-recognized models including various mice rats minipigs and Rhesus monkeys and provides extensive references for more in-depth study. It contains new and updated referenced reviews on animals with induced obesity as well as observations on retinopathy in spontaneous diabetes resembling human lesions. The book discusses nutritionally diabetes-prone animals and considerations of insulin resistance and obesity. The contributors also address the importance of recent findings on the pathogenesis of diabetes and its complications in relation to human disease. Including contributions from prominent experts in the field the book brings together scattered data and lucidly presents it. This promotes the understanding of the etiopathology of diabetes and offers a new grasp of the insulin action its negative feedback leading to insulin resistance and its detrimental outcomes. The book also includes new knowledge on specific complications of diabetes offering an incentive to test advanced modalities to prevent and inhibit their occurrence. | Animal Models of Diabetes Frontiers in Research

GBP 59.99
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Medicinal Plants in Asia for Metabolic Syndrome Natural Products and Molecular Basis

Medicinal Plants in Asia for Metabolic Syndrome Natural Products and Molecular Basis

Medicinal Plants in Asia for Metabolic Syndrome: Natural Products and Molecular Basis offers an in-depth view into the metabolic syndrome pharmacology of natural products with an emphasis on their molecular basis cellular pathways metabolic organs and endocrine regulations. This sensational volume provides the scientific names botanical classifications botanical descriptions medicinal uses chemical constituents and pharmacological activities of more than 100 Asian plants with high quality original botanical plates chemical structures and pharmacological diagrams. It also lists hundreds of carefully selected bibliographical references constituents on insulin resistance obesity atherosclerosis atherogenic dyslipidemia and endothelial dysfunction. | Medicinal Plants in Asia for Metabolic Syndrome Natural Products and Molecular Basis

GBP 69.99
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Ethanol and the Liver Mechanisms and Management

Ethanol and the Liver Mechanisms and Management

Distilling the available knowledge on ethanol-induced liver damage and directly complementing the available bio-medical literature Ethanol and the Liver covers pathogenic and clinical aspects of alcoholic liver disease. Providing broader coverage of the subject than any available monograph the editors and their panel of experts relate basic science to pathogenesis and treatment modalities and explore future developments. Coverage includes:Histopathology-fatty liver alcoholic hepatitis and cirrhosisEthanol metabolism and its consequencesMechanisms in the pathogenesis of ALD including genetics immunology and insulin-like growth factorsExtrahepatic effects of ALD and the role of alcohol in potentiating liver damage due to other etiologiesInteraction of alcohol with viral hepatitisEpidemiology diagnosis and treatmentManagement strategies including transplantationThe vast amount of knowledge and expertise gathered in this book make it an unparalleled resource. | Ethanol and the Liver Mechanisms and Management

GBP 59.99
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Digital Health Technologies Law Ethics and the Doctor-Patient Relationship

Digital Health Technologies Law Ethics and the Doctor-Patient Relationship

Increasingly digital technologies are used in healthcare. This book explores eight digital health technologies situated the context of a life span from high-throughput genomic sequencing technologies and do-it-yourself (DIY) insulin delivery for diabetes management in paediatrics to the use of robotic care assistants for older adults and digital advance care decisions. A scene-setting case scenario at the start of each chapter describes the digital technology and identifies the sometimes competing interests of the key stakeholders. Broad themes of resource allocation access to technologies informed consent privacy of health data and ethical concerns are considered in context alongside analysis of legal duties owed by healthcare professionals to act in their patients’ best interests. This book addresses legal and ethical issues arising from the use of emerging digital health technologies and is of interest to academics clinicians and regulators and anyone interested in the development of health technologies and the challenges they may present. It focusses on the Australian legal framework with some comparison to other jurisdictions. | Digital Health Technologies Law Ethics and the Doctor-Patient Relationship

GBP 34.99
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Phospholipid Metabolism in Cellular Signaling

Phospholipid Metabolism in Cellular Signaling

Phospholipids are no longer considered exclusively as the building blocks of biomembranes but are now regarded to be exceptionally important to cellular signalling. Another conclusion resulting from studies over the past several years is that no single general scheme for the role of phospholipids during cell activation can be drawn as representative of all cells. This book presents a comprehensive view of the recent advances made in certain major research areas within the field of phospholipid metabolism in cellular signalling. Topics discussed within this volume include lipid composition of cellular membranes and their organization in biological systems the dynamic aspects of phospholipid metabolism and its regulation by extracellular stimuli and the role of newly discovered glycosyl-phosphatidylinositols in insulin action . The book also discusses two biologically active phospholipids: the sphingolipids and ether-linked glycerophospholipids (the platelet activating factor). Phospholipid Metabolism in Cellular Signaling is an important research reference that should be considered required reading by all scientists and graduate students working on cell activation (e. g. growth factors hormones and oncogenes).

GBP 89.99
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Herbal Treatment of Major Depression Scientific Basis and Practical Use

Herbal Treatment of Major Depression Scientific Basis and Practical Use

This unique volume presents new understandings of the neurochemical nature of major depression and how herbs and their constituent flavonoids and terpenes appear to address some of the mechanisms now thought to be involved. It explores how recent studies of the rapid antidepressant effects of ketamine inform neuroscientists about deep intracellular mechanisms of antidepressant action that have little to do with simple enhancement of monoaminergic activity. These mechanisms include actions on PI3K Akt mTOR GSK3 BDNF and other intracellular pathways. New theories of the pathophysiology underlying major depression such as oxidative damage inflammation stress and insulin resistance are then explored. Key Features:Focuses on oxidative damage inflammation and metabolic syndrome. Explains that a significant percentage of people treated for major depression obtain little if any relief from standard antidepressant medications. These facts lead to discussion of herbs that can be used to treat major depression as well as consideration of the scientific basis for how these herbs act. The antidepressant properties of 66 herbs are discussed along with dosing and safety information. | Herbal Treatment of Major Depression Scientific Basis and Practical Use

GBP 44.99
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Artificial Intelligence with Uncertainty

Artificial Intelligence with Uncertainty

This book develops a framework that shows how uncertainty in Artificial Intelligence (AI) expands and generalizes traditional AI. It explores the uncertainties of knowledge and intelligence. The authors focus on the importance of natural language – the carrier of knowledge and intelligence and introduce efficient physical methods for data mining amd control. In this new edition we have more in-depth description of the models and methods of which the mathematical properties are proved strictly which make these theories and methods more complete. The authors also highlight their latest research results. | Artificial Intelligence with Uncertainty

GBP 44.99
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Nutrition and Integrative Medicine for Clinicians Volume Two

Nutrition and Integrative Medicine for Clinicians Volume Two

Mystery illnesses can be helped this book lays the groundwork for it. Building on its predecessor this new volume Nutrition and Integrative Medicine for Clinicians is an essential peer-reviewed resource for practitioners those in allied health care and complementary/alternative medicine. The book contains valuable information for healthcare providers to use by helping patients manage treat and even prevent illnesses and put them on a healthy path to recovery. This volume contains information on various subjects including: · Illnesses resulting from water damaged buildings and subsequent change in the microbiome of the building · Steps to heal from mold/mycotoxin illnesses · Effects of CIRS on metabolism and insulin resistance · Pediatric sleep-related breathing disorders and their effects on growth and development · Environmental hormone disruptors · Myalgic encephalitis/chronic fatigue syndrome · Regenerative agriculture · Circadian effects of artificial light and their effects on mitochondria · Nutritional support for Covid · The human body as a biological sound healing instrument · Art in medicine · Living life with intention and mindfulness · Making childbirth a positive experience Written by authors at the forefront of their respective fields this book presents information for people “written off” as having a “mystery illness. ” It is a comprehensive guide on evaluating illnesses that are difficult to diagnose. | Nutrition and Integrative Medicine for Clinicians Volume Two

GBP 42.99
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Controlled Drug Delivery Systems

Controlled Drug Delivery Systems

This book will describe current research on drug delivery systems that encompass four broad categories namely: routes of delivery delivery vehicles payload and targeting strategies. Where appropriate delivery vehicles and relevant release of specific agents in any of these categories in clinical application will be discussed. All chapters will highlight the translational aspects of the various technologies discussed and will provide insights into the advantages of such delivery systems over current ones in clinical or research use. Each technology reviewed in this book will have significant potential to improve patients' lives by enhancing the therapeutic efficacy of drugs. This book:Discusses the various factors that mitigate effective oral insulin delivery and the current status of research efforts to overcome these barriers along with recent clinical projectionsExamines the advantages and disadvantages of each drug delivery systemExamines the standard method of accomplishing controlled drug release through the incorporation of the drugs within polymeric biomaterials such as capsules and microcapsules as well as other vehicles such as liposomesDiscusses various controlled drug delivery systems including sustained release delivery systems and pulse or delayed release e. g. to target different regions of the gastrointestinal tract. In view of these wide-ranging technological areas and the up-to-date discussions of opportunities and challenges associated with these applications the book should provide readers from technology materials science pharmacology and clinical disciplines with very valuable information.

GBP 44.99
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Metabolism and Medicine The Metabolic Landscape of Health and Disease (Volume 2)

Metabolism and Medicine The Metabolic Landscape of Health and Disease (Volume 2)

Chronic disease states of aging should be viewed through the prism of metabolism and biophysical processes at all levels of physiological organization present in the human body. This book connects these insights to what causes them to go awry in the context of unhealthy human behaviors and aging aiming to buttress scientific creativity. It also provides links between the art and science of medicine that strengthens problem-solving in patient care. New and important discoveries in the area of metabolic health and metabolic diseases are discussed in exquisite detail. Key Features: Broad and up-to-date overview of the field of metabolic aspects of health and chronic disease development especially connecting the spectrum of topics that range from molecular clocks to stress response to nuclear hormone receptors and the role of microbiota in human health Provides a deeper basic science and interdisciplinary understanding of biological systems that broaden the perspectives and therapeutic problem solving by elaborating on the usefulness of the Physiological Fitness Landscape Describes the importance of insulin resistance in metabolic disease especially diabetes but also includes links to cancer and Alzheimer’s disease Examines the process of aging from the perspective of metabolic decline illustrating it with the Physiological Fitness Landscape This book the second volume in a two-volume set primarily targets an audience of clinical and science students biomedical researchers and physicians who would benefit from understanding each other’s language. | Metabolism and Medicine The Metabolic Landscape of Health and Disease (Volume 2)

GBP 130.00
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Today's Curiosity is Tomorrow's Cure The Case for Basic Biomedical Research

Today's Curiosity is Tomorrow's Cure The Case for Basic Biomedical Research

Basic curiosity-driven biomedical science has delivered many of today’s most significant medical advances. This book provides clearly explained examples from recent biomedical history and includes convincing arguments for sustaining a robust portfolio of basic research. Intended as an engaging read which will delight undergraduate and graduate students as well as scientific researchers it is full-throated advocacy of basic science. Illustrations and examples include the discoveries of penicillin and insulin and the breakthrough elucidation of the genetic code. Providing both compelling rationale in support of basic science and a fascinating look through the history of modern biomedical research this book highlights with stirring examples why basic biomedical research is so important and how so many key advances in medicine are derived from basic research. The book also offers a rationale for scientific inquiry and a broader understanding of the history of modern biomedical research missing from today’s classrooms. Key Features 1) Provides clear explanations of great scientific discoveries 2) Illustrates connections between basic research findings and modern medicine 3) Includes compelling graphics/diagrams/illustrations 4) Accessible to the general public 5) Offers background for more specialized readers including researchers as well as those with advanced degrees. Related Titles Staddon J. Scientific Method: How Science Works Fails to Work and Pretends to Work (ISBN 978-1-1382-9536-0) Helliwell J. R. Skills for Scientific Life (ISBN 978-1-4987-6875-7) MacRitchie F. Scientific Research as a Career (ISBN 978-1-4398-6965-9) | Today's Curiosity is Tomorrow's Cure The Case for Basic Biomedical Research

GBP 31.99
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The Development of British Naval Aviation 1914–1918

The Development of British Naval Aviation 1914–1918

The Royal Naval Air Service (RNAS) revolutionized warfare at sea on land and in the air. This little-known naval aviation organization introduced and operationalized aircraft carrier strike aerial anti-submarine warfare strategic bombing and the air defence of the British Isles more than 20 years before the outbreak of the Second World War. Traditionally marginalized in a literature dominated by the Royal Flying Corps and the Royal Air Force the RNAS and its innovative practitioners nevertheless shaped the fundamentals of air power and contributed significantly to the Allied victory in the First World War. The Development of British Naval Aviation utilizes archival documents and newly published research to resurrect the legacy of the RNAS and demonstrate its central role in Britain’s war effort. | The Development of British Naval Aviation 1914–1918

GBP 36.99
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Primary Care Nutrition Writing the Nutrition Prescription

Primary Care Nutrition Writing the Nutrition Prescription

This book contains the necessary knowledge and tools to incorporate nutrition into primary care practice. As a practical matter this effort is led by a dedicated primary care physician with the help of motivated registered dietitians nurses psychologists physical therapists and office staff whether within a known practice or by referral to the community. It is essential that the nutrition prescription provided by the physician be as efficient as possible. While many team members have superior knowledge in the areas of nutrition exercise and psychology the health practitioner remains the focus of patient confidence in a therapy plan. Therefore the endorsement of the plan rather than the implementation of the plan is the most important task of the physician. This book proposes a significant change in attitude of primary health care providers in terms of the power of nutrition in prevention and treatment of common disease. It features detailed and referenced information on the role of nutrition in the most common conditions encountered in primary care practice. In the past treatment focused primarily on drugs and surgery for the treatment of disease with nutrition as an afterthought. Advanced technologies and drugs are effective for the treatment of acute disease but many of the most common diseases such as heart disease diabetes and cancer are not preventable with drugs and surgery. While there is mention of prevention of heart disease this largely relates to the use of statins with some modest discussion of a healthy diet. Similarly prevention of type 2 diabetes is the early introduction of metformin or intensive insulin therapy. | Primary Care Nutrition Writing the Nutrition Prescription

GBP 46.99
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Perinatal Growth and Nutrition

Perinatal Growth and Nutrition

Preterm infants grow poorly after birth and very commonly develop ex utero growth restriction (EUGR). However the risks and benefits of catch-up growth in preterm infants must be weighed and evidence addressing this warrants examination. Perinatal Growth and Nutrition explores the reasons for EUGR and the long-term effects on developmental outcome and on metabolic risks. It provides clear information on the risks and benefits of faster post-natal growth and catch-up growth in preterm infants and offers tools for better assessment of growth and earlier identification of faltering growth. This book is divided into three sections. The first section covers advances in preterm infant growth standards diagnosis and causes of EUGR and assessments of preterm infant diets. The second section considers the extensive human literature on the effects of in utero and ex utero growth restriction and catch-up growth on long-term metabolic outcomes—such as obesity insulin resistance type 2 diabetes and cardiac disease—and long-term neurodevelopmental outcomes including cognition. It also examines evidence for the effect of growth on these outcomes in term and preterm infants. The final section of the book considers ways to reduce the incidence of EUGR in preterm infants and when EUGR does occur to optimize catch-up growth. Topics include assessment of dietary requirements of the diverse population of preterm infants examination of tools for prescribing nutrition to neonatal intensive care unit patients consideration of whether to customize or generalize nutrient intake and fortification of human milk. In addition the last chapter proposes using a Z-score growth chart for improved interpretation of growth data.

GBP 74.99
1

Lipoic Acid Energy Production Antioxidant Activity and Health Effects

Lipoic Acid Energy Production Antioxidant Activity and Health Effects

The recognition of oxidative stress as a major factor in health aging and disease has led to a surge in research aimed at uncovering effective countermeasures in the form of antioxidants. Unique in its two-fold protective function alpha-lipoic acid has drawn unprecedented interest as a coenzyme in mitochondrial energy metabolism and as an antioxidant and cell redox modulator. Mounting data regarding its potential health benefits demands an authoritative single-source reference to codify current knowledge and guide future research. A state-of-the-science compilation Lipoic Acid follows the history of this potent coenzyme and the latest discoveries regarding the chemistry biological action and significance in energy production antioxidant activity and health. The book is divided into three sections: · Section I: Discovery and Molecular Structure reviews the early studies leading to the discovery of alpha-lipoic acid and explains the molecular structure biosynthesis and the characterization of lipoic acid and its chemical derivatives. · Section II: Metabolic Aspects describes in detail the human pharmacokinetics of alpha-lipoic acid including the lipoic acid-derived dehydrogenase complexes and their roles in energy metabolism. It also explains antioxidant activity and redox modulation and how lipoic acid induces Phase II detoxification enzymes through activation of Nrf2-dependent gene expression. · Section III Clinical Aspects discusses enzyme deficiency disorders and the effects of lipoic acid on insulin. It defines lipoic acid influence on signaling pathways and AMP-activated kinase and considers the therapeutic implications for treatment of metabolic syndromes and the improvement of mitochondrial function by lipoic acid supplementation. Contributions from leading in | Lipoic Acid Energy Production Antioxidant Activity and Health Effects

GBP 59.99
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Photonics Modelling and Design

Photonics Modelling and Design

Photonics Modeling and Design delivers a concise introduction to the modeling and design of photonic devices. Assuming a general knowledge of photonics and the operating principles of fibre and semiconductor lasers this book: Describes the analysis of the light propagation in dielectric media Discusses heat diffusion and carrier transport Applies the presented theory to develop fibre and semiconductor laser models Addresses the propagation of short optical pulses in optical fibres Puts all modeling into practical context with examples of devices currently in development or on the market Providing hands-on guidance in the form of MATLAB® scripts tips and other downloadable content Photonics Modeling and Design is written for students and professionals interested in modeling photonic devices either for gaining a deeper understanding of the operation or to optimize the design. | Photonics Modelling and Design

GBP 69.99
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Nutrition and Diabetes Pathophysiology and Management

Nutrition and Diabetes Pathophysiology and Management

Diabetes occurs at such an alarming rate that it can be described as a global epidemic. Following its predecessor Nutrition and Diabetes: Pathophysiology and Management Second Edition is a comprehensive resource that describes various factors that drive the accumulation of excess body weight and fat resulting in obesity. The book discusses the metabolic aberrations found in obesity and how they lead to the association of obesity with diabetes. This new edition highlights the role played by diet and the interrelationships in the metabolism of key nutrients in the pathogenesis of obesity and diabetes which provides the scientific basis for treatment and management approaches. FeaturesHighlights the role of nutrition in the pathogenesis of obesity and diabetes Organized logically into two easy-to-use sections - Pathophysiology and Management of Obesity and Pathophysiology and Treatment of DiabetesFeatures emerging therapeutic approaches for management of obesity and diabetesDiscusses experience in the management of obesity and diabetes in developing countries Presents challenges in insulin therapy and provides guidelines to overcome themThe first section of the book retains key topics from the previous edition and contains new chapters including genetic determinants of nutrient processing; fat distribution and diabetes mellitus; combined effect of diet and physical activity in the management of obesity; pharmacologic treatment of obesity; and the role of gut microbiota in the pathogenesis and treatment of obesity. The second section features updated versions of most of the other chapters in the first edition comprising a modified chapter on oxidative stress and the effects of dietary supplements on glycemic control in Type 2 diabetes. In addition new chapters are added in this section and include the contribution of iron and transition metal micronutrients to diabetes; role of microbiota in the pathogenesis and treatment of diabetes; primary prevention of Type 2 diabetes; and the pathophysiology and management of Type 1 diabetes. | Nutrition and Diabetes Pathophysiology and Management

GBP 44.99
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Molecules That Amaze Us

Molecules That Amaze Us

This new book is by two knowledgeable and expert popularizers of chemistry and deals exclusively with molecules and compounds rather than with the simpler atoms and elements. It is based on the very successful �Molecule of the Month� website that was begun by Paul May fifteen years ago and to which his co-author Simon Cotton has been a frequent contributor. � The authors � strike an excellent balance between introducing the novice to the world of molecules while also keeping the expert chemist interested. � I highly recommend this book to all readers. It will vastly expand your knowledge and horizons of chemistry and the human ingenuity that surrounds it. �From the Foreword by Dr. Eric Scerri UCLA Los Angeles website: www. ericscerri. com Author of �The Periodic Table Its Story and Its Significance� and several other books on the elements and the periodic table. The world is composed of molecules. Some are synthetic while many others are products of nature. Molecules That Amaze Us presents the stories behind many of the most famous and infamous molecules that make up our modern world. Examples include the molecule responsible for the spicy heat in chilies (capsaicin) the world�s first synthetic painkiller (aspirin) the pigment responsible for the color of autumn leaves (carotene) the explosive in dynamite (nitroglycerine) the antimalarial drug (quinine) the drug known as speed (methamphetamine) and many others. Other molecules discussed include caffeine adrenaline cholesterol cocaine digitalis dopamine glucose insulin methane nicotine oxytocin penicillin carbon dioxide limonene and testosterone. In all the book includes 67 sections each describing a different molecule what it does how it is made and why it is so interesting. Written by experts in the field the book is accessible and easy to read. It includes amusing anecdotes

GBP 180.00
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Handbook of Obesity - Volume 1 Epidemiology Etiology and Physiopathology

Handbook of Obesity - Volume 1 Epidemiology Etiology and Physiopathology

The fifth edition of Volume 1 of Handbook of Obesity written by global experts covers the basic science aspects under the broad topic areas of epidemiology etiology and pathophysiology of obesity. Divided into 5 sections and detailed in 66 chapters this edition covers the important advances occurring over the past decades. With a focus on science of obesity and factors participating in the etiology of obesity this topic is studied from biological behavioural and environmental perspectives. Volume 1 is structured into 5 parts: Part 1 focuses on the history definitions and prevalence of the obesity. It identifies the historical references to excess weight obesity in art and literature direct and surrogate measurements of adiposity and obesity related traits epidemiology of obesity around the globe and age sex and ethnic variation completes this part of the volume Part 2 explains the biological determinants of obesity. It explains the bioenergetics energy dissipation mechanisms and exposure to experimental overfeeding genetic and epigenetic evidence metabolic rates energy expenditure and energy partitioning and the evidence on infections and adiposity Part 3 describes the behavioral determinants of obesity. It deals with chapters related to food beverages and ingestive behavior dealing with smoking breast-feeding and sleep duration and pattern and sedentary behavior occupational work and leisure-time physical activity and obesity Part 4 comprises of chapters explaining the environmental social and cultural determinants of obesity. The chapters in this section focus on the role of agriculture and the food industry in the current obesity epidemic social and economic aspects of obesity and ethnic and cultural differences and environmental pollutants Part 5 of this volume discusses the health consequences of obesity. The chapters address important topics such obesity and heart disease lipoprotein metabolism insulin resistance and diabetes metabolic syndrome cancer hepatic biology pulmonary functions and arthritis and gout mental health and quality of life growth and health disorders in pediatric populations and on bias and discrimination affecting the obese persons. | Handbook of Obesity - Volume 1 Epidemiology Etiology and Physiopathology

GBP 150.00
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Introductory Semiconductor Device Physics

Introductory Semiconductor Device Physics

Introduction to Semiconductor Device Physics is a popular and established text that offers a thorough introduction to the underlying physics of semiconductor devices. It begins with a review of basic solid state physics then goes on to describe the properties of semiconductors including energy bands the concept of effective mass carrier concentration and conduction in more detail. Thereafter the book is concerned with the principles of operation of specific devices beginning with the Gunn Diode and the p-n junction. The remaining chapters cover the on specific devices including the LED the bipolar transistor the field-effect transistor and the semiconductor laser. The book concludes with a chapter providing a brief introduction to quantum theory. Not overtly mathematical Introduction to Semiconductor Device Physics introduces only those physical concepts required for an understanding of the semiconductor devices being considered. The author's intuitive style coupled with an extensive set of worked problems make this the ideal introductory text for those concerned with understanding electrical and electronic engineering applied physics and related subjects. | Introductory Semiconductor Device Physics

GBP 180.00
1

Textbook of Ion Channels Volume III Regulation Physiology and Diseases

Textbook of Ion Channels Volume III Regulation Physiology and Diseases

The Textbook of Ion Channels is a set of three volumes that provides a wide-ranging reference source on ion channels for students instructors and researchers. Ion channels are mem- brane proteins that control the electrical properties of neurons and cardiac cells; medi- ate the detection and response to sensory stimuli like light sound odor and taste; and regulate the response to physical stimuli like temperature and pressure. In non-excitable tissues ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells giving them the unique ability to communicate with the environment as well as the membrane of intracellular organelles allowing them to regulate internal homeostasis. Ion channels are fundamentally important for human health and diseases and are important targets for pharmaceuticals in mental illness heart disease anesthesia pain and other clinical appli- cations. The modern methods used in their study are powerful and diverse ranging from single ion-channel measurement techniques to models of ion channel diseases in animals and human clinical trials for ion channel drugs. Volume III includes coverage of key ion channel regulators and their mechanisms the role of ion channels working in concert in selected physiological systems and examples of ion channel mutations and dysfunction in a selection of diseases. Chapters on ion channel regulation include splice variants calcium–calmodulin regulation regulation by G pro- teins and lipids. A selection of ion channels in physiological systems includes ion chan- nels of the heart ion channels in immune cells and their role in pancreatic beta cells and regulation of insulin secretion and the role of channels in sperm and eggs. While disease mechanisms are integrated into the chapters of Volume II Volume III offers special consid- eration of ion channels in epilepsy cystic fibrosis and pain syndromes. All three volumes give the reader an introduction to fundamental concepts needed to understand the mechanism of ion channels a guide to the technical aspects of ion channel research offer a modern guide to the properties of major ion channel families and includecoverage of key examples of regulatory physiological and disease roles for ion channels. | Textbook of Ion Channels Volume III Regulation Physiology and Diseases

GBP 89.99
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Designing Green Networks and Network Operations Saving Run-the-Engine Costs

Designing Green Networks and Network Operations Saving Run-the-Engine Costs

In recent years socio-political trends toward environmental responsibility and the pressing need to reduce Run-the-Engine (RTE) costs have resulted in the concept of Green IT. Although a significant amount of energy is used to operate routing switching and transmission equipment comparatively less attention has been paid to Green Networking. A clear and concise introduction to green networks and green network operations Designing Green Networks and Network Operations: Saving Run-the-Engine Costs guides you through the techniques available to achieve efficiency goals for corporate and carrier networks including deploying more efficient hardware blade form-factor routers and switches and pursuing consolidation virtualization and network and cloud computing. The book: Delineates techniques to minimize network power cooling floor space and online storage while optimizing service performance capacity and availability Discusses virtualization network computing and Web services as approaches for green data centers and networks Emphasizes best practices and compliance with international standards for green operations Extends the green data center techniques to the networking environment Incorporates green principles in the intranet extranet and the entire IT infrastructures Reviews networking power management HVAC and CRAC basics Presents methodical steps toward a seamless migration to Green IT and Green Networking | Designing Green Networks and Network Operations Saving Run-the-Engine Costs

GBP 69.99
1