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Cancer and Vitamin C

Cancer and Vitamin C

Vitamin C may offer significant therapeutic benefits in the treatment of cancer. This book includes chapters by a group of leading scientific researchers documenting the ways cancer can be affected by high doses of ascorbate. After an initial chapter providing a historical perspective subsequent chapters focus on cancer cell death reprogramming of somatic cells recent case studies and other ways vitamin C can improve outcomes of therapy. FeaturesIncludes chapters from a team of leading international scholarsReviews the history of beneficial uses of vitamin C in the treatment of cancerSummarizes recent case studiesDiscusses how vitamin C may synergistically affect other cancer treatment methods | Cancer and Vitamin C

GBP 44.99
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Vitamin C New Biochemical and Functional Insights

Vitamin C New Biochemical and Functional Insights

Vitamin C holds a unique place in scientific and cultural history. In this book a group of leading scientific researchers describe new insights into the myriad ways vitamin C is employed during normal physiological functioning. In addition the text provides an extensive overview of the following: the rationale for utilizing vitamin C in the clinic updates on recent uses of vitamin C in cancer treatment through high-dose intravenous therapies the role vitamin C plays in the treatment of sepsis and infectious disease management of the ways vitamin C can improve stem cell differentiation as well as vitamin C use in other important health situations. FeaturesIncludes chapters from a team of leading international scholarsReviews the history and recent research on the functions benefits and uses of vitamin CFocuses special attention on the way vitamin C can be used in the treatment of cancersDiscusses how vitamin C can be employed against infectious disease | Vitamin C New Biochemical and Functional Insights

GBP 44.99
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Screening American Independent Film

Screening American Independent Film

This indispensable collection offers 51 chapters each focused on a distinct American independent film. Screening American Independent Film presents these films chronologically addressing works from across more than a century (1915−2020) emphasizing the breadth and long duration of American independent cinema. The collection includes canonical examples as well as films that push against and expand the definitions of independence. The titles run from micro-budget films through marketing-friendly Indiewood projects from auteur-driven films and festival darlings to B-movies genre pics and exploitation films. The chapters also introduce students to different approaches within film studies including historical and contextual framing industrial and institutional analysis politics and ideology genre and authorship representation film analysis exhibition and reception and technology. Written by leading international scholars and emerging talents in film studies this volume is the first of its kind. Paying particular attention to issues of diversity and inclusion for both the participating scholars and the content and themes within the selected films Screening American Independent Film is an essential resource for anyone teaching or studying American cinema.

GBP 34.99
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A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery

A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery

The development of suitable assays the integration of appropriate technology and the effective management of the essential infrastructure are all critical to the success of any high-throughput screening (HTS) endeavor. However few scientists have the multidisciplinary experience needed to control all aspects of an HTS drug discovery project. A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery integrates the experience of diverse experts who offer fundamental and practical guidance across numerous situations. The book first discusses assay developments for important target classes such as protein kinases and phosphatases proteases nuclear receptors G protein-coupled receptors ion channels and heat shock proteins. It next examines assay developments for cell viability apoptosis and infectious diseases. The contributors explore the application of emerging technologies and systems including image-based high content screening RNA interference and primary cells. Finally they discuss the essential components of the integrated HTS process such as screening automation compound library management the screening of natural products from botanical sources and screening informatics. Designed to motivate researchers to bring further advances to the field this volume provides practical guidance on how to initiate validate optimize and manage a bioassay intended to screen large collections of compounds. Drawing on the knowledge from experts actively involved in assay development and HTS this is a resource that is both comprehensive and focused.

GBP 59.99
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Vitamin B12 Advances and Insights

Vitamin B12 Advances and Insights

Cobalamin (vitamin B12) was discovered in the first half of the 20th century. Vast amount of information on the role of the vitamins in human health and disease became available. Cobalamin science was however based on theoretical concepts that have been accepted without further proof of facts and hypotheses. Recently the breath-taking pace of development in research technologies has changed our understanding for the role of nutrients and the complex interaction between diet environment and diseases. Conditions like aging diet and drugs increase the risk of developing cobalamin deficiency probably because of diminished ability to liberate absorb or distribute the food-derived vitamin. From a basic science point of view understanding of the transport and function of the vitamin may pave the road for using this system for drug delivery. This book represents up-to-date literature on the discoveries and developments in the field of cobalamin. It includes multifaceted aspects of the vitamin in health and disease conditions. The book has been written by leading scientists who have significant contributions in this field and represents therefore a timely unique encyclopaedia on cobalamin. | Vitamin B12 Advances and Insights

GBP 44.99
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Screening The Sacred Religion Myth And Ideology In Popular American Film

Screening The Sacred Religion Myth And Ideology In Popular American Film

What are the religious impulses in the 1976 film Rocky and how can they work to shape one's social identity? Do the films Alien and Aliens signify the reemergence of the earth goddess as a vital cultural power? What female archetypes borne out of male desire inform the experience of women in Nine and a Half Weeks?These are among the several comp | Screening The Sacred Religion Myth And Ideology In Popular American Film

GBP 130.00
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Implementing Evidence-Based Practices in Gifted Education Professional Learning Modules on Universal Screening Grouping Acceleration and

Implementing Evidence-Based Practices in Gifted Education Professional Learning Modules on Universal Screening Grouping Acceleration and

According to the Every Student Succeeds Act (ESSA) evidence-based practices are supported by rigorous research designs and demonstrate that they improve student outcomes but the actual implementation of these practices in schools is limited. This essential guidebook assists coordinators of gifted education in implementing three evidence-based practices: universal screening grouping and acceleration. Each module includes an overview of research administrative and assessment considerations forms for implementing the practice scripted presentation slides for educators and parents and resources. Modules may be used by educators within a series of workshops for an entire school district on an individual campus or for important stakeholders. | Implementing Evidence-Based Practices in Gifted Education Professional Learning Modules on Universal Screening Grouping Acceleration and

GBP 66.99
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Digital Space and Embodiment in Contemporary Cinema Screening Composite Spaces

Digital Space and Embodiment in Contemporary Cinema Screening Composite Spaces

Digital Space and Embodiment in Contemporary Cinema examines how contemporary cinema has represented and engaged with the experience of simultaneously inhabiting digital and material spaces (i. e. composite spaces) in the context of the growing ubiquitousness of digital media and culture. Bringing together a range of key cinematic texts the book examines how these films represent composite space by depicting—often subtly and without explicit reference to technology—what it feels like to live in a world of ubiquitous digital media. The book explores composite spaces through the striking use of elements like colour symbolic graphics and music and covers topics like: music as mediator between levels of experience/perception in visionary films such as Sucker Punch (2011) and Spring Breakers (2012); digital colour as an interface in films including Under the Skin (2013); the integration of digital graphical elements drawn from game spaces into material spaces in films such as Scott Pilgrim vs The World (2010) and Nerve (2016); and films that take place on a computer screen including 2020’s widely discussed Zoom-produced pandemic horror film Host. Through the close analysis of these films the book offers fresh perspectives on conceptual issues of embodiment digital agency and subjectivity. This book is a valuable resource for advanced undergraduates postgraduates and scholars in the fields of film studies digital aesthetics and film theory digital culture and digital media. | Digital Space and Embodiment in Contemporary Cinema Screening Composite Spaces

GBP 130.00
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Thanatourism and Cinematic Representations of Risk Screening the End of Tourism

Thanatourism and Cinematic Representations of Risk Screening the End of Tourism

In today’s world the need to eliminate natural and human-made disasters has been at the forefront of national and international socio-political agendas. The management of risks such as terrorism labour strikes protests and environmental degradation has become pivotal for countries that depend on their economy’s tourist sector. Indeed there is fear that that ‘the end of tourism’ might be nigh due to inadequate institutional foresight. Yet in designing relevant policies to tackle this arts such as that of filmmaking have yet to receive due consideration. This book adopts an unorthodox approach to debates about ‘the end of tourism’. Through twenty-first century cinematic narratives of symbolically interconnected ‘risks’ it considers how art envisages the future of humanity’s well-being. These ‘risks’ include: migration as an infectious disease; alien incursions as racialized labour mobilities; cyborg rebellion as the fear of post-colonial otherness; and zombie anthropophagy as the replacement of rooted identities by nomadic lifestyles. Such filmic scenarios articulate the futuristic survival of community as the triumph of the technological human over otherness and provide a means to debate societal risks that weave identity politics into unequal mobilities. This book will appeal to researchers and students interested in mobilities theory tourism and travel theory film studies and aesthetics globalisation studies race labour and migration. | Thanatourism and Cinematic Representations of Risk Screening the End of Tourism

GBP 38.99
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Queer Representation Visibility and Race in American Film and Television Screening the Closet

Queer Representation Visibility and Race in American Film and Television Screening the Closet

This book traces the uneven history of queer media visibility through crucial turning points including the Hollywood Production Code era the AIDS crisis of the 1980s the so-called explosion of gay visibility on television during the1990s and the re-imagination of queer representations on TV after the events of 9/11. Kohnen intervenes in previous academic and popular accounts that paint the increase in queer visibility over the past four decades as a largely progressive development. She examines how and why a limited and limiting concept of queer visibility structured around white gay and lesbian characters in committed relationships has become the embodiment of progressive LGBT media representations. She also investigates queer visibility across film TV and print media and highlights previously unexplored connections such as the lingering traces of classical Hollywood cinema's queer tropes in the X-Men franchise. Across all chapters narratives and arguments emerge that demonstrate how queer visibility shapes and reflects not only media representations but the real and imagined geographies histories and people of the American nation. | Queer Representation Visibility and Race in American Film and Television Screening the Closet

GBP 44.99
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German Façade Design Traditions of Screening from 1500 to Modernism

German Façade Design Traditions of Screening from 1500 to Modernism

German architecture prior to the modern period has received less systemic analytical study than that of Italy France and Britain. Scholarly discussion of broad traditions or continuities within Germanic or Central European façade design is even sparser. Baroque era studies of the region mostly devote themselves to isolated architects monuments or movements. Modernism's advent decisively changed this: Germanic architecture enjoyed sudden ascendancy. Yet even so study specifically of that region's façades still lagged – nothing compares to the dozens of treatments of Le Corbusier's façade systems for example and how these juxtapose with French neoclassical or Italian Renaissance methods. Given the paucity of multi-period studies one can be forgiven for believing Germany's effervescence of radical modern works seems unprecedented. This book takes up these multiple quandaries. It identifies and documents a previously unrecognized compositional tradition - characterized here as the 'screen façade' – and posits it as a counter-narrative critiquing the essentialist 'authentic' canon currently dominant in Western architectural history. By crossing evenly over the dividing line between the historical and modern periods it offers valuable insights on indigenous roots underlying some aspects of Germany's invigorating early twentieth-century architectural developments. The book chronologically examines 400 years of closely related facades concentrated in Germany but also found in Austria the Czech Republic German-speaking Switzerland and nearby areas of Central Europe. While nearly 75 buildings are mentioned and illustrated a dozen are given extensive analysis and the book focuses on the works of three architects – Schinkel Behrens and Mies. Relationships between examples of these three architects' façades far transcend mere homage amongst masters. Glimmers of the system they eventually codify are apparent as early as at Heidelberg Castle in 1559 and Nürnberg's Rathaus in 1622. The book argues that in Germany northern Gothic affinities for bisection intense repetition and rote aggregation intersected with southern Classical affinities for symmetry hierarchy and centrality thereby spawning a unique hybrid product – the screen. Instead of graphic formality this study is guided by on-site perceptions propositional contrasts means of approach interpretive conflicts and emotion and it relates the design of these façades to concepts proposed by contemporary philosophers including Novalis Hegel Nietzsche Freud Adorno and most importantly Gadamer on hermeneutics. | German Façade Design Traditions of Screening from 1500 to Modernism

GBP 46.99
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Pharmaceutical Biocatalysis Drugs Genetic Diseases and Epigenetics

Pharmaceutical Biocatalysis Drugs Genetic Diseases and Epigenetics

Volume 7 of the Jenny Stanford Series on Biocatalysis deals with several different aspects of pharmaceuticals which include not only various applications of drugs and their metabolism but also natural resources for active pharmaceutical ingredients as well as the removal of pharmaceutical pollution. In detail novel approaches for developing microbial fermentation processes to produce vitamin B6 using microorganisms are described together with novel routes for vitamin B6 biosynthesis. The other topics discussed are new approaches for producing the successful anticancer drug Taxol from naturally occurring precursors molecular farming through plant engineering as a cost-effective means to produce therapeutic and prophylactic proteins and successful screening of potent microorganisms producing L-asparaginase for various chemotherapeutic applications. Furthermore microbial biotransformations in the production and degradation of fluorinated pharmaceuticals are described. The other chapters inform the reader about the biotransformation of xenobiotics/drugs in living systems the degradation of pharmaceuticals by white-rot fungi and their ligninolytic enzymes and the removal of pharmaceutical pollution from municipal sewage using laccase. | Pharmaceutical Biocatalysis Drugs Genetic Diseases and Epigenetics

GBP 193.00
1

The Student Guide to the Newborn Infant Physical Examination

The Student Guide to the Newborn Infant Physical Examination

This concise guide offers a comprehensive step-by-step framework for midwifery students to learn about all aspects of the newborn infant physical examination (NIPE) a screening assessment completed on all babies between 6 and 72 hours of age. The Student Guide to the Newborn Infant Physical Examination encourages the reader to approach the examination in a system-based format with case studies and practice tips to support learning. The book offers: • Evidence-based well-illustrated assessment tools which take into account the national screening committee standards and is written by authors with both academic and clinical experience; • A clear direction on how to perform the NIPE in practice while exploring the wider context of screening in healthcare today; • Coverage of the changing role of the midwife and the importance of understanding the whole context of the mother’s care health promotion and starting the practitioner-parent conversation. The Student Guide to the Newborn Infant Physical Examination is a core text for all pre-registration midwifery students and a useful resource for qualified midwives neonatal nurses and practice nurses.

GBP 29.99
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National Security in International and Domestic Investment Law Dynamics in China and Europe

National Security in International and Domestic Investment Law Dynamics in China and Europe

This book offers a dynamic introduction to the new developments on national security review of foreign direct investment (FDI) from the perspectives of both domestic law and international investment law. COVID-19 and the Russian invasion of Ukraine have intensified FDI screening to an unprecedented scale yet its purposes scope and potential impact remain ambiguous and controversial. The book first attests the legitimacy of FDI screening by using the theory of National Security Constitution. Part I explicates the national security public order and public health exceptions clauses in international investment law and the novel EU Regulation on FDI screening. Part II provides an in-depth analysis of FDI screening in China France Germany Italy the Netherlands Poland and the UK which have either witnessed momentous changes in domestic law recently or have adopted new laws to cope with the growing security concerns. The book illustrates how States and the EU are using legal instruments to tackle exigent and emerging challenges and the complexity of national security emanated from foreign investment in the context of evolving disruptive digital technologies and the structural change of the global economy. The volume will be of great value to a wide range of audiences including academics in investment and trade law legal practitioners in-house counsels policymakers business professionals and law and business students at the graduate level. | National Security in International and Domestic Investment Law Dynamics in China and Europe

GBP 130.00
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Adult Malnutrition Diagnosis and Treatment

Adult Malnutrition Diagnosis and Treatment

Malnutrition is a global health problem and results in significant clinical and financial consequences for people communities and healthcare institutions. Causes of malnutrition are often complex and multifactorial and can include acute illness or injury chronic disease and a variety of socioeconomic factors. While many professional articles have been published on malnutrition there is no single source of information that encompasses all aspects of the condition. Adult Malnutrition: Diagnosis and Treatment reviews the risk factors and etiologies of malnutrition as well as screening assessment diagnosis and treatment to aid healthcare professionals in the identification and successful care of individuals with this condition in a variety of settings. Features Discusses how to identify malnutrition risks through the use of validated nutrition screening tools in diverse settings Provides detailed instructions on conducting a nutrition-focused physical exam including illustrations depicting differing degrees of muscle wasting and fat loss Presents information on risk factors diagnosis and treatment of vitamin and mineral deficiencies including photos illustrating signs of deficiency to aid in diagnosis Details treatments for malnutrition related to acute illness/injury chronic illness social/environmental circumstances or starvation Reviews challenges and potential solutions to malnutrition identification and treatment in healthcare institutions Edited by Jennifer Doley MBA RDN CNSC FAND and Mary Marian DCN RDN CSO FAND FASPEN this book serves as a key text for registered dietitian nutritionists health practitioners and clinicians. | Adult Malnutrition Diagnosis and Treatment

GBP 42.99
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Phytochemistry of Plants of Genus Phyllanthus

Phytochemistry of Plants of Genus Phyllanthus

Several Phyllanthus species are widely used in traditional medicine and herbal formulation for the treatment of a variety of ailments such as flu dropsy diabetes jaundice and bladder calculus. The medicinal properties of these species are due to the presence of lignans flavonoids tannins alkaloids and terpenoids. Phyllanthin and hypophyllanthin are the major lignans from Phyllanthus species having estrogenic properties that reduce toxicity and vascular tension and protect hepatocytes. This book deals with the importance of separation techniques in screening of major lignans flavonoids and terpenoids in Phyllanthus species using HPLC/UPLC coupled with mass spectrometric techniques. Features: Collection of Ayurvedic features and scientific evidence of important medicinal plants. Screening of major lignans flavonoids and terpenoids in plant parts/whole plant extracts and their geographical variations in Phyllanthus amarus. Easy-to-use analytical procedure for the quality control of Phyllanthus and its products. | Phytochemistry of Plants of Genus Phyllanthus

GBP 56.99
1

Recent Advances in Cancer Diagnostics and Therapy A Nano-Based Approach

Recent Advances in Cancer Diagnostics and Therapy A Nano-Based Approach

This book provides information about different types and stages of cancer and their subtypes with their respective molecular mechanisms etiology histopathology and cellular origins. This book also provides detailed information about cancer incidence mortality and different types of technologies both bio and nano employed in cancer diagnosis and screening and their applications in cancer therapies. This book informs readers about molecular mechanisms of cancer diagnosis and therapies along with different computational techniques used on a single platform. The chapters include a broad and integrated perspective on cancer-related topics. This book covers both conventional and emerging techniques employed in cancer screening and diagnosis including imaging biomarker and electrochemical nanosensor-based approaches with detailed information on sensor development. Similarly this book also covers the mechanisms of different conventional and emerging herbal and nano therapies used in cancer treatment. The authors discuss applications of different computational and mathematical tools such as machine-learning methods that can be employed in cancer diagnosis and therapy at the level of personalized medicine. Features: Offers an integrated approach to provide information about all aspects of cancer biology diagnosis and therapy Focuses on both conventional and emerging tools/techniques applicable in cancer screening and diagnosis Covers the mechanisms of conventional and emerging anticancer drugs and therapies Provides insights about a personalized medicine-based approach in cancer diagnosis and therapy This book is essential for university students course lecturers researchers and industrialists working in the fields of cancer biology medicine and pharmacology. | Recent Advances in Cancer Diagnostics and Therapy A Nano-Based Approach

GBP 89.99
1

Prenatal Medicine

Prenatal Medicine

At the cutting-edge of maternal and neonatal management and research this reference presents the most recent advances in fetal DNA/RNA embryoscopy/fetoscopy open fetal surgery and ethnic population screening to manage pre-existing and newly detected maternal medical complications detect genetic and congenital abnormalities prevent preterm births and optimize pregnancy outcomes. With illustrative color photographs this source offers contributions by esteemed professionals at respected institutions around the globe and covers legal issues concerning prenatal assessment and diagnosis. | Prenatal Medicine

GBP 59.99
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Optimization of Hydraulic Fracture Stages and Sequencing in Unconventional Formations

Optimization of Hydraulic Fracture Stages and Sequencing in Unconventional Formations

Shale gas and/or oil play identification is subject to many screening processes for characteristics such as porosity permeability and brittleness. Evaluating shale gas and/or oil reservoirs and identifying potential sweet spots (portions of the reservoir rock that have high-quality kerogen content and brittle rock) requires taking into consideration multiple rock reservoir and geological parameters that govern production. The early determination of sweet spots for well site selection and fracturing in shale reservoirs is a challenge for many operators. With this limitation in mind Optimization of Hydraulic Fracture Stages and Sequencing in Unconventional Formations develops an approach to improve the industry’s ability to evaluate shale gas and oil plays and is structured to lead the reader from general shale oil and gas characteristics to detailed sweet-spot classifications. The approach uses a new candidate selection and evaluation algorithm and screening criteria based on key geomechanical petrophysical and geochemical parameters and indices to obtain results consistent with existing shale plays and gain insights on the best development strategies going forward. The work introduces new criteria that accurately guide the development process in unconventional reservoirs in addition to reducing uncertainty and cost.

GBP 44.99
1

Handbook of Psychological Assessment in Primary Care Settings Second Edition

Handbook of Psychological Assessment in Primary Care Settings Second Edition

The second edition of the Handbook of Psychological Assessment in Primary Care Settings offers an overview of the application of psychological screening and assessment instruments in primary care settings. This indispensable reference addresses current psychological assessment needs and practices in primary care settings to inform psychologists behavioral health clinicians and primary care providers of the clinical benefits that can result from utilizing psychological assessment and other behavioral health care services in primary care settings. | Handbook of Psychological Assessment in Primary Care Settings Second Edition

GBP 100.00
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Geriatric Diabetes

Geriatric Diabetes

The number of elderly patients with diabetes is increasing at a significant rate. Responding to this growth this source serves as a solid arsenal of information on the varying presentations and challenges associated with diabetes in the geriatric patient and supplies clearly written sections on the screening diagnosis and treatment of diabetes in elderly populations. With contributions from renowned authorities from the national and international institutions this reference will depict the role of specific co-morbidities socioeconomic aspects and caregiver issues on the effective management of diabetes in the older adult. | Geriatric Diabetes

GBP 56.99
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