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Principles of Toxicology Testing

Principles of Toxicology Testing

Nationally toxicology programs have evolved from a traditional exploration of the chemistry and applied toxicity of chemicals and drugs to a more comprehensive study of toxicology and toxicology testing as independent entities. Consequently the second edition of Principles of Toxicology Testing starts with basic toxicological principles including absorption distribution metabolism and elimination of toxins including chemicals and drugs. The book then continues with animal (in vivo) and in vitro toxicology testing methods associated with toxicological analysis and preclinical drug development. As in the first edition the book begins with an introduction into the fundamentals of toxicology (Section I) to prepare readers for the subsequent topics and continues through with a discussion of toxicokinetics and human risk assessment. This introductory material is useful in understanding the applications of toxicology testing. Section II describes the fundamental principles of toxicology testing in animals in greater detail. This section describes acute toxicity studies as well as subchronic and chronic studies performed on animals. Special emphasis is placed on study design and determination of classical indicators for acute and chronic testing such as the LD50. The book examines other short- and long-term animal toxicity testing methodologies including dermal ocular and reproductive toxicity testing. In addition mutagenicity and carcinogenicity studies are also discussed in separate chapters. Section III introduces and discusses in vitro alternatives to animal toxicology tests. This section emphasizes cell culture methodology and cellular methods for acute systemic toxicity target organ toxicity and local toxicity. The contributors present the advantages and disadvantages of alternative methods. They also describe the use of high-throughput screening and its applications the concepts of standardizatio

GBP 175.00
1

Olympus Om System ME-33 Boundary Microphone

Olympus Om System ME-33 Boundary Microphone

The ME33 is a powerful, omni-directional microphone that is purpose-built to record voices from a distance - even in the largest conference rooms. Combined with an Olympus | OM System professional voice recorder, it consistently produces audio files in crystal-clear sound quality by automatically cutting extremely high- and low-frequency sounds. It also gives you scalable recording power: By connecting multiple ME33 microphones using the bundled connector, it is possible to produce a stereo sound version (with six units) or a monoaural version (with three units) of whatever you wish to record.

GBP 104.99
2

PAT: Portable Appliance Testing In-Service Inspection and Testing of Electrical Equipment

PAT: Portable Appliance Testing In-Service Inspection and Testing of Electrical Equipment

Fully up-to-date with the relevant parts of the 17th Edition IET Wiring Regulations: Amendment 3 and the 2012 Code of Practice Provides all the required information on portable appliance testing in a user-friendly manner Expert advice from an engineering training consultant supported with colour diagrams examples and tables The Electricity at Work Regulations 1989 requires any electrical system to be constructed maintained and used in such a manner as to prevent danger. This means that inspection and testing of systems including portable appliances is needed in order to determine if maintenance is required. This book explains in clear language what needs to be done and includes expert advice on legislation as well as actual testing. The book contains an appendix providing the electrical fundamentals needed by non-specialists and also has sample questions (with answers) for the CandG 2377 exam. It is also an ideal revision guide for the non-specialist such as maintenance staff and caretakers who carry out these tasks part-time alongside their many other duties. | PAT: Portable Appliance Testing In-Service Inspection and Testing of Electrical Equipment

GBP 175.00
1

Pandora ME Gold Link Chain Bracelet, 20cm

Pandora ME Gold Link Chain Bracelet, 20cm

With this 20 cm long Pandora ME Gold Chain Bracelet, you will have the ability to link what you love in a way that has never been done before. They have designed this lovely 14kt gold-plated Link Chain Bracelet that has endless styling possibilities. Two openable connectors are featured in the design, each crafted with grooved surfaces to better distinguish them from one another. In addition, there are four links connecting each styling connector and a carabiner clasp on the back. As a first step, we need to customize your luxurious gold-plated link chain according to your specifications. It is possible to replace four links with one double or one single link. Keep the original length or adjust it to suit you. It's your choice! Using the Pandora ME connectors, you can style up to two meaningful medallions or eight mini dangles on each one. Show the world the kind of person you are with your personal style. It is important to note that medallions with openable tops can be styled on closed-styling links as well. ME Gold Link Chain Bracelet, 20 cm. Only compatible with other Pandora ME items. Genuine Pandora Bracelets. For Pandora ME charms only. Hand-crafted using silver with a unique 14kt gold blend. Bracelet size is 20 cm. Product code: 569662C00-4.

GBP 110.00
2

Pandora ME Gold Link Chain Bracelet, 17.5cm

Pandora ME Gold Link Chain Bracelet, 17.5cm

With this 17.5 cm long Pandora ME Gold Chain Bracelet, you will have the ability to link what you love in a way that has never been done before. They have designed this lovely 14kt gold-plated Link Chain Bracelet that has endless styling possibilities. Two openable connectors are featured in the design, each crafted with grooved surfaces to better distinguish them from one another. In addition, there are four links connecting each styling connector and a carabiner clasp on the back. As a first step, we need to customize your luxurious gold-plated link chain according to your specifications. It is possible to replace four links with one double or one single link. Keep the original length or adjust it to suit you. It's your choice! Using the Pandora ME connectors, you can style up to two meaningful medallions or eight mini dangles on each one. Show the world the kind of person you are with your personal style. It is important to note that medallions with openable tops can be styled on closed-styling links as well. ME Gold Link Chain Bracelet, 17.5 cm. Only compatible with other Pandora ME items. Genuine Pandora Bracelet. For Pandora ME charms only. Crafted by hand using silver with a unique 14kt gold blend. Bracelet size is 17.5 cm. Product code: 569662C00-3.

GBP 110.00
2